Clinical Nursing Research最新文献

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Examining Health Literacy and Appropriateness of Commercially Developed Patient Education Materials for Adults Living With Diabetes on the U.S./Mexico Border. 检查美国/墨西哥边境成人糖尿病患者的健康素养和商业开发的患者教育材料的适当性
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-26 DOI: 10.1177/10547738251343418
Shiloh A Williams, Shih-Fan Lin, Stephen Jaime, Beverly Carlson, Maria Keckler
{"title":"Examining Health Literacy and Appropriateness of Commercially Developed Patient Education Materials for Adults Living With Diabetes on the U.S./Mexico Border.","authors":"Shiloh A Williams, Shih-Fan Lin, Stephen Jaime, Beverly Carlson, Maria Keckler","doi":"10.1177/10547738251343418","DOIUrl":"https://doi.org/10.1177/10547738251343418","url":null,"abstract":"<p><p>Effective patient education is critical to an individual's treatment plan when living with diabetes, a debilitating disease requiring extensive knowledge and skills to effectively manage and prevent future morbidity. This descriptive, cross-sectional study assessed the appropriateness of commercially developed patient education materials for rural adults with diabetes. Using electronic health record data from patients (<i>n</i> = 132) with documented health literacy levels (HLL), their HLL scores were reviewed for suitability of educational materials provided by a single rural-border hospital. HLL was measured using the Newest Vital Sign, while educational materials were assessed by two independent reviewers using the Patient Education Materials Assessment Tool for Printable Materials to measure understandability and actionability, and the Simple Measure of Gobbledygook to measure the readability level of documents in both English and Spanish. The mean HLL for Spanish speakers (<i>n</i> = 77) was 2.01 (±1.56), while the mean HLL for English speakers (<i>n</i> = 55) was 2.09 (±1.46), indicating a high likelihood of low health literacy. The materials were evaluated with the English materials achieving an understandability score of 83.33% and an actionability score of 60.00%. By contrast, the Spanish materials scored lower, 61.54% and 20.00%, respectively. In addition, the readability of the materials measured a 9.0 grade level for English materials and a slightly higher 10.8 for Spanish materials. These findings highlight a significant discrepancy between the HLL and the appropriateness of educational materials for the sample population. Although commercially available educational products may provide a budget-concise solution to patient education, particularly in low-resourced organizations, they fail to address the health education needs of the individuals who receive them. Despite the project's limited sample size and single geographical location, it underscores the importance for healthcare organizations to address the health education needs of their communities.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"10547738251343418"},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonlinear Relationship Between Vital Signs and Hospitalization/Emergency Department Visits Among Older Home Healthcare Patients and Critical Vital Sign Cutoff for Adverse Outcomes: Application of Generalized Additive Model. 老年家庭保健患者生命体征与住院/急诊就诊的非线性关系及不良结局的临界生命体征截断:广义加性模型的应用
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-13 DOI: 10.1177/10547738251336488
Se Hee Min, Jiyoun Song, Lauren Evans, Kathryn H Bowles, Margaret V McDonald, Sena Chae, Sridevi Sridharan, Yolanda Barrón, Maxim Topaz
{"title":"Nonlinear Relationship Between Vital Signs and Hospitalization/Emergency Department Visits Among Older Home Healthcare Patients and Critical Vital Sign Cutoff for Adverse Outcomes: Application of Generalized Additive Model.","authors":"Se Hee Min, Jiyoun Song, Lauren Evans, Kathryn H Bowles, Margaret V McDonald, Sena Chae, Sridevi Sridharan, Yolanda Barrón, Maxim Topaz","doi":"10.1177/10547738251336488","DOIUrl":"https://doi.org/10.1177/10547738251336488","url":null,"abstract":"<p><p>Previous studies have focused on identifying risk factors for older adults receiving home healthcare services without considering vital signs. This may provide important information on deteriorating health conditions that may lead to hospitalization and/or emergency department (ED) visits. Thus, it is important to understand the relationship between vital signs and hospitalization and/or ED visits and critical vital sign points for mitigating the higher risks of hospitalization and/or ED visits. This secondary data analysis uses cross-sectional data from a large, urban home healthcare organization (<i>n</i> = 61,615). A generalized additive model was used to understand the nonlinear relationship between each vital sign and hospitalization and/or ED visits through three unadjusted and adjusted models, and to identify a critical vital sign point related to a higher risk of hospitalization and/or ED visits. A significant nonlinear relationship (effective degree of freedom >2.0) was found between systolic, diastolic blood pressure, heart rate, hospitalization, and/or ED visits. The critical inflection point for systolic blood pressure was 120.36 (SE 3.625, <i>p</i> < .001), diastolic blood pressure was 72.00 (SE 3.108, <i>p</i> < .001), and heart rate was 83.24 (SE 1.994, <i>p</i> = .052). Among all vital signs, the risk of hospitalization and/or ED visits sharply increased when an older adult's heart rate surpassed 83.24 bpm. Our findings reveal that vital signs may serve as a critical indicator of a patient's clinical condition, especially related to hospitalization and/or ED visit. Clinicians need to be cognizant of these critical thresholds for each vital sign and monitor any deviations from baseline to preempt adverse outcomes.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"10547738251336488"},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Psychiatric Services Become a Waiting Room: Situational Analysis of Involuntary Commitment and Treatment as Experienced by Patients and Nurses. 当精神科服务成为候诊室:病人和护士经历的非自愿承诺和治疗的情境分析。
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI: 10.1177/10547738251321067
Pierre Pariseau-Legault, David Pelosse, Emmanuelle Bernheim, Marie-Hélène Goulet, Guillaume Ouellet, Lisandre Labrecque-Lebeau, Jean-Daniel Jacob, Dave Holmes
{"title":"When Psychiatric Services Become a Waiting Room: Situational Analysis of Involuntary Commitment and Treatment as Experienced by Patients and Nurses.","authors":"Pierre Pariseau-Legault, David Pelosse, Emmanuelle Bernheim, Marie-Hélène Goulet, Guillaume Ouellet, Lisandre Labrecque-Lebeau, Jean-Daniel Jacob, Dave Holmes","doi":"10.1177/10547738251321067","DOIUrl":"10.1177/10547738251321067","url":null,"abstract":"<p><p>A growing body of literature highlights the involvement of nurses in the application of involuntary commitment and treatments in psychiatry. The violence underlying these coercive practices is often discussed, as they infringe on human rights and have negative effects on both patients and healthcare staff. The current state of knowledge on this subject, however, fails to inform us of what characterizes and influences these practices in psychiatric nursing. A situational analysis was conducted to gain a better understanding of this issue. This qualitative research aims to explore the characteristics of nursing care during involuntary commitment and treatments. In all, 10 nurses (<i>n</i> = 10) and 11 patients (<i>n</i> = 11) participated in semi-structured interviews and completed a sociodemographic questionnaire. Data analysis followed a grounded theory approach, involving a process of coding, conceptualizing, categorizing, constant comparison, and relational mapping, accompanied by analytical memos. Four conceptual categories emerged from data analysis: (1) Psychiatry as a waiting room, (2) nurses as subordinates, (3) nothing else but medication, and (4) resisting undignifying care. The results suggest that clinical issues surrounding involuntary commitment and treatments can be explained by how care is conceived. The psychiatric nursing practice seems to be limited to the application of coercive power, such as forced administration of medication. The distress potentially induced by involuntary commitment and treatments in patients comes to be ignored in favor of compliance with the legal procedures. The results describe a situation where patients felt abandoned to those procedures as if refusing to be hospitalized or treated were incompatible with any other form of care. Several participants also report having suffered negative consequences following one or more coerced psychiatric episodes. For them, refusal of care therefore seems to be associated with a resistance against the current violence of biomedical psychiatry, rather than a refusal to obtain help and support.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"168-178"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors and Predictors for Persistent Dyspnea Post-COVID-19: A Systematic Review. covid -19后持续性呼吸困难的危险因素和预测因素:一项系统综述
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-01-28 DOI: 10.1177/10547738251314076
Sandra Morgan, James M Smith, Bini Thomas, Maria Moreno, Constance Visovsky, Theresa Beckie
{"title":"Risk Factors and Predictors for Persistent Dyspnea Post-COVID-19: A Systematic Review.","authors":"Sandra Morgan, James M Smith, Bini Thomas, Maria Moreno, Constance Visovsky, Theresa Beckie","doi":"10.1177/10547738251314076","DOIUrl":"10.1177/10547738251314076","url":null,"abstract":"<p><p>The most frequently reported post-coronavirus disease of 2019 (COVID-19) symptoms include shortness of breath, fatigue, and cognitive disturbances, with reports of persistent dyspnea ranging between 26% and 41%. There is an urgent need to understand the risk factors and predictors for persistent COVID-19 dyspnea in individuals at all levels of COVID-19 illness severity, to enable the implementation of targeted interventions for those likely to be most affected with persistent dyspnea. Thus, the purpose of this systematic review is to explore the risk factors and predictors that are associated with persistent dyspnea in the post-COVID-19 population. This review was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines and registered prospectively in PROSPERO as CRD42023466713. A search strategy was conducted across <i>PubMed, CINAHL, Web of Science</i>, and <i>EMBASE</i> databases, that included studies conducted from 2020 to March 2024. The Covidence platform was used for screening studies, scoring methodologic quality, and performing data extraction using a two-step independent review process. This review included 33 studies, addressing 83,920 participants across 20 countries. The strongest predictive risk factors for persistent dyspnea included the following: female sex, elevated body mass index, pulmonary comorbidities, pre-existing anxiety and depression, pre-COVID-19 physical limitations, the severity of the COVID-19 illness, and socioeconomic differences. Potential risk factors included increased age, smoking history, and COVID-19 variant type. The presence of biomarkers for persistent dyspnea in the post-COVID-19 population can be used by clinicians to prospectively identify those individuals who should be flagged. Early identification may then be leveraged for timely referral for prophylactic and rehabilitative interventions for dyspnea. A personalized plan to target those risk factors that are modifiable should follow.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"195-212"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a Nomogram for Predicting Financial Toxicity Risk Among Lung Cancer Patients: A Cross-Sectional Study. 预测肺癌患者财务毒性风险的Nomogram:横断面研究。
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI: 10.1177/10547738251328410
Hui Shan, Weisong Wang, Xiaoying Wang
{"title":"Development of a Nomogram for Predicting Financial Toxicity Risk Among Lung Cancer Patients: A Cross-Sectional Study.","authors":"Hui Shan, Weisong Wang, Xiaoying Wang","doi":"10.1177/10547738251328410","DOIUrl":"10.1177/10547738251328410","url":null,"abstract":"<p><p>With the progress and development of medicine, the emergence of new treatment methods brings hope to patients with lung cancer. However, it is accompanied by high treatment costs. At present, the research on the financial toxicity of lung cancer by medical staff needs to be improved. The study was to describe and analyze the status and risk factors of financial toxicity in lung cancer patients. This was a cross-sectional study. The study recruited 218 lung cancer patients from the 2 hospitals in Qingdao and Tianjin. Lasso regression and random forest were combined to identify significant factors of financial toxicity. A nomogram was used to visualize the model. The discrimination, calibration, and clinical applicability of the nomogram were evaluated by the receiver operating characteristic curves, area under the curve, and decision curve analysis. Educational level, residence, family monthly income, out-of-pocket expenses, chemotherapy history, and radiotherapy history were found to be significant factors of financial toxicity. The area under the curve of the training set was 0.930, while that of the test set was 0.939. The risk prediction model of financial toxicity has high predictive discrimination, calibration, and clinical practicality, which is helpful for medical staff to screen for early financial toxicity risk in lung cancer patients. The financial toxicity of lung cancer patients is common and affected by many factors. Medical staff can formulate personalized intervention measures according to the patient's own situation and assessment results.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"179-185"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and Deployment of a Music Listening Intervention Mobile Application for a Two-Group Blinded Randomized Clinical Trial. 两组盲法随机临床试验中音乐聆听干预移动应用程序的开发和部署。
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-03-18 DOI: 10.1177/10547738251323007
Linda L Chlan, Joseph Hunter Downs, Annie Heiderscheit, Sikandar H Khan, Salwa Moiz, Babar A Khan
{"title":"Development and Deployment of a Music Listening Intervention Mobile Application for a Two-Group Blinded Randomized Clinical Trial.","authors":"Linda L Chlan, Joseph Hunter Downs, Annie Heiderscheit, Sikandar H Khan, Salwa Moiz, Babar A Khan","doi":"10.1177/10547738251323007","DOIUrl":"10.1177/10547738251323007","url":null,"abstract":"<p><p>Music is one nonpharmacological intervention to reduce anxiety and stress for mechanically ventilated patients. Efficient delivery of a music listening intervention can be enhanced through digital tools such as a mobile application (app) loaded onto an electronic tablet device. The objective of this study is to describe the iterative development and deployment of a novel app (Soundese) to deliver, record, and retrieve data associated with a two-arm randomized, blinded clinical trial testing music listening intervention compared to control silence condition on delirium severity among critically ill intensive care unit (ICU) older adult patients receiving mechanical ventilatory support. The Soundese mobile app was developed to deliver either experimental music listening intervention or a silence control listening condition to a sample of older adults receiving mechanical ventilatory support in the ICU and retrieve all protocol data. The Soundese app was developed using the Swift software language and is compatible with all iOS devices. The Soundese app consists of two components: (1) a mobile app that delivers the assigned, blinded listening intervention from an iPad through headphones to each subject and automatically logs each listening session, its duration, the randomization arm, and uploads these data to a server, and (2) an analysis app that generates a spreadsheet with summarized data of the respective listening session, music details, and reports for further analyses. A Dropbox application programmer interface enabled the secure storage of files on a designated Dropbox account. After initial field testing and iterative development changes based on research staff feedback, the Soundese app delivers the assigned experimental listening condition or silence control condition when deployed remotely in the field. The app's mobile nature allows for immediate and automatic data capture, which is summarized for statistical analysis. There is no need for any manual recording of any intervention data by busy ICU staff, including listening time or music selections. The Soundese mobile app efficiently delivers the research protocol with fidelity and collects the necessary data for an ICU-based clinical trial. The app may be useful in other clinical trials testing music listening interventions in various settings or for deploying other audio-based interventions.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"186-194"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atherosclerotic Cardiovascular Disease Risk Scores are Associated with Carotid Intima-Media Thickness. 动脉粥样硬化性心血管疾病风险评分与颈动脉内膜-中膜厚度相关
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-01-04 DOI: 10.1177/10547738241305784
Emily K Mewborn, Elizabeth A Tolley, David B Wright, Amy L Doneen, Ansley G Stanfill
{"title":"Atherosclerotic Cardiovascular Disease Risk Scores are Associated with Carotid Intima-Media Thickness.","authors":"Emily K Mewborn, Elizabeth A Tolley, David B Wright, Amy L Doneen, Ansley G Stanfill","doi":"10.1177/10547738241305784","DOIUrl":"10.1177/10547738241305784","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease (ASCVD) risk calculators estimate the 10-year incident risk of myocardial infarction (MI), coronary artery disease (CAD) death, or stroke; however, they lack comprehensiveness and accuracy. Carotid intima-media thickness (CIMT) is a surrogate marker that may improve risk estimation acumen. The objective of this study was to derive ASCVD risk scores from historical data and determine whether these risk scores are associated with the history of subclinical CAD and CIMT. This retrospective cross-sectional study used an existing dataset of individuals with prediabetes. Subclinical CAD history was defined as the history of CAD, coronary plaque, or coronary revascularization without a history of MI. The online ASCVD Risk Estimator Plus calculator was used to derive individual risk scores. Chi-square or Fisher's exact tests for categorical variables and ANOVA for continuous variables detected differences among ASCVD risk categories. Linear regression of CIMT measurements on ASCVD risk scores ascertained ASCVD risk scores' utility in predicting CIMT measurements. The sample included 86 participants, 28% with a history of CAD, 60% male, and 95% White. No differences in risk scores existed between participants with or without CAD. Individuals with higher ASCVD risk scores were older (<i>p</i> ≤ .001) and had higher systolic blood pressure (<i>p</i> ≤ .001), CIMT arterial age (<i>p</i> = .003), mean IMT common (<i>p</i> ≤ .001), mean IMT maximum (<i>p</i> ≤ .001), and plaque burden (<i>p</i> = .02) measurements. ASCVD risk scores were significantly associated and moderately correlated with CIMT measurements. ASCVD risk scores were not associated with CAD history but were associated with CIMT measurements. While risk calculators provide a starting point for ASCVD risk estimation, physical tools like CIMT can diagnose ASCVD, categorize plaque quality, and track intervention efficacy. CIMT may be used for more direct ASCVD risk estimation. Risk scores are easily imputed from existing records but are only intended for incident risk, and their accuracy relies on the variables' availability and validity and the boundaries of the calculators.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"160-167"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIF-1A Gene Polymorphisms are Associated With Clinical and Biochemical Parameters in COVID-19 Patients in Serbian Population. 塞尔维亚人群中COVID-19患者HIF-1A基因多态性与临床和生化参数相关
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-01-09 DOI: 10.1177/10547738241308972
Biljana Ljujic, Nela Maksimovic, Tatjana Damnjanovic, Ivana Novakovic, Milka Grk, Milica Gulic, Marija Dusanovic-Pjevic, Biljana Popovska Jovicic, Ivana Rakovic, Marina Gazdic Jankovic, Marina Miletic Kovacevic, Biljana Jekic
{"title":"<i>HIF-1A</i> Gene Polymorphisms are Associated With Clinical and Biochemical Parameters in COVID-19 Patients in Serbian Population.","authors":"Biljana Ljujic, Nela Maksimovic, Tatjana Damnjanovic, Ivana Novakovic, Milka Grk, Milica Gulic, Marija Dusanovic-Pjevic, Biljana Popovska Jovicic, Ivana Rakovic, Marina Gazdic Jankovic, Marina Miletic Kovacevic, Biljana Jekic","doi":"10.1177/10547738241308972","DOIUrl":"10.1177/10547738241308972","url":null,"abstract":"<p><p>The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of adaptive response to hypoxia, common in patients with severe coronavirus disease 2019 (COVID-19). In addition, HIF-1 alpha regulates the expression of the most important proteins necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells. The study included 129 hospitalized COVID-19 patients. Genotypes of <i>HIF-1A</i> gene polymorphisms rs11549465 and rs2057482 were determined by the RT-PCR method. We have observed lower mean platelet counts in carriers of <i>HIF-1A</i> rs11549465CC genotype (<i>p</i> = .050) and a significant association of thrombocytopenia with rs11549465CC/rs2057482CT <i>HIF-1A</i> genotypes combination (<i>p</i> = .037) in the group of patients under the age of 40. <i>HIF-1A</i> rs11549465CC genotype and rs11549465CC/rs2057482CT genotype combination could be predictive markers for thrombocytopenia in COVID-19 patients. Identification of such predictive markers for severe disease may contribute to a more efficient response of health systems to the SARS-CoV-2 pandemic.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"153-159"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition. 疲劳对covid -19后患者主客观认知功能的影响
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.1177/10547738251329412
Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre
{"title":"Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition.","authors":"Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre","doi":"10.1177/10547738251329412","DOIUrl":"https://doi.org/10.1177/10547738251329412","url":null,"abstract":"<p><p>Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":"34 3-4","pages":"143-152"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Perceptions of an Intervention for Cancer Distress and Traumatic Stress Symptoms: A Qualitative Analysis. 患者对癌症困扰和创伤应激症状干预的认知:定性分析。
IF 1.7 4区 医学
Clinical Nursing Research Pub Date : 2025-02-01 Epub Date: 2025-01-25 DOI: 10.1177/10547738241301895
Lori M Rhudy, Kristine A Donovan, Renee Foster, Adam Perlman, Aaron Spaulding, Shehzad Niazi, Cindy Tofthagen
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