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Recombinant snake antivenoms get closer to the clinic. 重组蛇类抗蛇毒血清更接近临床。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI: 10.1016/j.it.2024.03.001
Andreas H Laustsen
{"title":"Recombinant snake antivenoms get closer to the clinic.","authors":"Andreas H Laustsen","doi":"10.1016/j.it.2024.03.001","DOIUrl":"10.1016/j.it.2024.03.001","url":null,"abstract":"<p><p>Snakebite envenomings kill ~100 000 victims each year and leave many more with permanent sequelae. Antivenoms have been available for more than 125 years but are in need of innovation. A new study by Khalek et al. highlights broadly neutralizing human monoclonal antibodies (mAbs) that might be used to develop recombinant antivenoms with superior therapeutic benefits.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"225-227"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11021923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation and impact of tumor-specific CD4+ T cells in cancer and immunotherapy. 肿瘤特异性 CD4+ T 细胞在癌症和免疫疗法中的调节和影响。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-19 DOI: 10.1016/j.it.2024.02.005
Mengdi Guo, Melissa Yi Ran Liu, David G Brooks
{"title":"Regulation and impact of tumor-specific CD4<sup>+</sup> T cells in cancer and immunotherapy.","authors":"Mengdi Guo, Melissa Yi Ran Liu, David G Brooks","doi":"10.1016/j.it.2024.02.005","DOIUrl":"10.1016/j.it.2024.02.005","url":null,"abstract":"<p><p>CD4<sup>+</sup> T cells are crucial in generating and sustaining immune responses. They orchestrate and fine-tune mammalian innate and adaptive immunity through cell-based interactions and the release of cytokines. The role of these cells in contributing to the efficacy of antitumor immunity and immunotherapy has just started to be uncovered. Yet, many aspects of the CD4<sup>+</sup> T cell response are still unclear, including the differentiation pathways controlling such cells during cancer progression, the external signals that program them, and how the combination of these factors direct ensuing immune responses or immune-restorative therapies. In this review, we focus on recent advances in understanding CD4<sup>+</sup> T cell regulation during cancer progression and the importance of CD4<sup>+</sup> T cells in immunotherapies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"303-313"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affinity-independent plasma cell differentiation in germinal centers. 生殖中心中不依赖亲缘关系的浆细胞分化
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-22 DOI: 10.1016/j.it.2024.03.002
Roser Tachó-Piñot, Carola G Vinuesa
{"title":"Affinity-independent plasma cell differentiation in germinal centers.","authors":"Roser Tachó-Piñot, Carola G Vinuesa","doi":"10.1016/j.it.2024.03.002","DOIUrl":"10.1016/j.it.2024.03.002","url":null,"abstract":"<p><p>The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of affinities and lack signatures of affinity-based selection. Therefore, commitment to the PC lineage is affinity independent.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"234-236"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking potential: the role of the electron transport chain in immunometabolism. 释放潜能：电子传递链在免疫代谢中的作用。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-18 DOI: 10.1016/j.it.2024.02.002
Alessia Zotta, Luke A J O'Neill, Maureen Yin
{"title":"Unlocking potential: the role of the electron transport chain in immunometabolism.","authors":"Alessia Zotta, Luke A J O'Neill, Maureen Yin","doi":"10.1016/j.it.2024.02.002","DOIUrl":"10.1016/j.it.2024.02.002","url":null,"abstract":"<p><p>The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially linked to reactive oxygen species (ROS) produced from Complexes I and III, recent research suggests that an intact ETC fueling ATP is needed. Complex II may be responsible for Th1 cell proliferation and in some cases, effector cytokine production. Complex III is required for regulatory T (Treg) cell function, while oxidative phosphorylation (OXPHOS) and Complexes I, IV, and V sustain proliferation and antibody production in B lymphocytes, with OXPHOS also being required for B regulatory (Breg) cell function. Despite challenges, the ETC shows therapeutic targeting potential for immune-related diseases and in immuno-oncology.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"259-273"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement: you gutsy thing! 补充：你真有胆量！
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI: 10.1016/j.it.2024.03.003
Claudia Kemper
{"title":"Complement: you gutsy thing!","authors":"Claudia Kemper","doi":"10.1016/j.it.2024.03.003","DOIUrl":"10.1016/j.it.2024.03.003","url":null,"abstract":"<p><p>Complement, traditionally perceived as a liver-derived and plasma-operative guardian against bloodborne pathogens, is increasingly recognized as a local and central player in tissue immunity. Two recent studies, by Xu et al. and Wu et al., validate this concept in the mouse gut, where extrahepatic, intestine-produced, and/or operative C3 protects against enteric infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"228-230"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140307894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipocalin-2: a novel potential therapy for GVHD. 脂质体蛋白-2：一种潜在的新疗法，可用于治疗风湿性关节炎。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-27 DOI: 10.1016/j.it.2024.03.004
Kate A Markey
{"title":"Lipocalin-2: a novel potential therapy for GVHD.","authors":"Kate A Markey","doi":"10.1016/j.it.2024.03.004","DOIUrl":"10.1016/j.it.2024.03.004","url":null,"abstract":"<p><p>Czech et al. used mouse models of allogeneic hematopoietic stem cell transplantation (allo-HCT) to investigate the role of lipocalin-2 (LCN2) as a newfound regulator of intestinal graft-versus-host disease (GVHD). Administration of recombinant LCN2 protein after disease onset prevented GVHD progression, suggesting that it may play a role in reversing tissue damage that has already begun.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"231-233"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunological features of bats: resistance and tolerance to emerging viruses 蝙蝠的免疫特征：对新病毒的抵抗力和耐受力
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-03-06 DOI: 10.1016/j.it.2024.01.008
Wael L. Demian, Olga Cormier, Karen Mossman
{"title":"Immunological features of bats: resistance and tolerance to emerging viruses","authors":"Wael L. Demian, Olga Cormier, Karen Mossman","doi":"10.1016/j.it.2024.01.008","DOIUrl":"https://doi.org/10.1016/j.it.2024.01.008","url":null,"abstract":"Bats are among the most diverse mammalian species, representing over 20% of mammalian diversity. The past two decades have witnessed a disproportionate spillover of viruses from bats to humans compared with other mammalian hosts, attributed to the viral richness within bats, their phylogenetic likeness to humans, and increased human contact with wildlife. Unique evolutionary adaptations in bat genomes, particularly in antiviral protection and immune tolerance genes, enable bats to serve as reservoirs for pandemic-inducing viruses. Here, we discuss current limitations and advances made in understanding the role of bats as drivers of pandemic zoonoses. We also discuss novel technologies that have revealed spatial, dynamic, and physiological factors driving virus and host coevolution.","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"7 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity. 肠道相关淋巴组织：微生物群驱动的 B 细胞免疫中心。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-03-01 Epub Date: 2024-02-23 DOI: 10.1016/j.it.2024.01.006
Mats Bemark, Michael J Pitcher, Chiara Dionisi, Jo Spencer
{"title":"Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity.","authors":"Mats Bemark, Michael J Pitcher, Chiara Dionisi, Jo Spencer","doi":"10.1016/j.it.2024.01.006","DOIUrl":"10.1016/j.it.2024.01.006","url":null,"abstract":"<p><p>The diverse gut microbiota, which is associated with mucosal health and general wellbeing, maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including sustainment of germinal centers in a context of high antigenic load. This influences the rules for B cell engagement with antigen and the potential consequences. Recent data have highlighted differences between GALT and other lymphoid tissues. For example, GALT propagates IgA responses against glycans that show signs of having been generated in germinal centers. Other findings suggest that humans are among those species where GALT supports the diversification, propagation, and possibly selection of systemic B cells. Here, we review novel findings that identify GALT as distinctive, and able to support these processes.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"211-223"},"PeriodicalIF":13.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The translational potential of studying bat immunity. 研究蝙蝠免疫的转化潜力。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-03-01 Epub Date: 2024-03-06 DOI: 10.1016/j.it.2024.01.007
Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee
{"title":"The translational potential of studying bat immunity.","authors":"Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee","doi":"10.1016/j.it.2024.01.007","DOIUrl":"10.1016/j.it.2024.01.007","url":null,"abstract":"<p><p>Molecular studies in bats have led to the discovery of antiviral adaptations that may explain how some bat species have evolved enhanced immune tolerance towards viruses. Accumulating data suggest that some bat species have also evolved remarkable features of longevity and low rates of cancer. Furthermore, recent research strongly suggests that discovering immune adaptations in bat models can be translated to develop immune modulators and recognize alternate therapeutic strategies for diseases affecting humans. We posit that research in bat immunology will lead to discoveries that can potentially be translated to improve health outcomes in humans.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"188-197"},"PeriodicalIF":16.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tumor niche can reprogram long-lived protumorigenic neutrophils. 肿瘤龛可对长寿命的原癌中性粒细胞进行重编程。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-03-01 Epub Date: 2024-02-23 DOI: 10.1016/j.it.2024.02.001
Jiaming Wang, Xuetao Cao
{"title":"The tumor niche can reprogram long-lived protumorigenic neutrophils.","authors":"Jiaming Wang, Xuetao Cao","doi":"10.1016/j.it.2024.02.001","DOIUrl":"10.1016/j.it.2024.02.001","url":null,"abstract":"<p><p>The heterogeneity and plasticity of neutrophils in tumor-host interactions and how tumor signals induce reprogramming of neutrophil subpopulations need further investigation. Ng et al. recently reported that a hypoxic-glycolytic niche in mouse tumors could reprogram mature and immature neutrophils into a long-lived and terminally-differentiated subset, which promoted angiogenesis and tumor growth.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"155-157"},"PeriodicalIF":16.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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