Respiratory Syncytial Virus (RSV) Humoral Antibody Responses in Older Adults after Vaccination or Infection.

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2025-03-24 DOI:10.1093/infdis/jiaf149

Edward E Walsh, Michael Peasley, Angela Branche, Ann R Falsey

引用次数: 0

Abstract

Background: Immunity to RSV is short-lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection.

Methods: Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with two licensed RSV preF protein vaccines.

Results: Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV: 3306 vs 1254, p<0.0001; B1 RSV: 5153 vs 2186, p<0.0001).

Conclusion: Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.