Trends in Immunology最新文献

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SARS-CoV-2 humoral immunity in people living with HIV-1. HIV-1 感染者的 SARS-CoV-2 体液免疫。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-17 DOI: 10.1016/j.it.2024.05.005
Boitumelo M Motsoeneng, Jinal N Bhiman, Simone I Richardson, Penny L Moore
{"title":"SARS-CoV-2 humoral immunity in people living with HIV-1.","authors":"Boitumelo M Motsoeneng, Jinal N Bhiman, Simone I Richardson, Penny L Moore","doi":"10.1016/j.it.2024.05.005","DOIUrl":"10.1016/j.it.2024.05.005","url":null,"abstract":"<p><p>The effect of COVID-19 on the high number of immunocompromised people living with HIV-1 (PLWH), particularly in Africa, remains a critical concern. Here, we identify key areas that still require further investigation, by examining COVID-19 vaccine effectiveness, and understanding antibody responses in SARS-CoV-2 infection and vaccination in comparison with people without HIV-1 (PWOH). We also assess the potential impact of pre-existing immunity against endemic human coronaviruses on SARS-CoV-2 responses in these individuals. Lastly, we discuss the consequences of persistent infection in PLWH (or other immunocompromised individuals), including prolonged shedding, increased viral diversity within the host, and the implications on SARS-CoV-2 evolution in Africa.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"511-522"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141421894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Basophil differentiation, heterogeneity, and functional implications. 嗜碱性粒细胞的分化、异质性和功能影响。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-28 DOI: 10.1016/j.it.2024.05.009
Yan Chen, Haoyu Tang, Bingpeng Yao, Sheng Pan, Songmin Ying, Chao Zhang
{"title":"Basophil differentiation, heterogeneity, and functional implications.","authors":"Yan Chen, Haoyu Tang, Bingpeng Yao, Sheng Pan, Songmin Ying, Chao Zhang","doi":"10.1016/j.it.2024.05.009","DOIUrl":"10.1016/j.it.2024.05.009","url":null,"abstract":"<p><p>Basophils, rare granulocytes, have long been acknowledged for their roles in type 2 immune responses. However, the mechanisms by which basophils adapt their functions to diverse mammalian microenvironments remain unclear. Recent advancements in specific research tools and single-cell-based technologies have greatly enhanced our understanding of basophils. Several studies have shown that basophils play a role in maintaining homeostasis but can also contribute to pathology in various tissues and organs, including skin, lung, and others. Here, we provide an overview of recent basophil research, including cell development, characteristics, and functions. Based on an increasing understanding of basophil biology, we suggest that the precise targeting of basophil features might be beneficial in alleviating certain pathologies such as asthma, atopic dermatitis (AD), and others.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"523-534"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate-like T cells in liver disease. 肝病中的先天性 T 细胞
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-14 DOI: 10.1016/j.it.2024.05.008
Albert Ying-Po Yang, Kilian Wistuba-Hamprecht, Tim F Greten, Benjamin Ruf
{"title":"Innate-like T cells in liver disease.","authors":"Albert Ying-Po Yang, Kilian Wistuba-Hamprecht, Tim F Greten, Benjamin Ruf","doi":"10.1016/j.it.2024.05.008","DOIUrl":"10.1016/j.it.2024.05.008","url":null,"abstract":"<p><p>Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair, and immune homeostasis. This review explores the involvement of different ILTC subsets in liver diseases. We explore the mechanisms underlying the pro- and anti-inflammatory effector functions of ILTCs in a context-dependent manner. We highlight latest findings regarding the dynamic interplay between ILTC functional subsets and other immune and parenchymal cells which may inform candidate immunomodulatory strategies to achieve improved clinical outcomes in liver diseases. We present new insights into how distinct gene expression programs in hepatic ILTCs are induced, maintained, and reprogrammed in a context- and disease stage-dependent manner.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"535-548"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting metabolic pathways to counter cancer immunotherapy resistance. 以代谢途径为靶点,对抗癌症免疫疗法的抗药性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-13 DOI: 10.1016/j.it.2024.05.006
Yuki Agarwala, Timothy A Brauns, Ann E Sluder, Mark C Poznansky, Yohannes Gemechu
{"title":"Targeting metabolic pathways to counter cancer immunotherapy resistance.","authors":"Yuki Agarwala, Timothy A Brauns, Ann E Sluder, Mark C Poznansky, Yohannes Gemechu","doi":"10.1016/j.it.2024.05.006","DOIUrl":"10.1016/j.it.2024.05.006","url":null,"abstract":"<p><p>Immunotherapies have revolutionized the treatment of certain cancers, but challenges remain in overcoming immunotherapy resistance. Research shows that metabolic modulation of the tumor microenvironment can enhance antitumor immunity. Here, we discuss recent preclinical and clinical evidence for the efficacy of combining metabolic modifiers with immunotherapies. While this combination holds great promise, a few key areas must be addressed, which include identifying the effects of metabolic modifiers on immune cell metabolism, the putative biomarkers of therapeutic efficacy, the efficacy of modifiers on tumors harboring metabolic heterogeneity, and the potential development of resistance due to tumor reliance on alternative metabolic pathways. We propose solutions to these problems and posit that assessing these parameters is crucial for considering the potential of metabolic modifiers in sensitizing tumors to immunotherapies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"486-494"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming gender bias in STEM. 克服科学、技术、工程和数学领域的性别偏见。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-10 DOI: 10.1016/j.it.2024.05.004
Nicole Boivin, Susanne Täuber, Morteza Mahmoudi
{"title":"Overcoming gender bias in STEM.","authors":"Nicole Boivin, Susanne Täuber, Morteza Mahmoudi","doi":"10.1016/j.it.2024.05.004","DOIUrl":"10.1016/j.it.2024.05.004","url":null,"abstract":"<p><p>Despite prevalent diversity and inclusion programs in STEM, gender biases and stereotypes persist across educational and professional settings. Recognizing this enduring bias is crucial for achieving transformative change on gender equity and can help orient policy toward more effective strategies to address ongoing disparities.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"483-485"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new model of human lymphopoiesis across development and aging. 跨越发育和衰老的人类淋巴造血新模型。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-21 DOI: 10.1016/j.it.2024.05.007
Kutaiba Alhaj Hussen, Valentine Louis, Bruno Canque
{"title":"A new model of human lymphopoiesis across development and aging.","authors":"Kutaiba Alhaj Hussen, Valentine Louis, Bruno Canque","doi":"10.1016/j.it.2024.05.007","DOIUrl":"10.1016/j.it.2024.05.007","url":null,"abstract":"<p><p>Over the past decade our research has implemented a multimodal approach to human lymphopoiesis, combining clonal-scale mapping of lymphoid developmental architecture with the monitoring of dynamic changes in the pattern of lymphocyte generation across ontogeny. We propose that lymphopoiesis stems from founder populations of CD127/interleukin (IL)7R<sup>-</sup> or CD127/IL7R<sup>+</sup> early lymphoid progenitors (ELPs) polarized respectively toward the T-natural killer (NK)/innate lymphoid cell (ILC) or B lineages, arising from newly characterized CD117<sup>lo</sup> multi-lymphoid progenitors (MLPs). Recent data on the lifelong lymphocyte dynamics of healthy donors suggest that, after birth, lymphopoiesis may become increasingly oriented toward the production of B lymphocytes. Stemming from this, we posit that there are three major developmental transitions, the first occurring during the neonatal period, the next at puberty, and the last during aging.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"495-510"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-13 DOI: 10.1016/s1471-4906(24)00111-x
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00111-x","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00111-x","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"26 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141506914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-13 DOI: 10.1016/s1471-4906(24)00115-7
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00115-7","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00115-7","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"43 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141524518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction of the cover caption and Editorial of Trends in Immunology Volume 45, Issue 5 (May 2024): (Trends in Immunology, 45:5 p:315-317, 2024). 更正《免疫学趋势》第 45 卷第 5 期(2024 年 5 月)的封面标题和社论:(免疫学趋势》,45:5 p:315-317, 2024)。
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-30 DOI: 10.1016/j.it.2024.05.003
Catarina Sacristán
{"title":"Correction of the cover caption and Editorial of Trends in Immunology Volume 45, Issue 5 (May 2024): (Trends in Immunology, 45:5 p:315-317, 2024).","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.05.003","DOIUrl":"10.1016/j.it.2024.05.003","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"482"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages marc(o) the difference in liver inflammation? 巨噬细胞在肝脏炎症中的作用?
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-06-01 Epub Date: 2024-05-23 DOI: 10.1016/j.it.2024.05.002
Christian Zwicker, Charlotte L Scott
{"title":"Macrophages marc(o) the difference in liver inflammation?","authors":"Christian Zwicker, Charlotte L Scott","doi":"10.1016/j.it.2024.05.002","DOIUrl":"10.1016/j.it.2024.05.002","url":null,"abstract":"<p><p>Miyamoto et al. report that Marco expression demarcates a population of IL-10-expressing immunosuppressive Kupffer cells (KCs) that are preferentially peri-portally located in the mouse liver, and which limit bacterial dissemination and liver inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"400-402"},"PeriodicalIF":16.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141094330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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