发布求助
文献互助 智能选刊 最新文献

Trends in Immunology最新文献

筛选
英文 中文
Immunoferroptosis: ferroptosis meets tumor immunity and immunotherapy. 免疫铁下垂：铁下垂符合肿瘤免疫和免疫治疗。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-09 DOI: 10.1016/j.it.2026.03.008
Xin Chen
{"title":"Immunoferroptosis: ferroptosis meets tumor immunity and immunotherapy.","authors":"Xin Chen","doi":"10.1016/j.it.2026.03.008","DOIUrl":"https://doi.org/10.1016/j.it.2026.03.008","url":null,"abstract":"<p><p>Ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has attracted considerable attention in tumor biology and cancer therapy. Beyond its intrinsic role in tumor suppression, ferroptosis greatly influences the tumor immune microenvironment. Ferroptotic tumor cells release damage-associated molecular patterns, oxidized lipid mediators, and nucleic acids, which can either activate or suppress antitumor immunity. Conversely, immune cells modulate tumor cell sensitivity to ferroptosis through the secretion of cytokines and metabolites. In this review, we summarize the current understanding of the interplay between ferroptosis and tumor immunity. Targeting ferroptosis may offer broad opportunities to enhance tumor immunotherapy.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trained immunity responses across infectious diseases and cancer vaccines. 传染病和癌症疫苗的训练免疫反应。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-02 DOI: 10.1016/j.it.2026.03.005
Kaiyu Fu, Rui Zhang, Yusi Wang, Rutie Yin, Li Yang
{"title":"Trained immunity responses across infectious diseases and cancer vaccines.","authors":"Kaiyu Fu, Rui Zhang, Yusi Wang, Rutie Yin, Li Yang","doi":"10.1016/j.it.2026.03.005","DOIUrl":"https://doi.org/10.1016/j.it.2026.03.005","url":null,"abstract":"<p><p>Trained immunity (TRIM), a paradigm-shifting concept in immunology, refers to the long-term functional reprogramming of innate immune cells, enabling enhanced responsiveness to secondary challenges through metabolic and epigenetic remodeling. This phenomenon bridges the gap between innate and adaptive immunity, offering novel strategies for vaccine design that transcend traditional antigen-specific approaches. By exploiting the 'memorylike' properties of monocytes, macrophages, dendritic cells, neutrophils, and natural killer cells, next-generation vaccines aim to achieve broad-spectrum protection, prolonged durability, and heterologous immunity against pathogens and cancers. This review synthesizes recent advances in TRIM research in vaccines, focusing on its mechanisms, translational applications, and future directions in vaccinology.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet-induced death: microbiome-mediated lipid stress reduces intestinal ILC3s. 饮食引起的死亡：微生物组介导的脂质应激降低肠道ILC3s。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.1016/j.it.2026.03.002
Myeong Joon Kim, Gregory F Sonnenberg
{"title":"Diet-induced death: microbiome-mediated lipid stress reduces intestinal ILC3s.","authors":"Myeong Joon Kim, Gregory F Sonnenberg","doi":"10.1016/j.it.2026.03.002","DOIUrl":"10.1016/j.it.2026.03.002","url":null,"abstract":"<p><p>Group 3 innate lymphoid cells (ILC3s) promote gastrointestinal health, dynamically interface with diet and microbes, and become impaired during chronic inflammation or metabolic syndrome. Torrico and colleagues uncover a key pathway rapidly disrupting ILC3 homeostasis in the intestines of humans and mice following the consumption of a high-fat diet.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"252-254"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147522812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The translational potential of studying bat immunity: DOI of original article: https://doi.org/10.1016/j.it.2024.01.007 (Trends in Immunology, 45, 188-197, 2024). 蝙蝠免疫研究的转化潜力：原文DOI: https://doi.org/10.1016/j.it.2024.01.007 （Trends in Immunology, 45,188 - 197,2024）。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-03-19 DOI: 10.1016/j.it.2026.01.004
Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee
{"title":"The translational potential of studying bat immunity: DOI of original article: https://doi.org/10.1016/j.it.2024.01.007 (Trends in Immunology, 45, 188-197, 2024).","authors":"Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee","doi":"10.1016/j.it.2026.01.004","DOIUrl":"10.1016/j.it.2026.01.004","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"337"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IEL-IEC circuit in barrier immunity and beyond. 屏障抗扰及以上的IEL-IEC电路。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2025-12-05 DOI: 10.1016/j.it.2025.11.004
Siyan Che, Yue Wang, Zi Wang, Yulong Yin, Miaomiao Wu
{"title":"IEL-IEC circuit in barrier immunity and beyond.","authors":"Siyan Che, Yue Wang, Zi Wang, Yulong Yin, Miaomiao Wu","doi":"10.1016/j.it.2025.11.004","DOIUrl":"10.1016/j.it.2025.11.004","url":null,"abstract":"<p><p>The intestinal epithelium functions as an immune-metabolic interface, integrating environmental signals to maintain systemic homeostasis. Intraepithelial lymphocytes (IELs), interspersed within the epithelial layer, form a highly interactive network with intestinal epithelial cells (IECs) to coordinate barrier defense, immune tolerance, and metabolic regulation. IECs orchestrate IEL development, positioning, and functional programming. Reciprocally, IELs modulate epithelial physiology, nutrient uptake, and epithelial repair. Dysregulation of the IEL-IEC unit contributes to intestinal and extraintestinal pathologies. This review discusses current advances in IEL-IEC bidirectional communication, highlighting the influences of diet, microbial metabolites, and immune checkpoints on this interface. We propose a paradigm in which the IEL-IEC interplay functions as a key immunometabolic regulatory unit and represents a promising therapeutic target for systemic diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"307-319"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Get with the program: regulation of T cell death. 跟上程序：T细胞死亡的调节。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2025-11-25 DOI: 10.1016/j.it.2025.10.015
Timothy Patton, Hosna Sarani, Nazli Somuncuoglu, Kate E Lawlor, Alexandra J Corbett
{"title":"Get with the program: regulation of T cell death.","authors":"Timothy Patton, Hosna Sarani, Nazli Somuncuoglu, Kate E Lawlor, Alexandra J Corbett","doi":"10.1016/j.it.2025.10.015","DOIUrl":"10.1016/j.it.2025.10.015","url":null,"abstract":"<p><p>Programmed cell death (PCD) encompasses several tightly regulated molecular signalling pathways, leading to the controlled destruction of cells. Apoptosis is a non-immunogenic form of cell death that regulates homeostasis to cell stressors. In contrast, lytic forms of cell death - necroptosis, pyroptosis, and ferroptosis - promote inflammation, alerting the immune system to danger. As adaptive immune responders, T cells clonally expand in response to antigenic stimulation and rapidly contract following the clearance of infection. While the role of apoptosis in regulating these processes is relatively well understood, evidence for lytic death activity in T cells is emerging. This review provides an update on recent advances in the understanding of PCD pathways in conventional and unconventional T cells in diverse immune contexts.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"284-296"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resident T cells in the healthy and multiple sclerosis brain. 健康和多发性硬化症大脑中的常驻T细胞。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-01-07 DOI: 10.1016/j.it.2025.12.006
Joost Smolders, Cheng-Chih Hsiao, Inge Huitinga, Jörg Hamann
{"title":"Resident T cells in the healthy and multiple sclerosis brain.","authors":"Joost Smolders, Cheng-Chih Hsiao, Inge Huitinga, Jörg Hamann","doi":"10.1016/j.it.2025.12.006","DOIUrl":"10.1016/j.it.2025.12.006","url":null,"abstract":"<p><p>Insights into T-cell biology in the central nervous system (CNS) have evolved from early neuroinflammatory models demonstrating the pathogenic potential of autoreactive T cells to recent human studies defining resident T-cell populations in the healthy and diseased brain. We here discuss advances in postmortem brain tissue processing, flow cytometry, and transcriptional profiling revealing that human brain CD8<sup>+</sup> and CD4<sup>+</sup> T cells are tissue-resident memory T cells with distinct phenotypes shaped by CNS borders and parenchymal niches. These findings refine our understanding of CNS immune surveillance and provide a framework for dissecting T-cell contributions to multiple sclerosis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"297-306"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KLHL6: a proteostatic guardian against T-cell exhaustion. KLHL6：抗t细胞衰竭的蛋白抑制剂。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.it.2026.02.003
Yang Pu, Xuetao Cao
{"title":"KLHL6: a proteostatic guardian against T-cell exhaustion.","authors":"Yang Pu, Xuetao Cao","doi":"10.1016/j.it.2026.02.003","DOIUrl":"10.1016/j.it.2026.02.003","url":null,"abstract":"<p><p>Cheng et al.'s recent study identifies the Cullin3-RING E3 ubiquitin ligase complexes (CRL3) adaptor protein Kelch-like protein 6 (KLHL6) as a proteostasis regulator whose downregulation in chronically stimulated T cells leads to the accumulation of thymocyte selection-associated high mobility group box protein and phosphoglycerate mutase family member 5, driving T-cell dysfunction. This work positions T-cell exhaustion as a proteostatic disorder and highlights KLHL6 as a promising target for cancer immunotherapy.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"249-251"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147482239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine specificity in macrophages: JAK-STAT and beyond. 巨噬细胞的细胞因子特异性：JAK-STAT及其他。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-02-27 DOI: 10.1016/j.it.2026.01.002
Josje M A Huisman, Alexandra Drakaki, Thomas Decker, Marten A Hoeksema
{"title":"Cytokine specificity in macrophages: JAK-STAT and beyond.","authors":"Josje M A Huisman, Alexandra Drakaki, Thomas Decker, Marten A Hoeksema","doi":"10.1016/j.it.2026.01.002","DOIUrl":"10.1016/j.it.2026.01.002","url":null,"abstract":"<p><p>Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"255-258"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of long-lived IgE plasma cells for protracted allergies. 长期存在的IgE浆细胞对持续性过敏的重要性。
IF 13.9 1区 医学
Trends in Immunology Pub Date : 2026-04-01 Epub Date: 2026-03-17 DOI: 10.1016/j.it.2026.01.006
Marcus J Robinson
{"title":"The importance of long-lived IgE plasma cells for protracted allergies.","authors":"Marcus J Robinson","doi":"10.1016/j.it.2026.01.006","DOIUrl":"10.1016/j.it.2026.01.006","url":null,"abstract":"<p><p>IgE contributes to allergy, but its cellular sources are rare and hard to identify. Genetic fate mapping and single-cell sequencing approaches have now revealed that two cell populations maintain IgE: long-lived IgE plasma cells (PCs) and 'type 2' memory B cells. This forum piece discusses recent discoveries on long-lived IgE PCs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"259-261"},"PeriodicalIF":13.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书