Violetta S Gogoleva, Sarah Mundt, Donatella De Feo, Burkhard Becher
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引用次数: 0
Abstract
A healthy mammalian central nervous system (CNS) harbors a diverse population of leukocytes including members of the mononuclear phagocyte system (MPS). Exerting their specific functions, CNS tissue-resident macrophages as well as associated monocytes and dendritic cells (DCs) maintain CNS homeostasis. Under neuroinflammatory conditions, leukocytes from the systemic immune compartment invade the CNS. This review focuses on the newly discovered roles of the MPS in autoimmune neuroinflammation elicited by encephalitogenic T cells. We propose that CNS-associated DCs act as gatekeepers and antigen-presenting cells that guide the adaptive immune response while bone marrow (BM)-derived monocytes contribute to immunopathology and tissue damage. By contrast, CNS-resident macrophages primarily support tissue function and promote the repair and maintenance of CNS functions.
健康的哺乳动物中枢神经系统（CNS）中有多种多样的白细胞，包括单核吞噬细胞系统（MPS）的成员。中枢神经系统组织驻留的巨噬细胞以及相关的单核细胞和树突状细胞（DC）发挥着各自的特殊功能，维持着中枢神经系统的平衡。在神经炎症条件下，来自全身免疫系统的白细胞会侵入中枢神经系统。本综述将重点讨论新发现的 MPS 在致脑 T 细胞引发的自身免疫性神经炎症中的作用。我们认为，中枢神经系统相关的 DC 起着守门员和抗原递呈细胞的作用，可引导适应性免疫反应，而骨髓（BM）来源的单核细胞则会导致免疫病理和组织损伤。相比之下，中枢神经系统驻留的巨噬细胞主要支持组织功能，促进中枢神经系统功能的修复和维持。
期刊介绍：
Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
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