Journal of Infectious Diseases最新文献

The Gut Microbiome: Another Piece in the Puzzle of HIV-Associated Atherosclerosis. 肠道微生物组：肠道微生物组：艾滋病相关动脉粥样硬化之谜的另一块拼图。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiae244

Sergio Serrano-Villar, Esteban Martínez

引用次数: 0

Transcriptome Analysis of Monocytes Treated With Dengue Virus Nonstructural Protein 1 Revealed a Shift in Transcripts Involved in Self-Propagated Proinflammation and Antiviral Responses. 用登革热NS1治疗单核细胞的转录组分析揭示了参与自我繁殖的促炎症和抗病毒反应的转录本的转变。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf166

Khwankhao Saisingha, Tuksin Jearanaiwitayakul, Daniel Watterson, Naphak Modhiran, Marisa Ponpuak, Sukathida Ubol

引用次数: 0

Microbiome and Metabolome Restoration After Administration of Fecal Microbiota, Live-jslm (REBYOTA) for Preventing Recurrent Clostridioides difficile Infection. 服用粪便微生物群活体-jslm (REBYOTA®) 预防艰难梭菌复发性感染后的微生物组和代谢组恢复。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiae418

Ken F Blount, Romeo Papazyan, Nicky Ferdyan, Karthik Srinivasan, Carlos Gonzalez, William D Shannon, Bryan C Fuchs

{"title":"Microbiome and Metabolome Restoration After Administration of Fecal Microbiota, Live-jslm (REBYOTA) for Preventing Recurrent Clostridioides difficile Infection.","authors":"Ken F Blount, Romeo Papazyan, Nicky Ferdyan, Karthik Srinivasan, Carlos Gonzalez, William D Shannon, Bryan C Fuchs","doi":"10.1093/infdis/jiae418","DOIUrl":"10.1093/infdis/jiae418","url":null,"abstract":"Background: Microbiota-based treatments are effective in preventing recurrent Clostridioides difficile infection. Fecal microbiota, live-jslm (REBYOTA; RBL, previously RBX2660) was shown to prevent recurrent C difficile infection in a phase 3 clinical trial (PUNCH CD3) based on a randomized, double-blinded, placebo-controlled design.Methods: Stool samples from participants in PUNCH CD3 who received a single blinded dose of rectally administered RBL or placebo were sequenced to determine microbial community composition and calculate the Microbiome Health Index for postantibiotic dysbiosis. The composition of bile acids (BAs) in the same samples was quantified by liquid chromatography-mass spectrometry. Relationships between BA composition and microbiota community structure and correlations with treatment outcomes were assessed.Results: Before administration, Gammaproteobacteria and Bacilli dominated the microbiota community, and primary BAs were more prevalent than secondary BAs. Clinical success after administration correlated with shifts to predominantly Bacteroidia and Clostridia, a significant increase in Microbiome Health Index for postantibiotic dysbiosis, and a shift from primary to secondary BAs. Several microbiota and BA changes were more extensive in RBL-treated responders as compared with placebo-treated responders, and microbiota changes correlated with BA changes.Conclusions: Clinical response and RBL administration were associated with significant restoration of microbiota and BA composition.Clinical trials registration: NCT03244644 (https://clinicaltrials.gov/ct2/show/NCT03244644).","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e1022-e1033"},"PeriodicalIF":5.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human HKU1-Reactive CD4 T Cells Are Enriched for Cytolytic Potential That Persists in Older Adults. 人类hku1反应性CD4 T细胞富含细胞溶解潜能，这种潜能在老年人中持续存在。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf026

Chantelle L White, Katherine A Richards, Nelson Huertas, Jennifer L Nayak, Andrea J Sant

引用次数: 0

Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection. 老年人接种或感染呼吸道合胞病毒（RSV）体液抗体反应

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf149

Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey

引用次数: 0

The Impact of Coronavirus Disease 2019 Nonpharmaceutical Interventions on Incidence of Acute Gastroenteritis and Acute Respiratory Infections Among US Military and Dependents. COVID-19非药物干预对美国军人及其家属急性肠胃炎和急性呼吸道感染发生率的影响

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf153

Bevin Manuelpillai, Benjamin Lopman, Charlotte R Doran, Chad Porter

引用次数: 0

Leveraging Data From a Longitudinal Birth Cohort to Improve Attribution of Diarrhea Etiology Among Children in Low-Resource Settings. 利用纵向出生队列数据改进低资源环境中儿童腹泻病因的归因。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiae389

Maria Garcia Quesada, James A Platts-Mills, Jie Liu, Eric R Houpt, Elizabeth T Rogawski McQuade

{"title":"Leveraging Data From a Longitudinal Birth Cohort to Improve Attribution of Diarrhea Etiology Among Children in Low-Resource Settings.","authors":"Maria Garcia Quesada, James A Platts-Mills, Jie Liu, Eric R Houpt, Elizabeth T Rogawski McQuade","doi":"10.1093/infdis/jiae389","DOIUrl":"10.1093/infdis/jiae389","url":null,"abstract":"Attributing infectious causes of diarrhea is critical to inform treatment and burden estimates. The attributable fraction (AF) approach based on the association between pathogen quantity and diarrhea has been frequently used but may underestimate incidence. We leveraged data from the multisite birth-cohort Malnutrition and Enteric Disease (MAL-ED) Study, where diarrheal and nondiarrheal stools were collected from 1715 children aged 0-2 years. We compared attribution using a longitudinal AF method that considers the temporal association between pathogen quantity and diarrhea symptoms to previously published AF estimates. For rotavirus and Shigella, attribution did not meaningfully change. For others like adenovirus 40 and 41, astrovirus, norovirus GII, sapovirus, Campylobacter jejuni or Campylobacter coli, heat-stable toxin enterotoxigenic Escherichia coli, typical enteropathogenic E. coli, and Cryptosporidium attribution increased, demonstrating longitudinal data may be informative for pathogens with weak associations between quantity and diarrhea. We further derived accuracy-based, pathogen-specific quantity cutoffs that may improve attribution in the absence of longitudinal data.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1445-1454"},"PeriodicalIF":5.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMART Designs: Bridging the Gap Between Clinical Trials and Practice in Infectious Diseases. SMART 设计：缩小传染病临床试验与实践之间的差距。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiae493

Lara Maleyeff, Erica E M Moodie, Shirin Golchi

引用次数: 0

Strength and Durability of Respiratory Syncytial Virus Prefusion F Immunoglobulin G Following Infection and Exposure in a Household Cohort, 2014-2022. 2014-2022年家庭队列感染和暴露后RSV融合前F IgG的强度和持久性

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf168

Kalee E Rumfelt, Casey Juntila, Matthew Smith, Amy Callear, Yangyupei Yang, Arnold S Monto, Adam S Lauring, Emily T Martin

{"title":"Strength and Durability of Respiratory Syncytial Virus Prefusion F Immunoglobulin G Following Infection and Exposure in a Household Cohort, 2014-2022.","authors":"Kalee E Rumfelt, Casey Juntila, Matthew Smith, Amy Callear, Yangyupei Yang, Arnold S Monto, Adam S Lauring, Emily T Martin","doi":"10.1093/infdis/jiaf168","DOIUrl":"10.1093/infdis/jiaf168","url":null,"abstract":"Background: Little is known about the strength and durability of protection provided by prefusion F (pre-F) immunoglobulin G (IgG) after respiratory syncytial virus (RSV) infection/exposure.Methods: We analyzed 1019 sera from 422 individuals in 173 households, collected 365 days before and after RSV infection or exposure (2014-2022), from a longitudinal cohort with active respiratory infection surveillance. IgG against RSV pre-F was measured by electrochemiluminescence assay. We used a Cox model, adjusted for age, to assess the association between log4 preinfection/exposure IgG and risk of infection. We compared pre- and postinfection/exposure IgG geometric mean concentration increases among cases and household contacts to identify asymptomatic infections. Generalized additive mixed models predicted IgG concentrations over time.Results: We identified 113 confirmed RSV cases and 377 exposed household contacts. Cases had significantly lower pre-F IgG before infection (P < .05) and significantly higher levels after infection (P < .05). A 1-unit increase in log4 preinfection IgG decreased the risk of infection by 25% (P < .05). Among 58 cases with pre- to post-RSV geometric mean concentration increases, the mean fold increase was 1.12. Eight individuals without confirmed infections had ≥1.12-fold increases and were classified as probable asymptomatic infections. Cases had the highest IgG concentrations after infection, peaking at 1 month (P < .001).Conclusions: Pre-F IgG is a reliable correlate of protection for RSV infection risk. We found that RSV pre-F IgG-mediated protection starts to wane 6 months after infection. Therefore, scheduling of RSV vaccination should be evaluated so that individuals with the highest risk of severe disease are protected throughout the RSV season.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e1138-e1145"},"PeriodicalIF":5.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Viroimmunologic Model to Characterize the Antiviral Effect of Molnupiravir in Outpatients Infected With SARS-CoV-2: Implication for Treatment Duration. 用病毒免疫学模型描述莫仑匹拉韦对感染 SARS-CoV-2 的门诊患者的抗病毒效果：对治疗持续时间的影响。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI: 10.1093/infdis/jiaf158

Bach Tran Nguyen, Julie Bertrand, Akosua A Agyeman, Shengyuan Zhang, Ly-Mee Yu, Victoria Harris, Paul Little, Christopher C Butler, Judith Breuer, David M Lowe, Joseph F Standing, Jérémie Guedj

{"title":"A Viroimmunologic Model to Characterize the Antiviral Effect of Molnupiravir in Outpatients Infected With SARS-CoV-2: Implication for Treatment Duration.","authors":"Bach Tran Nguyen, Julie Bertrand, Akosua A Agyeman, Shengyuan Zhang, Ly-Mee Yu, Victoria Harris, Paul Little, Christopher C Butler, Judith Breuer, David M Lowe, Joseph F Standing, Jérémie Guedj","doi":"10.1093/infdis/jiaf158","DOIUrl":"10.1093/infdis/jiaf158","url":null,"abstract":"Background: The antiviral efficacy of molnupiravir against SARS-CoV-2 is controversial. Here, we develop a model integrating viral and immune dynamics to characterize the mechanism of action of molnupiravir in vivo and its impact on viral dynamics during and after treatment.Methods: We analyzed data from the PANORAMIC trial, where 577 outpatients were randomized shortly after symptom onset to receive usual care or molnupiravir for 5 days, with viral and immunologic data collected within 2 weeks. We developed a mathematical model that characterized virus-host interaction, accounting for the impact of molnupiravir on viral replication and mutagenesis. The model was used to explore the impact of longer treatment duration.Results: Molnupiravir reduced RNA replication with an efficacy that reached 93% at the end of a 5-day treatment. This effect was mediated through 2 pathways: 1 that increased transition mutation frequency and 1 that directly inhibited viral production. Accordingly, 5-day treatment shortened the median time to clearance of RNA and infectious virus by approximately 2 days. Ten-day treatment could reduce the time to RNA clearance by 5 days and the occurrence of viral rebounds. Longer treatment durations might be needed for postexposure prophylaxis.Conclusions: Our model suggests that molnupiravir acts primarily on viral replication, and not specifically on viral infectivity. Longer administration of molnupiravir may reduce the rebound rate, shortening the time to viral clearance.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e1080-e1090"},"PeriodicalIF":5.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0