Journal of Infectious Diseases最新文献

{"title":"Extended-Spectrum β-Lactamase Shigella sonnei Cluster Among Men Who Have Sex With Men in Chicago, Illinois, July-October 2022.","authors":"Emily A G Faherty, Kendall Kling, Hannah J Barbian, Chao Qi, Shana Altman, Vineet K Dhiman, Richard Teran, Kendall Anderson, Deniz Yuce, Shamika Smith, Morgan Richardson, Kara Vogelzang, Isaac Ghinai, Peter Ruestow, Ira Heimler, Adil Menon, Louise K Francois Watkins, Naeemah Logan, Do Young Kim, Massimo Pacilli, Janna Kerins, Stephanie Black","doi":"10.1093/infdis/jiae235","DOIUrl":"10.1093/infdis/jiae235","url":null,"abstract":"<p><p>Drug-resistant shigellosis is increasing, particularly among men who have sex with men (MSM). During July-October 2022, an extended-spectrum β-lactamase-producing Shigella sonnei cluster of 9 patients was identified in Chicago, of whom 8 were MSM and 6 were festival attendees. The cluster also included 4 domestic travelers to Chicago. Sexual health care for MSM should include shigellosis diagnosis and prevention.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"692-695"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory Viral Infections From 2015 to 2022 in the HIVE Cohort of American Households: Incidence, Illness Characteristics, and Seasonality.","authors":"Arnold S Monto, Joshua E Foster-Tucker, Amy P Callear, Aleda M Leis, Elie-Tino Godonou, Matthew Smith, Rachel Truscon, Emileigh Johnson, Lara J Thomas, Mark S Thompson, Alicia M Fry, Brendan Flannery, Ryan E Malosh, Joshua G Petrie, Adam S Lauring, Emily T Martin","doi":"10.1093/infdis/jiae423","DOIUrl":"10.1093/infdis/jiae423","url":null,"abstract":"<p><strong>Background: </strong>Viral respiratory illnesses are the most common acute illnesses experienced and generally follow a predicted pattern over time. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic interrupted that pattern.</p><p><strong>Methods: </strong>The HIVE (Household Influenza Vaccine Evaluation) study was established in 2010 to follow a cohort of Southeast Michigan households over time. Initially focused on influenza, surveillance was expanded to include other major respiratory pathogens, and, starting in 2015, the population was followed year round. Symptoms of acute illness were reported, and respiratory specimens were collected and tested to identify viral infections. Based on the known population being followed, virus-specific incidence was calculated.</p><p><strong>Results: </strong>From 2015 to 2022, 1755 participants were followed in HIVE for 7785 person-years with 7833 illnesses documented. Before the pandemic, rhinovirus (RV) and common cold human coronaviruses (HCoVs) were the viruses most frequently identified, and incidence decreased with increasing age. Type A influenza was next but with comparable incidence by age. Parainfluenza and respiratory syncytial viruses were less frequent overall, followed by human metapneumoviruses. Incidence was highest in young children, but infections were frequently documented in all age groups. Seasonality followed patterns established decades ago. The SARS-CoV-2 pandemic disrupted these patterns, except for RV and, to a lesser extent, HCoVs. In the first 2 years of the pandemic, RV incidence far exceeded that of SARS-CoV-2.</p><p><strong>Conclusions: </strong>Longitudinal cohort studies are important in comparing the incidence, seasonality, and characteristics of different respiratory viral infections. Studies documented the differential effect of the pandemic on the incidence of respiratory viruses in addition to SARS-CoV-2.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"795-804"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Mosquito Salivary Antigens Demonstrate Promise as Biomarkers of Recent Exposure to Plasmodium falciparum-Infected Mosquito Bites.","authors":"Sarah Lapidus, Morgan M Goheen, Mouhamad Sy, Awa B Deme, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Kelly A Hagadorn, Seynabou Diouf Sene, Mariama Nicole Pouye, Laty Gaye Thiam, Aboubacar Ba, Noemi Guerra, Alassane Mbengue, Hamidah Raduwan, Jacqueline Gagnon, Inés Vigan-Womas, Sunil Parikh, Albert I Ko, Daouda Ndiaye, Erol Fikrig, Yu-Min Chuang, Amy K Bei","doi":"10.1093/infdis/jiae525","DOIUrl":"10.1093/infdis/jiae525","url":null,"abstract":"<p><strong>Background: </strong>Measuring malaria transmission intensity using the traditional entomological inoculation rate is difficult. Antibody responses to mosquito salivary proteins like SG6 have been used as biomarkers of exposure to Anopheles mosquito bites. Here, we investigate 4 mosquito salivary proteins as potential biomarkers of human exposure to mosquitoes infected with Plasmodium falciparum: mosGILT, SAMSP1, AgSAP, and AgTRIO.</p><p><strong>Methods: </strong>We tested population-level human immune responses in longitudinal and cross-sectional plasma from individuals with known P falciparum infection from low- and moderate-transmission areas in Senegal using a multiplexed magnetic bead-based assay.</p><p><strong>Results: </strong>AgSAP and AgTRIO were the best indicators of recent exposure to infected mosquitoes. Antibody responses to AgSAP, in a moderate-endemicity area, and to AgTRIO in both low- and moderate-endemicity areas, were significantly higher than nonendemic controls. No antibody responses significantly differed between low- and moderate-transmission areas, or between equivalent groups during and outside the malaria transmission seasons. AgSAP and AgTRIO reactivity peaked 2-4 weeks after clinical P falciparum infection and declined 3 months after infection.</p><p><strong>Conclusions: </strong>Reactivity to AgSAP and AgTRIO reflects exposure to infectious mosquitoes or recent bites rather than general mosquito exposure, highlighting their promise for incorporation into multiplexed assays for serosurveillance of population-level changes in P falciparum-infected mosquito exposure.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e570-e581"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Relevance of Weighting Malnutrition for Infectious Diseases.","authors":"Scott K Heysell, Sana Syed","doi":"10.1093/infdis/jiae539","DOIUrl":"10.1093/infdis/jiae539","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"559-561"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Biomarker Profile Reflective of Preserved Thymic Function Is Associated With Reduced Comorbidities in Aging People With HIV: An AGEhIV Cohort Analysis.","authors":"Manon C Vanbellinghen, Anders Boyd, Neeltje A Kootstra, Maarten F Schim van der Loeff, Marc van der Valk, Peter Reiss","doi":"10.1093/infdis/jiae603","DOIUrl":"10.1093/infdis/jiae603","url":null,"abstract":"<p><strong>Background: </strong>People with HIV (PWH) experience a higher burden of aging-associated comorbidities, the underlying mechanisms of which remain to be fully elucidated. We aimed to identify profiles based on immune, inflammatory, and aging biomarkers in blood from PWH and controls, and explore their association with total comorbidities over time.</p><p><strong>Methods: </strong>Latent profile analysis was used to construct biomarker profiles in AGEhIV cohort participants (94 with well-controlled HIV on antiretroviral therapy [ART] and 95 controls without HIV) using baseline measurements of selected biomarkers. Factors associated with profile membership were assessed by multivariable logistic regression. The association between profiles and mean total comorbidities during follow-up was assessed by Poisson regression, stratified by HIV status. Comorbidities included type 2 diabetes, non-AIDS malignancies, cardiovascular disease, osteoporosis, chronic kidney disease. and frailty.</p><p><strong>Results: </strong>Three biomarker profiles were identified: \"high thymic output/low inflammation\" (HT/LI) profile (n = 27 PWH, n = 9 controls), \"low thymic output/high inflammation\" (LT/HI) profile (n = 29 PWH, n = 26 controls), and an \"intermediate\" profile (n = 38 PWH, n = 60 controls). Only HIV status was significantly associated with profile membership. PWH, relative to controls, more often exhibited the HT/LI profile compared to other profiles. In PWH, but not in controls, the HT/LI profile was associated with significantly lower mean comorbidities during a median 8.0 years (interquartile range, 7.1-8.1) of follow-up.</p><p><strong>Conclusions: </strong>People aging with well-controlled HIV on ART were more likely to exhibit a biomarker profile indicative of preserved thymic function and less chronic inflammation compared to controls. PWH with such a profile seemed relatively protected from developing aging-associated comorbidities.</p><p><strong>Clinical trials registration: </strong>NCT01466582.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"622-632"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction of: Associations Between Ticagrelor Use and the Risk of Infections: A Mendelian Randomization Study.","authors":"","doi":"10.1093/infdis/jiae356","DOIUrl":"10.1093/infdis/jiae356","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e582"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of an Ethinyl Estradiol/Etonogestrel Vaginal Ring Alters Vaginal Microbial Communities in Women With HIV.","authors":"Nicole H Tobin, Sarah L Brooker, Fan Li, Robert W Coombs, Susan E Cohn, Laura Moran, Mey Leon, Nuntisa Chotirosniramit, Emilia M Jalil, Unoda A Chakalisa, Kimberly K Scarsi, Carmen D Zorrilla, Catherine Godfrey, Grace M Aldrovandi","doi":"10.1093/infdis/jiae524","DOIUrl":"10.1093/infdis/jiae524","url":null,"abstract":"<p><strong>Background: </strong>Human immunodeficiency virus 1 (HIV-1) antiretroviral therapy (ART) alters hormonal contraceptive levels delivered via intravaginal ring (IVR) in a regimen-specific manner. We explored the role of the IVR on vaginal microbial communities, vaginal short chain fatty acids (SCFAs), vaginal HIV shedding, and the effect of vaginal microbes on hormone concentrations in cisgender women with HIV (WWH).</p><p><strong>Methods: </strong>Vaginal microbes were assessed by 16S RNA sequencing of weekly vaginal swabs, vaginal SCFA by mass spectrometry, HIV-1 shedding by nucleic acid amplification on vaginal aspirates, and bacterial vaginosis by Nugent scoring from 74 participants receiving an etonogestrel/ethinyl estradiol (ENG/EE) intravaginal ring while on no ART (n = 25), efavirenz-based ART (n = 25), or atazanavir-based ART (n = 24).</p><p><strong>Results: </strong>At baseline, microbial communities of the 64 substudy eligible participants robustly classified as Lactobacillus crispatus-dominant (n = 8), Lactobacillus gasseri-dominant (n = 2), Lactobacillus iners-dominant (n = 17), or mixed anaerobic communities (n = 37). During IVR therapy, there was an increased probability of Lactobacillus-dominant community state types (CSTs) (odds ratio = 1.61, P = .04). Vaginal CSTs were associated with Nugent scores. Bacterial vaginosis-associated bacteria were associated with significantly higher and L. iners with lower Nugent scores (all P adjusted <.1). Lactic acid levels were correlated with the relative abundance of Lactobacillus species (r2 = 0.574; P < .001). Vaginal shedding of HIV-1 was less common in women with L. crispatus-dominant microbiomes (P = .04). Mixed anaerobic vaginal communities modulated EE concentrations in a regimen-specific manner.</p><p><strong>Conclusions: </strong>Combined ENG/EE IVR therapy was associated with an increase in Lactobacillus-dominant vaginal microbial communities in WWH and may benefit those with bacterial vaginosis. EE levels were altered by the vaginal microbiota.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"583-594"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Longitudinal Analysis of Memory Immune Responses in Convalescent Crimean-Congo Hemorrhagic Fever Survivors in Uganda.","authors":"Courtney A Cohen, Stephen Balinandi, Ana I Kuehne, Michelle L Rock, Luke G Bonagofski, Keersten M Ricks, Ian Davis, Dafna Abelson, Spencer W Stonier, Matthew Odongo, Zachary A Bornholdt, Larry Zeitlin, Crystal Moyer, Stephen Cose, John M Dye, Julius J Lutwama, Andrew S Herbert","doi":"10.1093/infdis/jiae395","DOIUrl":"10.1093/infdis/jiae395","url":null,"abstract":"<p><p>Evaluating the adaptive immune responses to natural infection with Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) in human survivors is critical to the development of medical countermeasures. However, the correlates of protection are unknown. As the most prevalent tick-borne human hemorrhagic fever virus with case fatality rates of 5%-30% and worldwide distribution, there is an urgent need to fill these knowledge gaps. Here, we describe adaptive immune responses in a cohort of Ugandan CCHF survivors via serial sampling over 6 years. We demonstrate persistent antibodies after infection and cross-neutralization against various clades of authentic CCHFV, as well as potent effector function. Moreover, we show for the first time persistent, polyfunctional antigen-specific memory T-cell responses to multiple CCHFV proteins up to 9 years after infection. Together, this data provides immunological benchmarks for evaluating CCHFV medical countermeasures and information that can be leveraged toward vaccine immunogen design and viral target identification for monoclonal antibody therapies.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"762-772"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Surviving Neglected Tropical Diseases Is Not Enough.","authors":"Fernando Almeida-Val, Cássia da Luz Goulart, Wuelton Marcelo Monteiro, Guilherme Peixoto Tinoco Areas","doi":"10.1093/infdis/jiae579","DOIUrl":"10.1093/infdis/jiae579","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"822-823"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstitution of Norovirus-Specific T-Cell Responses Following Hematopoietic Stem Cell Transplantation in Patients With Inborn Errors of Immunity and Chronic Norovirus Infection.","authors":"Jessica Durkee-Shock, Ariella Cohen, Naseem Maghzian, Gloria Pezzella, Mariah Jensen-Wachspress, Anna Hostal, Karenna Barton, Krista Gangler, Blachy J Dávila Saldaña, Natthawan Chaimongkol, Catherine M Bollard, Stanislav V Sosnovtsev, Jeffrey Cohen, Bianca M Nagata, Derron A Alves, Rajarshi Ghosh, Bryce A Seifert, Alexandra Freeman, Corina Gonzalez, Luigi D Notarangelo, Kim Y Green, Michael D Keller","doi":"10.1093/infdis/jiae398","DOIUrl":"10.1093/infdis/jiae398","url":null,"abstract":"<p><strong>Background: </strong>Chronic norovirus infection (CNI) causes significant morbidity in immunocompromised patients. No effective prevention or treatment currently exists.</p><p><strong>Methods: </strong>Two patients with inborn errors of immunity, X-linked severe combined immunodeficiency (X-SCID) and DOCK8 deficiency, were followed longitudinally for clinical course, immune reconstitution, norovirus-specific T-cell (NST) response, B-cell reconstitution, and norovirus-specific antibody production. Samples were obtained in the peri-hematopoietic stem cell transplant (HSCT) setting before and after CNI clearance. The norovirus strain causing CNI was followed longitudinally for norovirus stool viral loads and sequencing.</p><p><strong>Results: </strong>The noroviruses were identified as GII.4 Sydney[P4 New Orleans] in 1 patient and GII.17[P17] in the other. An exacerbation of diarrhea post-HSCT in the patient with X-SCID was consistent with norovirus infection but not with graft-versus-host disease on pathologic samples. Both patients recovered polyfunctional NSTs in the CD4 and CD8 T-cell compartments that recognized multiple norovirus structural and nonstructural viral antigens. T-cell responses were minimal during active CNI but detectable after resolution. Mapping of NST responses between the patient with DOCK8 deficiency and his matched sibling donor were nearly identical. B-cell reconstitution or new endogenous antibody production for immunoglobulin A or immunoglobulin G was not observed.</p><p><strong>Conclusions: </strong>This report is the first to demonstrate reconstitution of NST immunity after HSCT closely temporally aligned with clearance of CNI, suggesting that cellular immunity is sufficient for norovirus clearance.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"773-783"},"PeriodicalIF":5.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}