COVID-19 血栓炎症：炎症纤维蛋白之谜。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI:10.1016/j.it.2024.09.003

Elena Magrini, Cecilia Garlanda

引用次数: 0

摘要

血栓栓塞性炎症是急性 COVID-19 发病机制中一个特殊而关键的组成部分，它导致了长 COVID。在最近的一项研究中，Ryu 等人证明，SARS-CoV-2 穗状病毒蛋白与纤维蛋白原相互作用，促进纤维蛋白聚合及其炎症活性。靶向炎性纤维蛋白肽可保护小鼠免受穗状蛋白依赖性纤维蛋白凝结和神经病理学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle.

Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate that the SARS-CoV-2 spike protein interacts with fibrinogen, promoting fibrin polymerization and its inflammatory activity. Targeting the inflammatory fibrin peptide protected mice from spike-dependent fibrin clotting and neuropathology.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.