Clinical Nursing Research最新文献

{"title":"Development of a Nomogram for Predicting Financial Toxicity Risk Among Lung Cancer Patients: A Cross-Sectional Study.","authors":"Hui Shan, Weisong Wang, Xiaoying Wang","doi":"10.1177/10547738251328410","DOIUrl":"10.1177/10547738251328410","url":null,"abstract":"<p><p>With the progress and development of medicine, the emergence of new treatment methods brings hope to patients with lung cancer. However, it is accompanied by high treatment costs. At present, the research on the financial toxicity of lung cancer by medical staff needs to be improved. The study was to describe and analyze the status and risk factors of financial toxicity in lung cancer patients. This was a cross-sectional study. The study recruited 218 lung cancer patients from the 2 hospitals in Qingdao and Tianjin. Lasso regression and random forest were combined to identify significant factors of financial toxicity. A nomogram was used to visualize the model. The discrimination, calibration, and clinical applicability of the nomogram were evaluated by the receiver operating characteristic curves, area under the curve, and decision curve analysis. Educational level, residence, family monthly income, out-of-pocket expenses, chemotherapy history, and radiotherapy history were found to be significant factors of financial toxicity. The area under the curve of the training set was 0.930, while that of the test set was 0.939. The risk prediction model of financial toxicity has high predictive discrimination, calibration, and clinical practicality, which is helpful for medical staff to screen for early financial toxicity risk in lung cancer patients. The financial toxicity of lung cancer patients is common and affected by many factors. Medical staff can formulate personalized intervention measures according to the patient's own situation and assessment results.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"179-185"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Deployment of a Music Listening Intervention Mobile Application for a Two-Group Blinded Randomized Clinical Trial.","authors":"Linda L Chlan, Joseph Hunter Downs, Annie Heiderscheit, Sikandar H Khan, Salwa Moiz, Babar A Khan","doi":"10.1177/10547738251323007","DOIUrl":"10.1177/10547738251323007","url":null,"abstract":"<p><p>Music is one nonpharmacological intervention to reduce anxiety and stress for mechanically ventilated patients. Efficient delivery of a music listening intervention can be enhanced through digital tools such as a mobile application (app) loaded onto an electronic tablet device. The objective of this study is to describe the iterative development and deployment of a novel app (Soundese) to deliver, record, and retrieve data associated with a two-arm randomized, blinded clinical trial testing music listening intervention compared to control silence condition on delirium severity among critically ill intensive care unit (ICU) older adult patients receiving mechanical ventilatory support. The Soundese mobile app was developed to deliver either experimental music listening intervention or a silence control listening condition to a sample of older adults receiving mechanical ventilatory support in the ICU and retrieve all protocol data. The Soundese app was developed using the Swift software language and is compatible with all iOS devices. The Soundese app consists of two components: (1) a mobile app that delivers the assigned, blinded listening intervention from an iPad through headphones to each subject and automatically logs each listening session, its duration, the randomization arm, and uploads these data to a server, and (2) an analysis app that generates a spreadsheet with summarized data of the respective listening session, music details, and reports for further analyses. A Dropbox application programmer interface enabled the secure storage of files on a designated Dropbox account. After initial field testing and iterative development changes based on research staff feedback, the Soundese app delivers the assigned experimental listening condition or silence control condition when deployed remotely in the field. The app's mobile nature allows for immediate and automatic data capture, which is summarized for statistical analysis. There is no need for any manual recording of any intervention data by busy ICU staff, including listening time or music selections. The Soundese mobile app efficiently delivers the research protocol with fidelity and collects the necessary data for an ICU-based clinical trial. The app may be useful in other clinical trials testing music listening interventions in various settings or for deploying other audio-based interventions.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"186-194"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherosclerotic Cardiovascular Disease Risk Scores are Associated with Carotid Intima-Media Thickness.","authors":"Emily K Mewborn, Elizabeth A Tolley, David B Wright, Amy L Doneen, Ansley G Stanfill","doi":"10.1177/10547738241305784","DOIUrl":"10.1177/10547738241305784","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease (ASCVD) risk calculators estimate the 10-year incident risk of myocardial infarction (MI), coronary artery disease (CAD) death, or stroke; however, they lack comprehensiveness and accuracy. Carotid intima-media thickness (CIMT) is a surrogate marker that may improve risk estimation acumen. The objective of this study was to derive ASCVD risk scores from historical data and determine whether these risk scores are associated with the history of subclinical CAD and CIMT. This retrospective cross-sectional study used an existing dataset of individuals with prediabetes. Subclinical CAD history was defined as the history of CAD, coronary plaque, or coronary revascularization without a history of MI. The online ASCVD Risk Estimator Plus calculator was used to derive individual risk scores. Chi-square or Fisher's exact tests for categorical variables and ANOVA for continuous variables detected differences among ASCVD risk categories. Linear regression of CIMT measurements on ASCVD risk scores ascertained ASCVD risk scores' utility in predicting CIMT measurements. The sample included 86 participants, 28% with a history of CAD, 60% male, and 95% White. No differences in risk scores existed between participants with or without CAD. Individuals with higher ASCVD risk scores were older (<i>p</i> ≤ .001) and had higher systolic blood pressure (<i>p</i> ≤ .001), CIMT arterial age (<i>p</i> = .003), mean IMT common (<i>p</i> ≤ .001), mean IMT maximum (<i>p</i> ≤ .001), and plaque burden (<i>p</i> = .02) measurements. ASCVD risk scores were significantly associated and moderately correlated with CIMT measurements. ASCVD risk scores were not associated with CAD history but were associated with CIMT measurements. While risk calculators provide a starting point for ASCVD risk estimation, physical tools like CIMT can diagnose ASCVD, categorize plaque quality, and track intervention efficacy. CIMT may be used for more direct ASCVD risk estimation. Risk scores are easily imputed from existing records but are only intended for incident risk, and their accuracy relies on the variables' availability and validity and the boundaries of the calculators.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"160-167"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>HIF-1A</i> Gene Polymorphisms are Associated With Clinical and Biochemical Parameters in COVID-19 Patients in Serbian Population.","authors":"Biljana Ljujic, Nela Maksimovic, Tatjana Damnjanovic, Ivana Novakovic, Milka Grk, Milica Gulic, Marija Dusanovic-Pjevic, Biljana Popovska Jovicic, Ivana Rakovic, Marina Gazdic Jankovic, Marina Miletic Kovacevic, Biljana Jekic","doi":"10.1177/10547738241308972","DOIUrl":"10.1177/10547738241308972","url":null,"abstract":"<p><p>The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of adaptive response to hypoxia, common in patients with severe coronavirus disease 2019 (COVID-19). In addition, HIF-1 alpha regulates the expression of the most important proteins necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells. The study included 129 hospitalized COVID-19 patients. Genotypes of <i>HIF-1A</i> gene polymorphisms rs11549465 and rs2057482 were determined by the RT-PCR method. We have observed lower mean platelet counts in carriers of <i>HIF-1A</i> rs11549465CC genotype (<i>p</i> = .050) and a significant association of thrombocytopenia with rs11549465CC/rs2057482CT <i>HIF-1A</i> genotypes combination (<i>p</i> = .037) in the group of patients under the age of 40. <i>HIF-1A</i> rs11549465CC genotype and rs11549465CC/rs2057482CT genotype combination could be predictive markers for thrombocytopenia in COVID-19 patients. Identification of such predictive markers for severe disease may contribute to a more efficient response of health systems to the SARS-CoV-2 pandemic.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"153-159"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142957152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition.","authors":"Gia Han Le, Angela T H Kwan, Ziji Guo, Donovan A Dev, Sabrina Wong, Sebastian Badulescu, Felicia Ceban, Kayla M Teopiz, Danica E Johnson, Hartej Gill, Joshua D Di Vincenzo, Shakila Meshkat, Taeho Greg Rhee, Roger Ho, Lee Phan, Joshua D Rosenblat, Rodrigo B Mansur, Mehala Subramaniapillai, Roger S McIntyre","doi":"10.1177/10547738251329412","DOIUrl":"https://doi.org/10.1177/10547738251329412","url":null,"abstract":"<p><p>Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":"34 3-4","pages":"143-152"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Perceptions of an Intervention for Cancer Distress and Traumatic Stress Symptoms: A Qualitative Analysis.","authors":"Lori M Rhudy, Kristine A Donovan, Renee Foster, Adam Perlman, Aaron Spaulding, Shehzad Niazi, Cindy Tofthagen","doi":"10.1177/10547738241301895","DOIUrl":"10.1177/10547738241301895","url":null,"abstract":"<p><p>This study aimed to explore contextual elements of the cancer experience that are consistently distressing and/or psychologically traumatic, as well as explore perceptions of Accelerated Resolution Therapy® (ART®) and its influence on the cancer experience. Using a qualitative descriptive design, semi-structured interviews were completed by 12 participants following the completion of ART. Interview data were analyzed using content analysis to identify major themes and patterns. Four themes included: (a) Cancer as the straw that broke the camel's back, (b) ART® is different from previous therapy, (c) Don't need to always be looking in the rearview mirror, and (d) Importance of early psychological intervention. Participants perceived that ART® was different and potentially more effective than other types of therapy they had previously received. Results support the diagnosis of cancer and the cumulative effects of previous life events and cancer-related stressors as traumatic events.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"71-78"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Determinants of Quality of Life in the Last Year of Life Among Community-Dwelling Older Adults with Multimorbidity.","authors":"Sangduan Ginggeaw, Raeann LeBlanc, Joohyun Chung","doi":"10.1177/10547738241304575","DOIUrl":"10.1177/10547738241304575","url":null,"abstract":"<p><p>Quality of life (QOL) at the end of life often declines in relation to various determinants, yet the role of social determinants, including social capital, in end-of-life care is frequently overlooked. This study aims to examine the association between social determinants and QOL in the last year of life and to test the mediating role of social capital in the relationship between social determinants and QOL among older adults with multimorbidity (MM). We used secondary data from the National Health and Aging Trends Study (NHATS) in Rounds 10 and 11, involving 3,085 adults aged 65 and older. The final analysis comprised 230 participants. Multiple linear regression was conducted to assess the associations between social determinants and QOL, and path analysis was used to evaluate the mediating effect of social capital. The regression model showed that social capital was positively and significantly associated with QOL (β = 0.378, 95% CI [0.099, 0.657], SE = 0.139), as were mental conditions (β = 0.614, 95% CI [0.167, 1.062], SE = 0.194). The mediation analysis demonstrated that social capital functioned as a complementary mediator, partially mediating the relationship between mental conditions and QOL in the last year of life. These findings underscore the potential role of social capital in enhancing QOL at the end of life, particularly through its influence on mental health. The study highlights the need for healthcare practices and policies that promote social support systems and community-based care for older adults with MM. By addressing social capital, end-of-life care could be improved, resulting in better overall well-being for individuals facing the last stages of life.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"107-119"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile Applications Designed for Sexual or Dating Violence Prevention Targeting Adolescents and Emerging Adults: A Scoping Review.","authors":"Hannah E Fraley, Laura Chechel, Balaji Varthala","doi":"10.1177/10547738241305785","DOIUrl":"10.1177/10547738241305785","url":null,"abstract":"<p><p>Adolescents and emerging adults are at highest risk for sexual violence. While technology-based interventions are emerging in the literature, little is known regarding mobile applications specifically for use with young people. The objective was to identify and map available mobile-based applications designed to reach adolescent or emerging adult users at risk of sexual or dating violence. The Joanna Briggs Institute methodology for scoping reviews and Preferred Reporting Items for Systematic Review and Meta-Analysis extension for scoping reviews were employed. All available English language studies and methodological papers describing mobile-based applications designed to prevent and/or mitigate sexual violence targeting young persons were included with no time limits. Abstracts and full-text readings were carried out by three independent reviewers, followed by data charting and thematic analysis, presented in narrative. Mobile applications targeting young people show promise (<i>N</i> = 15). Most applications target emerging adults over the age of 18 years, with a scarcity of mobile applications designed for adolescents. The myPlan Safety Planning app is the most reported in the literature, adapted to three countries, demonstrating promise across three available randomized controlled trials. Mobile applications can aid in reaching young people at the highest risk for sexual violence. Findings may inform further mobile application development and intervention research. This scoping review was registered prospectively on the Open Science Framework (https://doi.org/10.17605/OSF.IO/QWZBE).</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"120-137"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' Experiences of Person-Centered Care in the Context of Allogenic Stem Cell Transplantation.","authors":"Anna O'Sullivan, Carina Lundh Hagelin, Katarina Holmberg, Karin Bergkvist, Sidona-Valentina Bala, Yvonne Wengström, Annika Malmborg Kisch, Jeanette Winterling","doi":"10.1177/10547738241302393","DOIUrl":"10.1177/10547738241302393","url":null,"abstract":"<p><p>Studies addressing patients' experiences of person-centered care (PCC) in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce; hence, this study aimed to explore patients' experiences of PCC, and its associations with individual characteristics and health-related quality of life, in the context of allogeneic stem cell transplantation. It is a cross-sectional survey study, in patients who had undergone an allo-HSCT at one center in Sweden. The PCC instrument for outpatient care in rheumatology (PCCoc/rheum) was used. Descriptive and analytical statistics were employed. The study had 126 participants, evenly distributed males and females, 18-79 years old (>60% were 50-69 years old), and most were (>70%) married or cohabiting. The sum score for all items on PCCoc/rheum ranged from 20 to 72 (higher score = higher degree of PCC), with a mean value of 62.67 (SD: 9.863). Most participants (87-99%) agreed with the level of person-centeredness for 22 of the 24 items. Of the participants, 83.3% agreed that they had undisturbed conversations, that their problems had been taken seriously (79.0%), that they had an opportunity to tell their story (77.8%), and collaboration with the nurse was good (77.6%). A sizeable proportion disagreed that the care environment was welcoming (11.9%), family members' involvement (13.7%), and the possibility to influence the care (15.5%). The fulfillment of PCC was rated as high, but the results indicate that there is room for improvement regarding the possibility of influencing the care and family members' involvement.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"86-94"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Influencing Telehealth Satisfaction Among Liver and Kidney Transplant Recipients.","authors":"Dami Ko, Neha Singh, Jane Saczynski","doi":"10.1177/10547738241309703","DOIUrl":"10.1177/10547738241309703","url":null,"abstract":"<p><p>Solid organ transplant (SOT) recipients now have widespread access to telehealth, but the factors influencing their satisfaction still need to be understood. This cross-sectional study explored potential contributors to telehealth satisfaction among SOT recipients, including liver, kidney, and simultaneous liver-kidney recipients. A total of 136 adult SOT recipients completed an online survey. The survey assessed telehealth satisfaction, previous telehealth experiences, including confidence levels and the need for assistance from others, electronic health literacy (eHealth literacy), perceived physical and mental health status, and cognitive function, along with demographic and clinical characteristics. The multivariate regression backward selection method was used to identify potential factors contributing to telehealth satisfaction. Participants had a mean age of 60.1 years (standard deviation [<i>SD</i>] = 10.5) and were, on average, 92 months post-transplant (<i>SD</i> = 99.9). The mean telehealth satisfaction score was 5.3 out of 7 (<i>SD</i> = 1.2), indicating positive satisfaction with telehealth. However, lower telehealth satisfaction was associated with poor confidence in communicating with providers via telehealth, lower eHealth literacy, better perceived cognitive function, and a prolonged time since SOT (adjusted <i>R</i>² = 0.49). SOT recipients who perceive vulnerability in online technology, report better perceived cognitive function, and are farther out from their SOT may exhibit lower satisfaction with telehealth. When considering telehealth for transplant care, clinicians should prioritize addressing the specific concerns and challenges of SOT recipients who may perceive telehealth unfavorably.</p>","PeriodicalId":50677,"journal":{"name":"Clinical Nursing Research","volume":" ","pages":"79-85"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}