老年人接种或感染呼吸道合胞病毒（RSV）体液抗体反应

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-07-11 DOI:10.1093/infdis/jiaf149

Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey

{"title":"老年人接种或感染呼吸道合胞病毒（RSV）体液抗体反应","authors":"Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey","doi":"10.1093/infdis/jiaf149","DOIUrl":null,"url":null,"abstract":"Background: Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.Methods: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines.Results: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001).Conclusions: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e1146-e1150"},"PeriodicalIF":4.5000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247800/pdf/","citationCount":"0","resultStr":"{\"title\":\"Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection.\",\"authors\":\"Edward E Walsh, Michael Peasley, Angela R Branche, Ann R Falsey\",\"doi\":\"10.1093/infdis/jiaf149\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.Methods: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines.Results: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001).Conclusions: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.\",\"PeriodicalId\":50179,\"journal\":{\"name\":\"Journal of Infectious Diseases\",\"volume\":\" \",\"pages\":\"e1146-e1150\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247800/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infectious Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/infdis/jiaf149\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infectious Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/infdis/jiaf149","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：感染后对RSV的免疫是短暂的。我们确定最近批准的RSV预f疫苗是否比感染诱导更好的免疫反应。方法：测定老年人在RSV感染或接种两种RSV preF蛋白疫苗后的基线和30天血清中RSV A和B的preF结合和中和抗体。结果：与RSV感染相比，接种疫苗可诱导更高的血清preF结合抗体和中和反应（A2 RSV: 3306 vs 1254）。结论：接种preF蛋白疫苗可诱导比RSV感染更好的老年人体液免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection.

Background: Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.

Methods: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines.

Results: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001).

Conclusions: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.