T细胞对发热和生理性热的代谢和应激反应适应。

IF 13.1 1区 医学 Q1 IMMUNOLOGY
Trends in Immunology Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI:10.1016/j.it.2025.01.007
Benjamin A Wilander, Jeffrey C Rathmell
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引用次数: 0

摘要

发烧是炎症微环境的一个古老特征。虽然发烧可以改善对病原体的免疫反应,但机制尚不清楚。我们探讨了最近的研究如何发烧范围的温度通知哺乳动物T细胞代谢,分化和应激反应。最近的证据表明,在体温恢复正常后,由发烧启动的代谢程序得以维持,可能提供持久的益处。尽管它的影响,温度仍然被忽视,值得进一步研究。当考虑到体内组织之间和炎症性疾病进展期间的广泛温差时,这一点尤其明显。我们认为T细胞亚群在热应激时代谢和应激反应的差异有助于确定炎症期间免疫细胞的组成和命运。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic and stress response adaptations in T cells to fever and physiological heat.

Fevers are an ancient feature of the inflammatory microenvironment. While fevers may improve the immune response to pathogens, mechanisms are unclear. We explore recent studies of how fever-range temperatures inform mammalian T cell metabolism, differentiation, and stress responses. Recent evidence indicates that metabolic programs initiated by fever are maintained upon return to thermo-normality, potentially providing a lasting benefit. Despite its impact, temperature remains overlooked and warrants further study. This is especially apparent when considering the wide temperature differential between tissues within the body and during inflammatory disease progression. We propose that differences in the metabolic and stress responses between T cell subsets upon thermal stress contribute to determining immune cell makeup and fate during inflammation.

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来源期刊
Trends in Immunology
Trends in Immunology 医学-免疫学
CiteScore
25.10
自引率
0.60%
发文量
130
审稿时长
6-12 weeks
期刊介绍: Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.
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