APOE4 affects neutrophil-microglia crosstalk in Alzheimer's disease.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI:10.1016/j.it.2024.09.002

Eleonora Terrabuio, Gabriela Constantin

引用次数: 0

Abstract

Circulating immune cells contribute to the pathogenesis of Alzheimer's disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17⁺ neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion in neutrophils restored microglial responses and reduced murine amyloid pathology.

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APOE4 影响阿尔茨海默病中嗜中性粒细胞与小胶质细胞之间的串联。

循环免疫细胞是阿尔茨海默病（AD）的发病机制之一，但人们对它们的作用知之甚少。Rosenzweig 等人最近在女性 APOE4 携带者中发现了抑制神经保护性小胶质细胞的白细胞介素（IL）-17+ 中性粒细胞亚群。阻断 IL-17 信号传导或删除中性粒细胞中的 APOE4 可恢复小胶质细胞反应并减少小鼠淀粉样病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.