Cellular RNA acts as an antiviral MAVS signalosome scaffold.

IF 13.1 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2025-02-01 Epub Date: 2025-01-30 DOI:10.1016/j.it.2025.01.003

Yang Liu, Xuetao Cao

引用次数: 0

Abstract

The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular mRNAs assemble and activate the MAVS signalosome by directly binding to MAVS and regulating its interactors, consequently enhancing antiviral signaling and interferon expression to inhibit viral infection.

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细胞RNA作为抗病毒MAVS信号体支架。

接头蛋白线粒体抗病毒信号蛋白（MAVS）介导的先天免疫反应对宿主防御RNA病毒至关重要。Gokhale及其同事报告说，细胞mrna通过直接结合MAVS并调节其相互作用物来组装和激活MAVS信号体，从而增强抗病毒信号传导和干扰素表达，从而抑制病毒感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.