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Gasdermin D palmitoylation: to cleave or not to cleave? Gasdermin D棕榈酰化：裂解还是不裂解？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-16 DOI: 10.1016/j.it.2024.05.001
Laurel Stine, Fiachra Humphries
{"title":"Gasdermin D palmitoylation: to cleave or not to cleave?","authors":"Laurel Stine, Fiachra Humphries","doi":"10.1016/j.it.2024.05.001","DOIUrl":"10.1016/j.it.2024.05.001","url":null,"abstract":"<p><p>Recent studies have identified Cys<sup>191</sup> in gasdermin D (GSDMD) as a highly targeted regulatory module controlling pyroptosis. Using chemical biology and genetic models, Du, Healy et al. recently identified GSDMD palmitoylation as a key regulatory step in GSDMD activation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"403-405"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease 慢性阻塞性肺病中树突状细胞、自然杀伤细胞和调节性 T 细胞之间失调的串扰模型
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-18 DOI: 10.1016/j.it.2024.04.010
Dawit T. Mengistu, Jeffrey L. Curtis, Christine M. Freeman
{"title":"A model of dysregulated crosstalk between dendritic, natural killer, and regulatory T cells in chronic obstructive pulmonary disease","authors":"Dawit T. Mengistu, Jeffrey L. Curtis, Christine M. Freeman","doi":"10.1016/j.it.2024.04.010","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.010","url":null,"abstract":"<p>Chronic obstructive pulmonary disease (COPD) is characterized by infiltration of the airways and lung parenchyma by inflammatory cells. Lung pathology results from the cumulative effect of complex and aberrant interactions between multiple cell types. However, three cell types, natural killer cells (NK), dendritic cells (DCs), and regulatory T cells (Tregs), are understudied and underappreciated. We propose that their mutual interactions significantly contribute to the development of COPD. Here, we highlight recent advances in NK, DC, and Treg biology with relevance to COPD, discuss their pairwise bidirectional interactions, and identify knowledge gaps that must be bridged to develop novel therapies. Understanding their interactions will be crucial for therapeutic use of autologous Treg, an approach proving effective in other diseases with immune components.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"29 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141061388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-10 DOI: 10.1016/s1471-4906(24)00088-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00088-7","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00088-7","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"44 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140934507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-10 DOI: 10.1016/s1471-4906(24)00079-6
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00079-6","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00079-6","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"220 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140934572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of host immunity by sensory neurons 感觉神经元对宿主免疫力的调节
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-05-01 DOI: 10.1016/j.it.2024.03.005
Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro
{"title":"Modulation of host immunity by sensory neurons","authors":"Telma Saraiva-Santos, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro","doi":"10.1016/j.it.2024.03.005","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.005","url":null,"abstract":"<p>Recent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interactions between the nervous and immune systems, and also pave the way for developing candidate innovative therapeutic interventions in immune-mediated diseases highlighting the importance of this interdisciplinary research field.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"81 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partners and guardians of the nervous and immune systems 神经和免疫系统的伙伴和守护者
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-30 DOI: 10.1016/j.it.2024.04.007
Catarina Sacristán
{"title":"Partners and guardians of the nervous and immune systems","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.04.007","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.007","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"18 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140832468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory neuronal control of skin barrier immunity 皮肤屏障免疫的感觉神经元控制
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-22 DOI: 10.1016/j.it.2024.03.008
Xinyi Feng, Haoting Zhan, Caroline L. Sokol
{"title":"Sensory neuronal control of skin barrier immunity","authors":"Xinyi Feng, Haoting Zhan, Caroline L. Sokol","doi":"10.1016/j.it.2024.03.008","DOIUrl":"https://doi.org/10.1016/j.it.2024.03.008","url":null,"abstract":"<p>Peripheral sensory neurons recognize diverse noxious stimuli, including microbial products and allergens traditionally thought to be targets of the mammalian immune system. Activation of sensory neurons by these stimuli leads to pain and itch responses as well as the release of neuropeptides that interact with their cognate receptors expressed on immune cells, such as dendritic cells (DCs). Neuronal control of immune cell function through neuropeptide release not only affects local inflammatory responses but can impact adaptive immune responses through downstream effects on T cell priming. Numerous neuropeptide receptors are expressed by DCs but only a few have been characterized, presenting opportunities for further investigation of the pathways by which cutaneous neuroimmune interactions modulate host immunity.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"69 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond antiviral: role of IFN-I in brain development 超越抗病毒：IFN-I 在大脑发育中的作用
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-20 DOI: 10.1016/j.it.2024.04.004
Christopher A. Baker, Akiko Iwasaki
{"title":"Beyond antiviral: role of IFN-I in brain development","authors":"Christopher A. Baker, Akiko Iwasaki","doi":"10.1016/j.it.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.004","url":null,"abstract":"<p>Interferons and central nervous system resident macrophages, microglia, are well-known for their respective roles in antiviral defense and phagocytosis. Using a classic experimental paradigm for examining activity-dependent neural plasticity, <span>Escoubas, Dorman, <em>et al</em>.</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> recently identified a role for microglial type I interferon signaling in the clearance of unwanted neurons during mouse brain development.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"38 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Complement(ing) long-COVID thromboinflammation and pathogenesis 补充长期 COVID 血栓炎症和发病机制
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-17 DOI: 10.1016/j.it.2024.04.001
John D. Lee, Trent M. Woodruff
{"title":"Complement(ing) long-COVID thromboinflammation and pathogenesis","authors":"John D. Lee, Trent M. Woodruff","doi":"10.1016/j.it.2024.04.001","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.001","url":null,"abstract":"<p>The persistence or recurrence of symptoms after acute SARS-CoV-2 infection, termed ‘long COVID’, presents a formidable challenge to global healthcare systems. Recent research by <span>Cervia-Hasler and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> delves into the intricate immunological landscape in patients with long COVID, demonstrating an interplay between complement and coagulation, driven by antiviral antibodies and tissue damage.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"21 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymphoid tissue on the mind 心灵上的淋巴组织
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-04-17 DOI: 10.1016/j.it.2024.04.002
Nikhita Kirthivasan, Jason G. Cyster
{"title":"Lymphoid tissue on the mind","authors":"Nikhita Kirthivasan, Jason G. Cyster","doi":"10.1016/j.it.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.it.2024.04.002","url":null,"abstract":"<p>To surveil an organ for pathogens, lymphoid structures need to sample antigens locally. The full set of lymphoid structures involved in surveilling for brain-tropic pathogens has not been defined. Through comprehensive imaging of the mouse meninges, a new study by <span>Fitzpatrick <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"8px\" viewbox=\"0 0 8 8\" width=\"8px\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg> describes dural-associated lymphoid tissue (DALT) and its contribution to humoral responses following intranasal viral infection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"132 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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