Biophysics最新文献_第7页

Low-frequency Oscillations of Functional Indicators of the Body 人体功能指标的低频振荡

IF 4.033

Biophysics Pub Date : 2024-07-04 DOI: 10.1134/S000635092470012X

O. V. Grishin, V. G. Grishin

{"title":"Low-frequency Oscillations of Functional Indicators of the Body","authors":"O. V. Grishin, V. G. Grishin","doi":"10.1134/S000635092470012X","DOIUrl":"10.1134/S000635092470012X","url":null,"abstract":"<div><p>It has been shown in a number of our studies that low-frequency (LF) oscillations in the functional parameters of the oxygen transport system are stable and synchronized with each other. The literature presents a large number of examples of LF oscillations of various functional indicators that are directly or indirectly related to energy metabolism. In parallel, for more than 40 years, artificially induced attenuated and constant spontaneous oscillations in the energization levels of mitochondria in the same LF range have been studied. The aim of this review is to consider a possible relationship between oscillations in the functional parameters of the oxygen transport system and the functional parameters of mitochondria in the very-low-frequency (VLF) range common to them (0.003–0.03 Hz). We believe that a common source for all these oscillations is the periodic dynamics of “energization” in mitochondria united in mitochondrial networks. The process of generating these oscillations proceeds in two phases. In the first phase, the inflow of Ca<sup>2+</sup> into the mitochondria exceeds the outflow and enhances the activity of oxidative phosphorylation. In the second phase, the outflow of Ca<sup>2+</sup> from the mitochondria prevails over the inflow and is accompanied by the inhibition of oxidative phosphorylation. The oscillations are of a constant spontaneous nature and are based on autocatalytic regulation based on the feedback principle. The inertia of the full cycle processes (first and second phases) lasting 1–3 min may be due to the capacity of the mitochondrial phosphate buffer. The mitochondrial networks of excitable tissues can be the structural basis for synchronizing oscillations at the tissue level. Synchronization at the body level between mitochondrial oscillations and oscillations in indicators related to energy metabolism can be carried out through a system of tunneling nanotubes.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 1","pages":"110 - 123"},"PeriodicalIF":4.033,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141546806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hafnium Complexes as Contrast Media and Dose Enhancing Agents for Radiology and Contrast-Enhanced Radiotherapy 铪复合物作为放射学和对比增强放射治疗的对比介质和剂量增强剂

IF 4.033

Biophysics Pub Date : 2024-07-04 DOI: 10.1134/S0006350924700167

A. A. Lipengolts, V. A. Skribitsky, Yu. A. Finogenova, A. T. Shulyak, M. A. Abakumov, A. Yu. Bykov, E. Yu. Grigorieva, A. V. Smirnova, K. E. Shpakova, K. Yu. Zhizhin

{"title":"Hafnium Complexes as Contrast Media and Dose Enhancing Agents for Radiology and Contrast-Enhanced Radiotherapy","authors":"A. A. Lipengolts, V. A. Skribitsky, Yu. A. Finogenova, A. T. Shulyak, M. A. Abakumov, A. Yu. Bykov, E. Yu. Grigorieva, A. V. Smirnova, K. E. Shpakova, K. Yu. Zhizhin","doi":"10.1134/S0006350924700167","DOIUrl":"10.1134/S0006350924700167","url":null,"abstract":"<p>Hafnium is a promising element as contrast agent for diagnostic and therapeutic radiology. Currently there are no suitable hafnium drugs with renal excretion which can be used in radiology. In this work two new hafnium complexes with nitrilotriacetic acid (Hf-NTA) and 1,2-diaminocyclohexanetetraacetic acid (Hf-CDTA) were synthesized and studied for acute toxicity and biodistribution. Inorganic chemistry methods were used for Hf-NTA and Hf-CDTA synthesis. Acute toxicity was studied in female mice C57Bl/6. Median lethal dose (LD50) of Hf-CDTA was assessed as 408 ± 64 mg Hf/kg and of Hf-NTA less than 120 mg Hf/kg. Biodistribution and contrast properties studies of Hf-CDTA were performed in vivo using micro-CT in mice with transplanted subcutaneous mammary adenocarcinoma Ca755. CT imaging of mice intravenously injected with Hf-CDTA confirmed its renal excretion and contrast capability. CT imaging of tumor region with single intratumoral administration of Hf-CDTA showed promising hafnium concentration and retention in tumor for use in contrast-enhanced radiotherapy. Hf-CDTA showed acceptable toxicity and biodistribution in mice with subcutaneous tumors for biomedical application in radiology and radiotherapy. For diagnostic clinical application, the Hf-CDTA formulation must be improved to increase water solubility and decrease toxicity. Hf-NTA appeared to be unacceptably toxic for radiological application.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 1","pages":"148 - 155"},"PeriodicalIF":4.033,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141546810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regularities of Induction and Growth of Tumors in Mice upon Irradiation of Ehrlich Carcinoma Cells Ex Vivo and In Vivo with a Pencil Scanning Beam of Protons 用铅笔扫描质子束照射小鼠体内和体外艾氏癌细胞时肿瘤诱发和生长的规律性

IF 4.033

Biophysics Pub Date : 2024-07-04 DOI: 10.1134/S0006350924700179

O. M. Rozanova, E. N. Smirnova, T. A. Belyakova, N. S. Strelnikova, A. V. Smirnov

{"title":"Regularities of Induction and Growth of Tumors in Mice upon Irradiation of Ehrlich Carcinoma Cells Ex Vivo and In Vivo with a Pencil Scanning Beam of Protons","authors":"O. M. Rozanova, E. N. Smirnova, T. A. Belyakova, N. S. Strelnikova, A. V. Smirnov","doi":"10.1134/S0006350924700179","DOIUrl":"10.1134/S0006350924700179","url":null,"abstract":"<div><p>The patterns of tumor induction and growth in mice under single irradiation ex vivo and in vivo of ascitic Ehrlich carcinoma (EAC) cells with a proton beam at doses of 30, 60, and 80 Gy are studied. It is shown that the frequency of tumor induction after the proton irradiation of EAC cells at a dose of 30 Gy under ex vivo irradiation was lower than after in vivo irradiation, and at doses of 60 Gy and 80 Gy, the number of tumors was the same. The temporal patterns of tumor occurrence in the ex vivo irradiation of EAC cells differed significantly from those after in vivo irradiation of the tumor: the time period during which the appearance of new tumors was recorded in the ex vivo groups was the same for all the studied doses, while when tumors were irradiated in vivo, this interval depended on the dose. The rate of tumor growth after the ex vivo and in vivo irradiation of cells does not depend on the dose, irradiation conditions, or time of their occurrence, but is significantly lower than in the control nonirradiated groups. The results obtained are of interest for understanding the mechanisms of potentially lethal damage to tumor cells, the role of the tumor microenvironment in inducing relapses, and ways to overcome them using the potential of proton therapy, as well as for developing biomedical models to find optimal targets for hadron cancer therapy.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 1","pages":"156 - 164"},"PeriodicalIF":4.033,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141546811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the Pulsating Flow of Cerebrospinal Fluid on Spinal Pathologies 脑脊液脉动流对脊柱病变的影响

IF 4.033

Biophysics Pub Date : 2024-07-04 DOI: 10.1134/S0006350924700192

A. G. Zverev, Yu. N. Tokarev

引用次数: 0

Spatial Structure of the Casoxin C Molecule Casoxin C 分子的空间结构

IF 4.033

Biophysics Pub Date : 2024-07-04 DOI: 10.1134/S0006350924700052

N. A. Akhmedov, L. N. Agaeva, R. M. Abbasli, L. I. Ismailova

引用次数: 0

Interaction of Magnesium Ions with Semiquinone Radicals of Tiron, an Indicator of Reactive Oxygen Species 镁离子与铁酮的半醌自由基（一种活性氧指示剂）的相互作用

IF 4.033

Biophysics Pub Date : 2024-03-18 DOI: 10.1134/S0006350923060192

L. Yu. Ustynyuk, V. A. Medvedeva, S. O. Liubimovskii, E. K. Ruuge, A. N. Tikhonov

引用次数: 0

What Is the Reason that Gaseous Nitric Oxide Inhalation Does Not Affect Systemic Arterial Pressure in Humans and Animals? 吸入气态一氧化氮不会影响人类和动物全身动脉压的原因是什么？

IF 4.033

Biophysics Pub Date : 2024-03-18 DOI: 10.1134/S0006350923060209

A. F. Vanin, A. A. Abramov, A. B. Vagapov, A. A. Timoshin, A. V. Pekshev, V. L. Lakomkin, E. K. Ruuge

{"title":"What Is the Reason that Gaseous Nitric Oxide Inhalation Does Not Affect Systemic Arterial Pressure in Humans and Animals?","authors":"A. F. Vanin, A. A. Abramov, A. B. Vagapov, A. A. Timoshin, A. V. Pekshev, V. L. Lakomkin, E. K. Ruuge","doi":"10.1134/S0006350923060209","DOIUrl":"10.1134/S0006350923060209","url":null,"abstract":"<p>The reason for the lack of the hypotensive effect of gaseous NO, as introduced by inhalation into the bodies of animals and humans, has been identified. Since this defect was completely eliminated by inhalation of NO simultaneous with intravenous administration of low molecular mass thiol solutions to animals (rats), it is concluded that gaseous NO entering through the lungs into the blood circulating in a large circle of blood circulation converts into nitrosonium cation (NO<sup>+</sup>) as a result of single-electron oxidation, which is unable to exert vasodilating and thereby hypotensive effects on animals and humans. The binding of NO<sup>+</sup> to low molecular mass thiols leads to its transformation into S-nitrosothiols, followed by the release of this nitrosyl agent in the form of neutral NO molecules characterized by hypotensive activity. The formation of dinitrosyl iron complexes with thiol-containing ligands in the blood and tissues of organs of experimental animals in these experiments, which could cause a hypotensive effect, was not detected. The hypotensive effect of inhaled NO, which was found in the lungs, could be due to the penetration of NO through the outer wall of blood vessels with subsequent activation of the enzyme guanylate cyclase, an inducer of vasodilation and hypotension, directly in the walls of blood vessels.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"68 6","pages":"1048 - 1052"},"PeriodicalIF":4.033,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140172435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensor Systems: Determination of Optimal Time Parameters of Olfactory Stimulation 生物传感器系统：确定嗅觉刺激的最佳时间参数

IF 4.033

Biophysics Pub Date : 2024-03-18 DOI: 10.1134/S000635092306012X

A. E. Matukhno, M. V. Petrushan, L. V. Lysenko, V. N. Kiroy

引用次数: 0

Comparative Analysis of the Degree of Hydrolysis of Biopolymers in Hyaline Cartilage Homogenates in the Presence of Proteolytic Enzymes 蛋白水解酶作用下透明软骨匀浆中生物聚合物水解程度的比较分析

IF 4.033

Biophysics Pub Date : 2024-03-18 DOI: 10.1134/S0006350923060143

T. I. Nikolaeva, D. A. Barsuk, M. V. Molchanov, D. A. Prokhorov, V. I. Emelyanenko, P. V. Shekhovtsov

引用次数: 0

The Physicochemical Properties and Composition of Liposome Lipids from Lecithin Depending on the Conditions of Their Formation 卵磷脂脂质体的理化性质和组成取决于其形成条件