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Trends in Immunology最新文献

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Regional specialization within the mammalian respiratory immune system. 哺乳动物呼吸道免疫系统的区域特化。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.it.2024.09.011
David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni
{"title":"Regional specialization within the mammalian respiratory immune system.","authors":"David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni","doi":"10.1016/j.it.2024.09.011","DOIUrl":"10.1016/j.it.2024.09.011","url":null,"abstract":"<p><p>The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immune response along different areas of the respiratory tract has been lacking. Here, we discuss key recent findings regarding anatomical, functional, and microbial factors driving regional immune adaptation in the mammalian respiratory system, how they differ between mice and humans, and the similarities and differences with the gastrointestinal tract. We demonstrate that, under evolutionary pressure, mammals evolved spatially organized immune defenses that vary between the upper and lower respiratory tract. Overall, we propose that the functional specialization of the immune response along the respiratory tract has fundamental implications for the management of infectious or inflammatory diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"871-891"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal cord injury: T cells to the rescue? 脊髓损伤：T 细胞来救命？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-11 DOI: 10.1016/j.it.2024.10.001
Richard M Ransohoff
{"title":"Spinal cord injury: T cells to the rescue?","authors":"Richard M Ransohoff","doi":"10.1016/j.it.2024.10.001","DOIUrl":"10.1016/j.it.2024.10.001","url":null,"abstract":"<p><p>Gao, Kim, and colleagues recently reported that clonal populations of CD4<sup>+</sup> T cells could be detected in mice that underwent spinal cord injury (SCI). A subset of clones mediated enhanced motor recovery and suppressed inflammation. Further studies may point towards novel cell therapies for SCI, for which care is presently supportive only.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"849-850"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Channel plan: control of adaptive immune responses by pannexins. 通道计划：泛内联蛋白对适应性免疫反应的控制。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1016/j.it.2024.09.009
Igor Santiago-Carvalho, Masaki Ishikawa, Henrique Borges da Silva
{"title":"Channel plan: control of adaptive immune responses by pannexins.","authors":"Igor Santiago-Carvalho, Masaki Ishikawa, Henrique Borges da Silva","doi":"10.1016/j.it.2024.09.009","DOIUrl":"10.1016/j.it.2024.09.009","url":null,"abstract":"<p><p>The development of mammalian adaptive (i.e., B and T cell-mediated) immune responses is tightly controlled at transcriptional, epigenetic, and metabolic levels. Signals derived from the extracellular milieu are crucial regulators of adaptive immunity. Beyond the traditionally studied cytokines and chemokines, many other extracellular metabolites can bind to specialized receptors and regulate T and B cell immune responses. These molecules often accumulate extracellularly through active export by plasma membrane transporters. For example, mammalian immune and non-immune cells express pannexin (PANX)1-3 channels on the plasma membrane, which release many distinct small molecules, notably intracellular ATP. Here, we review novel findings defining PANXs as crucial regulators of T and B cell immune responses in disease contexts such as cancer or viral infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"892-902"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology. 构建多形核细胞：染色质折叠塑造核形态。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.it.2024.09.012
Cornelis Murre, Indumathi Patta, Shreya Mishra, Ming Hu
{"title":"Constructing polymorphonuclear cells: chromatin folding shapes nuclear morphology.","authors":"Cornelis Murre, Indumathi Patta, Shreya Mishra, Ming Hu","doi":"10.1016/j.it.2024.09.012","DOIUrl":"10.1016/j.it.2024.09.012","url":null,"abstract":"<p><p>Immune cell fate decisions are regulated, at least in part, by nuclear architecture. Here, we outline how nuclear architecture instructs mammalian polymorphonuclear cell differentiation. We discuss how in neutrophils loop extrusion mechanisms regulate the expression of genes involved in phagocytosis and shape nuclear morphology. We propose that diminished loop extrusion programs also orchestrate eosinophil and basophil differentiation. We portray a new model in which competitive physical forces, loop extrusion, and phase separation, instruct mononuclear versus polymorphonuclear cell fate decisions. We posit that loop extrusion programs instruct the spatial organization of cytoplasmic organelles, including neutrophil granules, mitochondria, and endoplasmic reticulum. Finally, we suggest that changing loop extrusion programs might allow the engineering of new nuclear shapes and artificial cytoplasmic architectures.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"851-860"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle. COVID-19 血栓炎症：炎症纤维蛋白之谜。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1016/j.it.2024.09.003
Elena Magrini, Cecilia Garlanda
{"title":"COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle.","authors":"Elena Magrini, Cecilia Garlanda","doi":"10.1016/j.it.2024.09.003","DOIUrl":"10.1016/j.it.2024.09.003","url":null,"abstract":"<p><p>Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin peptide protected mice from spike-dependent fibrin clotting and neuropathology.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"721-723"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Setting the tone: nociceptors as conductors of immune responses. 定调：作为免疫反应导体的痛觉感受器。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1016/j.it.2024.08.007
Pavel Hanč, Marie-Angèle Messou, Jainu Ajit, Ulrich H von Andrian
{"title":"Setting the tone: nociceptors as conductors of immune responses.","authors":"Pavel Hanč, Marie-Angèle Messou, Jainu Ajit, Ulrich H von Andrian","doi":"10.1016/j.it.2024.08.007","DOIUrl":"10.1016/j.it.2024.08.007","url":null,"abstract":"<p><p>Nociceptors have emerged as master regulators of immune responses in both homeostatic and pathologic settings; however, their seemingly contradictory effects on the functions of different immune cell subsets have been a source of confusion. Nevertheless, work by many groups in recent years has begun to identify patterns of the modalities and consequences of nociceptor-immune system communication. Here, we review recent findings of how nociceptors affect immunity and propose an integrated concept whereby nociceptors are neither inherently pro- nor anti-inflammatory. Rather, we propose that nociceptors have the role of a rheostat that, in a context-dependent manner, favors tissue homeostasis and fine-tunes immunity by preventing excessive histotoxic inflammation, promoting tissue repair, and potentiating anticipatory and adaptive immune responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"783-798"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease-associated oligodendroglia: a putative nexus in neurodegeneration. 与疾病相关的少突胶质细胞：神经退行性变的假定联系。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1016/j.it.2024.08.003
Gonçalo Castelo-Branco, Petra Kukanja, André O Guerreiro-Cacais, Leslie A Rubio Rodríguez-Kirby
{"title":"Disease-associated oligodendroglia: a putative nexus in neurodegeneration.","authors":"Gonçalo Castelo-Branco, Petra Kukanja, André O Guerreiro-Cacais, Leslie A Rubio Rodríguez-Kirby","doi":"10.1016/j.it.2024.08.003","DOIUrl":"10.1016/j.it.2024.08.003","url":null,"abstract":"<p><p>Neural cells in our central nervous system (CNS) have long been thought to be mere targets of neuroinflammatory events in neurodegenerative diseases such as multiple sclerosis (MS) or Alzheimer's disease. While glial populations such as microglia and astrocytes emerged as active responders and modifiers of pathological environments, oligodendroglia and neurons have been associated with altered homeostasis and eventual cell death. The advent of single-cell and spatial omics technologies has demonstrated transitions of CNS-resident glia, including oligodendroglia, into disease-associated (DA) states. Anchored in recent findings of their roles in MS, we propose that DA glia constitute key nexus of disease progression, with DA oligodendroglia contributing to the modulation of neuroinflammation in certain neurodegenerative diseases, constituting novel putative pharmacological targets for such pathologies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"750-759"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of astrocytes as immune effectors in the central nervous system. 星形胶质细胞作为中枢神经系统免疫效应因子的新作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.it.2024.08.008
Theodore M Fisher, Shane A Liddelow
{"title":"Emerging roles of astrocytes as immune effectors in the central nervous system.","authors":"Theodore M Fisher, Shane A Liddelow","doi":"10.1016/j.it.2024.08.008","DOIUrl":"10.1016/j.it.2024.08.008","url":null,"abstract":"<p><p>The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocytes have essential roles, such as providing neuron metabolic support, modulating synaptic function, and maintaining the blood-brain barrier (BBB). Recent evidence continues to underscore their functional heterogeneity and importance for CNS maintenance, as well as how these cells ensure optimal CNS and immune responses to disease, acute trauma, and infection. Advances in our understanding of neuroimmune interactions complement our knowledge of astrocyte functional heterogeneity, where astrocytes are now regarded as key effectors and propagators of immune signaling. This shift in perspective highlights the role of astrocytes not merely as support cells, but as active participants in CNS immune responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"824-836"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protect, repair, rewire, and defend. 保护、修复、重新接线和防御。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI: 10.1016/j.it.2024.09.008
Catarina Sacristán
{"title":"Protect, repair, rewire, and defend.","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.09.008","DOIUrl":"10.1016/j.it.2024.09.008","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"715-717"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Boosting peripheral immunity to fight neurodegeneration in the brain. 增强外周免疫力，对抗大脑神经变性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.it.2024.08.002
Michal Schwartz, Sarah Phoebeluc Colaiuta
{"title":"Boosting peripheral immunity to fight neurodegeneration in the brain.","authors":"Michal Schwartz, Sarah Phoebeluc Colaiuta","doi":"10.1016/j.it.2024.08.002","DOIUrl":"10.1016/j.it.2024.08.002","url":null,"abstract":"<p><p>Reciprocal communication between the brain and the immune system is essential for maintaining lifelong brain function. This interaction is mediated, at least in part, by immune cells recruited from both the circulation and niches at the borders of the brain. Here, we describe how immune exhaustion and senescence, even if not primary causative factors, can accelerate neurodegenerative diseases. We emphasize the role of a compromised peripheral immune system in driving neurodegeneration and discuss strategies for harnessing peripheral immunity to effectively treat neurodegenerative diseases, including the underlying mechanisms and opportunities for clinical translation. Specifically, we highlight the potential of boosting the immune system by blocking inhibitory checkpoint molecules to harness reparative immune cells in helping the brain to fight against neurodegeneration.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"760-767"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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