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Modulation of host immunity by sensory neurons 感觉神经元对宿主免疫力的调节
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-01 DOI: 10.1016/j.it.2024.03.005
Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro
{"title":"Modulation of host immunity by sensory neurons","authors":"Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro","doi":"10.1016/j.it.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.005","url":null,"abstract":"<p>Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary research field.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"81 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partners and guardians of the nervous and immune systems 神经和免疫系统的伙伴和守护者
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-30 DOI: 10.1016/j.it.2024.04.007
Catarina Sacristán
{"title":"Partners and guardians of the nervous and immune systems","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.007","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"18 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory neuronal control of skin barrier immunity 皮肤屏障免疫的感觉神经元控制
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-22 DOI: 10.1016/j.it.2024.03.008
Xinyi Feng, Haoting Zhan, Caroline L. Sokol
{"title":"Sensory neuronal control of skin barrier immunity","authors":"Xinyi Feng, Haoting Zhan, Caroline L. Sokol","doi":"10.1016/j.it.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.008","url":null,"abstract":"<p>Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products and allergens traditionally thought to be targets of the mammalian immune system. Activation of sensory neurons by these stimuli leads to pain and itch responses as well as the release of neuropeptides that interact with their cognate receptors expressed on immune cells, such as dendritic cells (DCs). Neuronal control of immune cell function through neuropeptide release not only affects local inflammatory responses but can impact adaptive immune responses through downstream effects on T cell priming. Numerous neuropeptide receptors are expressed by DCs but only a few have been characterized, presenting opportunities for further investigation of the pathways by which cutaneous neuroimmune interactions modulate host immunity.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"69 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond antiviral: role of IFN-I in brain development 超越抗病毒：IFN-I 在大脑发育中的作用
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-20 DOI: 10.1016/j.it.2024.04.004
Christopher A. Baker, Akiko Iwasaki
{"title":"Beyond antiviral: role of IFN-I in brain development","authors":"Christopher A. Baker, Akiko Iwasaki","doi":"10.1016/j.it.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.004","url":null,"abstract":"<p>Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, <span>Escoubas, Dorman, <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"38 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement(ing) long-COVID thromboinflammation and pathogenesis 补充长期 COVID 血栓炎症和发病机制
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-17 DOI: 10.1016/j.it.2024.04.001
John D. Lee, Trent M. Woodruff
{"title":"Complement(ing) long-COVID thromboinflammation and pathogenesis","authors":"John D. Lee, Trent M. Woodruff","doi":"10.1016/j.it.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.001","url":null,"abstract":"<p>The persistence or recurrence of symptoms after acute SARS-CoV-2 infection, termed ‘long COVID’, presents a formidable challenge to global healthcare systems. Recent research by <span>Cervia-Hasler and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> delves into the intricate immunological landscape in patients with long COVID, demonstrating an interplay between complement and coagulation, driven by antiviral antibodies and tissue damage.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"21 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoid tissue on the mind 心灵上的淋巴组织
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-17 DOI: 10.1016/j.it.2024.04.002
Nikhita Kirthivasan, Jason G. Cyster
{"title":"Lymphoid tissue on the mind","authors":"Nikhita Kirthivasan, Jason G. Cyster","doi":"10.1016/j.it.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.002","url":null,"abstract":"<p>To surveil an organ for pathogens, lymphoid structures need to sample antigens locally. The full set of lymphoid structures involved in surveilling for brain-tropic pathogens has not been defined. Through comprehensive imaging of the mouse meninges, a new study by <span>Fitzpatrick <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> describes dural-associated lymphoid tissue (DALT) and its contribution to humoral responses following intranasal viral infection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"132 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocytes ACLYmate to chronic neuroinflammation 星形胶质细胞与慢性神经炎症的 ACLYmate
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-16 DOI: 10.1016/j.it.2024.04.003
Kevin Champagne-Jorgensen, Jennifer Gommerman
{"title":"Astrocytes ACLYmate to chronic neuroinflammation","authors":"Kevin Champagne-Jorgensen, Jennifer Gommerman","doi":"10.1016/j.it.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.003","url":null,"abstract":"<p>Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. <span>Lee and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS).</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"122 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease? 脑边界相关巨噬细胞：感染、衰老和阿尔茨海默病的共同特征？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-16 DOI: 10.1016/j.it.2024.03.007
Sandro Da Mesquita, Rejane Rua
{"title":"Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?","authors":"Sandro Da Mesquita, Rejane Rua","doi":"10.1016/j.it.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.007","url":null,"abstract":"<p>Mammalian brain border-associated macrophages (BAMs) are strategically positioned to support vital properties and processes: for example, the composition of the brain’s perivascular extracellular matrix and cerebrospinal fluid flow via the glymphatic pathway. BAMs also effectively restrict the spread of infectious microbes into the brain. However, while fighting infections, BAMs sustain long-term transcriptomic changes and can be replaced by inflammatory monocytes, potentially leading to a gradual loss of their beneficial homeostatic functions. We hypothesize that by expediting the deterioration of BAMs, multiple infection episodes might be associated with accelerated brain aging and the putative development of neurodegenerative diseases. Our viewpoint is supported by recent studies suggesting that rejuvenating aged BAMs, and counterbalancing their detrimental inflammatory signatures during infections, might hold promise in treating aging-related neurological disorders, including Alzheimer’s disease (AD).</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"40 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia pack a toolbox for life 小胶质细胞的生命工具箱
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-13 DOI: 10.1016/j.it.2024.03.010
Kristine E. Zengeler, John R. Lukens
{"title":"Microglia pack a toolbox for life","authors":"Kristine E. Zengeler, John R. Lukens","doi":"10.1016/j.it.2024.03.010","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.010","url":null,"abstract":"<p>After decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain proper neural network functions, as well as orchestrate responses to toxic stimuli to limit harm. Many microglial transcriptional programs, extracellular sensing molecules, and functional outputs are seen throughout life. A stark example is the similarity of microglial responses to stressors during neurodevelopment and neurodegeneration. The same themes often match that of other tissue-resident macrophages, presenting an opportunity to apply known concepts as therapeutics develop. We argue that microglial signaling during development and neurologic disease overlap with one another and with other tissue-resident macrophage pathways, in part due to similar sensed stimuli and a conserved sensome of receptors and signaling molecules, akin to a toolkit.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"141 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-11 DOI: 10.1016/s1471-4906(24)00055-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00055-3","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00055-3","url":null,"abstract":"Abstract not available","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"98 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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