Journal of Thoracic Imaging最新文献_第3页

Pulmonary Developmental Disorders in Adults: An Integrative Review of Embryology, Pathogenesis, Imaging, and Management. 成人肺部发育障碍：胚胎学、发病机制、影像学和治疗的综合综述。

IF 1.3 4区医学

Journal of Thoracic Imaging Pub Date : 2026-07-13 DOI: 10.1097/RTI.0000000000000895

Subha Ghosh, Anne-Marie G Sykes, Allison Ferreira, Livia Frota Kruger, Lewis D Hahn, Alexander K Bratt, Mnahi Bin Saeedan, Neel Vora, Isha Singh, Himanshu Deshwal

{"title":"Pulmonary Developmental Disorders in Adults: An Integrative Review of Embryology, Pathogenesis, Imaging, and Management.","authors":"Subha Ghosh, Anne-Marie G Sykes, Allison Ferreira, Livia Frota Kruger, Lewis D Hahn, Alexander K Bratt, Mnahi Bin Saeedan, Neel Vora, Isha Singh, Himanshu Deshwal","doi":"10.1097/RTI.0000000000000895","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000895","url":null,"abstract":"Pulmonary developmental disorders comprise a heterogeneous group of congenital abnormalities involving the airways, lung parenchyma, pulmonary vasculature, or overlapping developmental pathways. Although these conditions commonly present during infancy or childhood, many remain clinically silent until adulthood, when they are discovered incidentally or manifest with recurrent respiratory symptoms such as infection, hemoptysis, or progressive dyspnea. These abnormalities may be broadly categorized into airway, vascular, parenchymal, and mixed developmental anomalies. Airway abnormalities include congenital tracheobronchomegaly, branching anomalies of the tracheobronchial tree, bronchial atresia, bronchogenic cysts, congenital pulmonary airway malformations (CPAM), and bronchopulmonary sequestration (BPS). Vascular anomalies include pulmonary artery sling, proximal interruption of the pulmonary artery, Scimitar syndrome, and meandering pulmonary veins. Parenchymal disorders encompass congenital lobar overinflation and pulmonary hypoplasia. Increasing recognition of overlapping lesions, particularly combinations of CPAM, sequestration, and bronchial atresia, has challenged traditional compartmental classification systems and supports a developmental spectrum model. This review synthesizes contemporary concepts regarding embryologic mechanisms, pathogenesis, imaging findings, and management of these entities in adults. Particular emphasis is placed on imaging evaluation with CT and MRI, updated terminology, evolving molecular understanding of CPAMs, including lesions with malignant potential, and distinctions between congenital sequestration and pseudosequestration. Recognition of these disorders and their associated anomalies is essential for accurate diagnosis, appropriate management, and surgical planning in adult patients.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Performance of 3 Artificial Intelligence Systems for Lung Nodule Characterization in Low-Dose Computed Tomography Screening. 3种人工智能系统在低剂量计算机断层扫描中肺结节表征的比较性能。

IF 1.3 4区医学

Journal of Thoracic Imaging Pub Date : 2026-07-01 DOI: 10.1097/RTI.0000000000000877

Khulan Khurelsukh, Yen-Po Lin, Hsuan-Ming Chang, Wen-Chi Hsu, Pei-Ching Huang, Chen-Te Wu, Yung-Liang Wan

{"title":"Comparative Performance of 3 Artificial Intelligence Systems for Lung Nodule Characterization in Low-Dose Computed Tomography Screening.","authors":"Khulan Khurelsukh, Yen-Po Lin, Hsuan-Ming Chang, Wen-Chi Hsu, Pei-Ching Huang, Chen-Te Wu, Yung-Liang Wan","doi":"10.1097/RTI.0000000000000877","DOIUrl":"10.1097/RTI.0000000000000877","url":null,"abstract":"Purpose: This study evaluates 3 artificial intelligence (AI) systems in detecting, characterizing, and classifying lung nodules on low-dose computed tomography (LDCT) scans of 100 subjects, assessing agreement with a reference standard and inter-vendor consistency.Materials and methods: Performance of 3 commercially available AI platforms-AI 1, AI 2, and AI 3-was retrospectively analyzed against evaluations by 2 thoracic radiologists, with discordances resolved by consensus as reference standard. Agreements were assessed for nodule presence, type (solid, part-solid, ground-glass), and Lung-RADS category using Cohen Kappa. Agreement for continuous measurements (nodule diameter and volume) across AI systems was evaluated using intraclass correlation coefficients (ICC). Group comparisons for continuous variables were performed using the Kruskal-Wallis test, with Mann-Whitney U tests for post hoc pairwise comparisons. Categorical variables were compared using χ 2 tests. Bland-Altman analysis evaluated variability in diameter and volume measurements.Results: The 3 AI systems detected 435, 152, and 70 nodules, respectively, whereas radiologists identified 126 nodules ( P <0.001). Sensitivity, specificity, and accuracy were 77.0%, 8.2%, and 25.7% for AI 1; 72.2%, 83.4%, and 80.6% for AI 2; and 42.9%, 95.7%, and 82.2% for AI 3. Agreement with the reference standard was perfect for AI 2 and almost perfect for AI 3, but absent for AI 1. Inter-AI agreement was substantial (κ=0.66 to 0.78), and diameter/volume measurements showed moderate to good reliability (ICC=0.57 to 0.87).Conclusion: Commercial AI systems show variable performance in nodule detection and classification, underscoring the need for users to understand each system's characteristics and interpret results within clinical context.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147436951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Microvascular Obstruction on Left Atrial and Ventricular Myocardial Deformation and In-hospital Complications in Reperfused ST-segment Elevation Myocardial Infarction Patients. 微血管阻塞对再灌注st段抬高型心肌梗死患者左房室心肌变形及院内并发症的影响

IF 1.3 4区医学

Journal of Thoracic Imaging Pub Date : 2026-07-01 DOI: 10.1097/RTI.0000000000000865

Riccardo Cau, Alessandro Pinna, Pier Paolo Bassareo, Jasjit S Suri, Antonio Esposito, Luca Saba

{"title":"Impact of Microvascular Obstruction on Left Atrial and Ventricular Myocardial Deformation and In-hospital Complications in Reperfused ST-segment Elevation Myocardial Infarction Patients.","authors":"Riccardo Cau, Alessandro Pinna, Pier Paolo Bassareo, Jasjit S Suri, Antonio Esposito, Luca Saba","doi":"10.1097/RTI.0000000000000865","DOIUrl":"10.1097/RTI.0000000000000865","url":null,"abstract":"Purpose: The purpose of this study was to explore the impact of microvascular obstruction (MVO) on left atrial and ventricular parameters, as well as in-hospital complications, in patients with reperfused ST-segment elevation myocardial infarction (STEMI) who underwent cardiovascular magnetic resonance (CMR) within 7 days.Materials and methods: This retrospective study included CMR scans of 95 consecutive patients with reperfused STEMI (79 males, mean age: 64.2 ± 10.3 y). Among them, 30 showed MVO presence (28 males, 93%; mean age: 64.1 ± 10.5 y), defined as a hypo-enhanced core surrounded by hyper-enhanced myocardium in late gadolinium enhancement (LGE) sequences.Results: Patients with MVO demonstrated a higher prevalence of hypertension ( P = 0.012) and a lower LV ejection fraction (30.5 ± 9.1% vs 37.8 ± 13.8%, P = 0.011) compared with patients without MVO. In addition, patients with MVO showed impaired reservoir, conduit, booster function, global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), higher LGE extent, and in-hospital complications compared with STEMI patients without MVO ( P = 0.001 for all).In multivariable analysis, reservoir, conduit, booster function, GLS, GCS, and GRS were associated with MVO presence, independently of LV ejection fraction and LGE extent ( P = 0.001 for all).Conclusion: In reperfused STEMI patients, left atrial and ventricular strain parameters are altered by the presence of MVO, in addition to impaired LV ejection fraction and LGE extent.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147730630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis. 心脏MRI多室应变分析对淀粉样变性的诊断及预后价值。

IF 1.3 4区医学

Journal of Thoracic Imaging Pub Date : 2026-07-01 DOI: 10.1097/RTI.0000000000000878

Sushmita Keerthi Chilkuri, Romina Dsouza, Christian Houbois, Khashayar Namdar, Stephanie Poon, Amit Singnurkar, Binita Riya Chacko

{"title":"The Diagnostic and Prognostic Value of Multi-Chamber Strain Analysis by Cardiac MRI in Amyloidosis.","authors":"Sushmita Keerthi Chilkuri, Romina Dsouza, Christian Houbois, Khashayar Namdar, Stephanie Poon, Amit Singnurkar, Binita Riya Chacko","doi":"10.1097/RTI.0000000000000878","DOIUrl":"10.1097/RTI.0000000000000878","url":null,"abstract":"Purpose: To evaluate the diagnostic and prognostic utility of multi-chamber myocardial strain, and its correlation with native T1 mapping and late gadolinium enhancement (LGE) imaging, by cardiac magnetic resonance (CMR) in cardiac amyloidosis.Materials and methods: A total of 47 patients were retrospectively included and the strain of the ventricles and atria were quantified. Native T1 and Query Amyloid Late Enhancement (QALE) values were assessed. Follow-up data on major adverse cardiovascular events (MACE) were retrieved from medical records. Spearman correlations between strain, LGE, and mapping were assessed. The strain parameters were analyzed using receiver operating characteristic curves and Cox regression analysis.Results: LV strain indices, RV GLS, RV GRS, LA reservoir, LA conduit strain, and RA reservoir strain demonstrated diagnostic ability ( P <0.05), with the highest diagnostic accuracy for LV GCS (AUC=0.897; cutoff=-12.9). Native T1 and QALE showed moderate correlations with LV and LA strain, reflecting amyloid infiltration and fibrosis-related dysfunction. For prognosis, RV GLS (AUC=0.687; cutoff=-12.5) and RA conduit strain (AUC=0.737; cutoff=+10) independently predicted MACE on univariable Cox analysis (HR=1.05 and 0.96; P <0.05). Importantly, multivariable Cox regression identified LV GLS (HR=5.27; P =0.016) and LA reservoir strain (HR=0.025; P =0.03) as strong independent predictors of MACE.Conclusion: Multi-chamber strain, and its integration with T1 and QALE, enhances diagnostic accuracy and prognostic precision in cardiac amyloidosis, enabling earlier recognition of myocardial dysfunction.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed Tomography-Derived Nakata Index as a Predictor of Functional Impairment in Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study. 计算机断层扫描衍生的Nakata指数作为慢性阻塞性肺疾病功能损害的预测因子：一项回顾性队列研究。

IF 1.9 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-27 DOI: 10.1097/RTI.0000000000000893

Şahhan Kılıç, Süha Asal, Kenan Kadirli, Erhan Oğur, Mert Babaoğlu, Emrecan Uygun, Tufan Çinar, Mehmet Uzun

{"title":"Computed Tomography-Derived Nakata Index as a Predictor of Functional Impairment in Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.","authors":"Şahhan Kılıç, Süha Asal, Kenan Kadirli, Erhan Oğur, Mert Babaoğlu, Emrecan Uygun, Tufan Çinar, Mehmet Uzun","doi":"10.1097/RTI.0000000000000893","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000893","url":null,"abstract":"Purpose: Pulmonary vascular remodeling is a key factor in chronic obstructive pulmonary disease (COPD) progression, but noninvasive prognostic markers are limited. This study assessed whether the computed tomography (CT)-derived Nakata index, a measure of body surface area-adjusted pulmonary arterial cross-sectional area, predicts functional impairment in COPD patients.Materials and methods: This retrospective cohort study included 82 COPD patients who underwent thoracic CT and six-minute walk testing (6MWT) from 2023 to 2025. Patients were divided into severely impaired (<334 m, n=18) and less impaired (≥334 m, n=64) groups based on 6MWT distance. Nakata index, pulmonary artery diameters, McGoon ratio, and echocardiographic parameters were evaluated. Multivariate logistic regression identified predictors of severe functional impairment, and receiver operating characteristic (ROC) analysis determined optimal thresholds.Results: Severely impaired patients had a higher Nakata index (395 vs. 330 mm2/m2, P<0.001) and larger left (21.5 vs. 19 mm, P=0.002) and right (22.2 vs. 20 mm, P=0.004) pulmonary artery diameters. Multivariate analysis identified elevated Nakata index (odds ratio: 1.0110, P=0.036), increased left pulmonary artery diameter (odds ratio: 1.3683, P=0.038), and enlarged left atrial diameter (odds ratio: 1.1075, P=0.015) as independent predictors of severe impairment. A Nakata index >373 mm2/m2 showed optimal discriminatory performance (area under the curve: 0.791, sensitivity: 75%, and specificity: 72%).Conclusions: CT-derived Nakata index is independently associated with severe functional impairment in chronic obstructive pulmonary disease, offering superior discriminatory value over simple diameter measurements. This marker may enhance risk stratification and guide treatment strategies.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Fungal Infections in Immunocompetent Patients. 免疫正常患者肺部真菌感染。

IF 1.9 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-25 DOI: 10.1097/RTI.0000000000000889

Juan José Arenas-Jiménez, Tomás Franquet, Randall Rojas-Varela, Irene Arco-Montoro, David Ferrández-Ferrández

{"title":"Pulmonary Fungal Infections in Immunocompetent Patients.","authors":"Juan José Arenas-Jiménez, Tomás Franquet, Randall Rojas-Varela, Irene Arco-Montoro, David Ferrández-Ferrández","doi":"10.1097/RTI.0000000000000889","DOIUrl":"https://doi.org/10.1097/RTI.0000000000000889","url":null,"abstract":"Fungi are a group of microorganisms encompassing thousands of species, with only a minority causing disease in humans. Fungal pathogens and infections are increasing global public health problems. They are an important cause of opportunistic infections in immunocompromised patients; however, they can also affect immunocompetent individuals. This paper reviews the incidence, clinical features, radiographic manifestations, and pathological findings of major fungal infections in non-immunocompromised patients. Only a restricted subset of fungi, specifically the endemic dimorphic fungi, selected Aspergillus manifestations, and Cryptococcus gattii are consistently associated with pulmonary infection in immunocompetent individuals. Endemic mycoses are determined by their geographic distribution, which makes it necessary to consider the diagnosis when pulmonary infection occurs in endemic areas. However, their clinical and radiological manifestations are frequently nonspecific. On the other hand, other fungi, mainly Aspergillusspp. are involved in a variety of diseases, including allergic bronchopulmonary aspergillosis, which is frequently diagnosed based on imaging criteria, and a series of conditions in the spectrum of chronic aspergillosis, including simple aspergilloma, chronic cavitary pulmonary aspergillosis, chronic fibrosing pulmonary aspergillosis, subacute invasive pulmonary aspergillosis, and aspergillus nodules.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of a Prediction Model of Hemoptysis After Computed Tomography-guided Percutaneous Transthoracic Needle Biopsy. 计算机断层扫描引导下经皮经胸穿刺活检后咯血预测模型的建立与验证。

IF 1.9 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-01 DOI: 10.1097/RTI.0000000000000863

Sowon Jang, Minseon Kim, Jeong Sub Lee, Sung Hyun Yoon, Junghoon Kim, Jihang Kim, Kyung Won Lee

{"title":"Development and Validation of a Prediction Model of Hemoptysis After Computed Tomography-guided Percutaneous Transthoracic Needle Biopsy.","authors":"Sowon Jang, Minseon Kim, Jeong Sub Lee, Sung Hyun Yoon, Junghoon Kim, Jihang Kim, Kyung Won Lee","doi":"10.1097/RTI.0000000000000863","DOIUrl":"10.1097/RTI.0000000000000863","url":null,"abstract":"Purpose: To develop and validate a nomogram to predict hemoptysis after percutaneous transthoracic needle biopsy (PTNB) by integrating clinical and radiologic data, facilitating pre-biopsy decision-making.Materials and methods: This single-center, retrospective cohort study included 1383 patients who underwent 1389 PTNB procedures between 2020 and 2022. The participants were randomly allocated to the training and validation cohorts. Logistic regression was performed to discern the independent predictors of hemoptysis within the clinical and radiologic variables. A nomogram was developed based on pre-biopsy variables obtained before the biopsy, and its performance was subsequently evaluated. The goodness of fit of the nomogram was compared with that of another model, which integrated pre-biopsy and post-biopsy variables.Results: Among the 1389 procedures, hemoptysis was observed in 128 (9.2%) cases. Current smoking status, lesion size of <25 mm, consolidation-type lesions, presence of the computed tomography bronchus sign, and perilesional vascularity were independent predictors of PTNB-related hemoptysis. The nomogram based on the pre-biopsy variables showed fair discrimination abilities (area under the receiver operating characteristic curve = 0.79 and 0.76 in the training and validation cohorts, respectively) and strong calibration agreement in the training and validation cohorts. The model fit was good in both cohorts ( P = 0.41 and 0.55 in the training and validation cohorts, respectively). No significant difference was observed in the model fit between the pre-biopsy nomogram and the model incorporating pre-biopsy and post-biopsy variables ( P = 0.88).Conclusion: The proposed nomogram utilizing pre-biopsy variables could predict hemoptysis before PTNB.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolving Landscape of Chest Wall Reconstruction: A Multimodality Imaging Approach. 胸壁重建的演变景观：多模态成像方法。

IF 1.3 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-01 DOI: 10.1097/RTI.0000000000000871

Rupali Jain, Julia C Jacob, John D Jacob, Drew A Torigian, Achala Donuru

引用次数: 0

A Novel Approach to Quantify Acute Pulmonary Embolism Using Computed Tomography Pulmonary Angiography. 一种利用计算机断层肺血管造影量化急性肺栓塞的新方法。

IF 1.9 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-01 DOI: 10.1097/RTI.0000000000000868

Michal Buk, Jiri Weichet, Josef Kroupa, Viktor Kocka, Hana Malikova

{"title":"A Novel Approach to Quantify Acute Pulmonary Embolism Using Computed Tomography Pulmonary Angiography.","authors":"Michal Buk, Jiri Weichet, Josef Kroupa, Viktor Kocka, Hana Malikova","doi":"10.1097/RTI.0000000000000868","DOIUrl":"10.1097/RTI.0000000000000868","url":null,"abstract":"Purpose: Acute pulmonary embolism (APE) is the third leading cardiovascular cause of death. Current risk assessment approaches emphasize right ventricular (RV) dysfunction and thrombus burden quantification via computed tomography pulmonary angiography (CTPA). Traditional scoring systems, such as the Modified Miller Score (MMS) or Refined Miller Score (RMS), estimate thrombus burden but tend to oversimplify partial vessel occlusion. This study proposes a novel Obstruction Index (OI) derived from direct thrombus and vessel area measurements from CTPA imaging to improve quantification accuracy.Materials and methods: This retrospective study analyzed imaging data from 20 patients with intermediate- to high-risk APE. Pre-randomization and posttreatment CTPA scans were assessed for RV/LV ratio, MMS, RMS, and OI. OI was derived from measured thrombus and vessel areas at defined pulmonary artery levels and from the calculated obstruction ratio. Correlations between RV/LV ratio reduction and reduction of MMS, RMS, and OI were evaluated using the Spearman correlation.Results: Mean RV/LV ratio reduced significantly post treatment (1.498±0.396 to 1.156±0.275), as did MMS (-4.5±4.3), RMS (-4.925±4.2), and OI (-4.49±3.9). OI demonstrated a stronger correlation with RV/LV ratio reduction ( r =0.448, P =0.048) compared with MMS ( r =0.279, P =0.234) and RMS ( r =0.261, P =0.265).Conclusions: The OI outperforms MMS and RMS in accuracy when reflecting thrombus burden reduction and shows statistically significant correlation with RV/LV ratio reduction. Direct thrombus and vessel area measurements appear to be superior for precise and reproducible APE quantification, and are especially useful for posttreatment imaging follow-ups.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial Fibrosis Evaluated by T1 Mapping and Its Relationship to Left Ventricular Hypertrophy, Strain, and T2 Value in Hypertrophic Cardiomyopathy Without Late Gadolinium Enhancement. 无晚期钆增强的肥厚性心肌病患者T1定位评价心肌纤维化及其与左室肥厚、劳损和T2值的关系

IF 1.9 4区医学

Journal of Thoracic Imaging Pub Date : 2026-05-01 DOI: 10.1097/RTI.0000000000000862

Yang Zhi, Tian-Yue Zhang, Fu-Dan Gui, Miao Wen, Liang-Chao Gao, Yi-Tian Long, You Yi, Fu Bing, Shu-Yue Pan

{"title":"Myocardial Fibrosis Evaluated by T1 Mapping and Its Relationship to Left Ventricular Hypertrophy, Strain, and T2 Value in Hypertrophic Cardiomyopathy Without Late Gadolinium Enhancement.","authors":"Yang Zhi, Tian-Yue Zhang, Fu-Dan Gui, Miao Wen, Liang-Chao Gao, Yi-Tian Long, You Yi, Fu Bing, Shu-Yue Pan","doi":"10.1097/RTI.0000000000000862","DOIUrl":"10.1097/RTI.0000000000000862","url":null,"abstract":"Purpose: The aim of this study was to evaluate T1 and T2 values and to investigate their association with left ventricular (LV) hypertrophy and strains in hypertrophic cardiomyopathy (HCM) without late gadolinium enhancement (LGE).Materials and methods: Forty-eight HCM patients without LGE and 20 age-matched and sex-matched healthy subjects who underwent 3.0 T cardiovascular magnetic resonance imaging (CMR) were enrolled. Cine, T1, and T2 mapping and LGE sequencing were conducted. Unpaired t test, Mann-Whitney U test, χ 2 test, Spearman correlation analysis, and univariable and multivariable linear regression were performed in this study.Results: Patients with HCM without LGE had a relatively higher global circumferential strain (GCS) than the control group (-19.82% [-21.81%, -17.52%] vs -17.48% ± 3.42; P = 0.020). In contrast, the global longitudinal strain (GLS) in HCM patients without LGE was lower than that in the control group (-12.07% ± 2.89 vs -13.93% ± 3.03; P = 0.021). In addition, native T1 values, extracellular volume (ECV), and T2 values were elevated in HCM patients without LGE compared with those in the control group (all P < 0.05). Moreover, higher native T1 values were associated with elevated T2 values (r = 0.301, P = 0.038). LV mass index (β = 0.375 [95% CI: 8.107 to 35.151], P = 0.002) and GCS (β = 0.623 [95% CI: 0.974 to 2.883], P < 0.001) were independently associated with elevated LV ejection fraction when max LV wall thickness, T2 value, global radial strain (GRS), and GLS were added to the multivariate regression model.Conclusions: In HCM without LGE, elevated T1, T2, and ECV values and reduced GLS occurred despite preserved LV ejection fraction. These findings demonstrate that myocardial interstitial fibrosis and cellular edema may precede the early stages of HCM.","PeriodicalId":49974,"journal":{"name":"Journal of Thoracic Imaging","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145287565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0