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Lymph node fibroblast-produced extracellular matrix shapes immune function. 淋巴结成纤维细胞产生的细胞外基质形状免疫功能。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-28 DOI: 10.1016/j.it.2025.02.002
Daphne Panocha, Janna E G Roet, Jesse E Kuipers, Charlotte M de Winde, Reina E Mebius
{"title":"Lymph node fibroblast-produced extracellular matrix shapes immune function.","authors":"Daphne Panocha, Janna E G Roet, Jesse E Kuipers, Charlotte M de Winde, Reina E Mebius","doi":"10.1016/j.it.2025.02.002","DOIUrl":"10.1016/j.it.2025.02.002","url":null,"abstract":"<p><p>Lymph node (LN) fibroblastic reticular cells (FRCs) are key regulators of mammalian adaptive immune responses. Together with their deposited extracellular matrix (ECM), FRCs form a reticular network that provides mechanical strength to LNs. Furthermore, the ECM regulates various cell functions including proliferation and differentiation. The ECM is dynamically remodeled in activated LNs, thereby affecting immune cell survival and function. Although both the LN ECM and FRCs can affect immune reactivity, a link between altered LN ECM during an immune response and ECM-producing FRCs is lacking. We explore recent work on the complex interplay between FRCs, ECM, and immune cells in health and disease, and provide guidance for future research to understand the complex regulation of the adaptive immune system within LNs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"229-243"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New thoughts on the gut-immune axis of arthritis. 对关节炎肠道免疫轴的新认识。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1016/j.it.2025.01.006
Alexandra Thiran, Lars Vereecke
{"title":"New thoughts on the gut-immune axis of arthritis.","authors":"Alexandra Thiran, Lars Vereecke","doi":"10.1016/j.it.2025.01.006","DOIUrl":"10.1016/j.it.2025.01.006","url":null,"abstract":"<p><p>Arthritis is associated with varying degrees of intestinal inflammation and microbiota dysbiosis, leading to the 'gut-joint axis hypothesis' in which intestinal and joint inflammation are suggested to be interconnected through immune-microbiota interactions. While clinical observations support this, causality remains uncertain. Rodent models have provided insights into potential mechanisms by uncovering microbial influences and immune pathways that either connect or uncouple gut and joint inflammation. Based on recent findings, we propose the 'immune hypersensitivity hypothesis' whereby central immune hyper-reactivity can independently drive joint inflammation via local sterile triggers, and gut inflammation via microbial triggers. We argue that this suggests a more nuanced role of the microbiota in arthritis pathogenesis that varies according to the predominant immune mechanisms in disease subtypes. We explore gut-immune interactions in arthritis, highlight ongoing challenges, and propose future research directions.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"206-218"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helper ILCs in the human hematopoietic system. 人造血系统中的辅助ilc。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.1016/j.it.2025.01.009
Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu
{"title":"Helper ILCs in the human hematopoietic system.","authors":"Xiaoyu Su, Zhaoqun Deng, Yu Lan, Bing Liu, Chen Liu","doi":"10.1016/j.it.2025.01.009","DOIUrl":"10.1016/j.it.2025.01.009","url":null,"abstract":"<p><p>Helper innate lymphoid cells (ILCs), comprising groups ILC1, ILC2, and ILC3, possess unique advantages in eliciting rapid immune responses and were recently found to exhibit direct tumor-killing capacities comparable with those of cytotoxic ILCs [natural killer (NK) cells] in humans and mice. Although ILCs are primarily tissue-resident cells, their role in the hematopoietic system is increasingly being recognized. This review provides an overview of ILC ontogeny, as well as the physiological and pathological roles of these cells within the human and murine hematopoietic systems. We recapitulate recent advancements regarding ILC embryonic hematopoietic origin and the dynamic interactions between ILCs and leukemic cells or other immune cell populations, highlighting the dual roles ILCs can play in carcinogenesis. Exploring the functional potential of ILCs can inform the design of rational immunotherapeutic strategies against hematological malignancies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"244-257"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoallelic expression in human immune cells: linking genotype to phenotype. 人类免疫细胞中的单等位基因表达：将基因型与表型联系起来。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1016/j.it.2025.02.005
Lennart Hammarström, Qiang Pan-Hammarström
{"title":"Monoallelic expression in human immune cells: linking genotype to phenotype.","authors":"Lennart Hammarström, Qiang Pan-Hammarström","doi":"10.1016/j.it.2025.02.005","DOIUrl":"10.1016/j.it.2025.02.005","url":null,"abstract":"<p><p>Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was recently and elegantly demonstrated by Stewart et al.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"186-188"},"PeriodicalIF":13.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouse gut blueprint: regionality and resilience. 小鼠肠道蓝图：地域性和弹性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-28 DOI: 10.1016/j.it.2025.01.004
Qiwei Ge, Shujie Chen
{"title":"Mouse gut blueprint: regionality and resilience.","authors":"Qiwei Ge, Shujie Chen","doi":"10.1016/j.it.2025.01.004","DOIUrl":"10.1016/j.it.2025.01.004","url":null,"abstract":"<p><p>Mayassi and colleagues utilized spatial transcriptomics to create a comprehensive blueprint of the mouse gut, exploring its adaptability and resilience under perturbed conditions. Their work highlights the adaptive capabilities of the murine gut's regionalized structure, providing insights into how it functions in a coordinated manner and how it responds to external challenges.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"94-96"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic? 2型常规树突状细胞功能异质性：致个体性还是环境可塑性？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.it.2024.12.005
Beatriz León
{"title":"Type 2 conventional dendritic cell functional heterogeneity: ontogenically committed or environmentally plastic?","authors":"Beatriz León","doi":"10.1016/j.it.2024.12.005","DOIUrl":"10.1016/j.it.2024.12.005","url":null,"abstract":"<p><p>Conventional dendritic cells (cDCs) are sentinels of the mammalian immune system that sense a wide range of danger and homeostatic signals to induce appropriately targeted T cell immune responses. Traditionally classified into two main subsets, cDC1 and cDC2, recent research shows that cDC2s exhibit significant heterogeneity and can be further subdivided. Studies in mice and humans show that, beyond their ontogeny, cDC2s acquire dynamic and tissue-specific characteristics that are influenced by local environmental signals, which impact on their functions during homeostasis, inflammation, and infection. The novel concept is proposed that tissue-derived signals and tissue plasticity can override preestablished developmental programming, thereby redefining developmental trajectories and cDC2 functionality. Ultimately, understanding cDC2 heterogeneity and plasticity has important implications for modulating T cell immunity in health and disease.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"104-120"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular RNA acts as an antiviral MAVS signalosome scaffold. 细胞RNA作为抗病毒MAVS信号体支架。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1016/j.it.2025.01.003
Yang Liu, Xuetao Cao
{"title":"Cellular RNA acts as an antiviral MAVS signalosome scaffold.","authors":"Yang Liu, Xuetao Cao","doi":"10.1016/j.it.2025.01.003","DOIUrl":"10.1016/j.it.2025.01.003","url":null,"abstract":"<p><p>The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"97-99"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells. CCR8：抗肿瘤浸润性调节性T细胞的治疗靶点
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI: 10.1016/j.it.2025.01.001
Yuanjia Wen, Yu Xia, Xiangping Yang, Huayi Li, Qinglei Gao
{"title":"CCR8: a promising therapeutic target against tumor-infiltrating regulatory T cells.","authors":"Yuanjia Wen, Yu Xia, Xiangping Yang, Huayi Li, Qinglei Gao","doi":"10.1016/j.it.2025.01.001","DOIUrl":"10.1016/j.it.2025.01.001","url":null,"abstract":"<p><p>Tumor-infiltrating regulatory T (TI-Treg) cells constitute key components within the tumor microenvironment (TME) to suppress antitumor immunity and facilitate tumor progression. Although multiple therapies have been developed to eliminate TI-Treg cells, most of them exhibit only modest efficacy and harbor risks of inducing immune-related adverse events (irAEs). Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers. Here, we concentrate on the latest understanding of CCR8 regarding its expression, functions, and regulation, and summarize the current landscape of CCR8-targeted therapies. With favorable efficacy and safety, the latter represent an important class of next-generation putative cancer immunotherapies.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"153-165"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy. 蜕膜间质细胞：妊娠期间专门参与免疫调节的成纤维细胞。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-02-13 DOI: 10.1016/j.it.2024.12.007
Tatiana Llorca, María José Ruiz-Magaña, Ana C Abadía, Carmen Ruiz-Ruiz, Enrique G Olivares
{"title":"Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy.","authors":"Tatiana Llorca, María José Ruiz-Magaña, Ana C Abadía, Carmen Ruiz-Ruiz, Enrique G Olivares","doi":"10.1016/j.it.2024.12.007","DOIUrl":"10.1016/j.it.2024.12.007","url":null,"abstract":"<p><p>Decidual stromal cells (DSCs) are involved in immunoregulatory mechanisms that prevent fetal rejection by the mammalian maternal immune system. Recent studies using single-cell RNA sequencing demonstrated the existence of different types of human and mouse DSCs, highlighting corresponding differentiation (decidualization) pathways, and suggesting their involvement in the immune response during normal and pathological pregnancy. DSCs may be considered tissue-specialized fibroblasts because both DSCs and fibroblasts share phenotypic and functional similarities in immunologically challenged tissues, especially in terms of their immune functions. Indeed, fibroblasts can setup, support, and suppress immune responses and these functions are also performed by DSCs. Moreover, fibroblasts and DSCs can induce ectopic foci as tertiary lymphoid structures (TLSs), and endometriosis, respectively. Thus, understanding DSC immunoregulatory functions is of timely relevance.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"138-152"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging community engagement to shape biomedical research priorities. 利用社区参与来确定生物医学研究的优先事项。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-21 DOI: 10.1016/j.it.2024.12.004
Sara Suliman, Lillian Agyei, Shaista A Afzal, Shanell Williams
{"title":"Leveraging community engagement to shape biomedical research priorities.","authors":"Sara Suliman, Lillian Agyei, Shaista A Afzal, Shanell Williams","doi":"10.1016/j.it.2024.12.004","DOIUrl":"10.1016/j.it.2024.12.004","url":null,"abstract":"<p><p>Community engagement is essential for shaping equitable biomedical research priorities, but it is often underutilized, especially for marginalized populations. To integrate community feedback from the public into research, herein we describe a collaborative pilot funded by the Chan Zuckerberg Initiative which pairs the University of California San Francisco (UCSF) with the Rafiki Coalition for Health and Wellness. Utilizing focus groups modeled on Research Prioritization by Affected Communities, participants identified themes that included mistrust in healthcare, representation gaps, and the need for culturally responsive research. Priorities such as mental health, chronic disease, and access to black providers were highlighted. The findings emphasize the need for sustained, grassroots partnerships to drive inclusive research agendas.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"100-103"},"PeriodicalIF":13.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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