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Monoclonal Antibodies to Treat Diphtheria. 治疗白喉的单克隆抗体。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-21 DOI: 10.1093/infdis/jiae500
N J White
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引用次数: 0
Impact of multi-cohort HPV vaccination on cervical cancer in women below 30 years of age: Lessons learned from the Scandinavian countries. 多队列 HPV 疫苗接种对 30 岁以下女性宫颈癌的影响：斯堪的纳维亚国家的经验教训。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-21 DOI: 10.1093/infdis/jiae584
Ståle Nygård, Thea Falkenthal, Tina Sture, Elsebeth Lynge, Miriam Elfström, Mari Nygård
{"title":"Impact of multi-cohort HPV vaccination on cervical cancer in women below 30 years of age: Lessons learned from the Scandinavian countries.","authors":"Ståle Nygård, Thea Falkenthal, Tina Sture, Elsebeth Lynge, Miriam Elfström, Mari Nygård","doi":"10.1093/infdis/jiae584","DOIUrl":"https://doi.org/10.1093/infdis/jiae584","url":null,"abstract":"<p><p>In Scandinavia, HPV vaccination programs started in 2007/8; in Sweden and Denmark with HPV vaccination offered to multiple cohorts of young girls, while in Norway offered to a single cohort only. Interestingly, in Sweden and Denmark, cervical cancer incidence in young women decreased markedly from 2017/2018, while in Norway a steady increase was seen until 2020. As the three countries are very similar in other factors important for cervical cancer incidence rates like cervical cancer screening, the observed difference is most likely due to differences in the multi-cohort vaccination.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Phase 1 Study in Healthy Subjects to Evaluate the Safety and Pharmacokinetics of a Human Monoclonal Antibody (S315) Against Diphtheria Toxin. 一项在健康受试者中进行的 1 期研究，以评估一种抗白喉毒素的人类单克隆抗体 (S315) 的安全性和药代动力学。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-21 DOI: 10.1093/infdis/jiae499
John Z Sullivan-Bólyai, Larry B Allen, Rebecca Cannon, Kenya P Cohane, Elise Dunzo, Ronald Goldwater, Kathleen StCyr, Yang Wang, Mark S Klempner
{"title":"A Phase 1 Study in Healthy Subjects to Evaluate the Safety and Pharmacokinetics of a Human Monoclonal Antibody (S315) Against Diphtheria Toxin.","authors":"John Z Sullivan-Bólyai, Larry B Allen, Rebecca Cannon, Kenya P Cohane, Elise Dunzo, Ronald Goldwater, Kathleen StCyr, Yang Wang, Mark S Klempner","doi":"10.1093/infdis/jiae499","DOIUrl":"https://doi.org/10.1093/infdis/jiae499","url":null,"abstract":"<p><strong>Background: </strong>Diphtheria is a recurrent threat with endemic still occurs in many parts of the world. The standard of care is horse serum-derived diphtheria antitoxin (eDAT), which is in critical short supply globally. S315 is a fully human, monoclonal immunoglobulin G1 neutralizing antibody, specific to the receptor-binding domain of diphtheria toxin. S315 is intended to be a safer, more readily available alternative to replace eDAT.</p><p><strong>Methods: </strong>This first-in-human, randomized, double-blind, dose escalation study evaluated the safety, tolerability, and pharmacokinetics of S315 in healthy adults. Cohorts of study subjects received single intravenous infusions of S315 (480 mg, 960 mg, 1920 mg, 3840 mg, and 7680 mg) or matched placebo. Safety was assessed by standard clinical and laboratory evaluations. Serum S315 concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and an in vitro diphtheria toxin neutralization assay, followed by pharmacokinetic analyses.</p><p><strong>Results: </strong>Forty-one subjects were enrolled. S315 was safe and well tolerated. Most adverse events were mild or moderate. Peak mean serum concentrations ranged from 199 µg/mL to 2872 µg/mL (ELISA) and from 234 AU/mL to 1147 AU/mL (neutralization assay), with low variability. Mean serum half-life ranged from 12 to 27 days (ELISA) and from 17 to 22 days (neutralization assay).</p><p><strong>Conclusions: </strong>S315 was generally safe and well tolerated by healthy subjects. Pharmacokinetic data suggest that S315 serum neutralizing activity is an order of magnitude greater than that attained by eDAT. The results of this study support continued development of S315 as a replacement for eDAT to address critical global supply issues. Clinical Trials Registration. NCT04075175.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Safety and Immunogenicity of a 4-Component Generalized Modules for Membrane Antigens Shigella Vaccine in Healthy European Adults: Randomized, Phase 1/2 Study. 更正：在欧洲健康成人中接种由 4 种成分组成的膜抗原通用模块志贺氏杆菌疫苗的安全性和免疫原性：随机、1/2 期研究。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-20 DOI: 10.1093/infdis/jiae564
{"title":"Correction to: Safety and Immunogenicity of a 4-Component Generalized Modules for Membrane Antigens Shigella Vaccine in Healthy European Adults: Randomized, Phase 1/2 Study.","authors":"","doi":"10.1093/infdis/jiae564","DOIUrl":"https://doi.org/10.1093/infdis/jiae564","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: EDP-938 Has a High Barrier to Resistance in Healthy Adults Experimentally Infected with Respiratory Syncytial Virus. 更正：EDP-938对实验性感染呼吸道合胞病毒的健康成人具有很高的抗药性屏障。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-20 DOI: 10.1093/infdis/jiae563
{"title":"Correction to: EDP-938 Has a High Barrier to Resistance in Healthy Adults Experimentally Infected with Respiratory Syncytial Virus.","authors":"","doi":"10.1093/infdis/jiae563","DOIUrl":"https://doi.org/10.1093/infdis/jiae563","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correspondence to "Escape Velocity-the Launch of Microbiome Therapies". 逃逸速度--微生物组疗法的启动》通讯。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-20 DOI: 10.1093/infdis/jiae575
Bernat Olle, Ryan Ranallo, L Clifford McDonald
{"title":"Correspondence to \"Escape Velocity-the Launch of Microbiome Therapies\".","authors":"Bernat Olle, Ryan Ranallo, L Clifford McDonald","doi":"10.1093/infdis/jiae575","DOIUrl":"https://doi.org/10.1093/infdis/jiae575","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to: Medically Attended Illness due to Respiratory Syncytial Virus Infection Among Infants Born in the United States Between 2016 and 2020. 更正：2016年至2020年期间在美国出生的婴儿中因呼吸道合胞病毒感染而就医的疾病。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-20 DOI: 10.1093/infdis/jiae566
{"title":"Corrigendum to: Medically Attended Illness due to Respiratory Syncytial Virus Infection Among Infants Born in the United States Between 2016 and 2020.","authors":"","doi":"10.1093/infdis/jiae566","DOIUrl":"https://doi.org/10.1093/infdis/jiae566","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice. 药物抑制巨噬细胞甘油三酯生物合成途径并不能改善受感染小鼠对结核分枝杆菌的控制。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-19 DOI: 10.1093/infdis/jiae577
Jennie Ruelas Castillo, Valentina Guerrini, Darla Quijada, Styliani Karanika, Pranita Neupane, Michael E Urbanowski, Babajide Shenkoya, Harley Harris, Andrew Garcia, Addis Yilma, Hannah Annunziata, Rehan Khan, Mathangi Gopalakrishnan, Maria L Gennaro, Petros C Karakousis
{"title":"Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice.","authors":"Jennie Ruelas Castillo, Valentina Guerrini, Darla Quijada, Styliani Karanika, Pranita Neupane, Michael E Urbanowski, Babajide Shenkoya, Harley Harris, Andrew Garcia, Addis Yilma, Hannah Annunziata, Rehan Khan, Mathangi Gopalakrishnan, Maria L Gennaro, Petros C Karakousis","doi":"10.1093/infdis/jiae577","DOIUrl":"10.1093/infdis/jiae577","url":null,"abstract":"<p><p>Tuberculosis (TB) necrotic granulomas contain triglyceride-rich macrophages (foam cells) with reduced antimicrobial functions. We assessed the ability of two compounds to reduce triglyceride content and Mycobacterium tuberculosis (Mtb) burden in infected human monocyte-derived macrophages and in the lungs of Mtb-infected C3HeB/FeJ mice: A-922500 (DGATi), an inhibitor of diacylglycerol acyltransferase 1; and LY2584702 (p70S6Ki), an inhibitor of p70 S6 kinase. DGATi and p70S6Ki significantly reduced the lipid content and bacillary burden in Mtb-infected macrophages. Each inhibitor reduced the cellular triglyceride content in bronchoalveolar lavage samples of Mtb-infected mice. After 6 weeks of treatment, p70S6Ki alone reduced the lung bacterial burden in Mtb-infected mice. However, DGATi alone, and DGATi or p70S6Ki in combination with isoniazid did not reduce lung bacterial burden or alter lung inflammation. These findings provide further insight into the role of foam cells in tuberculosis pathogenesis and the utility of interventions targeting these cell populations as adjunctive host-directed therapies.</p>","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When surviving neglected tropical diseases is not enough: reply to Connor and Taylor, 2024. 当被忽视的热带疾病不足以生存时：对 Connor 和 Taylor 的答复，2024 年。
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-19 DOI: 10.1093/infdis/jiae579
Fernando Almeida-Val, Cássia da Luz Goulart, Wuelton Marcelo Monteiro, Guilherme Peixoto Tinoco Areas
{"title":"When surviving neglected tropical diseases is not enough: reply to Connor and Taylor, 2024.","authors":"Fernando Almeida-Val, Cássia da Luz Goulart, Wuelton Marcelo Monteiro, Guilherme Peixoto Tinoco Areas","doi":"10.1093/infdis/jiae579","DOIUrl":"https://doi.org/10.1093/infdis/jiae579","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Olle et al. 对 Olle 等人的答复
IF 5 2区 医学
Journal of Infectious Diseases Pub Date : 2024-11-19 DOI: 10.1093/infdis/jiae576
Brendan J Kelly, Jennie H Kwon, Michael H Woodworth
{"title":"Reply to Olle et al.","authors":"Brendan J Kelly, Jennie H Kwon, Michael H Woodworth","doi":"10.1093/infdis/jiae576","DOIUrl":"10.1093/infdis/jiae576","url":null,"abstract":"","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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