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Trends in Immunology最新文献

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Complement: you gutsy thing!: (Trends in Immunology 45, 228-230; 2024).
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-15 DOI: 10.1016/j.it.2025.02.001
Claudia Kemper
{"title":"Complement: you gutsy thing!: (Trends in Immunology 45, 228-230; 2024).","authors":"Claudia Kemper","doi":"10.1016/j.it.2025.02.001","DOIUrl":"10.1016/j.it.2025.02.001","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"258"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel insights and recent progress in osteoimmunology.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.it.2025.02.003
Iannis E Adamopoulos, Yongwon Choi, Hiroshi Takayanagi
{"title":"Novel insights and recent progress in osteoimmunology.","authors":"Iannis E Adamopoulos, Yongwon Choi, Hiroshi Takayanagi","doi":"10.1016/j.it.2025.02.003","DOIUrl":"10.1016/j.it.2025.02.003","url":null,"abstract":"<p><p>Osteoimmunology is an interdisciplinary branch of immunology studying bidirectional interactions between the immune and skeletal systems. Bone marrow is vital for the production of immune cells and is implicated in multiple diseases across all immunology disciplines. Here, we briefly discuss recent progress from the past 5 years in the field and how it impacts our current understanding of health and disease.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"192-194"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rest and rinse: sleeping rhythms drive brain detox.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.1016/j.it.2025.02.007
Leon C D Smyth, Benjamin A Plog, Jonathan Kipnis
{"title":"Rest and rinse: sleeping rhythms drive brain detox.","authors":"Leon C D Smyth, Benjamin A Plog, Jonathan Kipnis","doi":"10.1016/j.it.2025.02.007","DOIUrl":"10.1016/j.it.2025.02.007","url":null,"abstract":"<p><p>Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"189-191"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.1016/j.it.2025.02.004
Bhesh Raj Sharma, Thirumala-Devi Kanneganti
{"title":"Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death.","authors":"Bhesh Raj Sharma, Thirumala-Devi Kanneganti","doi":"10.1016/j.it.2025.02.004","DOIUrl":"10.1016/j.it.2025.02.004","url":null,"abstract":"<p><p>Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"183-185"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoallelic expression in human immune cells: linking genotype to phenotype.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1016/j.it.2025.02.005
Lennart Hammarström, Qiang Pan-Hammarström
{"title":"Monoallelic expression in human immune cells: linking genotype to phenotype.","authors":"Lennart Hammarström, Qiang Pan-Hammarström","doi":"10.1016/j.it.2025.02.005","DOIUrl":"10.1016/j.it.2025.02.005","url":null,"abstract":"<p><p>Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was recently and elegantly demonstrated by Stewart et al.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"186-188"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New thoughts on the gut-immune axis of arthritis.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1016/j.it.2025.01.006
Alexandra Thiran, Lars Vereecke
{"title":"New thoughts on the gut-immune axis of arthritis.","authors":"Alexandra Thiran, Lars Vereecke","doi":"10.1016/j.it.2025.01.006","DOIUrl":"10.1016/j.it.2025.01.006","url":null,"abstract":"<p><p>Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the 'gut-joint axis hypothesis' in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have provided insights into potential mechanisms by uncovering microbial influences and immune pathways that either connect or uncouple gut and joint inflammation. Based on recent findings, we propose the 'immune hypersensitivity hypothesis' whereby central immune hyper-reactivity can independently drive joint inflammation via local sterile triggers, and gut inflammation via microbial triggers. We argue that this suggests a more nuanced role of the microbiota in arthritis pathogenesis that varies according to the predominant immune mechanisms in disease subtypes. We explore gut-immune interactions in arthritis, highlight ongoing challenges, and propose future research directions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"206-218"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic and stress response adaptations in T cells to fever and physiological heat.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI: 10.1016/j.it.2025.01.007
Benjamin A Wilander, Jeffrey C Rathmell
{"title":"Metabolic and stress response adaptations in T cells to fever and physiological heat.","authors":"Benjamin A Wilander, Jeffrey C Rathmell","doi":"10.1016/j.it.2025.01.007","DOIUrl":"10.1016/j.it.2025.01.007","url":null,"abstract":"<p><p>Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform mammalian T cell metabolism, differentiation, and stress responses. Recent evidence indicates that metabolic programs initiated by fever are maintained upon return to thermo-normality, potentially providing a lasting benefit. Despite its impact, temperature remains overlooked and warrants further study. This is especially apparent when considering the wide temperature differential between tissues within the body and during inflammatory disease progression. We propose that differences in the metabolic and stress responses between T cell subsets upon thermal stress contribute to determining immune cell makeup and fate during inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"195-205"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-03-04 DOI: 10.1016/j.it.2025.01.008
Maryam Shojaei, Anthony S McLean
{"title":"Interferon-stimulated gene IFI27 as a multifaceted candidate target in precision medicine.","authors":"Maryam Shojaei, Anthony S McLean","doi":"10.1016/j.it.2025.01.008","DOIUrl":"10.1016/j.it.2025.01.008","url":null,"abstract":"<p><p>IFI27, an interferon (IFN)-stimulated gene, is emerging as a crucial player in immune responses across various species, with significant implications for precision medicine. Commonly found among the most upregulated genes in infections, cancers, as well as inflammatory and autoimmune disorders, IFI27 is ready to be trialed in clinical practice for certain indications, and holds promise as an immunomodulatory target. We hypothesize that IFI27 plays a dual role, typically supporting immune defense but sometimes contributing to disease progression, which might render it a putative biomarker for diagnosis, prognosis, and treatment response. We advocate for focused research on IFI27 to unlock its potential in precision medicine and to contribute to a unifying framework of its mechanisms in the immune response. Our viewpoint is supported by numerous studies highlighting IFI27's involvement across various conditions and the possibilities for clinical application.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"219-228"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helper ILCs in the human hematopoietic system.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.it.2025.01.009
Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu
{"title":"Helper ILCs in the human hematopoietic system.","authors":"Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu","doi":"10.1016/j.it.2025.01.009","DOIUrl":"10.1016/j.it.2025.01.009","url":null,"abstract":"<p><p>Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural killer (NK) cells] in humans and mice. Although ILCs are primarily tissue-resident cells, their role in the hematopoietic system is increasingly being recognized. This review provides an overview of ILC ontogeny, as well as the physiological and pathological roles of these cells within the human and murine hematopoietic systems. We recapitulate recent advancements regarding ILC embryonic hematopoietic origin and the dynamic interactions between ILCs and leukemic cells or other immune cell populations, highlighting the dual roles ILCs can play in carcinogenesis. Exploring the functional potential of ILCs can inform the design of rational immunotherapeutic strategies against hematological malignancies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"244-257"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lymph node fibroblast-produced extracellular matrix shapes immune function.
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.1016/j.it.2025.02.002
Daphne Panocha, Janna E G Roet, Jesse E Kuipers, Charlotte M de Winde, Reina E Mebius
{"title":"Lymph node fibroblast-produced extracellular matrix shapes immune function.","authors":"Daphne Panocha, Janna E G Roet, Jesse E Kuipers, Charlotte M de Winde, Reina E Mebius","doi":"10.1016/j.it.2025.02.002","DOIUrl":"10.1016/j.it.2025.02.002","url":null,"abstract":"<p><p>Lymph node (LN) fibroblastic reticular cells (FRCs) are key regulators of mammalian adaptive immune responses. Together with their deposited extracellular matrix (ECM), FRCs form a reticular network that provides mechanical strength to LNs. Furthermore, the ECM regulates various cell functions including proliferation and differentiation. The ECM is dynamically remodeled in activated LNs, thereby affecting immune cell survival and function. Although both the LN ECM and FRCs can affect immune reactivity, a link between altered LN ECM during an immune response and ECM-producing FRCs is lacking. We explore recent work on the complex interplay between FRCs, ECM, and immune cells in health and disease, and provide guidance for future research to understand the complex regulation of the adaptive immune system within LNs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"229-243"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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