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IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-13 DOI: 10.1016/s1471-4906(24)00115-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00115-7","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00115-7","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"43 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141524518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction of the cover caption and Editorial of Trends in Immunology Volume 45, Issue 5 (May 2024): (Trends in Immunology, 45:5 p:315-317, 2024). 更正《免疫学趋势》第 45 卷第 5 期（2024 年 5 月）的封面标题和社论：(免疫学趋势》，45:5 p:315-317, 2024）。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-30 DOI: 10.1016/j.it.2024.05.003
Catarina Sacristán
{"title":"Correction of the cover caption and Editorial of Trends in Immunology Volume 45, Issue 5 (May 2024): (Trends in Immunology, 45:5 p:315-317, 2024).","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.05.003","DOIUrl":"10.1016/j.it.2024.05.003","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"482"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages marc(o) the difference in liver inflammation? 巨噬细胞在肝脏炎症中的作用？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-23 DOI: 10.1016/j.it.2024.05.002
Christian Zwicker, Charlotte L Scott
{"title":"Macrophages marc(o) the difference in liver inflammation?","authors":"Christian Zwicker, Charlotte L Scott","doi":"10.1016/j.it.2024.05.002","DOIUrl":"10.1016/j.it.2024.05.002","url":null,"abstract":"<p><p>Miyamoto et al. report that Marco expression demarcates a population of IL-10-expressing immunosuppressive Kupffer cells (KCs) that are preferentially peri-portally located in the mouse liver, and which limit bacterial dissemination and liver inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"400-402"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid-liquid phase separation in innate immunity. 先天性免疫中的液-液相分离
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-17 DOI: 10.1016/j.it.2024.04.009
Dawei Liu, Jinhang Yang, Ileana M Cristea
{"title":"Liquid-liquid phase separation in innate immunity.","authors":"Dawei Liu, Jinhang Yang, Ileana M Cristea","doi":"10.1016/j.it.2024.04.009","DOIUrl":"10.1016/j.it.2024.04.009","url":null,"abstract":"<p><p>Intrinsic and innate immune responses are essential lines of defense in the body's constant surveillance of pathogens. The discovery of liquid-liquid phase separation (LLPS) as a key regulator of this primal response to infection brings an updated perspective to our understanding of cellular defense mechanisms. Here, we review the emerging multifaceted role of LLPS in diverse aspects of mammalian innate immunity, including DNA and RNA sensing and inflammasome activity. We discuss the intricate regulation of LLPS by post-translational modifications (PTMs), and the subversive tactics used by viruses to antagonize LLPS. This Review, therefore, underscores the significance of LLPS as a regulatory node that offers rapid and plastic control over host immune signaling, representing a promising target for future therapeutic strategies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"454-469"},"PeriodicalIF":13.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11247960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Humoral pathways of innate immune regulation in granuloma formation. 肉芽肿形成过程中先天免疫调节的体液途径
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-17 DOI: 10.1016/j.it.2024.04.008
Diana Santos-Ribeiro, Cristina Cunha, Agostinho Carvalho
{"title":"Humoral pathways of innate immune regulation in granuloma formation.","authors":"Diana Santos-Ribeiro, Cristina Cunha, Agostinho Carvalho","doi":"10.1016/j.it.2024.04.008","DOIUrl":"10.1016/j.it.2024.04.008","url":null,"abstract":"<p><p>The humoral arm of mammalian innate immunity regulates several molecular mechanisms involved in resistance to pathogens, inflammation, and tissue repair. Recent studies highlight the crucial role played by humoral mediators in granulomatous inflammation. However the molecular mechanisms linking the function of these soluble molecules to the initiation and maintenance of granulomas remain elusive. We propose that humoral innate immunity coordinates fundamental physiological processes in macrophages which, in turn, initiate activation and transformation events that enable granuloma formation. We discuss the involvement of humoral mediators in processes such as immune activation, phagocytosis, metabolism, and tissue remodeling, and how these can dictate macrophage functionality during granuloma formation. These advances present opportunities for discovering novel disease factors and developing targeted, more effective treatments for granulomatous diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"419-427"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial features of skip lesions in Crohn's disease. 克罗恩病跳灶的空间特征。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI: 10.1016/j.it.2024.04.011
Rachel Herren, Naama Geva-Zatorsky
{"title":"Spatial features of skip lesions in Crohn's disease.","authors":"Rachel Herren, Naama Geva-Zatorsky","doi":"10.1016/j.it.2024.04.011","DOIUrl":"10.1016/j.it.2024.04.011","url":null,"abstract":"<p><p>Skip lesions are an enigmatic spatial feature characterizing Crohn's disease (CD). They comprise inflamed and adjacent non-inflamed tissue sections with a clear demarcation. Currently, spatial features of the human gastrointestinal (GI) system lack clarity regarding the organization of microbes, mucus, tissue, and host cells during inflammation. New technologies with multiplexing abilities and innovative approaches provide ways of examining the spatial organization of inflamed and non-inflamed tissues in CD, which may open new avenues for diagnosis, prognosis, and treatment. In this review, we present evidence of the relevance of spatial context in patients with CD and the methods and ideas recently published in studies of spatiality during inflammation. With this review, we aim to provide inspiration for further research to address existing gaps.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"470-481"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD8 is down(regulated) for tolerance. CD8 下调（调节）是为了获得耐受性。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-22 DOI: 10.1016/j.it.2024.04.012
Noé Rodríguez-Rodríguez, Florencia Rosetti, José C Crispín
{"title":"CD8 is down(regulated) for tolerance.","authors":"Noé Rodríguez-Rodríguez, Florencia Rosetti, José C Crispín","doi":"10.1016/j.it.2024.04.012","DOIUrl":"10.1016/j.it.2024.04.012","url":null,"abstract":"<p><p>Activated CD8<sup>+</sup> T cells directly kill target cells. Therefore, the regulation of their function is central to avoiding immunopathology. Mechanisms that curb effector functions in CD4<sup>+</sup> and CD8<sup>+</sup> T cells are mostly shared, yet important differences occur. Here, we focus on the control of CD8<sup>+</sup> T cell activity and discuss the importance of a poorly understood aspect of tolerance that directly impairs engagement of target cells: the downregulation of CD8. We contextualize this process and propose that it represents a key element during CD8<sup>+</sup> T cell modulation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"442-453"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141088405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gasdermin D palmitoylation: to cleave or not to cleave? Gasdermin D棕榈酰化：裂解还是不裂解？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.1016/j.it.2024.05.001
Laurel Stine, Fiachra Humphries
{"title":"Gasdermin D palmitoylation: to cleave or not to cleave?","authors":"Laurel Stine, Fiachra Humphries","doi":"10.1016/j.it.2024.05.001","DOIUrl":"10.1016/j.it.2024.05.001","url":null,"abstract":"<p><p>Recent studies have identified Cys<sup>191</sup> in gasdermin D (GSDMD) as a highly targeted regulatory module controlling pyroptosis. Using chemical biology and genetic models, Du, Healy et al. recently identified GSDMD palmitoylation as a key regulatory step in GSDMD activation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"403-405"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease 慢性阻塞性肺病中树突状细胞、自然杀伤细胞和调节性 T 细胞之间失调的串扰模型
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-18 DOI: 10.1016/j.it.2024.04.010
Dawit T. Mengistu, Jeffrey L. Curtis, Christine M. Freeman
{"title":"A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease","authors":"Dawit T. Mengistu, Jeffrey L. Curtis, Christine M. Freeman","doi":"10.1016/j.it.2024.04.010","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.010","url":null,"abstract":"<p>Chronic obstructive pulmonary disease (COPD) is characterized by infiltration of the airways and lung parenchyma by inflammatory cells. Lung pathology results from the cumulative effect of complex and aberrant interactions between multiple cell types. However, three cell types, natural killer cells (NK), dendritic cells (DCs), and regulatory T cells (Tregs), are understudied and underappreciated. We propose that their mutual interactions significantly contribute to the development of COPD. Here, we highlight recent advances in NK, DC, and Treg biology with relevance to COPD, discuss their pairwise bidirectional interactions, and identify knowledge gaps that must be bridged to develop novel therapies. Understanding their interactions will be crucial for therapeutic use of autologous Treg, an approach proving effective in other diseases with immune components.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"29 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141061388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-10 DOI: 10.1016/s1471-4906(24)00088-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00088-7","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00088-7","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"44 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140934507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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