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Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface. 嗅觉上皮细胞的神经免疫相互作用：在免疫屏障界面上维持一个感觉器官。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1016/j.it.2024.10.005
Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane
{"title":"Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface.","authors":"Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane","doi":"10.1016/j.it.2024.10.005","DOIUrl":"10.1016/j.it.2024.10.005","url":null,"abstract":"<p><p>While primarily a sensory organ, the mammalian olfactory epithelium (OE) also plays a critical role as an immune barrier. Mechanisms governing interactions between the immune system and this specialized chemosensory tissue are gaining interest, in part sparked by the COVID-19 pandemic. Regulated inflammation is intrinsic to normal mucosal healing and homeostasis, but prolonged OE inflammation is associated with persistent loss of smell, belying the intertwining of local mucosal immunology and olfactory function. Evidence supports bidirectional communication between OE cells and the immune system in health and disease. Recent investigations suggest that neuro-immune cross-talk modulates olfactory stem cell behavior and neuronal regeneration dynamics, prioritizing the epithelial-like non-neuronal framework with immune barrier function at the expense of the neurosensory organ in chronic inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"987-1000"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. SARS-CoV-2 使小鼠肺泡巨噬细胞重编程，从而抑制流感。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1016/j.it.2024.11.002
Alexandra Tabachnikova, Akiko Iwasaki
{"title":"SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu.","authors":"Alexandra Tabachnikova, Akiko Iwasaki","doi":"10.1016/j.it.2024.11.002","DOIUrl":"10.1016/j.it.2024.11.002","url":null,"abstract":"<p><p>Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"925-927"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytosolic delivery of innate immune agonists. 先天性免疫激动剂的胞浆输送。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1016/j.it.2024.10.007
Ravi Bharadwaj, Swati Jaiswal, Neal Silverman
{"title":"Cytosolic delivery of innate immune agonists.","authors":"Ravi Bharadwaj, Swati Jaiswal, Neal Silverman","doi":"10.1016/j.it.2024.10.007","DOIUrl":"10.1016/j.it.2024.10.007","url":null,"abstract":"<p><p>Solute carrier proteins (SLCs) are pivotal for maintaining cellular homeostasis by transporting small molecules across cellular membranes. Recent discoveries have uncovered their involvement in modulating innate immunity, particularly within the cytosol. We review emerging evidence that links SLC transporters to cytosolic innate immune recognition and highlight their role in regulating inflammation. We explore how SLC transporters influence the activation of endosomal Toll-like receptors, cytosolic NODs, and STING sensors. Understanding the contribution of SLCs to innate immune recognition provides insight into their fundamental biological functions and opens new avenues to develop possible therapeutic interventions for autoimmune and inflammatory diseases. This review aims to discuss current knowledge and identify key gaps in this rapidly evolving field.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"1001-1014"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weapon of choice: viruses share cross-kingdom tools. 首选武器：病毒共享跨领域工具。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1016/j.it.2024.11.006
C J E Metcalf, B Koskella
{"title":"Weapon of choice: viruses share cross-kingdom tools.","authors":"C J E Metcalf, B Koskella","doi":"10.1016/j.it.2024.11.006","DOIUrl":"10.1016/j.it.2024.11.006","url":null,"abstract":"<p><p>Following on from the discovery that innate immune pathways are shared widely across the tree of life comes another surprise: Hobbs et al. show that viruses targeting animals and bacteria also use highly conserved tools to fight back. Why such mechanisms remain seemingly unchanged despite the rapid coevolution among hosts and pathogens is now a key open question for the field.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"937-938"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches for studying neuroimmune interactions in Alzheimer's disease. 研究阿尔茨海默病神经免疫相互作用的方法。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-12 DOI: 10.1016/j.it.2024.10.002
Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi
{"title":"Approaches for studying neuroimmune interactions in Alzheimer's disease.","authors":"Chih-Chung 'Jerry' Lin, Yuyao Tian, Rudolph E Tanzi, Mehdi Jorfi","doi":"10.1016/j.it.2024.10.002","DOIUrl":"10.1016/j.it.2024.10.002","url":null,"abstract":"<p><p>Peripheral immune cells play an important role in the pathology of Alzheimer's disease (AD), impacting processes such as amyloid and tau protein aggregation, glial activation, neuronal integrity, and cognitive decline. Here, we examine cutting-edge strategies - encompassing animal and cellular models - used to investigate the roles of peripheral immune cells in AD. Approaches such as antibody-mediated depletion, genetic ablation, and bone marrow chimeras in mouse models have been instrumental in uncovering T, B, and innate immune cell disease-modifying functions. However, challenges such as specificity, off-target effects, and differences between human and mouse immune systems underscore the need for more human-relevant models. Emerging multicellular models replicating critical aspects of human brain tissue and neuroimmune interactions increasingly offer fresh insights into the role of immune cells in AD pathogenesis. Refining these methodologies can deepen our understanding of immune cell contributions to AD and support the development of novel immune-related therapeutic interventions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"971-986"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases. 多肽选择性模型：解读 NK 细胞 KIR-HLA-I 结合相互作用及其与人类疾病的关联。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1016/j.it.2024.10.006
Malcolm J W Sim, Eric O Long
{"title":"The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases.","authors":"Malcolm J W Sim, Eric O Long","doi":"10.1016/j.it.2024.10.006","DOIUrl":"10.1016/j.it.2024.10.006","url":null,"abstract":"<p><p>Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular understanding of the multiple killer-cell immunoglobulin-like receptor (KIR)-human leukocyte antigen-1 (HLA-I) receptor-ligand interactions on natural killer (NK) cells and identifying the salient features that underlie disease risk. We hypothesize that a critical discriminating factor in KIR-HLA-I interactions is the selective detection of HLA-I-bound peptides by KIRs. We propose a 'peptide selectivity model', where high-avidity KIR-HLA-I interactions reflect low selectivity for peptides conferring consistent NK cell inhibition across different tissue immunopeptidomes. Conversely, lower-avidity interactions (including those with activating KIRs) are more dependent on HLA-I-bound peptide sequence, requiring an appreciation of how HLA-I immunopeptidomes influence KIR binding and regulate NK cell function. Relevant to understanding NK cell function and pathology, we interpret known KIR-HLA-I combinations and their associations with certain human diseases in the context of this 'peptide selectivity model'.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"959-970"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Please don't go: retinoic acid 'retains' tissue-specific memory. 请不要走：维甲酸 "保留 "组织特异性记忆。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.it.2024.11.005
Michal A Stanczak, Erika L Pearce
{"title":"Please don't go: retinoic acid 'retains' tissue-specific memory.","authors":"Michal A Stanczak, Erika L Pearce","doi":"10.1016/j.it.2024.11.005","DOIUrl":"10.1016/j.it.2024.11.005","url":null,"abstract":"<p><p>Tissue-resident memory (T<sub>RM</sub>) T cells not only control infection and cancer, but also contribute to inflammatory disease. In a recent study, Obers et al. demonstrate that retinoic acid (RA) and TGF-β direct T<sub>RM</sub> residency in mice, with RA uniquely retaining cells in the intestine by limiting migration. This discovery highlights the potential for harnessing local residency cues to enhance tissue-specific T<sub>RM</sub> responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"920-921"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol sensing and metabolic adaptation in tissue immunity. 组织免疫中的胆固醇感应和代谢适应。
IF 4.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-17 DOI: 10.1016/j.it.2024.09.013
Eric V Dang, Andrea Reboldi
{"title":"Cholesterol sensing and metabolic adaptation in tissue immunity.","authors":"Eric V Dang, Andrea Reboldi","doi":"10.1016/j.it.2024.09.013","DOIUrl":"10.1016/j.it.2024.09.013","url":null,"abstract":"<p><p>Cholesterol metabolites, particularly oxidized forms known as oxysterols, play crucial roles in modulating immune and metabolic processes across various tissues. Concentrations of local cholesterol and its metabolites influence tissue-specific immune responses by shaping the metabolic and spatial organization of immune cells in barrier organs like the small intestine (SI) and lungs. We explore recent molecular and cellular evidence supporting the metabolic adaptation of innate and adaptive immune cells in the SI and lung, driven by cholesterol and cholesterol metabolites. Further research should unravel the detailed molecular mechanisms and spatiotemporal adaptations involving cholesterol metabolites in distinct mucosal tissues in homeostasis or infection. We posit that pharmacological interventions targeting the generation or sensing of cholesterol metabolites might be leveraged to enhance long-term immune protection in mucosal tissues or prevent autoinflammatory states.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"861-870"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional specialization within the mammalian respiratory immune system. 哺乳动物呼吸道免疫系统的区域特化。
IF 4.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-21 DOI: 10.1016/j.it.2024.09.011
David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni
{"title":"Regional specialization within the mammalian respiratory immune system.","authors":"David P Hoytema van Konijnenburg, Peter A Nigrovic, Ivan Zanoni","doi":"10.1016/j.it.2024.09.011","DOIUrl":"10.1016/j.it.2024.09.011","url":null,"abstract":"<p><p>The respiratory tract is exposed to infection from inhaled pathogens, including viruses, bacteria, and fungi. So far, a comprehensive assessment that integrates common and distinct aspects of the immune response along different areas of the respiratory tract has been lacking. Here, we discuss key recent findings regarding anatomical, functional, and microbial factors driving regional immune adaptation in the mammalian respiratory system, how they differ between mice and humans, and the similarities and differences with the gastrointestinal tract. We demonstrate that, under evolutionary pressure, mammals evolved spatially organized immune defenses that vary between the upper and lower respiratory tract. Overall, we propose that the functional specialization of the immune response along the respiratory tract has fundamental implications for the management of infectious or inflammatory diseases.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"871-891"},"PeriodicalIF":4.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systems immunology insights into brain metastasis. 系统免疫学洞察脑转移。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-11-01 Epub Date: 2024-10-22 DOI: 10.1016/j.it.2024.09.010
Wenjuan Dong, Jianting Sheng, Johnny Z M Cui, Hong Zhao, Stephen T C Wong
{"title":"Systems immunology insights into brain metastasis.","authors":"Wenjuan Dong, Jianting Sheng, Johnny Z M Cui, Hong Zhao, Stephen T C Wong","doi":"10.1016/j.it.2024.09.010","DOIUrl":"10.1016/j.it.2024.09.010","url":null,"abstract":"<p><p>Brain metastasis poses formidable clinical challenges due to its intricate interactions with the brain's unique immune environment, often resulting in poor prognoses. This review delves into systems immunology's role in uncovering the dynamic interplay between metastatic cancer cells and brain immunity. Leveraging spatial and single-cell technologies, along with advanced computational modeling, systems immunology offers unprecedented insights into mechanisms of immune evasion and tumor proliferation. Recent studies highlight potential immunotherapeutic targets, suggesting strategies to boost antitumor immunity and counteract cancer cell evasion in the brain. Despite substantial progress, challenges persist, particularly in accurately simulating human conditions. This review underscores the need for interdisciplinary collaboration to harness systems immunology's full potential, aiming to dramatically improve outcomes for patients with brain metastasis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"903-916"},"PeriodicalIF":13.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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