发布求助
文献互助 智能选刊 最新文献

Trends in Immunology最新文献

筛选
英文 中文
VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases. VAV1 作为自身免疫性疾病和慢性炎症性疾病的潜在治疗靶点。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-26 DOI: 10.1016/j.it.2024.06.004
Markus F Neurath, Leslie J Berg
{"title":"VAV1 as a putative therapeutic target in autoimmune and chronic inflammatory diseases.","authors":"Markus F Neurath, Leslie J Berg","doi":"10.1016/j.it.2024.06.004","DOIUrl":"10.1016/j.it.2024.06.004","url":null,"abstract":"<p><p>The guanine nucleotide exchange factor (GEF) VAV1, a previously 'undruggable' protein integral to T/B lymphocyte antigen-receptor signaling, promotes actin polymerization, immunological synapse formation, T cell activation and differentiation, and cytokine production. With the development of novel modalities for targeting proteins, we hypothesize that interventions targeting VAV1 will have therapeutic potential in T and T/B cell-mediated autoimmune and chronic inflammatory diseases. This opinion is supported by recent CRISPR-Cas9 studies showing VAV1 as a key positive regulator of T cell receptor (TCR) activation and cytokine production in primary human CD4<sup>+</sup> and CD8<sup>+</sup> T cells; data demonstrating that loss/suppression of VAV1 regulates autoimmunity and inflammation; and promising preclinical data from T and T/B cell-mediated disease models of arthritis and colitis showing the effectiveness of selective VAV1 targeting via protein degradation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"580-596"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious diseases and discrimination: Sicily's Lampedusa migrants. 传染病与歧视：西西里岛的兰佩杜萨岛移民。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-11 DOI: 10.1016/j.it.2024.06.002
Bruno Douradinha
{"title":"Infectious diseases and discrimination: Sicily's Lampedusa migrants.","authors":"Bruno Douradinha","doi":"10.1016/j.it.2024.06.002","DOIUrl":"10.1016/j.it.2024.06.002","url":null,"abstract":"<p><p>Lampedusa, a picturesque Italian island in the Mediterranean, serves as a gateway for migrants from Africa and Asia to Europe. Despite populist rhetoric portraying migrants as carriers of disease, epidemiological data reveal very low levels of communicable diseases among migrants, challenging false narratives and xenophobic sentiments propagated by populist governments.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"577-579"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141602188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron scavenging and myeloid cell polarization. 铁清除和骨髓细胞极化
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-24 DOI: 10.1016/j.it.2024.06.006
Natalie Ludwig, Stefania Cucinelli, Simon Hametner, Martina U Muckenthaler, Lucas Schirmer
{"title":"Iron scavenging and myeloid cell polarization.","authors":"Natalie Ludwig, Stefania Cucinelli, Simon Hametner, Martina U Muckenthaler, Lucas Schirmer","doi":"10.1016/j.it.2024.06.006","DOIUrl":"10.1016/j.it.2024.06.006","url":null,"abstract":"<p><p>Myeloid cells that populate all human organs and blood are a versatile class of innate immune cells. They are crucial for sensing and regulating processes as diverse as tissue homeostasis and inflammation and are frequently characterized by their roles in either regulating or promoting inflammation. Recent studies in cultured cells and mouse models highlight the role of iron in skewing the functional properties of myeloid cells in tissue damage and repair. Here, we review certain emerging concepts on how iron influences and determines myeloid cell polarization in the context of its uptake, storage, and metabolism, including in conditions such as multiple sclerosis (MS), sickle cell disease, and tumors.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"625-638"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of ARID1A 'loops' in STING. ARID1A 在 STING 中的 "循环 "缺失。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-25 DOI: 10.1016/j.it.2024.07.001
Sangeeta Goswami, Padmanee Sharma
{"title":"Loss of ARID1A 'loops' in STING.","authors":"Sangeeta Goswami, Padmanee Sharma","doi":"10.1016/j.it.2024.07.001","DOIUrl":"10.1016/j.it.2024.07.001","url":null,"abstract":"<p><p>In a recent article, Maxwell et al. report that loss of tumor cell-specific AT-rich interaction domain 1A (ARID1A), a component of the chromatin remodeling SWI/SNF complex, triggers antitumor immunity via R-loop-mediated upregulation of the type-I interferon (IFN) pathway. These recent findings uncover a molecular mechanism underlying improved responses to immune checkpoint therapy (ICT) seen in patients harboring an ARID1A loss-of-function mutation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"568-570"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuro-immune crosstalk in hematopoiesis, inflammation, and repair. 造血、炎症和修复过程中的神经-免疫相互作用
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI: 10.1016/j.it.2024.06.005
Damilola Emmanuel Akinyemi, Raphael Chevre, Oliver Soehnlein
{"title":"Neuro-immune crosstalk in hematopoiesis, inflammation, and repair.","authors":"Damilola Emmanuel Akinyemi, Raphael Chevre, Oliver Soehnlein","doi":"10.1016/j.it.2024.06.005","DOIUrl":"10.1016/j.it.2024.06.005","url":null,"abstract":"<p><p>Innate immune cells are primary effectors during host defense and in sterile inflammation. Their production in the bone marrow is tightly regulated by growth and niche factors, and their activity at sites of inflammation is orchestrated by a network of alarmins and cytokines. Yet, recent work highlights a significant role of the peripheral nervous system in these processes. Sympathetic neural pathways play a key role in regulating blood cell homeostasis, and sensory neural pathways mediate pro- or anti-inflammatory signaling in a tissue-specific manner. Here, we review emerging evidence of the fine titration of hematopoiesis, leukocyte trafficking, and tissue repair via neuro-immune crosstalk, and how its derailment can accelerate chronic inflammation, as in atherosclerosis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"597-608"},"PeriodicalIF":13.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NLRC5: back to innate immunity NLRC5：回归先天免疫
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-07-31 DOI: 10.1016/j.it.2024.07.002
{"title":"NLRC5: back to innate immunity","authors":"","doi":"10.1016/j.it.2024.07.002","DOIUrl":"https://doi.org/10.1016/j.it.2024.07.002","url":null,"abstract":"<p>NLRC5 is a transcriptional regulator of genes governing T cell responses. Most characterized NLRs are instead innate immune sensors forming complexes leading to pyroptosis. Raising exciting questions, <span><span>Sundaram and colleagues</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> now demonstrate that NLRC5 forms large complexes and causes PANoptosis (immunogenic cell death), in response to heme in inflammatory contexts.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"87 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141868141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mutant ARID1A: igniting cancer immunotherapy 突变 ARID1A：点燃癌症免疫疗法的火种
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-07-26 DOI: 10.1016/j.it.2024.07.003
{"title":"Mutant ARID1A: igniting cancer immunotherapy","authors":"","doi":"10.1016/j.it.2024.07.003","DOIUrl":"https://doi.org/10.1016/j.it.2024.07.003","url":null,"abstract":"<p><span><span>Maxwell <em>et al.</em></span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span> show that ARID1A loss enhances antitumor immunity by triggering a type I IFN response through the cGAS–STING pathway, thereby promoting T cell infiltration and cytotoxicity. These findings highlight SWI/SNF inhibitors as a strategy to augment immunotherapy efficacy by potentially transforming non-responsive tumors into responders and advancing approaches to cancer treatment.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"39 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-07-11 DOI: 10.1016/s1471-4906(24)00143-1
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/s1471-4906(24)00143-1","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00143-1","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"16 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 16.8 1区 医学
Trends in Immunology Pub Date : 2024-07-11 DOI: 10.1016/s1471-4906(24)00134-0
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/s1471-4906(24)00134-0","DOIUrl":"https://doi.org/10.1016/s1471-4906(24)00134-0","url":null,"abstract":"No Abstract","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":"40 1","pages":""},"PeriodicalIF":16.8,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141609970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The emergence of cancer sono-immunotherapy. 癌症超声免疫疗法的出现。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-07-01 Epub Date: 2024-06-23 DOI: 10.1016/j.it.2024.06.001
Yuqi Yang, Yuan Cheng, Liang Cheng
{"title":"The emergence of cancer sono-immunotherapy.","authors":"Yuqi Yang, Yuan Cheng, Liang Cheng","doi":"10.1016/j.it.2024.06.001","DOIUrl":"10.1016/j.it.2024.06.001","url":null,"abstract":"<p><p>Owing to its remarkable ease of use, ultrasound has recently been explored for stimulating or amplifying immune responses during cancer therapy, termed 'sono-immunotherapy'. Ultrasound can cause immunogenic cell death in cancer cells via thermal and nonthermal effects to regulate the tumor microenvironment, thereby priming anticancer immunity; by integrating well-designed biomaterials, novel sono-immunotherapy approaches with augmented efficacy can also be developed. Here, we review the advances in sono-immunotherapy for cancer treatment and summarize existing limitations along with potential trends. We offer emerging insights into this realm, which might prompt breakthroughs and expand its potential applications to other diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"549-563"},"PeriodicalIF":13.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信