Journal of Infectious Diseases最新文献_第2页

High Mortality Rates Among Individuals Misdiagnosed With Tuberculosis: A Matched Retrospective Cohort Study of Individuals Diagnosed With Tuberculosis in Brazil. 被误诊为肺结核患者的高死亡率：对巴西被诊断为肺结核患者的匹配回顾性队列研究。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae531

Ryan R Thompson, Sun Kim, Daniele Maria Pelissari, Luiza Ohana Harada, José Nildo de Barros Silva, Patricia Bartholomay Oliveira, Marcia C Castro, Ted Cohen, Nicolas A Menzies

引用次数: 0

Estimating Standard-Dose and High-Dose Fluzone Vaccine Efficacies for Influenza A Based on Hemagglutination Inhibition Titers. 根据 HAI 滴度估算甲型流感的标准剂量和高剂量 Fluzone 疫苗效力。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae615

Savannah M Hammerton, W Zane Billings, Hayley Hemme, Ted M Ross, Ye Shen, Andreas Handel

{"title":"Estimating Standard-Dose and High-Dose Fluzone Vaccine Efficacies for Influenza A Based on Hemagglutination Inhibition Titers.","authors":"Savannah M Hammerton, W Zane Billings, Hayley Hemme, Ted M Ross, Ye Shen, Andreas Handel","doi":"10.1093/infdis/jiae615","DOIUrl":"10.1093/infdis/jiae615","url":null,"abstract":"Background: The high-dose (HD) Fluzone influenza vaccine is recommended for individuals aged ≥65 years due to its improved antibody responses and vaccine efficacy (VE) over the standard-dose (SD) formulation. Since influenza vaccines are frequently reformulated, monitoring VE changes is crucial. Traditional efficacy trials are costly and time-consuming, but immunogenicity studies using hemagglutination inhibition (HAI) titers-a reliable correlate of protection-can be used to estimate VE more efficiently.Methods: We analyzed data from a human vaccine cohort who received either the SD or HD Fluzone split-inactivated influenza vaccine during influenza seasons 2013-2014 to 2021-2022. We used a previously developed statistical model to map pre- and postvaccination HAI titers to protection probabilities, and computed differences in VE of the HD vaccine in older (≥65 years) populations compared to SD vaccines in the same age group and in younger (<65 years) adults.Results: We found that the HD vaccine generally improved the estimated VE in older adults. We also found that HD recipients often had a lower estimated VE than younger SD recipients.Conclusions: While HD vaccines lead to a small increase in estimated VE compared to SD in older adults, further increases in dose or other developments to improve VE should be considered.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1336-1345"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of c-Src During Listeria monocytogenes Cell-to-Cell Spreading. 单核增生李斯特菌细胞间扩散过程中c-Src的表征。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiaf063

Petra A McLeod, Aaron S Dhanda, Julian A Guttman

引用次数: 0

Expression of Concern: Relative Effectiveness and Waning of a Third Dose of mRNA COVID-19 Vaccine in Medicare Beneficiaries Aged 65 Years and Older during the BA.1/BA.2 Omicron Period. 关注的表达：在BA.1/BA.2期间，65岁及以上的医疗保险受益人中第三剂mRNA COVID-19疫苗的相对有效性和衰减买卖。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae549

引用次数: 0

SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets. 人肺ALI培养物的SARS-CoV-2感染揭示基底细胞是相关靶点。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiaf125

Morris Baumgardt, Benedikt Obermayer, Anita Balázs, Anna Löwa, Emanuel Wyler, Luiz Gustavo Teixeira Alves, Katharina Hellwig, Dieter Beule, Markus Landthaler, Marcel A Müller, Christian Drosten, Marcus A Mall, Stefan Hippenstiel, Katja Hönzke, Andreas C Hocke

{"title":"SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets.","authors":"Morris Baumgardt, Benedikt Obermayer, Anita Balázs, Anna Löwa, Emanuel Wyler, Luiz Gustavo Teixeira Alves, Katharina Hellwig, Dieter Beule, Markus Landthaler, Marcel A Müller, Christian Drosten, Marcus A Mall, Stefan Hippenstiel, Katja Hönzke, Andreas C Hocke","doi":"10.1093/infdis/jiaf125","DOIUrl":"10.1093/infdis/jiaf125","url":null,"abstract":"Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily targets ciliated cells during the initial infection of the upper respiratory tract. However, uncertainties persist regarding other involved epithelial cell types.Methods: We here utilized viral replication analysis, single-cell RNA sequencing, and spectral microscopy on infected air-liquid interface cultures of human primary nasal and bronchial epithelial cells to discern cell type proportions in relation to SARS-CoV-2 tropism and immune activation.Results: We revealed that, next to ciliated and secretory cells, SARS-CoV-2 (wild type and lineage B1.1.7 [Alpha variant]) strongly infects basal cells, significantly contributing to the epithelial immune response in a donor-specific manner. Moreover, local Camostat mesylate treatment was effective in both the basal and apical cell compartment, resulting in a notable reduction in viral load and reduced immune activation.Conclusions: Collectively, our data emphasize the critical role of basal cells in facilitating SARS-CoV-2 dissemination within the upper respiratory tract and their substantial contribution to the epithelial immune response. Furthermore, our results highlight the potential of local application of Camostat mesylate as an effective strategy for inhibiting SARS-CoV-2 infection and mitigating associated immune activation early on.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1210-1220"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacologic Inhibition of Macrophage Triglyceride Biosynthesis Pathways Does Not Improve Mycobacterium tuberculosis Control in Infected Mice. 药物抑制巨噬细胞甘油三酯生物合成途径并不能改善受感染小鼠对结核分枝杆菌的控制。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae577

Jennie Ruelas Castillo, Valentina Guerrini, Darla Quijada, Styliani Karanika, Pranita Neupane, Michael E Urbanowski, Babajide Shenkoya, Harley Harris, Andrew Garcia, Addis Yilma, Hannah Annunziata, Rehan Khan, Mathangi Gopalakrishnan, Maria L Gennaro, Petros C Karakousis

{"title":"Pharmacologic Inhibition of Macrophage Triglyceride Biosynthesis Pathways Does Not Improve Mycobacterium tuberculosis Control in Infected Mice.","authors":"Jennie Ruelas Castillo, Valentina Guerrini, Darla Quijada, Styliani Karanika, Pranita Neupane, Michael E Urbanowski, Babajide Shenkoya, Harley Harris, Andrew Garcia, Addis Yilma, Hannah Annunziata, Rehan Khan, Mathangi Gopalakrishnan, Maria L Gennaro, Petros C Karakousis","doi":"10.1093/infdis/jiae577","DOIUrl":"10.1093/infdis/jiae577","url":null,"abstract":"Tuberculosis necrotic granulomas contain triglyceride-rich macrophages (foam cells) with reduced antimicrobial functions. We assessed the ability of 2 compounds to reduce the triglyceride content and Mycobacterium tuberculosis (Mtb) burden in infected human monocyte-derived macrophages and in the lungs of Mtb-infected C3HeB/FeJ mice: A-922500 (DGATi), an inhibitor of diacylglycerol O-acyltransferase 1, and LY2584702 (p70S6Ki), an inhibitor of p70 S6 kinase. DGATi and p70S6Ki significantly reduced the lipid content and bacillary burden in Mtb-infected macrophages. Each inhibitor reduced the cellular triglyceride content in bronchoalveolar lavage samples of Mtb-infected mice. After 6 weeks of treatment, p70S6Ki alone reduced the lung bacterial burden in Mtb-infected mice. However, DGATi alone and DGATi or p70S6Ki in combination with isoniazid did not reduce lung bacterial burden or alter lung inflammation. These findings provide further insight into the role of foam cells in tuberculosis pathogenesis and the utility of interventions targeting these cell populations as adjunctive host-directed therapies.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1141-1149"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Cytokine Patterns Identify Acute and Convalescent Myocardial Involvement After Coronavirus Disease 2019: A Multicohort Biomarker Study. 不同的细胞因子模式识别冠状病毒病2019后急性和恢复期心肌受累：一项多队列生物标志物研究

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiaf045

David A Zidar, Grace A McComsey, Donald D Anthony, John McDaniel, Timothy A Chan, Sadeer G Al-Kindi

引用次数: 0

Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental Plasmodium falciparum Malaria. VAR2CSA特异性免疫球蛋白G的Fc-岩藻糖基化与恶性疟原虫疟疾胎盘的临床免疫力

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae529

Mary Lopez-Perez, Firmine Viwami, Paulina Ampomah, Tonći Šuštić, Mads Delbo Larsen, Manfred Wuhrer, Gestur Vidarsson, Michael F Ofori, Nicaise Tuikue Ndam, Lars Hviid

{"title":"Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental Plasmodium falciparum Malaria.","authors":"Mary Lopez-Perez, Firmine Viwami, Paulina Ampomah, Tonći Šuštić, Mads Delbo Larsen, Manfred Wuhrer, Gestur Vidarsson, Michael F Ofori, Nicaise Tuikue Ndam, Lars Hviid","doi":"10.1093/infdis/jiae529","DOIUrl":"10.1093/infdis/jiae529","url":null,"abstract":"Background: Acquired immunity to Plasmodium falciparum malaria is mainly mediated by immunoglobulin G (IgG) targeting erythrocyte membrane protein 1 (PfEMP1). These adhesins mediate infected erythrocyte (IE) sequestration, protecting IEs from splenic destruction. PfEMP1-specific IgG is therefore thought to protect mainly by inhibiting IE sequestration. VAR2CSA-type PfEMP1 mediates placental IE sequestration, putting pregnant women exposed to P falciparum parasites at risk of placental malaria (PM).Methods: Levels and Fc-afucosylation of VAR2CSA-specific plasma IgG were measured by a modified enzyme-linked immunosorbent assay (FEASI). We also measured the ability of the IgG to inhibit IE adhesion and to induce natural killer (NK) cell degranulation. The results were related to parity and clinical pregnancy outcomes.Results: Parity was positively correlated with levels and Fc-afucosylation of VAR2CSA-specific IgG, and with birth weight and plasma IgG inhibition of IE adhesion in vitro. Fc-afucosylation of VAR2CSA-specific IgG increased NK-cell degranulation. Women with Fc-afucosylated VAR2CSA-specific IgG had a reduced risk of delivering a low birth weight (LBW) baby, but not of PM or anemia.Conclusions: Fc-afucosylated VAR2CSA-specific IgG effectively induced NK-cell degranulation and was associated with protection against LBW, independent of IgG levels. Our study has implications for the development of VAR2CSA-based subunit vaccines, which exclusively induce Fc-fucosylated IgG.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"e956-e965"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Rapid, Culture-Free, Universal Microbial Identification System Using Internal Transcribed Spacer Targeting Primers. 利用内部转录间隔目标引物开发快速、无培养、通用微生物鉴定系统。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae545

Vishwaratn Asthana, Erika Martínez Nieves, Pallavi Bugga, Clara Smith, Tim Dunn, Satish Narayanasamy, Robert P Dickson, J Scott VanEpps

{"title":"Development of a Rapid, Culture-Free, Universal Microbial Identification System Using Internal Transcribed Spacer Targeting Primers.","authors":"Vishwaratn Asthana, Erika Martínez Nieves, Pallavi Bugga, Clara Smith, Tim Dunn, Satish Narayanasamy, Robert P Dickson, J Scott VanEpps","doi":"10.1093/infdis/jiae545","DOIUrl":"10.1093/infdis/jiae545","url":null,"abstract":"The indiscriminate administration of broad-spectrum antibiotics is a primary contributor to the increasing prevalence of antibiotic resistance. Unfortunately, culture, the gold standard for bacterial identification is a time intensive process. Due to this extended diagnostic period, broad-spectrum antibiotics are generally prescribed to prevent poor outcomes. To overcome the deficits of culture-based methods, we have developed a rapid universal bacterial identification system. The platform uses a unique universal polymerase chain reaction primer set that targets the internal transcribed spacer regions between conserved bacterial genes, creating a distinguishable amplicon signature for every bacterial species. Bioinformatic simulation demonstrates that nearly every bacteria in a set of 45 commonly isolated pathogenic species can be uniquely identified using this approach. We experimentally confirmed these predictions on a representative set of pathogenic bacterial species. We further showed that the system can determine the corresponding concentration of each pathogen. Finally, we validated performance in clinical urinary tract infection samples.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1155-1164"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health and Economic Impacts of Introducing Vaccae and Enhanced Drug-Resistant Tuberculosis Management Strategies in China. 中国引入Vaccae和耐药结核病强化管理策略的健康和经济影响。

IF 5 2区医学

Journal of Infectious Diseases Pub Date : 2025-06-02 DOI: 10.1093/infdis/jiae590

Pei-Yao Zhai, Xiao Zang, Ting Jiang, Jian Feng, Bin Zhang, Lei Zhang, Zhi-Xian Chen, Yan-Lin Zhao, Gang Qin

{"title":"Health and Economic Impacts of Introducing Vaccae and Enhanced Drug-Resistant Tuberculosis Management Strategies in China.","authors":"Pei-Yao Zhai, Xiao Zang, Ting Jiang, Jian Feng, Bin Zhang, Lei Zhang, Zhi-Xian Chen, Yan-Lin Zhao, Gang Qin","doi":"10.1093/infdis/jiae590","DOIUrl":"10.1093/infdis/jiae590","url":null,"abstract":"Background: China faces high burden of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB). We aimed to evaluate the impacts of Vaccae vaccination and enhanced drug-resistant TB (DR-TB) management strategies.Methods: Using a compartmental model calibrated with national TB data, we evaluated 9 interventions: enhanced DR-TB management (S1); Vaccae vaccination for those with latent TB infection, targeting specific age groups (S2: adolescents, S3: adolescents and young adults, S4: working-age adults, S5: elderly); and combined strategies S6-S9. Vaccae's efficacy was 0.547 for the first 5 years, then waning annually. Costs were US$28/dose for Vaccae, US$87/test for Xpert MTB/RIF, and US$13 818/course for BPaLM.Results: Strategy S1 is projected to reduce MDR/RR-TB incidence and mortality by 21% (95% UI, 8%-46%) and 54% (38%-67%), respectively, by 2050. Strategy S9 (S5+S1) is more effective, reducing the incidence by 44% (35%-61%) and mortality by 68% (52%-78%), with an ICER of US$7222 (4460-10 779) per DALY averted compared with S1. Additionally, S9 could prevent 24.2 (13.5-32.9) million patient-months of second-line treatment from 2025 to 2050.Conclusions: Prioritizing Vaccae vaccination for the elderly and enhancing DR-TB management offer a promising and cost-effective opportunity for China. The findings may have policy implications for other low- and middle-income countries with high MDR/RR-TB burden.","PeriodicalId":50179,"journal":{"name":"Journal of Infectious Diseases","volume":" ","pages":"1271-1280"},"PeriodicalIF":5.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0