Biophysics最新文献_第8页

Study of the Role of Resonance Phenomena in Brain Responses to Rhythmic Photostimulation with Linearly Increasing Frequency 共振现象在频率线性递增的节律性光刺激脑反应中的作用研究

IF 4.033

Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701131

A. I. Fedotchev

引用次数: 0

Comparative Study of Antioxidant Activity of 4-H Pyran Acids Using Optical Methods and Quantum-Chemical Calculations 4-H吡喃酸抗氧化活性的光学与量子化学对比研究

IF 4.033

Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925701003

S. V. Kozin, O. M. Lyasota, A. A. Kravtsov, E. A. Kozlova, A. D. Rubailo, A. V. Moiseev, K. A. Popov, A. V. Bespalov, K. V. Gordeev

{"title":"Comparative Study of Antioxidant Activity of 4-H Pyran Acids Using Optical Methods and Quantum-Chemical Calculations","authors":"S. V. Kozin, O. M. Lyasota, A. A. Kravtsov, E. A. Kozlova, A. D. Rubailo, A. V. Moiseev, K. A. Popov, A. V. Bespalov, K. V. Gordeev","doi":"10.1134/S0006350925701003","DOIUrl":"10.1134/S0006350925701003","url":null,"abstract":"The main representatives of the 4-H-pyran series of acids are meconic, comenic, chelidonic and kojic acids. A wide range of physiological activity has been established with respect to these substances, including neuroprotective, anti-inflammatory, immunomodulatory and regenerating activity. A comparative study of the antioxidant activity of these acids in various model systems has been performed using chemiluminescent, spectrophotometric, and fluorescent analysis methods, as well as computational methods of quantum chemistry. It was found that, with respect to lipid, luminol, and pyroxyl radicals, all the acids studied in the work caused a dose-dependent decrease in the intensity of the chemiluminescent reaction, expressed by varying degrees of inhibition for each compound. With respect to the stable radical ABTS+•, all the studied acids also had an inhibitory effect. The studied compounds showed a chelating effect on Fe2+ cations with varying efficiencies and inhibited the development of the Fenton reaction in the model system. The experimental data obtained on the antiradical activity of the studied compounds correlated with the theoretical calculations of their antioxidant potential. The established antioxidant and chelating properties of the basic acids of the 4-N-pyran series allow them to be considered as potential ligands and components in the synthesis of new complex and hybrid compounds.","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 6","pages":"930 - 943"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Features of Smooth Muscle Cells of the Thoracic Aorta of SHR Rats in the Early Stages of Arterial Hypertension 高血压早期SHR大鼠胸主动脉平滑肌细胞的特征

IF 4.033

Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S0006350925700861

V. K. Zhalimov, E. I. Meshcheryakova, I. M. Vikhlyantsev, Yu. V. Gritsyna

{"title":"The Features of Smooth Muscle Cells of the Thoracic Aorta of SHR Rats in the Early Stages of Arterial Hypertension","authors":"V. K. Zhalimov, E. I. Meshcheryakova, I. M. Vikhlyantsev, Yu. V. Gritsyna","doi":"10.1134/S0006350925700861","DOIUrl":"10.1134/S0006350925700861","url":null,"abstract":"<div>The contractile, proliferative, and migratory activity of thoracic aortic smooth muscle cells in SHR rats at ages of 1, 2, and 3 weeks from birth was studied. To assess the proliferative activity of cells, real–time PCR was used by comparing the relative amount of genomic DNA between the control and experiment; to determine the migration activity of smooth muscle cells, a wound healing assay was used; to assess the level of contractile activity of cells, a method for assessing the degree of compression of a collagen gel was employed. An increase in proliferative (by ~20%, p ≤ 0.01) and a decrease in migration (by ~47%, p ≤ 0.01) and contractile (by ~43%, p ≤ 0.01) activities of smooth muscle cells of the aorta of 1-week-old rats relative to those of cells of normotensive animals was found. In 2-week-old rats, the proliferative and migratory activity of aortic smooth muscle cells did not differ from those in normotensive rats, while the contractile activity of cells in rats of this age group was reduced by ~69%, ≤0.01). In the smooth muscle cells of the aorta of 3-week-old rats, there was a decrease in proliferative (by ~54%, p ≤ 0.01) and migratory (by ~47%, p ≤ 0.01) activities. Thus, the detected changes in the studied activities of thoracic aortic smooth muscle cells in SHR rats compared with those in normotensive rats are already observed in 1-week-old animals in the early neonatal period of development.</div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 5","pages":"807 - 815"},"PeriodicalIF":4.033,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147606387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Compact Terahertz Radiation Source/Detector based on a Periodically Corrugated Waveguide 基于周期性波纹波导的紧凑太赫兹辐射源/探测器

IF 4.033

Biophysics Pub Date : 2026-04-01 DOI: 10.1134/S000635092570109X

L. Yu. Shchurova, V. A. Namiot

引用次数: 0

Investigation of the Interaction of Charged Nanoparticles with the Cell Membrane of Erythrocytes 带电荷纳米粒子与红细胞细胞膜相互作用的研究

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700629

E. A. Shlyapnikova, I. L. Kanev, Yu. M. Shlyapnikov

引用次数: 0

The Effect of Gel Materials Based on Collagen and Taxifolin Derivatives on the Healing of Burn Wounds Induced by Acetic Acid 胶原蛋白凝胶材料及其衍生物对醋酸烧伤创面愈合的影响

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700794

Yu. V. Shatalin, V. S. Shubina

引用次数: 0

Should Wistar Laboratory Rats Be Used in Experimental Studies on Visual Image-Related Learning? Wistar实验大鼠是否可以用于视觉图像相关学习的实验研究？

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700782

A. V. Kulikov, N. N. Vsevolodov

引用次数: 0

Optimization of a Method for Measuring 2,3-Diphosphoglycerate in Erythrocytes Using 31P NMR Analysis 用31P核磁共振分析测定红细胞中2,3-二磷酸甘油酸的方法优化

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700630

M. V. Molchanov, A. Ye. Yegorov, A. V. Kholina, E. A. Kalabina, N. A. Borozdina, S. I. Baydarova, M. S. Kazakova, E. V. Arshintseva, S. Yu. Pushkin, M. A. Timchenko

{"title":"Optimization of a Method for Measuring 2,3-Diphosphoglycerate in Erythrocytes Using 31P NMR Analysis","authors":"M. V. Molchanov, A. Ye. Yegorov, A. V. Kholina, E. A. Kalabina, N. A. Borozdina, S. I. Baydarova, M. S. Kazakova, E. V. Arshintseva, S. Yu. Pushkin, M. A. Timchenko","doi":"10.1134/S0006350925700630","DOIUrl":"10.1134/S0006350925700630","url":null,"abstract":"2,3-Diphosphoglycerate is present in large quantities in mammalian red blood cells and controls the affinity of hemoglobin to oxygen. The level of 2,3-diphosphoglycerate changes with the development of certain pathologies, such as chronic lung diseases, anemia, and hyperthyroidism. 31P NMR spectroscopy has shown that reducing the number of washings of rat erythrocytes significantly increases the stability of 2,3-diphosphoglycerate in these samples. The level of 2,3-diphosphoglycerate does not change for 3.5 h with a single wash and for 4 h without washing. At the same time, with standard double washing, the content of 2,3-diphosphoglycerate decreases after 2.5 h. Analysis of its distribution between red blood cells and removed plasma, as well as analysis of the serum of one animal, showed that all the 2,3-diphosphoglycerate remains in the suspension of red blood cells and is absent in the plasma and serum. The results we obtained should be taken into account when working with intact erythrocytes.","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 4","pages":"593 - 599"},"PeriodicalIF":4.033,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of the TSKY Peptide on the Physiological Activity of Bovine Spermatozoa TSKY肽对牛精子生理活性的影响

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700666

N. A. Ivlicheva, N. V. Shishova, E. N. Gakhova, V. K. Uteshev, R. H. Ziganshin, L. I. Kramarova

引用次数: 0

Binuclear Dinitrosyl Iron Complexes with Cysteine Inhibit the Development of Experimental Tumor 双核二硝基铁配合物与半胱氨酸抑制实验性肿瘤的发展

IF 4.033

Biophysics Pub Date : 2026-01-14 DOI: 10.1134/S0006350925700757

A. F. Vanin, L. A. Ostrovskaya, D. B. Korman, N. V. Bluhterova, V. A. Rykova, V. D. Mikoyan, N. A. Tkachev

{"title":"Binuclear Dinitrosyl Iron Complexes with Cysteine Inhibit the Development of Experimental Tumor","authors":"A. F. Vanin, L. A. Ostrovskaya, D. B. Korman, N. V. Bluhterova, V. A. Rykova, V. D. Mikoyan, N. A. Tkachev","doi":"10.1134/S0006350925700757","DOIUrl":"10.1134/S0006350925700757","url":null,"abstract":"Binuclear dinitrosyl iron complexes with cysteine, which are donors of nitrosonium (NO+) cations, exhibit high antitumor activity when exposed to a formed tumor (Lewis lung carcinoma) with a mass of 0.42 g (12 days after grafting), causing an 11-day inhibition of tumor growth by 90% and an increase in the time of doubling the tumor mass by 9.3 times compared with the control. At the early stage of the administration of the complexes, on the next day after the tumor grafting, their noticeable effect on the tumor growth rate was not observed. It is assumed that the difference in the antitumor effect of dinitrosyl iron complexes with cysteine, depending on the size of the tumor, is due to the different ratio between the level of immunocompetent cells (macrophages) that selectively tolerate these complexes and retain this ability, and the concentration of tumor cells that accept the complexes. Upon late administration of dinitrosyl iron complexes with cysteine, this ratio increases due to a decrease in the number of tumor cells available to immunocompetent cells, it is limited to cells localized only in the peripheral (“surface”) layer of the tumor.","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"70 4","pages":"701 - 707"},"PeriodicalIF":4.033,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0