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Contribution of gut-derived T cells to extraintestinal autoimmune diseases. 肠源性 T 细胞对肠外自身免疫性疾病的影响
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI: 10.1016/j.it.2024.07.006
Qiaolin Wang, Yutong Wu, Qianjin Lu, Ming Zhao
{"title":"Contribution of gut-derived T cells to extraintestinal autoimmune diseases.","authors":"Qiaolin Wang, Yutong Wu, Qianjin Lu, Ming Zhao","doi":"10.1016/j.it.2024.07.006","DOIUrl":"10.1016/j.it.2024.07.006","url":null,"abstract":"<p><p>The mammalian intestine harbors abundant T cells with high motility, where these cells can affect both intestinal and extraintestinal disorders. Growing evidence shows that gut-derived T cells migrate to extraintestinal organs, contributing to the pathogenesis of certain autoimmune diseases, including type 1 diabetes (T1D) and multiple sclerosis (MS). However, three key questions require further elucidation. First, how do intestinal T cells egress from the intestine? Second, how do gut-derived T cells enter organs outside the gut? Third, what is the pathogenicity of gut-derived T cells and their correlation with the gut microenvironment? In this Opinion, we propose answers to these questions. Understanding the migration and functional regulation of gut-derived T cells might inform precise targeting for achieving safe and effective approaches to treat certain extraintestinal autoimmune diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"639-648"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Restriction factors regulating human herpesvirus infections. 调节人类疱疹病毒感染的限制因子。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-27 DOI: 10.1016/j.it.2024.07.010
Manutea C Serrero, Søren R Paludan
{"title":"Restriction factors regulating human herpesvirus infections.","authors":"Manutea C Serrero, Søren R Paludan","doi":"10.1016/j.it.2024.07.010","DOIUrl":"10.1016/j.it.2024.07.010","url":null,"abstract":"<p><p>Herpesviruses are DNA viruses and the cause of diseases ranging from mild skin conditions to severe brain diseases. Mammalian antiviral host defense comprises an array of mechanisms, including restriction factors (RFs), which block specific steps in viral replication cycles. In recent years, knowledge of RFs that contribute to controlling herpesvirus infections has expanded significantly, along with a new understanding of viral evasion mechanisms and disease pathogenesis. By integrating findings from human genetics, murine models, and cellular studies, this review provides a current view of RF control of herpesvirus infections. We also explore the regulation of RF expression, discuss the roles of RFs in diseases, and point towards their growing potential as candidate therapeutic targets.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"662-677"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The extracellular matrix in solid tumor immunotherapy. 实体瘤免疫疗法中的细胞外基质。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI: 10.1016/j.it.2024.07.009
Yongbum Cho, Junsang Doh
{"title":"The extracellular matrix in solid tumor immunotherapy.","authors":"Yongbum Cho, Junsang Doh","doi":"10.1016/j.it.2024.07.009","DOIUrl":"10.1016/j.it.2024.07.009","url":null,"abstract":"<p><p>The extracellular matrix (ECM) of solid tumors impacts the antitumor activities of CD8<sup>+</sup> T and natural killer (NK) cells in a variety of ways. Cell motility is restricted by the tumor ECM which creates physical barriers. The tumor ECM directly alter the phenotypes and functions of cytotoxic lymphocytes, and indirectly influences immunological synapse-mediated interactions between cytotoxic lymphocytes and cancer cells. Therefore, strategies to improve solid tumor immunotherapy should be established by considering complex ternary interactions between cytotoxic lymphocytes, cancer cells, and the tumor ECM. Novel bioengineering tools approximating key characteristics of the tumor ECM, such as in vitro reconstituted 3D ECMs and microfluidics are valuable from a fundamental study viewpoint and from a translational perspective, aiming to enable systematic screening approaches.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"705-714"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BCR signaling in germinal center B cell selection. 生殖中心 B 细胞选择中的 BCR 信号转导
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-20 DOI: 10.1016/j.it.2024.07.005
Takeshi Inoue, Yoshihiro Baba, Tomohiro Kurosaki
{"title":"BCR signaling in germinal center B cell selection.","authors":"Takeshi Inoue, Yoshihiro Baba, Tomohiro Kurosaki","doi":"10.1016/j.it.2024.07.005","DOIUrl":"10.1016/j.it.2024.07.005","url":null,"abstract":"<p><p>When mature B cells are activated by antigens, the selection of these activated B cells takes place particularly during T cell-dependent immune responses in which an improved antibody repertoire is generated through somatic hypermutation in germinal centers (GCs). In this process the importance of antigen presentation by GC B cells, and subsequent T follicular helper (Tfh) cell help in positive selection of GC B cells, has been well appreciated. By contrast, the role of B cell receptor (BCR) signaling per se remains unclear. Strong experimental support for the involvement of BCR signaling in GC B cell selection has now been provided. Interestingly, these studies suggest that several checkpoints operating through the BCR ensure affinity maturation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"693-704"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-08-08 DOI: 10.1016/s1471-4906(24)00172-8
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00172-8","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00172-8","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"2010 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-08-08 DOI: 10.1016/s1471-4906(24)00163-7
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00163-7","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00163-7","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"27 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141935565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective non-neutralizing SARS-CoV-2 monoclonal antibodies. 保护性非中和性 SARS-CoV-2 单克隆抗体。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-20 DOI: 10.1016/j.it.2024.06.003
Arman Izadi, Pontus Nordenfelt
{"title":"Protective non-neutralizing SARS-CoV-2 monoclonal antibodies.","authors":"Arman Izadi, Pontus Nordenfelt","doi":"10.1016/j.it.2024.06.003","DOIUrl":"10.1016/j.it.2024.06.003","url":null,"abstract":"<p><p>Recent studies show an important role for non-neutralizing anti-spike antibodies, including monoclonal antibodies (mAbs), in robustly protecting against SARS-CoV-2 infection. These mAbs use Fc-mediated functions such as complement activation, phagocytosis, and cellular cytotoxicity. There is an untapped potential for using non-neutralizing mAbs in durable antibody treatments; because of their available conserved epitopes, they may not be as sensitive to virus mutations as neutralizing mAbs. Here, we discuss evidence of non-neutralizing mAb-mediated protection against SARS-CoV-2 infection. We explore how non-neutralizing mAb Fc-mediated functions can be enhanced via novel antibody-engineering techniques. Important questions remain to be answered regarding the characteristics of protective non-neutralizing mAbs, including the models and assays used for study, the risks of ensuing detrimental inflammation, as well as the durability and mechanisms of protection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"609-624"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141735675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aching to defend: spleen innervation drives humoral immunity. 渴望防御：脾脏神经支配驱动体液免疫。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-25 DOI: 10.1016/j.it.2024.07.004
Tuany Eichwald, Sebastien Talbot
{"title":"Aching to defend: spleen innervation drives humoral immunity.","authors":"Tuany Eichwald, Sebastien Talbot","doi":"10.1016/j.it.2024.07.004","DOIUrl":"10.1016/j.it.2024.07.004","url":null,"abstract":"<p><p>The immune and sensory nervous systems communicate to maintain homeostasis. Wu et al. recently demonstrated that sensory neurons innervate the mouse spleen. These neurons promote calcitonin gene-related peptide (CGRP)-dependent responses in splenic B cell germinal centers (GCs) and antigen-specific antibody production. Dietary capsaicin activates these neurons to enhance humoral immunity against influenza virus infection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"574-576"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. VAV1 作为自身免疫性疾病和慢性炎症性疾病的潜在治疗靶点。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-26 DOI: 10.1016/j.it.2024.06.004
Markus F Neurath, Leslie J Berg
{"title":"VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases.","authors":"Markus F Neurath, Leslie J Berg","doi":"10.1016/j.it.2024.06.004","DOIUrl":"10.1016/j.it.2024.06.004","url":null,"abstract":"<p><p>The guanine nucleotide exchange factor (GEF) VAV1, a previously 'undruggable' protein integral to T/B lymphocyte antigen-receptor signaling, promotes actin polymerization, immunological synapse formation, T cell activation and differentiation, and cytokine production. With the development of novel modalities for targeting proteins, we hypothesize that interventions targeting VAV1 will have therapeutic potential in T and T/B cell-mediated autoimmune and chronic inflammatory diseases. This opinion is supported by recent CRISPR-Cas9 studies showing VAV1 as a key positive regulator of T cell receptor (TCR) activation and cytokine production in primary human CD4<sup>+</sup> and CD8<sup>+</sup> T cells; data demonstrating that loss/suppression of VAV1 regulates autoimmunity and inflammation; and promising preclinical data from T and T/B cell-mediated disease models of arthritis and colitis showing the effectiveness of selective VAV1 targeting via protein degradation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"580-596"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious diseases and discrimination: Sicily's Lampedusa migrants. 传染病与歧视：西西里岛的兰佩杜萨岛移民。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-11 DOI: 10.1016/j.it.2024.06.002
Bruno Douradinha
{"title":"Infectious diseases and discrimination: Sicily's Lampedusa migrants.","authors":"Bruno Douradinha","doi":"10.1016/j.it.2024.06.002","DOIUrl":"10.1016/j.it.2024.06.002","url":null,"abstract":"<p><p>Lampedusa, a picturesque Italian island in the Mediterranean, serves as a gateway for migrants from Africa and Asia to Europe. Despite populist rhetoric portraying migrants as carriers of disease, epidemiological data reveal very low levels of communicable diseases among migrants, challenging false narratives and xenophobic sentiments propagated by populist governments.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"577-579"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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