Enlightening Per2-suasive role of neutrophils in antibacterial immunity.

IF 13.9 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-07-15 DOI:10.1016/j.it.2025.07.003

María Casanova-Acebes

引用次数: 0

Abstract

Neutrophil numbers fluctuate over time, peaking during active phases to enhance immunity. The molecular link between circadian signals and cellular clocks remains unclear. Yi Du et al. show that light-regulated Per2 increases reactive oxygen species (ROS) production and bacterial killing in zebrafish neutrophils by controlling Hmgb1 expression, highlighting the impact of light on immune function.

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中性粒细胞在抗菌免疫中的启蒙作用。

中性粒细胞数量随时间波动，在活跃阶段达到峰值以增强免疫力。昼夜节律信号和细胞时钟之间的分子联系尚不清楚。Yi Du等人的研究表明，光调节的Per2通过控制Hmgb1表达增加斑马鱼中性粒细胞中活性氧（ROS）的产生和细菌杀灭，突出了光对免疫功能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.