发布求助
文献互助 智能选刊 最新文献

Trends in Immunology最新文献

筛选
英文 中文
Emerging roles of astrocytes as immune effectors in the central nervous system. 星形胶质细胞作为中枢神经系统免疫效应因子的新作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.it.2024.08.008
Theodore M Fisher, Shane A Liddelow
{"title":"Emerging roles of astrocytes as immune effectors in the central nervous system.","authors":"Theodore M Fisher, Shane A Liddelow","doi":"10.1016/j.it.2024.08.008","DOIUrl":"10.1016/j.it.2024.08.008","url":null,"abstract":"<p><p>The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded as a functionally diverse mediator of homeostasis. During development and throughout adulthood, astrocytes have essential roles, such as providing neuron metabolic support, modulating synaptic function, and maintaining the blood-brain barrier (BBB). Recent evidence continues to underscore their functional heterogeneity and importance for CNS maintenance, as well as how these cells ensure optimal CNS and immune responses to disease, acute trauma, and infection. Advances in our understanding of neuroimmune interactions complement our knowledge of astrocyte functional heterogeneity, where astrocytes are now regarded as key effectors and propagators of immune signaling. This shift in perspective highlights the role of astrocytes not merely as support cells, but as active participants in CNS immune responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"824-836"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Boosting peripheral immunity to fight neurodegeneration in the brain. 增强外周免疫力，对抗大脑神经变性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 DOI: 10.1016/j.it.2024.08.002
Michal Schwartz, Sarah Phoebeluc Colaiuta
{"title":"Boosting peripheral immunity to fight neurodegeneration in the brain.","authors":"Michal Schwartz, Sarah Phoebeluc Colaiuta","doi":"10.1016/j.it.2024.08.002","DOIUrl":"10.1016/j.it.2024.08.002","url":null,"abstract":"<p><p>Reciprocal communication between the brain and the immune system is essential for maintaining lifelong brain function. This interaction is mediated, at least in part, by immune cells recruited from both the circulation and niches at the borders of the brain. Here, we describe how immune exhaustion and senescence, even if not primary causative factors, can accelerate neurodegenerative diseases. We emphasize the role of a compromised peripheral immune system in driving neurodegeneration and discuss strategies for harnessing peripheral immunity to effectively treat neurodegenerative diseases, including the underlying mechanisms and opportunities for clinical translation. Specifically, we highlight the potential of boosting the immune system by blocking inhibitory checkpoint molecules to harness reparative immune cells in helping the brain to fight against neurodegeneration.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"760-767"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOE4 affects neutrophil-microglia crosstalk in Alzheimer's disease. APOE4 影响阿尔茨海默病中嗜中性粒细胞与小胶质细胞之间的串联。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-24 DOI: 10.1016/j.it.2024.09.002
Eleonora Terrabuio, Gabriela Constantin
{"title":"APOE4 affects neutrophil-microglia crosstalk in Alzheimer's disease.","authors":"Eleonora Terrabuio, Gabriela Constantin","doi":"10.1016/j.it.2024.09.002","DOIUrl":"10.1016/j.it.2024.09.002","url":null,"abstract":"<p><p>Circulating immune cells contribute to the pathogenesis of Alzheimer's disease (AD), but their role is poorly understood. Rosenzweig et al. recently identified a subset of interleukin (IL)-17<sup>+</sup> neutrophils that inhibit neuroprotective microglia in female APOE4 carriers. Blockade of IL-17 signaling or APOE4 deletion in neutrophils restored microglial responses and reduced murine amyloid pathology.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"726-728"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protect, repair, rewire, and defend. 保护、修复、重新接线和防御。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-23 DOI: 10.1016/j.it.2024.09.008
Catarina Sacristán
{"title":"Protect, repair, rewire, and defend.","authors":"Catarina Sacristán","doi":"10.1016/j.it.2024.09.008","DOIUrl":"10.1016/j.it.2024.09.008","url":null,"abstract":"","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"715-717"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mononuclear phagocytes in autoimmune neuroinflammation. 自身免疫性神经炎症中的单核吞噬细胞
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1016/j.it.2024.08.005
Violetta S Gogoleva, Sarah Mundt, Donatella De Feo, Burkhard Becher
{"title":"Mononuclear phagocytes in autoimmune neuroinflammation.","authors":"Violetta S Gogoleva, Sarah Mundt, Donatella De Feo, Burkhard Becher","doi":"10.1016/j.it.2024.08.005","DOIUrl":"10.1016/j.it.2024.08.005","url":null,"abstract":"<p><p>A healthy mammalian central nervous system (CNS) harbors a diverse population of leukocytes including members of the mononuclear phagocyte system (MPS). Exerting their specific functions, CNS tissue-resident macrophages as well as associated monocytes and dendritic cells (DCs) maintain CNS homeostasis. Under neuroinflammatory conditions, leukocytes from the systemic immune compartment invade the CNS. This review focuses on the newly discovered roles of the MPS in autoimmune neuroinflammation elicited by encephalitogenic T cells. We propose that CNS-associated DCs act as gatekeepers and antigen-presenting cells that guide the adaptive immune response while bone marrow (BM)-derived monocytes contribute to immunopathology and tissue damage. By contrast, CNS-resident macrophages primarily support tissue function and promote the repair and maintenance of CNS functions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"814-823"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The putative contribution of cellular senescence to driving tauopathies. 细胞衰老对牛磺酸病的推定驱动作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI: 10.1016/j.it.2024.08.006
Deniz Karabag, Michael T Heneka, Christina Ising
{"title":"The putative contribution of cellular senescence to driving tauopathies.","authors":"Deniz Karabag, Michael T Heneka, Christina Ising","doi":"10.1016/j.it.2024.08.006","DOIUrl":"10.1016/j.it.2024.08.006","url":null,"abstract":"<p><p>During mammalian aging, senescent cells accumulate in the body. Recent evidence suggests that senescent cells potentially contribute to age-related neurodegenerative diseases in the central nervous system (CNS), including tauopathies such as Alzheimer's disease (AD). Senescent cells undergo irreversible cell cycle arrest and release an inflammatory 'senescence-associated secretory profile' (SASP), which can exert devastating effects on surrounding cells. Senescent markers and SASP factors have been detected in multiple brain cells in tauopathies, including microglia, astrocytes, and perhaps even post-mitotic neurons, possibly contributing to the initiation as well as progression of these diseases. Here, we discuss the implications of presenting a senescent phenotype in tauopathies and highlight a potential role for the NOD-like receptor protein 3 (NLRP3) inflammasome as a newfound mechanism implicated in senescence and SASP formation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"837-848"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory nerves unlock the TOLL-7 gate for cancer spread. 感觉神经开启了 TOLL-7 癌症扩散的大门。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1016/j.it.2024.09.005
R K Subbarao Malireddi, Thirumala-Devi Kanneganti
{"title":"Sensory nerves unlock the TOLL-7 gate for cancer spread.","authors":"R K Subbarao Malireddi, Thirumala-Devi Kanneganti","doi":"10.1016/j.it.2024.09.005","DOIUrl":"10.1016/j.it.2024.09.005","url":null,"abstract":"<p><p>Cancers hijack the nervous system for growth and spread. Thus, disrupting neuron-cancer crosstalk holds promise for blocking metastasis. Recently, Padmanaban et al. reported new therapeutic targets and showed that breast cancer cells activate sensory neurons to secrete the neuropeptide substance P (SP), leading to single-strand (ss)RNA release and noncanonical Toll-like receptor (TLR)7 signaling that drives metastasis.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"732-734"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine. 神经退行性疾病和再生医学中神经炎症的新型人类 iPSC 模型。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-21 DOI: 10.1016/j.it.2024.08.004
Rose Ana Summers, Francesca Fagiani, David H Rowitch, Martina Absinta, Daniel S Reich
{"title":"Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine.","authors":"Rose Ana Summers, Francesca Fagiani, David H Rowitch, Martina Absinta, Daniel S Reich","doi":"10.1016/j.it.2024.08.004","DOIUrl":"10.1016/j.it.2024.08.004","url":null,"abstract":"<p><p>The importance of neuroinflammation in neurodegenerative diseases is becoming increasingly evident, and, in parallel, human induced pluripotent stem cell (hiPSC) models of physiology and pathology are emerging. Here, we review new advancements in the differentiation of hiPSCs into glial, neural, and blood-brain barrier (BBB) cell types, and the integration of these cells into complex organoids and chimeras. These advancements are relevant for modeling neuroinflammation in the context of prevalent neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). With awareness of current limitations, recent progress in the development and application of various hiPSC-derived models shows potential for aiding the identification of candidate therapeutic targets and immunotherapy approaches.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"799-813"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feeding the wrath with myelin. 用髓鞘喂养愤怒
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-27 DOI: 10.1016/j.it.2024.09.004
Sourav Ghosh, Carla V Rothlin
{"title":"Feeding the wrath with myelin.","authors":"Sourav Ghosh, Carla V Rothlin","doi":"10.1016/j.it.2024.09.004","DOIUrl":"10.1016/j.it.2024.09.004","url":null,"abstract":"<p><p>Kloosterman and colleagues studied molecular and cellular changes during radiation therapy and disease recurrence across molecular subtypes of glioblastoma. They uncovered a distinct immune-cancer cell metabolic crosstalk during proneural/oligodendrocyte progenitor cell-like to mesenchymal-like transition, wherein macrophages feed on cholesterol-rich myelin debris to provide lipids to mesenchymal tumor cells, thereby fueling glioblastoma growth.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"729-731"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11471388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular C1q - an unexpected player in neuronal proteostasis. 细胞内 C1q--神经元蛋白稳态的意外参与者
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1016/j.it.2024.09.006
Erin E West, Claudia Kemper
{"title":"Intracellular C1q - an unexpected player in neuronal proteostasis.","authors":"Erin E West, Claudia Kemper","doi":"10.1016/j.it.2024.09.006","DOIUrl":"10.1016/j.it.2024.09.006","url":null,"abstract":"<p><p>Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"718-720"},"PeriodicalIF":13.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信