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Intracellular C1q - an unexpected player in neuronal proteostasis. 细胞内 C1q--神经元蛋白稳态的意外参与者
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1016/j.it.2024.09.006
Erin E West, Claudia Kemper
{"title":"Intracellular C1q - an unexpected player in neuronal proteostasis.","authors":"Erin E West, Claudia Kemper","doi":"10.1016/j.it.2024.09.006","DOIUrl":"10.1016/j.it.2024.09.006","url":null,"abstract":"<p><p>Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"718-720"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking SARS-CoV-2's coagulation conspiracy: the role of Spike. 揭开 SARS-CoV-2 的凝血阴谋：Spike 的作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-26 DOI: 10.1016/j.it.2024.09.007
Tom Aschman, Helena Radbruch
{"title":"Unmasking SARS-CoV-2's coagulation conspiracy: the role of Spike.","authors":"Tom Aschman, Helena Radbruch","doi":"10.1016/j.it.2024.09.007","DOIUrl":"10.1016/j.it.2024.09.007","url":null,"abstract":"<p><p>The recent study by Ryu et al. demonstrates that the SARS-CoV-2 Spike protein binds fibrin(ogen), impacting coagulation and immune responses in mice. In this spotlight article we focus on the described effects on natural killer (NK) cell responses as well as the suggested translation into potential new therapeutic targets against COVID-19.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"724-725"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feeding the wrath with myelin. 用髓鞘喂养愤怒
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.it.2024.09.004
Sourav Ghosh, Carla V Rothlin
{"title":"Feeding the wrath with myelin.","authors":"Sourav Ghosh, Carla V Rothlin","doi":"10.1016/j.it.2024.09.004","DOIUrl":"10.1016/j.it.2024.09.004","url":null,"abstract":"<p><p>Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"729-731"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Myeloid cells take ischemic insult to heart 髓系细胞对缺血造成的伤害感同身受
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-09-20 DOI: 10.1016/j.it.2024.09.001
Leo Nicolai, Steffen Massberg
{"title":"Myeloid cells take ischemic insult to heart","authors":"Leo Nicolai, Steffen Massberg","doi":"10.1016/j.it.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.it.2024.09.001","url":null,"abstract":"<p>Morbidity and mortality associated with stroke cannot be attributed solely to the acute ischemic event, but are also rooted in long-term complications, including heart disease. <span><span>Simats, Zhang, and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> now demonstrate that interleukin (IL)-1ß-mediated innate immune memory after brain ischemic stroke leads to proinflammatory changes in the heart causing myocardial fibrosis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"189 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why do central nervous system barriers host a diverse immune landscape? 为什么中枢神经系统屏障能承载多样化的免疫景观？
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-09-18 DOI: 10.1016/j.it.2024.08.009
{"title":"Why do central nervous system barriers host a diverse immune landscape?","authors":"","doi":"10.1016/j.it.2024.08.009","DOIUrl":"https://doi.org/10.1016/j.it.2024.08.009","url":null,"abstract":"The meninges in vertebrates comprise three layers (dura, arachnoid, pia mater), representing an important barrier surrounding and protecting the centr…","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"3 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies 阿尔茨海默病先天免疫新发现：从 APOE 保护性变异到疗法
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-09-14 DOI: 10.1016/j.it.2024.08.001
Yun Chen, David M. Holtzman
{"title":"New insights into innate immunity in Alzheimer’s disease: from APOE protective variants to therapies","authors":"Yun Chen, David M. Holtzman","doi":"10.1016/j.it.2024.08.001","DOIUrl":"https://doi.org/10.1016/j.it.2024.08.001","url":null,"abstract":"<p>Recent discoveries of rare variants of human APOE may shed light on novel therapeutic strategies for Alzheimer’s disease (AD). Here, we highlight the newly identified protective variant [APOE3 Christchurch (APOE3ch, R136S)] as an example. We summarize human AD and mouse amyloidosis and tauopathy studies from the past 5 years that have been associated with this R136S variant. We also propose a potential mechanism for how this point mutation might lead to protection against AD pathology, from the molecular level, to cells, to mouse models, and potentially, to humans. Lastly, we extend our discussion of the recent insights gained regarding different APOE variants to putative therapeutic approaches in AD.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"50 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142265600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-09-12 DOI: 10.1016/s1471-4906(24)00200-x
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00200-x","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00200-x","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"8 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-09-12 DOI: 10.1016/s1471-4906(24)00198-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00198-4","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00198-4","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"149 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanocarrier design for pathogen-inspired innate immune agonist delivery. 用于病原体激发的先天性免疫激动剂递送的纳米载体设计。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-26 DOI: 10.1016/j.it.2024.07.007
Griffin I Kane, Meghan L Brassil, Miranda B Diaz-Infante, Prabhani U Atukorale
{"title":"Nanocarrier design for pathogen-inspired innate immune agonist delivery.","authors":"Griffin I Kane, Meghan L Brassil, Miranda B Diaz-Infante, Prabhani U Atukorale","doi":"10.1016/j.it.2024.07.007","DOIUrl":"10.1016/j.it.2024.07.007","url":null,"abstract":"<p><p>In complex diseases such as cancer, modulating cytokine signatures of disease using innate immune agonists holds therapeutic promise. Novel multi-agonist treatments offer tunable control of the immune system because they are uniquely pathogen inspired, eliciting robust antitumor responses by promoting synergistic cytokine responses. However, the chief strategic hurdle is ensuring multi-agonist delivery to the same target cells, highlighting the importance of using nanomaterial-based carriers. Here, we place nanocarriers in center stage and review the delivery hurdles related to the varying extra- and intracellular localizations of innate immune receptors. We discuss a range of nanomaterials used for multi-agonist delivery, highlighting their respective benefits and drawbacks. Our overarching stance is that rational nanocarrier design is crucial for developing pathogen-inspired multi-agonist immunotherapies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"678-692"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unmasking the hidden impact of viruses on tuberculosis risk. 揭开病毒对结核病风险的隐性影响。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI: 10.1016/j.it.2024.07.008
Fatoumatta Darboe, Josephine F Reijneveld, David P Maison, Leonardo Martinez, Sara Suliman
{"title":"Unmasking the hidden impact of viruses on tuberculosis risk.","authors":"Fatoumatta Darboe, Josephine F Reijneveld, David P Maison, Leonardo Martinez, Sara Suliman","doi":"10.1016/j.it.2024.07.008","DOIUrl":"10.1016/j.it.2024.07.008","url":null,"abstract":"<p><p>Tuberculosis (TB) is a leading cause of mortality from an infectious disease. In this opinion article, we focus on accumulating scientific evidence indicating that viral infections may contribute to TB progression, possibly allowing novel preventive interventions. Viruses can remodel the mammalian immune system, potentially modulating the risk of reactivating latent microbes such as Mycobacterium tuberculosis (Mtb). Evidence is mixed regarding the impact of emergent viruses such as SARS-CoV-2 on the risk of TB. Therefore, we posit that important knowledge gaps include elucidating which viral families increase TB risk and whether these provide unique or shared immune mechanisms. We also propose potential future research to define the contribution of viruses to TB pathogenesis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"649-661"},"PeriodicalIF":13.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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