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Biomolecular condensates: phasing in regulated host-pathogen interactions. 生物分子凝聚体：宿主与病原体相互作用的相位调节。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2024-12-12 DOI: 10.1016/j.it.2024.11.010
Kun Chen, Xuetao Cao
{"title":"Biomolecular condensates: phasing in regulated host-pathogen interactions.","authors":"Kun Chen, Xuetao Cao","doi":"10.1016/j.it.2024.11.010","DOIUrl":"10.1016/j.it.2024.11.010","url":null,"abstract":"<p><p>Biomolecular condensates are membraneless organelles formed through liquid-liquid phase separation. Innate immunity is essential to host defense against infections, but pathogens also harbor sophisticated mechanisms to evade host defense. The formation of biomolecular condensates emerges as a key biophysical mechanism in host-pathogen interactions, playing pivotal roles in regulating immune responses and pathogen life cycles within the host. In this review we summarize recent advances in our understanding of how biomolecular condensates remodel membrane-bound organelles, influence infection-induced cell death, and are hijacked by pathogens for survival, as well as how they modulate mammalian innate immunity. We discuss the implications of dysregulated formation of biomolecular condensates during host-pathogen interactions and infectious diseases and propose future directions for developing potential treatments against such infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"29-45"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for studying neuroimmune interactions in Alzheimer's diseases: (Trends in Immunology 45, 971-986; December 2024). 阿尔茨海默病中神经免疫相互作用的研究方法[j] .免疫学趋势，45,971-986；2024年12月)。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1016/j.it.2024.12.003
Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi
{"title":"Approaches for studying neuroimmune interactions in Alzheimer's diseases: (Trends in Immunology 45, 971-986; December 2024).","authors":"Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi","doi":"10.1016/j.it.2024.12.003","DOIUrl":"10.1016/j.it.2024.12.003","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"90"},"PeriodicalIF":13.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotube-mediated mitochondrial transfer: power to the T cells! 纳米管介导的线粒体转移：为 T 细胞提供动力！
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.it.2024.11.001
Cosima T Baldari
{"title":"Nanotube-mediated mitochondrial transfer: power to the T cells!","authors":"Cosima T Baldari","doi":"10.1016/j.it.2024.11.001","DOIUrl":"10.1016/j.it.2024.11.001","url":null,"abstract":"<p><p>The success of T cell-based immunotherapies is limited by exhaustion, which is associated with mitochondrial dysfunction. Baldwin and colleagues show that bone marrow stromal cells (BMSCs) use nanotubes to transfer mitochondria to T cells, which increases mitochondria mass and fitness and boosts antitumor efficacy. The results pave the way to organelle-based therapies against cancer.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"917-919"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do autoimmune CD4+ T cells handle exhaustion? 自身免疫 CD4+ T 细胞如何处理衰竭？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.004
Astrid Fabri, Lucy S K Walker
{"title":"How do autoimmune CD4<sup>+</sup> T cells handle exhaustion?","authors":"Astrid Fabri, Lucy S K Walker","doi":"10.1016/j.it.2024.11.004","DOIUrl":"10.1016/j.it.2024.11.004","url":null,"abstract":"<p><p>Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4<sup>+</sup> T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L<sup>+</sup> CD4<sup>+</sup> T cells seems to sustain the local autoimmune response.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"922-924"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing tumor immunity via in vivo cDC1 reprogramming. 通过体内 cDC1 重编程增强肿瘤免疫力。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1016/j.it.2024.11.008
Yoojung Kwon, Kyunghee Choi
{"title":"Enhancing tumor immunity via in vivo cDC1 reprogramming.","authors":"Yoojung Kwon, Kyunghee Choi","doi":"10.1016/j.it.2024.11.008","DOIUrl":"10.1016/j.it.2024.11.008","url":null,"abstract":"<p><p>A recent study by Ascic et al. demonstrates that in situ reprogramming of tumor cells into conventional dendritic cell (cDC)-like cells using viral-PIB transcription factors creates an immunogenic tumor microenvironment with T cell recruitment and activation. The study highlights the potential of tumor-specific cancer immunotherapy using in vivo reprogrammed cDCs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"934-936"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions. 分解 IgA：嗜免疫通明菌揭示微生物与免疫的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.003
Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan
{"title":"Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.","authors":"Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan","doi":"10.1016/j.it.2024.11.003","DOIUrl":"10.1016/j.it.2024.11.003","url":null,"abstract":"<p><p>The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"928-930"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering immunity: bacterial delivery of cancer neoantigen vaccines. 工程免疫：癌症新抗原疫苗的细菌递送。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.007
Christopher D Johnston, Jennifer A Wargo
{"title":"Engineering immunity: bacterial delivery of cancer neoantigen vaccines.","authors":"Christopher D Johnston, Jennifer A Wargo","doi":"10.1016/j.it.2024.11.007","DOIUrl":"10.1016/j.it.2024.11.007","url":null,"abstract":"<p><p>In the battle against cancer, researchers are exploring the use of engineered bacteria as living medicines. Redenti and colleagues demonstrate that Escherichia coli Nissle 1917 (EcN) can be engineered to deliver cancer neoantigen payloads, stimulating antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells and mediating antitumor immunity in preclinical models of colorectal cancer and melanoma.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"931-933"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel insights into the dynamic function of PRC2 in innate immunity. 对 PRC2 在先天性免疫中动态功能的新认识。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.10.003
Rosalie W M Kempkes, Rab K Prinjha, Menno P J de Winther, Annette E Neele
{"title":"Novel insights into the dynamic function of PRC2 in innate immunity.","authors":"Rosalie W M Kempkes, Rab K Prinjha, Menno P J de Winther, Annette E Neele","doi":"10.1016/j.it.2024.10.003","DOIUrl":"10.1016/j.it.2024.10.003","url":null,"abstract":"<p><p>The polycomb repressive complex 2 (PRC2) is an established therapeutic target in cancer. PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that modulation of PRC2 not only impacts cell differentiation and tumor growth but also has immunomodulatory properties. Here, we integrate multiple immunological fields to understand PRC2 and its subunits in epigenetic canonical regulation and non-canonical mechanisms within innate immunity. We discuss how PRC2 regulates hematopoietic stem cell proliferation, myeloid cell differentiation, and shapes innate immune responses. The PRC2 catalytic domain EZH2 is upregulated in various human inflammatory diseases and its deletion or inhibition in experimental mouse models can reduce disease severity, emphasizing its importance in regulating inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"1015-1030"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unanticipated specificity in effector-triggered immunity. 效应器触发免疫中意想不到的特异性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1016/j.it.2024.10.008
Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking
{"title":"Unanticipated specificity in effector-triggered immunity.","authors":"Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking","doi":"10.1016/j.it.2024.10.008","DOIUrl":"10.1016/j.it.2024.10.008","url":null,"abstract":"<p><p>Effector-triggered immunity (ETI) enables hosts to react to pathogens by monitoring few key cellular processes. ETI responses are assumed to be similar toward related pathogen effectors. However, recent evidence from the invertebrate model Caenorhabditis elegans and pore-forming toxins indicates a much more complex and specific ETI than previously anticipated.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"939-942"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immune-endocrine interplay in sex differential responses to viral infection and COVID-19. 免疫-内分泌在对病毒感染和 COVID-19 的性别差异反应中的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1016/j.it.2024.10.004
Valentino D'Onofrio, Rafick Pierre Sékaly
{"title":"The immune-endocrine interplay in sex differential responses to viral infection and COVID-19.","authors":"Valentino D'Onofrio, Rafick Pierre Sékaly","doi":"10.1016/j.it.2024.10.004","DOIUrl":"10.1016/j.it.2024.10.004","url":null,"abstract":"<p><p>Men are at higher risk for developing severe COVID-19 than women, while women are at higher risk for developing post-acute sequelae of COVID-19 (PASC). This highlights the impact of sex differences on immune responses and clinical outcomes of acute COVID-19 or PASC. A dynamic immune-endocrine interface plays an important role in the development of effective immune responses impacting the control of viral infections. In this opinion article we discuss mechanisms underlying the transcriptional and epigenetic regulation of immune responses by sex hormones during viral infections. We propose that disruption of this delicate immune-endocrine interplay can result in worsened outcomes of viral disease. We also posit that insights into these immune mechanisms can propel the development of novel immunomodulatory interventions that leverage immune-endocrine pathways to treat viral infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"943-958"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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