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Astrocytes ACLYmate to chronic neuroinflammation 星形胶质细胞与慢性神经炎症的 ACLYmate
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-16 DOI: 10.1016/j.it.2024.04.003
Kevin Champagne-Jorgensen, Jennifer Gommerman
{"title":"Astrocytes ACLYmate to chronic neuroinflammation","authors":"Kevin Champagne-Jorgensen, Jennifer Gommerman","doi":"10.1016/j.it.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.003","url":null,"abstract":"<p>Astrocytes are essential cells of the mammalian central nervous system (CNS), with key roles in development, homeostasis, and disease. <span>Lee and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> recently showed that astrocytes can develop epigenetic memory, which enhances proinflammatory responses to subsequent stimulation, potentially driving sustained neurological disease pathology, such as in multiple sclerosis (MS).</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"122 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease? 脑边界相关巨噬细胞：感染、衰老和阿尔茨海默病的共同特征？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-16 DOI: 10.1016/j.it.2024.03.007
Sandro Da Mesquita, Rejane Rua
{"title":"Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?","authors":"Sandro Da Mesquita, Rejane Rua","doi":"10.1016/j.it.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.007","url":null,"abstract":"<p>Mammalian brain border-associated macrophages (BAMs) are strategically positioned to support vital properties and processes: for example, the composition of the brain’s perivascular extracellular matrix and cerebrospinal fluid flow via the glymphatic pathway. BAMs also effectively restrict the spread of infectious microbes into the brain. However, while fighting infections, BAMs sustain long-term transcriptomic changes and can be replaced by inflammatory monocytes, potentially leading to a gradual loss of their beneficial homeostatic functions. We hypothesize that by expediting the deterioration of BAMs, multiple infection episodes might be associated with accelerated brain aging and the putative development of neurodegenerative diseases. Our viewpoint is supported by recent studies suggesting that rejuvenating aged BAMs, and counterbalancing their detrimental inflammatory signatures during infections, might hold promise in treating aging-related neurological disorders, including Alzheimer’s disease (AD).</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"40 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia pack a toolbox for life 小胶质细胞的生命工具箱
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-13 DOI: 10.1016/j.it.2024.03.010
Kristine E. Zengeler, John R. Lukens
{"title":"Microglia pack a toolbox for life","authors":"Kristine E. Zengeler, John R. Lukens","doi":"10.1016/j.it.2024.03.010","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.010","url":null,"abstract":"<p>After decades of being overlooked, a recent wave of studies have explored the roles of microglia in brain health and disease. Microglia perform important physiological functions to set up and maintain proper neural network functions, as well as orchestrate responses to toxic stimuli to limit harm. Many microglial transcriptional programs, extracellular sensing molecules, and functional outputs are seen throughout life. A stark example is the similarity of microglial responses to stressors during neurodevelopment and neurodegeneration. The same themes often match that of other tissue-resident macrophages, presenting an opportunity to apply known concepts as therapeutics develop. We argue that microglial signaling during development and neurologic disease overlap with one another and with other tissue-resident macrophage pathways, in part due to similar sensed stimuli and a conserved sensome of receptors and signaling molecules, akin to a toolkit.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"141 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-11 DOI: 10.1016/s1471-4906(24)00055-3
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00055-3","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00055-3","url":null,"abstract":"Abstract not available","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"98 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-11 DOI: 10.1016/s1471-4906(24)00052-8
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00052-8","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00052-8","url":null,"abstract":"Abstract not available","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"21 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Will cellular immunotherapies end neurodegenerative diseases? 细胞免疫疗法能否终结神经退行性疾病？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-09 DOI: 10.1016/j.it.2024.03.006
Pavle Boskovic, Wenqing Gao, Jonathan Kipnis
{"title":"Will cellular immunotherapies end neurodegenerative diseases?","authors":"Pavle Boskovic, Wenqing Gao, Jonathan Kipnis","doi":"10.1016/j.it.2024.03.006","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.006","url":null,"abstract":"<p>Neurodegenerative disorders present major challenges to global health, exacerbated by an aging population and the absence of therapies. Despite diverse pathological manifestations, they share a common hallmark, loosely termed ‘neuroinflammation’. The prevailing dogma is that the immune system is an active contributor to neurodegeneration; however, recent evidence challenges this. By analogy with road construction, which causes temporary closures and disruptions, the immune system’s actions in the central nervous system (CNS) might initially appear destructive, and might even cause harm, while aiming to combat neurodegeneration. We propose that the application of cellular immunotherapies to coordinate the immune response towards remodeling might pave the way for new modes of tackling the roadblocks of neurodegenerative diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"122 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140624691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for studying human macrophages 研究人类巨噬细胞的方法
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-04 DOI: 10.1016/j.it.2024.02.007
Yuzhou Bao, Guanlin Wang, Hanjie Li
{"title":"Approaches for studying human macrophages","authors":"Yuzhou Bao, Guanlin Wang, Hanjie Li","doi":"10.1016/j.it.2024.02.007","DOIUrl":"https://doi.org/10.1016/j.it.2024.02.007","url":null,"abstract":"Macrophages are vital tissue components involved in organogenesis, maintaining homeostasis, and responses to disease. Mouse models have significantly improved our understanding of macrophages. Further investigations into the characteristics and development of human macrophages are crucial, considering the substantial anatomical and physiological distinctions between mice and humans. Despite challenges in human macrophage research, recent studies are shedding light on the ontogeny and function of human macrophages. In this opinion, we propose combinations of cutting-edge approaches to examine the diversity, development, niche, and function of human tissue-resident macrophages. These methodologies can facilitate our exploration of human macrophages more efficiently, ideally providing new therapeutic avenues for macrophage-relevant disorders.","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"124 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140564748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipopolysaccharide delivery systems in innate immunity. 先天性免疫中的脂多糖输送系统。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-16 DOI: 10.1016/j.it.2024.02.003
Jiao Liu, Rui Kang, Daolin Tang
{"title":"Lipopolysaccharide delivery systems in innate immunity.","authors":"Jiao Liu, Rui Kang, Daolin Tang","doi":"10.1016/j.it.2024.02.003","DOIUrl":"10.1016/j.it.2024.02.003","url":null,"abstract":"<p><p>Lipopolysaccharide (LPS), a key component of the outer membrane in Gram-negative bacteria (GNB), is widely recognized for its crucial role in mammalian innate immunity and its link to mortality in intensive care units. While its recognition via the Toll-like receptor (TLR)-4 receptor on cell membranes is well established, the activation of the cytosolic receptor caspase-11 by LPS is now known to lead to inflammasome activation and subsequent induction of pyroptosis. Nevertheless, a fundamental question persists regarding the mechanism by which LPS enters host cells. Recent investigations have identified at least four primary pathways that can facilitate this process: bacterial outer membrane vesicles (OMVs); the spike (S) protein of SARS-CoV-2; host-secreted proteins; and host extracellular vesicles (EVs). These delivery systems provide new avenues for therapeutic interventions against sepsis and infectious diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"274-287"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140144580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammasome diversity: exploring novel frontiers in the innate immune response. 炎症小体多样性：探索先天性免疫反应的新前沿。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-21 DOI: 10.1016/j.it.2024.02.004
Gyeongju Yu, Young Ki Choi, SangJoon Lee
{"title":"Inflammasome diversity: exploring novel frontiers in the innate immune response.","authors":"Gyeongju Yu, Young Ki Choi, SangJoon Lee","doi":"10.1016/j.it.2024.02.004","DOIUrl":"10.1016/j.it.2024.02.004","url":null,"abstract":"<p><p>Pathogens elicit complex mammalian immune responses by activating multiple sensors within inflammasomes, which recognize diverse pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). This simultaneous activation induces the formation of protein complexes referred to as multiple inflammasomes, that orchestrate a spectrum of programmed cell death pathways, including pyroptosis, apoptosis, and necroptosis. This concept is crucial for comprehending the complexity of the innate immune system's response to diverse pathogens and its implications for various diseases. Novel contributions here include emphasizing simultaneous sensor activation by pathogens, proposing the existence of multiple inflammasome complexes, and advocating for further exploration of their structural basis. Understanding these mechanisms may offer insights into disease pathogenesis, paving the way for potential therapeutic interventions targeting inflammasome-mediated immune responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"248-258"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140190334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathways and mechanisms of CD4+CD8αα+ intraepithelial T cell development. CD4+CD8αα+ 上皮内 T 细胞发育的途径和机制。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-01 Epub Date: 2024-03-20 DOI: 10.1016/j.it.2024.02.006
Can Li, Dominic Lanasa, Jung-Hyun Park
{"title":"Pathways and mechanisms of CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial T cell development.","authors":"Can Li, Dominic Lanasa, Jung-Hyun Park","doi":"10.1016/j.it.2024.02.006","DOIUrl":"10.1016/j.it.2024.02.006","url":null,"abstract":"<p><p>The mammalian small intestine epithelium harbors a peculiar population of CD4<sup>+</sup>CD8αα<sup>+</sup> T cells that are derived from mature CD4<sup>+</sup> T cells through reprogramming of lineage-specific transcription factors. CD4<sup>+</sup>CD8αα<sup>+</sup> T cells occupy a unique niche in T cell biology because they exhibit mixed phenotypes and functional characteristics of both CD4<sup>+</sup> helper and CD8<sup>+</sup> cytotoxic T cells. The molecular pathways driving their generation are not fully mapped. However, recent studies demonstrate the unique role of the commensal gut microbiota as well as distinct cytokine and chemokine requirements in the differentiation and survival of these cells. We review the established and newly identified factors involved in the generation of CD4<sup>+</sup>CD8αα<sup>+</sup> intraepithelial lymphocytes (IELs) and place them in the context of the molecular machinery that drives their phenotypic and functional differentiation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"288-302"},"PeriodicalIF":16.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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