感觉神经开启了 TOLL-7 癌症扩散的大门。

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI:10.1016/j.it.2024.09.005

R K Subbarao Malireddi, Thirumala-Devi Kanneganti

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引用次数: 0

摘要

癌症会劫持神经系统进行生长和扩散。因此，破坏神经元与癌症的串联有望阻止癌症转移。最近，Padmanaban 等人报告了新的治疗靶点，并表明乳腺癌细胞激活感觉神经元分泌神经肽 P 物质（SP），导致单链（ss）RNA 释放和非经典 Toll 样受体（TLR）7 信号传导，从而推动转移。

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Sensory nerves unlock the TOLL-7 gate for cancer spread.

Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading to single-strand (ss)RNA release and noncanonical Toll-like receptor (TLR)7 signaling that drives metastasis.

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.