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Brain macrophages in vascular health and dysfunction. 巨噬细胞在脑血管健康和功能障碍中的作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.it.2024.11.012
Mitchell Bijnen, Sucheta Sridhar, Annika Keller, Melanie Greter
{"title":"Brain macrophages in vascular health and dysfunction.","authors":"Mitchell Bijnen, Sucheta Sridhar, Annika Keller, Melanie Greter","doi":"10.1016/j.it.2024.11.012","DOIUrl":"10.1016/j.it.2024.11.012","url":null,"abstract":"<p><p>Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they also play diverse roles in neurological diseases. In this review, we highlight the emerging roles of CNS macrophages in regulating vascular function in health and disease. We discuss that, in addition to microglia, BAMs, including perivascular macrophages, play roles in supporting vascular integrity and maintaining blood flow. We highlight recent advancements in understanding how these macrophages are implicated in protecting against vascular dysfunction and modulating the progression of cerebrovascular diseases, as seen in vessel-associated neurodegeneration.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"46-60"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis. Epstein-Barr病毒劫持B细胞代谢，建立持续感染并驱动发病机制。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.1016/j.it.2024.11.011
Bojana Müller-Durovic, Jessica Jäger, Glenn R Bantug, Christoph Hess
{"title":"Epstein-Barr virus hijacks B cell metabolism to establish persistent infection and drive pathogenesis.","authors":"Bojana Müller-Durovic, Jessica Jäger, Glenn R Bantug, Christoph Hess","doi":"10.1016/j.it.2024.11.011","DOIUrl":"10.1016/j.it.2024.11.011","url":null,"abstract":"<p><p>When B cells engage in an immune response, metabolic reprogramming is key to meeting cellular energetic and biosynthetic demands. Epstein-Barr virus (EBV) is a highly prevalent gamma-herpesvirus, latently infecting B cells for the human host's lifetime. By hijacking signaling pathways of T cell-dependent humoral immunity, EBV activates B cells in a T cell-independent manner, forcing lymphoblastoid transformation. Interlinked with this coercion of signaling pathways, EBV has also evolved strategies to manipulate B cell metabolism. In this opinion article we integrate recent findings from studies of B cell metabolic reprogramming after EBV infection and during antigen-specific activation, respectively. We hypothesize that defining EBV host-cell metabolic vulnerabilities that differ from pathways required for B cell immunity might uncover novel therapeutic targets against EBV-related diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"7-16"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics. 全身性脓疱性牛皮癣：免疫机制，遗传学和新兴治疗方法。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1016/j.it.2024.12.001
Chih-Chun Lee, Yu-Huei Huang, Ching-Chi Chi, Wen-Hung Chung, Chun-Bing Chen
{"title":"Generalized pustular psoriasis: immunological mechanisms, genetics, and emerging therapeutics.","authors":"Chih-Chun Lee, Yu-Huei Huang, Ching-Chi Chi, Wen-Hung Chung, Chun-Bing Chen","doi":"10.1016/j.it.2024.12.001","DOIUrl":"10.1016/j.it.2024.12.001","url":null,"abstract":"<p><p>Generalized pustular psoriasis (GPP) is a rare human autoinflammatory disorder with life-threatening systemic effects. Keratinocyte-derived interleukin (IL)-36 signaling has been identified as a key mediator of immune response in the skin of affected individuals. Recognition of various mutations along the IL-36 axis and the downstream nuclear transcription factor κB (NF-κB) signaling have established GPP as genetically, immunologically, and histopathologically distinct and amenable to immunomodulation, which is epitomized by the recent success of IL-36 antagonism. This review covers recent discoveries of the genetic and immunological underpinnings of GPP, which have proved fertile ground for improving the quality of care of this clinically challenging and debilitating condition.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"74-89"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomolecular condensates: phasing in regulated host-pathogen interactions. 生物分子凝聚体：宿主与病原体相互作用的相位调节。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1016/j.it.2024.11.010
Kun Chen, Xuetao Cao
{"title":"Biomolecular condensates: phasing in regulated host-pathogen interactions.","authors":"Kun Chen, Xuetao Cao","doi":"10.1016/j.it.2024.11.010","DOIUrl":"10.1016/j.it.2024.11.010","url":null,"abstract":"<p><p>Biomolecular condensates are membraneless organelles formed through liquid-liquid phase separation. Innate immunity is essential to host defense against infections, but pathogens also harbor sophisticated mechanisms to evade host defense. The formation of biomolecular condensates emerges as a key biophysical mechanism in host-pathogen interactions, playing pivotal roles in regulating immune responses and pathogen life cycles within the host. In this review we summarize recent advances in our understanding of how biomolecular condensates remodel membrane-bound organelles, influence infection-induced cell death, and are hijacked by pathogens for survival, as well as how they modulate mammalian innate immunity. We discuss the implications of dysregulated formation of biomolecular condensates during host-pathogen interactions and infectious diseases and propose future directions for developing potential treatments against such infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"29-45"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for studying neuroimmune interactions in Alzheimer's diseases: (Trends in Immunology 45, 971-986; December 2024). 阿尔茨海默病中神经免疫相互作用的研究方法[j] .免疫学趋势，45,971-986；2024年12月)。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1016/j.it.2024.12.003
Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi
{"title":"Approaches for studying neuroimmune interactions in Alzheimer's diseases: (Trends in Immunology 45, 971-986; December 2024).","authors":"Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi","doi":"10.1016/j.it.2024.12.003","DOIUrl":"10.1016/j.it.2024.12.003","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"90"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotube-mediated mitochondrial transfer: power to the T cells! 纳米管介导的线粒体转移：为 T 细胞提供动力！
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.it.2024.11.001
Cosima T Baldari
{"title":"Nanotube-mediated mitochondrial transfer: power to the T cells!","authors":"Cosima T Baldari","doi":"10.1016/j.it.2024.11.001","DOIUrl":"10.1016/j.it.2024.11.001","url":null,"abstract":"<p><p>The success of T cell-based immunotherapies is limited by exhaustion, which is associated with mitochondrial dysfunction. Baldwin and colleagues show that bone marrow stromal cells (BMSCs) use nanotubes to transfer mitochondria to T cells, which increases mitochondria mass and fitness and boosts antitumor efficacy. The results pave the way to organelle-based therapies against cancer.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"917-919"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do autoimmune CD4+ T cells handle exhaustion? 自身免疫 CD4+ T 细胞如何处理衰竭？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.004
Astrid Fabri, Lucy S K Walker
{"title":"How do autoimmune CD4<sup>+</sup> T cells handle exhaustion?","authors":"Astrid Fabri, Lucy S K Walker","doi":"10.1016/j.it.2024.11.004","DOIUrl":"10.1016/j.it.2024.11.004","url":null,"abstract":"<p><p>Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4<sup>+</sup> T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L<sup>+</sup> CD4<sup>+</sup> T cells seems to sustain the local autoimmune response.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"922-924"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing tumor immunity via in vivo cDC1 reprogramming. 通过体内 cDC1 重编程增强肿瘤免疫力。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1016/j.it.2024.11.008
Yoojung Kwon, Kyunghee Choi
{"title":"Enhancing tumor immunity via in vivo cDC1 reprogramming.","authors":"Yoojung Kwon, Kyunghee Choi","doi":"10.1016/j.it.2024.11.008","DOIUrl":"10.1016/j.it.2024.11.008","url":null,"abstract":"<p><p>A recent study by Ascic et al. demonstrates that in situ reprogramming of tumor cells into conventional dendritic cell (cDC)-like cells using viral-PIB transcription factors creates an immunogenic tumor microenvironment with T cell recruitment and activation. The study highlights the potential of tumor-specific cancer immunotherapy using in vivo reprogrammed cDCs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"934-936"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions. 分解 IgA：嗜免疫通明菌揭示微生物与免疫的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.003
Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan
{"title":"Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.","authors":"Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan","doi":"10.1016/j.it.2024.11.003","DOIUrl":"10.1016/j.it.2024.11.003","url":null,"abstract":"<p><p>The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"928-930"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering immunity: bacterial delivery of cancer neoantigen vaccines. 工程免疫：癌症新抗原疫苗的细菌递送。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.007
Christopher D Johnston, Jennifer A Wargo
{"title":"Engineering immunity: bacterial delivery of cancer neoantigen vaccines.","authors":"Christopher D Johnston, Jennifer A Wargo","doi":"10.1016/j.it.2024.11.007","DOIUrl":"10.1016/j.it.2024.11.007","url":null,"abstract":"<p><p>In the battle against cancer, researchers are exploring the use of engineered bacteria as living medicines. Redenti and colleagues demonstrate that Escherichia coli Nissle 1917 (EcN) can be engineered to deliver cancer neoantigen payloads, stimulating antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells and mediating antitumor immunity in preclinical models of colorectal cancer and melanoma.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"931-933"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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