Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI:10.1016/j.it.2024.11.003

Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan

引用次数: 0

Abstract

The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.

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分解 IgA：嗜免疫通明菌揭示微生物与免疫的相互作用。

Lu 及其同事最近发现了一种能降解 IgA 的细菌 Tomasiella immunophila，这为了解微生物对粘膜免疫的影响以及进化过程中的免疫权衡提供了启示。通过调节 IgA 滴度，嗜免疫球菌影响了宿主和病原体之间的动态互动和平衡。这对免疫健康、微生物组研究和治疗都有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.