Microelectronics International最新文献

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Identification of printed circuit boards mechanical properties using response surface methods 用响应面法识别印刷电路板的机械性能
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-12-03 DOI: 10.1108/mi-09-2021-0085
Mohammad A. Gharaibeh
{"title":"Identification of printed circuit boards mechanical properties using response surface methods","authors":"Mohammad A. Gharaibeh","doi":"10.1108/mi-09-2021-0085","DOIUrl":"https://doi.org/10.1108/mi-09-2021-0085","url":null,"abstract":"\u0000Purpose\u0000This study aims to discuss the determination of the unknown in-plane mechanical material properties of printed circuit boards (PCBs) by correlating the results from dynamic testing and finite element (FE) models using the response surface method (RSM).\u0000\u0000\u0000Design/methodology/approach\u0000The first 10 resonant frequencies and vibratory mode shapes are measured using modal analysis with hammer testing experiment, and hence, systematically compared with finite element analysis (FEA) results. The RSM is consequently used to minimize the cumulative error between dynamic testing and FEA results by continuously modifying the FE model, to acquire material properties of PCBs.\u0000\u0000\u0000Findings\u0000Great agreement is shown when comparing FEA to measurements, the optimum in-plane material properties were identified, and hence, verified.\u0000\u0000\u0000Originality/value\u0000This paper used FEA and RSMs along with modal measurements to obtain in-plane material properties of PCBs. The methodology presented here can be easily generalized and repeated for different board designs and configurations.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45573098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of inter layer dielectric crack for LQFP C90FG wafer technology devices in copper wire bonding process LQFP C90FG晶圆工艺器件在铜线键合过程中层间介电裂纹的改进
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-11-23 DOI: 10.1108/mi-07-2021-0059
Xiuqiang Wu, D. Ye, Hanmin Zhang, Li Song, L. Guo
{"title":"Improvement of inter layer dielectric crack for LQFP C90FG wafer technology devices in copper wire bonding process","authors":"Xiuqiang Wu, D. Ye, Hanmin Zhang, Li Song, L. Guo","doi":"10.1108/mi-07-2021-0059","DOIUrl":"https://doi.org/10.1108/mi-07-2021-0059","url":null,"abstract":"\u0000Purpose\u0000This paper aims to investigate the root causes of and implement the improvements for the inter layer dielectric (ILD) crack for LQFP C90FG (CMOS90 Floating Gate) wafer technology devices in copper wire bonding process.\u0000\u0000\u0000Design/methodology/approach\u0000Failure analysis was conducted including cratering, scanning electron microscopy inspection and focus ion beam cross-section analysis, which showed ILD crack. Root cause investigation of ILD crack rate sudden jumping was carried out with cause-and-effect analysis, which revealed the root cause is shallower lead frame down-set. ILD crack mechanism deep-dive on ILD crack due to shallower lead frame down-set, which revealed the mechanism is lead frame flag floating on heat insert. Further investigation and energy dispersive X-ray analysis found the Cu particles on heat insert is another factor that can result in lead frame flag floating.\u0000\u0000\u0000Findings\u0000Lead frame flag floating on heat insert caused by shallower lead frame down-set or foreign matter on heat insert is a critical factor of ILD crack that has never been revealed before. Weak wafer structure strength caused by thinner wafer passivation1 thickness and sharp corner at Metal Trench (compared with the benchmarking fab) are other factors that can impact ILD crack.\u0000\u0000\u0000Originality/value\u0000For ILD crack improvement in copper wire bonding, besides the obvious factors such as wafer structure and wire bonding parameters, also should take other factors into consideration including lead frame flag floating on heat insert and heat insert maintenance.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44459360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A novel miniaturized Koch-Minkowski hybrid fractal antenna 一种新型微型化科赫-闵可夫斯基混合分形天线
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-11-17 DOI: 10.1108/mi-07-2021-0069
Zain ul Abidin Jaffri, Zeeshan Ahmad, Asif Kabir, S. Bukhari
{"title":"A novel miniaturized Koch-Minkowski hybrid fractal antenna","authors":"Zain ul Abidin Jaffri, Zeeshan Ahmad, Asif Kabir, S. Bukhari","doi":"10.1108/mi-07-2021-0069","DOIUrl":"https://doi.org/10.1108/mi-07-2021-0069","url":null,"abstract":"\u0000Purpose\u0000Antenna miniaturization, multiband operation and wider operational bandwidth are vital to achieve optimal design for modern wireless communication devices. Using fractal geometries is recognized as one of the most promising solutions to attain these characteristics. The purpose of this paper is to present a unique structure of patch antenna using hybrid fractal technique to enhance the performance characteristics for various wireless applications and to achieve better miniaturization.\u0000\u0000\u0000Design/methodology/approach\u0000In this paper, the authors propose a novel hybrid fractal antenna by combining Koch and Minkowski (K-M) fractal geometries. A microstrip patch antenna (MPA) operating at 1.8 GHz is incorporated with a novel K-M hybrid fractal geometry. The proposed fractal antenna is designed and simulated in CST Microwave studio and compared with existing Koch fractal geometry. The prototype for the third iteration of the K-M fractal antenna is then fabricated on FR-4 substrate and tested through vector network analyzer for operating band/voltage standing wave ratio.\u0000\u0000\u0000Findings\u0000The third iteration of the proposed K-M fractal geometry results in achieving a 20% size reduction as compared to an ordinary MPA for the same resonant frequency with impedance bandwidth of 16.25 MHz and a directional gain of 6.48 dB, respectively. The operating frequency of MPA also lowers down to 1.44 GHz.\u0000\u0000\u0000Originality/value\u0000Further testing for the radiation patterns in an anechoic chamber shows good agreement to those of simulated results.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46405354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Influence of selected factors on parameters of a cooling system with a Peltier module and forced air flow 选定因素对带珀尔帖模块和强制气流的冷却系统参数的影响
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-11-16 DOI: 10.1108/mi-07-2021-0058
K. Posobkiewicz, K. Górecki
{"title":"Influence of selected factors on parameters of a cooling system with a Peltier module and forced air flow","authors":"K. Posobkiewicz, K. Górecki","doi":"10.1108/mi-07-2021-0058","DOIUrl":"https://doi.org/10.1108/mi-07-2021-0058","url":null,"abstract":"\u0000Purpose\u0000The purpose of this study is to investigate the validation of the usefulness of cooling systems containing Peltier modules for cooling power devices based on measurements of the influence of selected factors on the value of thermal resistance of such a cooling system.\u0000\u0000\u0000Design/methodology/approach\u0000A cooling system containing a heat-sink, a Peltier module and a fan was built by the authors and the measurements of temperatures and thermal resistance in various supply conditions of the Peltier module and the fan were carried out and discussed.\u0000\u0000\u0000Findings\u0000Conclusions from the research carried out answer the question if the use of Peltier modules in active cooling systems provides any benefits comparing with cooling systems containing just passive heat-sinks or conventional active heat-sinks constructed of a heat-sink and a fan.\u0000\u0000\u0000Research limitations/implications\u0000The research carried out is the preliminary stage to asses if a compact thermal model of the investigated cooling system can be formulated.\u0000\u0000\u0000Originality/value\u0000In the paper, the original results of measurements and calculations of parameters of a cooling system containing a Peltier module and an active heat-sink are presented and discussed. An influence of power dissipated in the components of the cooling system on its efficiency is investigated.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43129996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Improving the electromagnetic compatibility of electronic products by using response surface methodology and artificial neural network 利用响应面法和人工神经网络提高电子产品的电磁兼容性
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-11-03 DOI: 10.1108/mi-06-2021-0052
Ching-Hsiang Chen, Chien-Yi Huang, Yan-Ci Huang
{"title":"Improving the electromagnetic compatibility of electronic products by using response surface methodology and artificial neural network","authors":"Ching-Hsiang Chen, Chien-Yi Huang, Yan-Ci Huang","doi":"10.1108/mi-06-2021-0052","DOIUrl":"https://doi.org/10.1108/mi-06-2021-0052","url":null,"abstract":"\u0000Purpose\u0000The purpose of this study is to use the Taguchi Method for parametric design in the early stages of product development. electromagnetic compatibility (EMC) issues can be considered in the early stages of product design to reduce counter-measure components, product cost and labor consumption increases due to a number of design changes in the R&D cycle and to accelerate the R&D process.\u0000\u0000\u0000Design/methodology/approach\u0000The three EMC characteristics, including radiated emission, conducted emission and fast transient impulse immunity of power, are considered response values; control factors are determined with respect to the relevant parameters for printed circuit board and mechanical design of the product and peripheral devices used in conjunction with the product are considered as noise factors. The optimal parameter set is determined by using the principal component gray relational analysis in conjunction with both response surface methodology and artificial neural network.\u0000\u0000\u0000Findings\u0000Market specifications and cost of components are considered to propose an optimal parameter design set with the number of grounded screw holes being 14, the size of the shell heat dissipation holes being 3 mm and the arrangement angle of shell heat dissipation holes being 45 degrees, to dispose of 390 O filters on the noise source.\u0000\u0000\u0000Originality/value\u0000The optimal parameter set can improve EMC effectively to accommodate the design specifications required by customers and pass test regulations.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44720943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
On the methodology of calculating volume charge density in a MIFGMOS substrate using Poisson’s equation 用泊松方程计算MIFGMOS衬底中体积电荷密度的方法
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-10-14 DOI: 10.1108/mi-01-2021-0004
Francisco Javier Plascencia Jauregui, A. M. Medina Vázquez, Edwin Christian Becerra Álvarez, José Manuel Arce Zavala, Sandra Fabiola Flores Ruiz
{"title":"On the methodology of calculating volume charge density in a MIFGMOS substrate using Poisson’s equation","authors":"Francisco Javier Plascencia Jauregui, A. M. Medina Vázquez, Edwin Christian Becerra Álvarez, José Manuel Arce Zavala, Sandra Fabiola Flores Ruiz","doi":"10.1108/mi-01-2021-0004","DOIUrl":"https://doi.org/10.1108/mi-01-2021-0004","url":null,"abstract":"\u0000Purpose\u0000This study aims to present a mathematical method based on Poisson’s equation to calculate the voltage and volume charge density formed in the substrate under the floating gate area of a multiple-input floating-gate metal-oxide semiconductor metal-oxide semiconductor (MOS) transistor.\u0000\u0000\u0000Design/methodology/approach\u0000Based on this method, the authors calculate electric fields and electric potentials from the charges generated when voltages are applied to the control gates (CG). This technique allows us to consider cases when the floating gate has any trapped charge generated during the manufacturing process. Moreover, the authors introduce a mathematical function to describe the potential behavior through the substrate. From the resultant electric field, the authors compute the volume charge density at different depths.\u0000\u0000\u0000Findings\u0000The authors generate some three-dimensional graphics to show the volume charge density behavior, which allows us to predict regions in which the volume charge density tends to increase. This will be determined by the voltages on terminals, which reveal the relationship between CG and volume charge density and will allow us to analyze some superior-order phenomena.\u0000\u0000\u0000Originality/value\u0000The procedure presented here and based on coordinates has not been reported before, and it is an aid to generate a model of the device and to build simulation tools in an analog design environment.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43241176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of flexible printed circuit board’s cooling with air flow and thermal effects using response surface methodology 用响应面法优化气流和热效应对柔性印刷电路板的冷却
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-10-04 DOI: 10.1108/mi-06-2021-0049
Chongqing Li, M. Z. Abdullah, Ishak Abdul Aziz, C. Khor, M. S. Abdul Aziz
{"title":"Optimization of flexible printed circuit board’s cooling with air flow and thermal effects using response surface methodology","authors":"Chongqing Li, M. Z. Abdullah, Ishak Abdul Aziz, C. Khor, M. S. Abdul Aziz","doi":"10.1108/mi-06-2021-0049","DOIUrl":"https://doi.org/10.1108/mi-06-2021-0049","url":null,"abstract":"\u0000Purpose\u0000This study aims to investigate the interaction of independent variables [Reynolds number (Re), thermal power and the number of ball grid array (BGA) packages] and the relation of the variables with the responses [Nusselt number ((Nu) ¯ ), deflection/FPCB’s length (d/L) and von Mises stress]. The airflow and thermal effects were considered for optimizing the Re of various numbers of BGA packages with thermal power attached on flexible printed circuit board (FPCB) for optimum cooling performance with least deflection and stress by using the response surface method (RSM).\u0000\u0000\u0000Design/methodology/approach\u0000Flow and thermal effects on FPCB with heat source generated in the BGA packages have been examined in the simulation. The interactive relationship between factors (i.e. Re, thermal power and number of BGA packages) and responses (i.e. deflection over FPCB length ratio, stress and average Nusselt number) were analysed using analysis of variance. RSM was used to optimize the Re for the different number of BGA packages attached to the FPCB.\u0000\u0000\u0000Findings\u0000It is important to understand the behaviour of FPCB when exposed to both flow and thermal effects simultaneously under the operating conditions. Maximum d/L and von Misses stress were significantly affected by all parametric factors whilst (Nu)¯ is significantly affected by Re and thermal power. Optimized Re for 1–3 BGA packages with maximum thermal power applied has been identified as 21,364, 23,858 and 29,367, respectively.\u0000\u0000\u0000Practical implications\u0000This analysis offers a better interpretation of the parameter control in FPCB with optimized Re for the use of force convection electronic cooling. Optimal Re could be used as a reference in the thermal management aspect in designing the BGA package.\u0000\u0000\u0000Originality/value\u0000This research presents the parameters’ effects on the reliability and heat transfer in FPCB design. It also presents a method to optimize Re for the different number of BGA packages attached to increase the reliability in FPCB’s design.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48536493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Influence of copper pillar bump structure on flip chip packaging during reflow soldering: a numerical approach 回流焊过程中铜柱凹凸结构对倒装芯片封装的影响:数值方法
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-09-23 DOI: 10.1108/mi-05-2021-0044
M. Ishak, M. Aziz, F. Ismail, M. Z. Abdullah
{"title":"Influence of copper pillar bump structure on flip chip packaging during reflow soldering: a numerical approach","authors":"M. Ishak, M. Aziz, F. Ismail, M. Z. Abdullah","doi":"10.1108/mi-05-2021-0044","DOIUrl":"https://doi.org/10.1108/mi-05-2021-0044","url":null,"abstract":"\u0000Purpose\u0000The purpose of this paper is to present the experimental and simulation studies on the influence of copper pillar bump structure on flip chip packaging during reflow soldering.\u0000\u0000\u0000Design/methodology/approach\u0000In this work, solidification/melting modelling and volume of fluid modelling were used. Reflow soldering process of Cu pillar type FC was modelled using computational fluid dynamic software (FLUENT). The experimental results have been validated with the simulation results to prove the accuracy of the numerical method.\u0000\u0000\u0000Findings\u0000The findings of this study reveal that solder volume is the most important element influencing reflow soldering. The solder cap volume reduces as the Cu pillar bump diameter lowers, making the reflow process more difficult to establish a good solder union, as less solder is allowed to flow. Last but not least, the solder cap height for the reflow process must be optimized to enable proper solder joint formation.\u0000\u0000\u0000Practical implications\u0000This study provides a basis and insights into the impact of copper pillar bump structure on flip chip packaging during reflow soldering that will be advancing the future design of 3D stack package. This study also provides a superior visualization and knowledge of the melting and solidification phenomenon during the reflow soldering process.\u0000\u0000\u0000Originality/value\u0000The computational fluid dynamics analysis of copper pillar bump structure on flip chip packaging during reflow soldering is scant. To the authors’ best knowledge, no research has been concentrated on copper pillar bump size configurations in a thorough manner. Without the in-depth study, copper pillar bump size might have the impact of copper pillar bump structure on flip chip packaging during reflow soldering. Five design of parameter of flip chip IC package model was proposed for the investigation of copper pillar bump structure on flip chip packaging during reflow soldering.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42301150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Computer‐aided selective production of low-resistance NiP and NiCuP layers 低阻NiP和NiCuP层的计算机辅助选择性生产
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-09-22 DOI: 10.1108/mi-04-2021-0032
P. Kowalik, E. Wróbel
{"title":"Computer‐aided selective production of low-resistance NiP and NiCuP layers","authors":"P. Kowalik, E. Wróbel","doi":"10.1108/mi-04-2021-0032","DOIUrl":"https://doi.org/10.1108/mi-04-2021-0032","url":null,"abstract":"\u0000Purpose\u0000This paper aims to present the possibility of computer-aided technology of chemical metallization for the production of electrodes and resistors based on Ni-P and Ni-Cu-P layers.\u0000\u0000\u0000Design/methodology/approach\u0000Based on the calculated parameters of the process, test structures were made on an alumina substrate using the selective metallization method. Dependences of the surface resistance on the metallization time were made. These dependencies take into account the comparison of the calculations with the performed experiment.\u0000\u0000\u0000Findings\u0000The author created a convenient and easy-to-use tool for calculating basic Ni-P and Ni-Cu-P layer parameters, namely, surface resistance and temperature coefficient of resistance (TCR) of test resistor, based on chemical metallization parameters. The values are calculated for a given level of surface resistance of Ni-P and Ni-Cu-P layer and defined required range of changes of TCR of test resistor. The calculations are possible for surface resistance values in the range of 0.4 Ohm/square ÷ 2.5 Ohm/square. As a result of the experiment, surface resistances were obtained that practically coincide with the calculations made with the use of the program created by the authors. The quality of the structures made is very good.\u0000\u0000\u0000Originality/value\u0000To the best of the authors’ knowledge, the paper presents a new, unpublished method of manufacturing electrodes (resistors) on silicon, Al2O3 and low temperature co-fired ceramic substrates based on the authors developed computer program.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43148611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Preliminary dielectrophoresis study: Manipulation of protein albumin and electrical quantification by using cyclic voltammetry technique 初步的电泳研究:白蛋白的操作和循环伏安技术的电定量
IF 1.1 4区 工程技术
Microelectronics International Pub Date : 2021-09-05 DOI: 10.1108/mi-02-2021-0026
Nur Shahira Abdul Nasir, Revathy Deivasigamani, Muhammad Khairulanwar Abdul Rahim, Siti Nur AshakirinMohd Nashruddin, A. A. Hamzah, M. R. Wee, M. R. Buyong
{"title":"Preliminary dielectrophoresis study: Manipulation of protein albumin and electrical quantification by using cyclic voltammetry technique","authors":"Nur Shahira Abdul Nasir, Revathy Deivasigamani, Muhammad Khairulanwar Abdul Rahim, Siti Nur AshakirinMohd Nashruddin, A. A. Hamzah, M. R. Wee, M. R. Buyong","doi":"10.1108/mi-02-2021-0026","DOIUrl":"https://doi.org/10.1108/mi-02-2021-0026","url":null,"abstract":"\u0000Purpose\u0000The purpose of this paper is to visualize protein manipulation using dielectrophoresis (DEP) as a substantial perspective on being an effective protein analysis and biosensor method as DEP is able to be used as a means for manipulation, fractionation, pre-concentration and separation. This research aims to quantify DEP using an electrochemical technique known as cyclic voltammetry (CV), as albumin is non-visible without any fluorescent probe or dye.\u0000\u0000\u0000Design/methodology/approach\u0000The principles of DEP were generated by an electric field on tapered DEP microelectrodes. The principle of CV was analysed using different concentrations of albumin on a screen-printed carbon electrode. Using preliminary data from both DEP and CV methods as a future prospect for the integration of both techniques to do electrical quantification of DEP forces.\u0000\u0000\u0000Findings\u0000The size of the albumin is known to be 0.027 µm. Engineered polystyrene particle of size 0.05 µm was selected to mimic the DEP actuation of albumin. Positive DEP of the sample engineered polystyrene particle was able to be visualized clearly at 10 MHz supplied with 20 Vpp. However, negative DEP was not able to be visualized because of the limitation of the apparatus. However, albumin was not able to be visualized under the fluorescent microscope because of its translucent properties. Thus, a method of electrical quantification known as the CV technique is used. The detection of bovine serum albumin (BSA) using the CV method is successful. As the concentration of BSA increases, the peak current obtained from the voltammogram decreases. The peak current can be an indicator of DEP response as it correlates to the adsorption of the protein onto the electrodes. The importance of the results from both CV and DEP shows that the integration of both techniques is possible.\u0000\u0000\u0000Originality/value\u0000The integration of both methods could give rise to a new technique with precision to be implemented into the dialyzers used in renal haemodialysis treatment for manipulation and sensing of protein albumin.\u0000","PeriodicalId":49817,"journal":{"name":"Microelectronics International","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2021-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46677417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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