Yuanli Zhang, Hong Huang, Chongzhi Yin, Guizhi Zhang, Yang Wang, Rui Gao, Jinlin Song
{"title":"Clinical Evaluation of ODIS-1 Orthodontic Operation and Image Quality of Digital Imaging System.","authors":"Yuanli Zhang, Hong Huang, Chongzhi Yin, Guizhi Zhang, Yang Wang, Rui Gao, Jinlin Song","doi":"10.2174/0115734056345020250223150845","DOIUrl":"https://doi.org/10.2174/0115734056345020250223150845","url":null,"abstract":"<p><strong>Background: </strong>With the rapid development of computer technology, the application of digital technology to the display and processing of medical images has become a common concern. In recent years, oral digital imaging technology has received more and more attention.</p><p><strong>Objective: </strong>This paper mainly aims at the ODIS-1 oral digital imaging system to analyze and study the image quality and image aims at the ODIS-1 oral digital imaging system to analyze and study the image quality and processing technology, of which X-ray imaging is indispensable.</p><p><strong>Methods: </strong>In this paper, the ODIS-1 digital scanning technology is used to detect different types of dental tissues, and its application in diagnosing oral diseases is evaluated. This paper takes 320 inpatients as the research object and uses Kodak dental film to compare the image quality of different positions.</p><p><strong>Results: </strong>It is found that there is no significant difference in image quality between the maxillary anterior teeth and mandibular anterior teeth and the maxillary posterior teeth and mandibular posterior teeth (P>0.05); the image quality of maxillary anterior teeth, mandibular anterior teeth, and maxillary posterior teeth and mandibular teeth are significantly different (P<0.05); among the various positions of the ODIS-1 oral digital imaging system, the image quality of the anterior teeth area is the best, while the image quality of the maxillary posterior teeth area is the worst.</p><p><strong>Conclusion: </strong>However, the system has a variety of image post-processing functions, which can adjust the brightness and contrast of the image arbitrarily, select the area of interest in the image according to the detection requirements, and perform local amplification, edge enhancement, and other technologies to make the image achieve the best effect. In the case of poor image quality, the clarity of the image can be further improved through image post-processing and analysis.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qianqian Mao, Heng Wang, Jun Yao, Huiyou Chen, Yu-Chen Chen, Xindao Yin, Zhengqian Wang
{"title":"Left Basal Ganglia Stroke-induced more Alterations of Functional Connectivity: Evidence from an fMRI Study.","authors":"Qianqian Mao, Heng Wang, Jun Yao, Huiyou Chen, Yu-Chen Chen, Xindao Yin, Zhengqian Wang","doi":"10.2174/0115734056344477250222060225","DOIUrl":"https://doi.org/10.2174/0115734056344477250222060225","url":null,"abstract":"<p><strong>Background: </strong>The basal ganglia area is a frequent site of stroke, which commonly causes intricate functional impairments. This study aims to uncover disparities in static and dynamic functional connectivity (FC) of the brain in patients afflicted with left-sided basal ganglia stroke (L-BGS) and right-sided basal ganglia region stroke (R-BGS), furthermore scrutinising the mechanism behind the lateralisation of the stroke.</p><p><strong>Methods: </strong>A total of 23 patients with L-BGS and 20 patients with R-BGS were recruited, alongside 20 healthy control subjects. Resting-state functional magnetic resonance imaging and sliding window techniques were employed to conduct static and dynamic FC analyses on both patient groups and controls, which can enable a more refined evaluation of the variations in neural signals.</p><p><strong>Results: </strong>The inter-network connectivity analysis showed significant changes only in the L-BGS patient group (p < 0.05). The R-BGS group showed increased connectivity in the auditory and posterior visual networks, while the L-BGS group showed reduced connectivity. In dynamic connectivity analyses, the L-BGS group exhibited greater positive network connectivity reorganization.</p><p><strong>Conclusion: </strong>Within one month of stroke onset, the L-BGS group showed a more pronounced impairment of inter-network connectivity, alongside enhanced FC compensatory changes of a positive nature. Differential changes in the two patient groups may provide useful information for individualized rehabilitation strategies.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application Value of A Clinical Radiomic Nomogram for Identifying Diabetic Nephropathy and Nondiabetic Renal Disease.","authors":"Xiaoling Liu, Weihan Xiao, Jing Qiao, Xiachuan Qin","doi":"10.2174/0115734056332507250210105723","DOIUrl":"https://doi.org/10.2174/0115734056332507250210105723","url":null,"abstract":"<p><strong>Objective: </strong>An ultrasound-based radiomics Machine Learning Model (ML) was utilized to assess non-invasively the conditions of diabetic nephropathy and non-diabetic renal disease in diabetic patients.</p><p><strong>Methods: </strong>A retrospective examination was conducted on 166 diabetic patients who had undergone renal biopsies guided by ultrasound, with the group comprising 114 individuals diagnosed with diabetic nephropathy and 52 with non-diabetic renal disease. The participants were randomly divided into the training set and the testing set (7:3). Following the extraction of radiomics features from the renal ultrasound images, a univariate analysis was conducted, and the Least Absolute Shrinkage And Selection Operator (LASSO) algorithm was applied to select the most significant features. Three ML algorithms were applied to construct the prediction models. Subsequently, the patients' clinical characteristics were evaluated through both univariate and multivariate logistic regression analyses, which facilitated the development of a clinical model, following a clinical radiomics model was formulated, integrating the radiomics scores (Radscore), along with the independent clinical variables identified through the screening process. The diagnostic performance of the three models constructed was evaluated using the receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Among the three radiomics ML models, the logistic regression (LR) model achieved the best performance, with the area under the curve (AUC) values of 0.872 (95%CI, 0.800-0.944) and 0.836 (95%CI, 0.716-0.957) for the training set and the testing set, respectively. The decision curve analysis (DCA) verified the clinical practicability of the ML model. Within the same testing set, the AUC of the clinical model was 0.761 (95%CI, 0.606-0.916). The nomogram model based on clinical features plus Radscore showed the best discrimination, with an AUC value of 0.881 (95%CI, 0.779-0.982), which was better than that of the single clinical model and the radiomics model.</p><p><strong>Conclusion: </strong>The ML model of radiomics based on ultrasound images has potential value in the non-invasive differential diagnosis of patients with diabetic nephropathy. The nomogram constructed based on rad score and clinical features could effectively distinguish DN from NDRD.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mei-Ying Jian, Xiao-Yan Luo, Xiu-Qin Luo, Ai-Fang Jin, Zhe-Huang Luo
{"title":"Intestinal Lipoma Acting as a Lead Point of Intussusception: A Case Series.","authors":"Mei-Ying Jian, Xiao-Yan Luo, Xiu-Qin Luo, Ai-Fang Jin, Zhe-Huang Luo","doi":"10.2174/0115734056337435250206100026","DOIUrl":"https://doi.org/10.2174/0115734056337435250206100026","url":null,"abstract":"<p><strong>Background: </strong>Lipomas represent a rare benign etiology of intussusception in adults, affecting both the small intestine and the colon. Diagnosing intussusception in adults can be challenging, and there are no reports on the use of positron emission tomography/CT (PET/CT) in the diagnosis of lipoma-induced intussusception. This study aimed to preliminarily explore the potential diagnostic utility of 18F-FDG PET/CT in the diagnosis of intussusception caused by lipomas.</p><p><strong>Methods: </strong>We conducted a retrospective review of the clinical characteristics and imaging findings of three patients diagnosed with lipoma-induced intussusception using 18F-FDG PET/CT from 2019 to 2023 at our hospital.</p><p><strong>Results: </strong>The three cases presented with diverse clinical presentations and were diagnosed based on PET/CT imaging. Surgical confirmation was obtained in two cases. Lipomas were identified in both the small intestine and the colon, with one case displaying increased metabolic activity on FDG uptake, suggesting a possible link between FDG uptake and clinical severity.</p><p><strong>Conclusion: </strong>Lipoma is a benign cause of intussusception that can occur in both the small intestine and the colon. The symptoms of adult intussusception are often atypical and variable. Imaging modalities, particularly PET/CT, are instrumental in diagnosing intussusception due to lipomas, differentiating between benign and malignant causes, and assessing the severity to inform treatment strategies.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Siying Zhang, Zhenping Wu, Guo Sa, Zhan Feng, Feng Chen
{"title":"Impact of CT-Relevant Skeletal Muscle Parameters on Post-Chemotherapy Survival in Patients with Unresectable Pancreatic Ductal Adenocarcinoma.","authors":"Siying Zhang, Zhenping Wu, Guo Sa, Zhan Feng, Feng Chen","doi":"10.2174/0115734056356822250205174104","DOIUrl":"https://doi.org/10.2174/0115734056356822250205174104","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the association of CT-relevant skeletal muscle parameters, such as sarcopenia and myosteatosis, with survival outcomes in patients receiving chemotherapy for unresectable pancreatic ductal adenocarcinoma (PDAC).</p><p><strong>Methods: </strong>In this retrospective analysis, patients who began chemotherapy for unresectable PDAC were included. Sarcopenia and myosteatosis were assessed on pretreatment CT at the L3 level by skeletal muscle index and mean muscle attenuation with predefined cutoff values. The Cox proportional hazards model was used to analyze the factors associated with progression-free survival (PFS) and overall survival (OS).</p><p><strong>Results: </strong>A total of 150 patients were enrolled. Compared to patients without sarcopenia, patients with sarcopenia had significantly worse PFS (p=0.003) and OS (p<0.001). Patients with myosteatosis had significantly worse PFS (p=0.01) and OS (p=0.002) compared to those without myosteatosis. In multivariate analysis, after adjusting for age, sex, tumor size, location, treatment modality, smoking, drinking, underlying diseases, and partial laboratory tests, sarcopenia remained an independent predictor of PFS (p=0.006) and OS (p<0.001). Myosteatosis remained an independent predictor of OS (p=0.008), but not of PFS.</p><p><strong>Conclusion: </strong>Sarcopenia and myosteatosis are independent prognostic factors for patients with unresectable pancreatic ductal adenocarcinoma after chemotherapy.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdullahi Umar Ibrahim, Ikedichukwu Onyemaucheya Nwaneri, Mercel Vubangsi, Fadi Al-Turjman
{"title":"I-Brainer: Artificial intelligence/Internet of Things (AI/IoT)-Powered Detection of Brain Cancer.","authors":"Abdullahi Umar Ibrahim, Ikedichukwu Onyemaucheya Nwaneri, Mercel Vubangsi, Fadi Al-Turjman","doi":"10.2174/0115734056333393250117164020","DOIUrl":"https://doi.org/10.2174/0115734056333393250117164020","url":null,"abstract":"<p><strong>Background/objective: </strong>Brain tumour is characterized by its aggressive nature and low survival rate and thus regarded as one of the deadliest diseases. Thus, miss-diagnosis or miss-classification of brain tumour can lead to miss treatment or incorrect treatment and reduce survival chances. Therefore, there is need to develop a technique that can identify and detect brain tumour at early stages.</p><p><strong>Methods: </strong>Here, we proposed a framework titled I-Brainer which is an Artificial Intelligence/Internet of Things (AI/IoT)-powered classification of MRI. We employed a Br35H+SARTAJ brain MRI dataset which contain 7023 total images which include No tumour, pituitary, meningioma and glioma. In order to accurately classified MRI into 4-class, we developed LeNet model from scratch, implemented 2 pretrained models which include EfficientNet and ResNet-50 as well feature extraction of these models coupled with 2 Machine Learning classifiers k-Nearest Neighbours (KNN) and Support Vector Machines (SVM).</p><p><strong>Result: </strong>Evaluation and comparison of the performance of 3 models has shown that EfficientNet+SVM achieved the best result in terms of AUC (99%) and ResNet-50-KNN ranked higher in terms of accuracy (94%) on testing dataset.</p><p><strong>Conclusion: </strong>This framework can be harness by patients residing in remote areas and as confirmatory approach for medical experts.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huayang Du, Xin Sui, Ruijie Zhao, Jiaru Wang, Ying Ming, Sirong Piao, Jinhua Wang, Xiaomei Lu, Lan Song, Wei Song
{"title":"Withdrawal to: Assessing Pulmonary Embolisms on Unenhanced CT Images Using Electron Density Images Derived from Dual-Layer Spectral Detector CT: A Single-centre Prospective Study Conducted at the Emergency Department","authors":"Huayang Du, Xin Sui, Ruijie Zhao, Jiaru Wang, Ying Ming, Sirong Piao, Jinhua Wang, Xiaomei Lu, Lan Song, Wei Song","doi":"10.2174/0115734056316803241021102932","DOIUrl":"10.2174/0115734056316803241021102932","url":null,"abstract":"<p><p>Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, the article has been withdrawn.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure, or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication, the authors agree that the publishers have the legal right to take appropriate action against the authors if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingjing Zhao, Linping Pian, Jie Chen, Quanjiang Wang, Feiyan Han, Yameng Liu
{"title":"Study Hotspot and Trend in the Field of Shear Wave Elastography: A Bibliometric Analysis from 2004 to 2024.","authors":"Jingjing Zhao, Linping Pian, Jie Chen, Quanjiang Wang, Feiyan Han, Yameng Liu","doi":"10.2174/0115734056353590250109081225","DOIUrl":"https://doi.org/10.2174/0115734056353590250109081225","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to comprehensively review the literature on Shear Wave Elastography (SWE), a non-invasive imaging technique prevalent in medical ultrasound. SWE is instrumental in assessing superficial glandular tissues, abdominal organs, tendons, joints, carotid vessels, and peripheral nerve tissues, among others. By employing bibliometric analysis, we aimed to encapsulate the scholarly contributions over the past two decades, identifying key research areas and tracing the evolutionary trajectory of SWE.</p><p><strong>Methods: </strong>For this study, we selected research articles related to SWE published between 2004 and March 2024 from the Web of Science Core Collection (WOSCC). We utilized sophisticated bibliometric tools, such as CiteSpace, VOSviewer, and SCImago Graphica, to analyze the trends in annual publications, contributing countries and institutions, journals, authors, co-cited authors, co-cited references, and keywords.</p><p><strong>Results: </strong>Our analysis yielded a total of 3606 papers. China emerged as the leading country in terms of publication output, with a strong collaborative relationship with the United States. Sun Yat-Sen University was identified as the institution with the highest number of publications. The keyword \"transient elastography\" was the most prevalent, with \"acoustic radiation force\" being a focal point in the initial stages of SWE research. Recently, Contrast-enhanced Ultrasound (CEUS) has emerged as a new research focus, signaling a potential direction for future research and development.</p><p><strong>Conclusion: </strong>The global research landscape for SWE is projected to expand continuously. Future research is likely to concentrate on the integrated application of SWE and CEUS for diagnostic purposes, along with exploring the clinical utility of multimodal ultrasound that synergistically combines SWE with other ultrasound technologies. This bibliometric research offers a comprehensive overview of the SWE literature, guiding researchers in their pursuit of further exploration and discovery.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tianyu Zhao, Chunjing Zhang, Hang Dai, Jingyu Li, Liguo Hao, Yanan Liu
{"title":"A Comparative Study of CT-Guided Radiofrequency Ablation and Targeted Therapy: Intervention Efficacy and Survival Rates in Lung Cancer Patients.","authors":"Tianyu Zhao, Chunjing Zhang, Hang Dai, Jingyu Li, Liguo Hao, Yanan Liu","doi":"10.2174/0115734056311827241211092432","DOIUrl":"https://doi.org/10.2174/0115734056311827241211092432","url":null,"abstract":"<p><strong>Objective: </strong>The study aims to evaluate the clinical efficacy of CT-guided radiofrequency ablation in conjunction with targeted therapy in lung cancer patients.</p><p><strong>Method: </strong>We retrospectively analyzed 80 lung cancer patients. They were stratified into the Observation Group (OG, n=40, treated with CT-guided radiofrequency ablation in conjunction with targeted therapy) and the Control Group (CG, n=40, treated solely with targeted therapy).</p><p><strong>Results: </strong>The OG group reported 4 cases of Complete Response (CR), 24 cases of Partial Response (PR), 10 cases of Stable Disease (SD), and 2 cases of Progressive Disease (PD). The Overall Response Rate (ORR) was 70.00% (28/40), and the Disease Control Rate (DCR) was 95.00% (38/40). In contrast, the CG group exhibited 3 cases of CR, 20 cases of PR, 12 cases of SD, and 5 cases of PD. The ORR was 57.50% (23/40), and the DCR was 87.50% (35/40). The ORR and DCR in the OG group were significantly higher than those in the CG group. After 6 weeks of treatment, the levels of SCC, CEA, and CA125 in the OG group were significantly lower than those in the CG group; The CD4+ levels in the OG group were significantly higher and the CD8+ levels significantly lower than those in the CG group. A 24-month follow-up showed that the survival rate of the OG group was 47.50% (19/40), which was significantly higher than that of the CG group at 27.50% (11/40).</p><p><strong>Conclusion: </strong>CT-guided radiofrequency ablation and targeted therapy have been proven effective in treating lung cancer.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pei Huang, Sheng Li, Zhikang Deng, Fangfang Hu, Di Jin, Situ Xiong, Bing Fan
{"title":"Machine-Learning Based Computed Tomography Radiomics Nomgram For Predicting Perineural Invasion In Gastric Cancer.","authors":"Pei Huang, Sheng Li, Zhikang Deng, Fangfang Hu, Di Jin, Situ Xiong, Bing Fan","doi":"10.2174/0115734056323323250102073559","DOIUrl":"10.2174/0115734056323323250102073559","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to develop and validate predictive models for perineural invasion (PNI) in gastric cancer (GC) using clinical factors and radiomics features derived from contrast-enhanced computed tomography (CE-CT) scans and to compare the performance of these models.</p><p><strong>Methods: </strong>This study included 205 GC patients, who were randomly divided into a training set (n=143) and a validation set (n=62) in a 7:3 ratio. Optimal radiomics features were selected using the least absolute shrinkage and selection operator (LASSO) algorithm. A radiomics model was constructed utilizing the optimal among five machine learning filters, and a radiomics score (rad-score) was computed for each participant. A clinical model was built based on clinical factors identified through multivariate logistic regression. Independent clinical factors were combined with the radscore to create a combined radiomics nomogram. The discrimination ability of the models was evaluated by receiver operating characteristic (ROC) curves and the DeLong test.</p><p><strong>Results: </strong>Independent predictive factors of the clinical model included tumor T stage, N stage, and tumor differentiation, with AUC values of 0.777 and 0.809 in the training and validation sets. The radiomics model was constructed using the support vector machine (SVM) classifier with the best AUC (0.875 in the training set and 0.826 in the validation set). The combined radiomics nomogram, which combines independent clinical predictors and the rad-score, demonstrated better predictive performance (AUC=0.889 in the training set; AUC=0.885 in the validation set).</p><p><strong>Conclusion: </strong>The nomogram integrating independent clinical predictors and CE-CT radiomics was constructed to predict PNI in GC. This model demonstrated favorable performance and could potentially assist in prognosis evaluation and clinical decision-making for GC patients.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":"e15734056323323"},"PeriodicalIF":1.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}