Breaking tolerance: an update of Treg dysfunction in autoimmunity.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-07-18 DOI:10.1016/j.it.2025.06.007

Nardos T Cheru, Yemi Osayame, Tomokazu S Sumida

引用次数: 0

Abstract

FOXP3⁺ regulatory T cells (Tregs) are essential for maintaining immune tolerance, and their dysfunction is a hallmark of autoimmune diseases. Recent studies have identified key transcriptional, metabolic, and environmental drivers of Treg instability and loss of function. Understanding these mechanisms opens new avenues for therapeutic interventions aimed at restoring immune homeostasis in autoimmunity.

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破坏耐受性：自身免疫中Treg功能障碍的最新进展。

FOXP3+调节性T细胞（Tregs）对于维持免疫耐受至关重要，其功能障碍是自身免疫性疾病的标志。最近的研究已经确定了Treg不稳定和功能丧失的关键转录、代谢和环境驱动因素。了解这些机制为旨在恢复自身免疫平衡的治疗干预开辟了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.