Primed to be primed: a new, second phase.

IF 13.9 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-07-18 DOI:10.1016/j.it.2025.07.006

Benjamin M Kahn, Ben Z Stanger

引用次数: 0

Abstract

CD8 T cell activation and acquisition of cytolytic activity, which is essential for adaptive immunity, begins with priming in the lymph node (LN). Jobin et al. recently identified a second, delayed priming phase driven by competition with regulatory T cells for IL-2, revealing a rate-limiting step with significant clinical implications.

查看原文本刊更多论文

准备被准备：一个新的，第二阶段。

CD8 T细胞的活化和细胞溶解活性的获得是适应性免疫所必需的，始于淋巴结（LN）的启动。Jobin等人最近发现了第二个延迟启动阶段，由IL-2与调节性T细胞的竞争驱动，揭示了具有重要临床意义的速率限制步骤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.