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Nanotube-mediated mitochondrial transfer: power to the T cells! 纳米管介导的线粒体转移：为 T 细胞提供动力！
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1016/j.it.2024.11.001
Cosima T Baldari
{"title":"Nanotube-mediated mitochondrial transfer: power to the T cells!","authors":"Cosima T Baldari","doi":"10.1016/j.it.2024.11.001","DOIUrl":"10.1016/j.it.2024.11.001","url":null,"abstract":"<p><p>The success of T cell-based immunotherapies is limited by exhaustion, which is associated with mitochondrial dysfunction. Baldwin and colleagues show that bone marrow stromal cells (BMSCs) use nanotubes to transfer mitochondria to T cells, which increases mitochondria mass and fitness and boosts antitumor efficacy. The results pave the way to organelle-based therapies against cancer.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"917-919"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How do autoimmune CD4+ T cells handle exhaustion? 自身免疫 CD4+ T 细胞如何处理衰竭？
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.004
Astrid Fabri, Lucy S K Walker
{"title":"How do autoimmune CD4<sup>+</sup> T cells handle exhaustion?","authors":"Astrid Fabri, Lucy S K Walker","doi":"10.1016/j.it.2024.11.004","DOIUrl":"10.1016/j.it.2024.11.004","url":null,"abstract":"<p><p>Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4<sup>+</sup> T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L<sup>+</sup> CD4<sup>+</sup> T cells seems to sustain the local autoimmune response.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"922-924"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing tumor immunity via in vivo cDC1 reprogramming. 通过体内 cDC1 重编程增强肿瘤免疫力。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-21 DOI: 10.1016/j.it.2024.11.008
Yoojung Kwon, Kyunghee Choi
{"title":"Enhancing tumor immunity via in vivo cDC1 reprogramming.","authors":"Yoojung Kwon, Kyunghee Choi","doi":"10.1016/j.it.2024.11.008","DOIUrl":"10.1016/j.it.2024.11.008","url":null,"abstract":"<p><p>A recent study by Ascic et al. demonstrates that in situ reprogramming of tumor cells into conventional dendritic cell (cDC)-like cells using viral-PIB transcription factors creates an immunogenic tumor microenvironment with T cell recruitment and activation. The study highlights the potential of tumor-specific cancer immunotherapy using in vivo reprogrammed cDCs.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"934-936"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions. 分解 IgA：嗜免疫通明菌揭示微生物与免疫的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.003
Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan
{"title":"Breaking down IgA: Tomasiella immunophila enlightens microbiome-immune interactions.","authors":"Duncan B Sutherland, Lucia M Kato, Sidonia Fagarasan","doi":"10.1016/j.it.2024.11.003","DOIUrl":"10.1016/j.it.2024.11.003","url":null,"abstract":"<p><p>The recent discovery by Lu and colleagues of Tomasiella immunophila, a bacterium that degrades IgA, offers insights into microbial influences on mucosal immunity and evolutionary immune trade-offs. By modulating IgA titers, T. immunophila influences the dynamic interactions and balance between the host and pathogen. This has implications for immune health, microbiome research, and therapeutics.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"928-930"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering immunity: bacterial delivery of cancer neoantigen vaccines. 工程免疫：癌症新抗原疫苗的细菌递送。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.11.007
Christopher D Johnston, Jennifer A Wargo
{"title":"Engineering immunity: bacterial delivery of cancer neoantigen vaccines.","authors":"Christopher D Johnston, Jennifer A Wargo","doi":"10.1016/j.it.2024.11.007","DOIUrl":"10.1016/j.it.2024.11.007","url":null,"abstract":"<p><p>In the battle against cancer, researchers are exploring the use of engineered bacteria as living medicines. Redenti and colleagues demonstrate that Escherichia coli Nissle 1917 (EcN) can be engineered to deliver cancer neoantigen payloads, stimulating antigen-specific CD4<sup>+</sup> and CD8<sup>+</sup> T cells and mediating antitumor immunity in preclinical models of colorectal cancer and melanoma.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"931-933"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel insights into the dynamic function of PRC2 in innate immunity. 对 PRC2 在先天性免疫中动态功能的新认识。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.it.2024.10.003
Rosalie W M Kempkes, Rab K Prinjha, Menno P J de Winther, Annette E Neele
{"title":"Novel insights into the dynamic function of PRC2 in innate immunity.","authors":"Rosalie W M Kempkes, Rab K Prinjha, Menno P J de Winther, Annette E Neele","doi":"10.1016/j.it.2024.10.003","DOIUrl":"10.1016/j.it.2024.10.003","url":null,"abstract":"<p><p>The polycomb repressive complex 2 (PRC2) is an established therapeutic target in cancer. PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that modulation of PRC2 not only impacts cell differentiation and tumor growth but also has immunomodulatory properties. Here, we integrate multiple immunological fields to understand PRC2 and its subunits in epigenetic canonical regulation and non-canonical mechanisms within innate immunity. We discuss how PRC2 regulates hematopoietic stem cell proliferation, myeloid cell differentiation, and shapes innate immune responses. The PRC2 catalytic domain EZH2 is upregulated in various human inflammatory diseases and its deletion or inhibition in experimental mouse models can reduce disease severity, emphasizing its importance in regulating inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"1015-1030"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142740853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unanticipated specificity in effector-triggered immunity. 效应器触发免疫中意想不到的特异性。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1016/j.it.2024.10.008
Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking
{"title":"Unanticipated specificity in effector-triggered immunity.","authors":"Alejandra Zárate-Potes, Hinrich Schulenburg, Katja Dierking","doi":"10.1016/j.it.2024.10.008","DOIUrl":"10.1016/j.it.2024.10.008","url":null,"abstract":"<p><p>Effector-triggered immunity (ETI) enables hosts to react to pathogens by monitoring few key cellular processes. ETI responses are assumed to be similar toward related pathogen effectors. However, recent evidence from the invertebrate model Caenorhabditis elegans and pore-forming toxins indicates a much more complex and specific ETI than previously anticipated.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"939-942"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The immune-endocrine interplay in sex differential responses to viral infection and COVID-19. 免疫-内分泌在对病毒感染和 COVID-19 的性别差异反应中的相互作用。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-18 DOI: 10.1016/j.it.2024.10.004
Valentino D'Onofrio, Rafick Pierre Sékaly
{"title":"The immune-endocrine interplay in sex differential responses to viral infection and COVID-19.","authors":"Valentino D'Onofrio, Rafick Pierre Sékaly","doi":"10.1016/j.it.2024.10.004","DOIUrl":"10.1016/j.it.2024.10.004","url":null,"abstract":"<p><p>Men are at higher risk for developing severe COVID-19 than women, while women are at higher risk for developing post-acute sequelae of COVID-19 (PASC). This highlights the impact of sex differences on immune responses and clinical outcomes of acute COVID-19 or PASC. A dynamic immune-endocrine interface plays an important role in the development of effective immune responses impacting the control of viral infections. In this opinion article we discuss mechanisms underlying the transcriptional and epigenetic regulation of immune responses by sex hormones during viral infections. We propose that disruption of this delicate immune-endocrine interplay can result in worsened outcomes of viral disease. We also posit that insights into these immune mechanisms can propel the development of novel immunomodulatory interventions that leverage immune-endocrine pathways to treat viral infections.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"943-958"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface. 嗅觉上皮细胞的神经免疫相互作用：在免疫屏障界面上维持一个感觉器官。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1016/j.it.2024.10.005
Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane
{"title":"Neuroimmune interactions in the olfactory epithelium: maintaining a sensory organ at an immune barrier interface.","authors":"Mohammed N Ullah, Nicholas R Rowan, Andrew P Lane","doi":"10.1016/j.it.2024.10.005","DOIUrl":"10.1016/j.it.2024.10.005","url":null,"abstract":"<p><p>While primarily a sensory organ, the mammalian olfactory epithelium (OE) also plays a critical role as an immune barrier. Mechanisms governing interactions between the immune system and this specialized chemosensory tissue are gaining interest, in part sparked by the COVID-19 pandemic. Regulated inflammation is intrinsic to normal mucosal healing and homeostasis, but prolonged OE inflammation is associated with persistent loss of smell, belying the intertwining of local mucosal immunology and olfactory function. Evidence supports bidirectional communication between OE cells and the immune system in health and disease. Recent investigations suggest that neuro-immune cross-talk modulates olfactory stem cell behavior and neuronal regeneration dynamics, prioritizing the epithelial-like non-neuronal framework with immune barrier function at the expense of the neurosensory organ in chronic inflammation.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"987-1000"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu. SARS-CoV-2 使小鼠肺泡巨噬细胞重编程，从而抑制流感。
IF 13.1 1区 医学
Trends in Immunology Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1016/j.it.2024.11.002
Alexandra Tabachnikova, Akiko Iwasaki
{"title":"SARS-CoV-2 reprograms murine alveolar macrophages to dampen flu.","authors":"Alexandra Tabachnikova, Akiko Iwasaki","doi":"10.1016/j.it.2024.11.002","DOIUrl":"10.1016/j.it.2024.11.002","url":null,"abstract":"<p><p>Innate immune cells that are epigenetically reprogrammed by infection can modify host responses to subsequent infections. Lercher et al. have identified epigenetic reprogramming of murine airway-resident macrophages following recovery from SARS-CoV-2 infection, conferring protection from pathology and lethality following secondary influenza A virus (IAV) challenge without reducing viral titers.</p>","PeriodicalId":54412,"journal":{"name":"Trends in Immunology","volume":" ","pages":"925-927"},"PeriodicalIF":13.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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