昼夜免疫系统的发展。

IF 13.9 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-07-12 DOI:10.1016/j.it.2025.06.004

Xia Li, Paula Rothämel, Claudia Nussbaum, Markus Sperandio, Christoph Scheiermann

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引用次数: 0

摘要

昼夜节律是免疫功能的关键调节因子。这些内源性振荡有助于维持免疫稳态，调节对病原体的反应，并影响疫苗的效力。最近的研究进一步表明，它们在癌症免疫治疗中具有临床意义。尽管人们认为昼夜免疫节律在成人中很重要，但尚不清楚这些节律在发育的哪个阶段开始表现出来。在这篇观点文章中，我们回顾了啮齿动物和人类免疫系统中昼夜节律的发展，重点关注它们在围产期的相互作用。了解它们在生命早期的出现可能有助于指导基于时间的婴儿临床干预。

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Development of a circadian immune system.

Circadian rhythms are key regulators of immune functions. These endogenous oscillations help to maintain immune homeostasis, regulate responses to pathogens, and shape vaccine efficacy. Recent studies further indicate that they are of clinical relevance for cancer immunotherapies. While circadian immune rhythms are thus recognized to be important in adults, it is unknown at what developmental stage these rhythms begin to manifest. In this opinion article we review the development of circadian rhythms in the immune system in both rodents and humans, with a focus on their interactions during the perinatal period. Understanding their emergence in early life may help guide time-based clinical interventions for infants.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.