用髓鞘喂养愤怒

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI:10.1016/j.it.2024.09.004

Sourav Ghosh, Carla V Rothlin

引用次数: 0

摘要

Kloosterman 及其同事研究了胶质母细胞瘤不同分子亚型在放疗和疾病复发期间的分子和细胞变化。他们发现，在绒毛膜/橄榄枝祖细胞样向间充质样转变的过程中，免疫细胞与癌细胞之间存在着独特的代谢串扰，巨噬细胞以富含胆固醇的髓鞘碎片为食，为间充质肿瘤细胞提供脂质，从而助长了胶质母细胞瘤的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Feeding the wrath with myelin.

Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.