靶向WSTF降解治疗慢性炎症。

IF 13.9 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-07-29 DOI:10.1016/j.it.2025.07.009

Weiqiong Feng, Wenzhe She, Rong Xiang

引用次数: 0

摘要

慢性炎症导致骨关节炎和MASH等疾病，但其与急性炎症的分子区别尚不清楚。在最近的Nature研究中，Wang等人发现慢性应激通过核自噬触发WSTF降解，放大NF-κB反应。阻断这一途径可减轻慢性炎症，同时保留急性免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting WSTF degradation to resolve chronic inflammation.

Chronic inflammation drives diseases like osteoarthritis and MASH, yet its molecular distinction from acute inflammation remains unclear. In a recent Nature study, Wang et al. revealed that chronic stress triggers WSTF degradation via nuclear autophagy, amplifying NF-κB responses. Blocking this pathway attenuates chronic inflammation while sparing acute immunity.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.