Ultrasound in Medicine and Biology最新文献

{"title":"The Use of Diagnostic Ultrasound for the Assessment of Rotator Cuff Tendinopathy: A Systematic Review","authors":"Gabriella Gould ,&nbsp;Chloe Macindoe ,&nbsp;Joshua Wong ,&nbsp;Wesley Matthews","doi":"10.1016/j.ultrasmedbio.2025.10.241","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.241","url":null,"abstract":"<div><h3>Background</h3><div>Rotator cuff tendinopathy (RCT) is a common clinical diagnosis of pain and dysfunction in the shoulder. In conjunction with clinical tests, diagnostic ultrasound (US) is beneficial in the diagnosis of RCT through its ability to visualise tendon structural change. However, there is currently no standardised method to assess RCT with US.</div></div><div><h3>Aims/Purpose</h3><div>The primary aim of this systematic review was to identify the common US parameters used to diagnose RCT with US. The secondary aim was to determine whether a nominal or ordinal scale should be used to diagnose RCT with US.</div></div><div><h3>Methods</h3><div>A systematic review was conducted in July 2024 according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Studies were selected based on the following inclusion criteria: adults with RCT diagnosed with US, defined classification criteria for symptomatic tendinopathy, the US parameter used to measure structural change was reported with a grading scale (nominal or ordinal) and retrievable in full English text. Primary diagnosis of previous shoulder operations, partial or full-thickness tears, were excluded. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal tools by two independent reviewers.</div></div><div><h3>Results</h3><div>A total of 1286 records were identified; eight studies met the inclusion criteria. The quality of the studies ranged from poor (12%) to good (88%). The most common US parameters were echogenicity (88%, <em>n</em> = 7), thickness (88%, <em>n</em> = 7), vascularity (50%, <em>n</em> = 4) and calcification (25%, <em>n</em> = 2). A nominal grading scale was most commonly utilised when assessing echogenicity (86%, <em>n</em> = 6 of 7), thickness (71%, <em>n</em> = 5 of 7) and calcification (100%, <em>n</em> = 2 of 2), while an ordinal scale was utilised in 100% of studies assessing vascularisation. Additionally, it was noted positioning and operator experience varied between studies.</div></div><div><h3>Conclusion</h3><div>This systematic review demonstrates the heterogeneity between methods used to diagnose RCT through US. Future studies should develop a standardised method to assess echogenicity, thickness, vascularisation and calcification in RCT, potentially using an ordinal scale to align with tendinopathy research in the lower limb.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 485-495"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Intervals of Lateral Ventricles for Extremely Pre-Term Infants: Multicenter Cohort Research","authors":"Junyi Yan ,&nbsp;Yang Gao ,&nbsp;Liangyu Guo ,&nbsp;Dongmei Liu ,&nbsp;Yuqi Tan ,&nbsp;Jingyi Lu ,&nbsp;Qiufang Tian ,&nbsp;Lingyu Yan ,&nbsp;Rong Gao ,&nbsp;Yulin Peng","doi":"10.1016/j.ultrasmedbio.2025.11.009","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.009","url":null,"abstract":"<div><h3>Objective</h3><div>To establish reference intervals and intervention cutoffs for lateral ventricles in extremely pre-mature infants.</div></div><div><h3>Methods</h3><div>This prospective study recruited neurologically healthy extremely pre-mature infants born or treated at two Chinese Grade 3A Hospitals between 2021 and 2024. Upon enrollment (U1), anterior horn width (AHW), ventricular index (VI) and thalamo-occipital distance (TOD) were measured to establish reference values and surgical intervention cutoffs. Four weeks later, the same indices were measured (U2). We analyzed the correlations between AHW, VI and TOD and independent variables in U1 data using multiple linear regressions and compared the time-varying trends of AHW, VI and TOD between U1 and U2 data via mixed linear models.</div></div><div><h3>Results</h3><div>A total of 353 extremely pre-mature infants were included. Special attention was paid to the 97th percentile and 4 mm above it, internationally regarded as upper reference limits and intervention cutoffs for post-hemorrhagic ventricular dilation, respectively. The AHW, VI and TOD were all positively correlated with birth weight (<em>p</em> values &lt;0.05) and increased over time (<em>p</em> values &lt;0.001).</div></div><div><h3>Conclusion</h3><div>The study presents reference values and intervention cutoffs for AHW, VI and TOD in extremely pre-mature infants and provides an extensive comparison of all available reference values.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 629-637"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Implementation of Ultrasound-Based Shear Wave Elastography in Individuals With Knee Osteoarthritis: A Scoping Review","authors":"Ryan Matthews ,&nbsp;Sophie Rayner ,&nbsp;Meaghan Hannigan ,&nbsp;Anne Doan ,&nbsp;Rebecca Moyer","doi":"10.1016/j.ultrasmedbio.2025.11.667","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.667","url":null,"abstract":"<div><div>Ultrasound shear wave elastography (SWE) enables the reliable assessment of tissue stiffness <em>in vivo</em>. Recently, SWE has emerged as a tool to study musculoskeletal tissue mechanics in healthy and pathological populations, such as individuals with knee osteoarthritis (KOA). No previous articles have explicitly reviewed the implementation of SWE methodology in KOA populations. Therefore, a scoping review of published literature was performed to investigate study equipment details, measurement protocols and participant/transducer positioning as they relate to SWE methodology. The databases PubMed, CINAHL, Scopus and Embase were searched for published literature, yielding <em>n</em> = 29 articles that met inclusion criteria. Results were summarized by tissue type under investigation (<em>n</em> = 7, muscle, tendon, adipose, multiple tissues, cartilage, nerve and joint capsule). Examined in over half of all included studies (55%), muscle was the predominant tissue under investigation, while relatively few studies focused on direct KOA-related structures, such as cartilage. Transducer type and orientation were the only relatively homogenous SWE methods, with 93% of all included studies using linear transducers and 91% of reporting studies using parallel orientation. Notable heterogeneity in SWE methods was present across device modes, settings, stiffness measures and body, knee and transducer positioning. These findings indicate that methodological variability remains a significant challenge for SWE research in KOA, potentially limiting the reproducibility and generalizability of the stiffness outcomes that drive our current understanding of tissue mechanics in this population. Collectively, these results highlight the need for tissue-specific SWE methodology standardization to enhance the reliability, comparability and clinical interpretability of SWE in KOA research.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 496-505"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Low-intensity Pulsed Ultrasound Therapy Mitigates Intestinal Damage and Microbial Dysbiosis in Diabetic Mice","authors":"Liang Tang ,&nbsp;Huiyuan Zhang ,&nbsp;Yanan Yu ,&nbsp;Mengshu Cao ,&nbsp;Xiushan Fan ,&nbsp;Jianzhong Guo ,&nbsp;Lijun Sun ,&nbsp;Dean Ta","doi":"10.1016/j.ultrasmedbio.2025.11.661","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.661","url":null,"abstract":"<div><h3>Objective</h3><div>Diabetes impairs intestinal barrier integrity and disrupts gut microbiota balance, exacerbating hyperglycemia. While low-intensity pulsed ultrasound (LIPUS) has been shown to alleviate inflammatory bowel disease (IBD), its role in diabetes-related gut dysfunction remains unclear. This study aimed to investigate whether LIPUS could improve intestinal barrier function, modulate gut microbiota, and mitigate hyperglycemia in type 1 diabetic (T1D) mice.</div></div><div><h3>Methods</h3><div>Streptozotocin-induced type 1 diabetic (T1D) mice received a daily 20-min abdominal LIPUS treatment (30 mW/cm²) for 6 wk. Body weight and blood glucose levels were monitored weekly throughout the intervention period. After sacrifice, the intestinal morphology was examined, and barrier integrity was systematically evaluated. The composition of the gut microbiota was analyzed, along with the quantification of microbial-derived metabolites.</div></div><div><h3>Results</h3><div>T1D mice exhibited weight loss, hyperglycemia, intestinal damage, and microbial dysbiosis. LIPUS treatment upregulated the intestinal mRNA expression of ZO-1 and Occludin, enhancing barrier function. LIPUS increased the abundance of beneficial bacteria (<em>e.g.</em>, Lactobacillus, Intestinimonas) and the levels of short-chain fatty acids (acetate, propionate, butyrate), while reducing lipopolysaccharides. Crucially, LIPUS significantly lowered blood glucose levels in the diabetic mice.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that abdominal LIPUS restores gut barrier integrity and microbiota homeostasis, offering a novel therapeutic strategy for mitigating the progression of diabetes.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 673-683"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectus Femoris Indirect Head Enthesis: A Reliable Adjunct Landmark to Detect Hip Dysplasia With Ultrasound in Infants","authors":"Yumiao Qiao ,&nbsp;Lei Ye ,&nbsp;Kai Hong,&nbsp;Ying Zhao,&nbsp;Pin Lv,&nbsp;Jiayu Wang,&nbsp;Chao Zhang","doi":"10.1016/j.ultrasmedbio.2025.10.240","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.240","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the indirect head of rectus femoris tendon (IHRFT) enthesis as a stable adjunct anatomical landmark for standardizing coronal plane acquisition in ultrasound detection of developmental dysplasia of the hip (DDH) and characterize its diagnostic utility.</div></div><div><h3>Methods</h3><div>In this prospective study, 200 infants (400 hips, median age 89 days) underwent hip ultrasound. Spatial relationships between the Graf standard coronal plane and IHRFT enthesis were quantified. A modified coronal plane was acquired using the posterior IHRFT margin as an adjunct landmark with flexed hips. Alpha angles from both planes were compared. IHRFT enthesis thickness was measured in an axial oblique plane; its diagnostic accuracy for DDH (Graf type ≥IIa) was assessed.</div></div><div><h3>Results</h3><div>The posterior IHRFT margin consistently aligned with the Graf standard plane (mean offset: −1.0 ± 1.1 mm). Alpha angles derived using the IHRFT as an adjunct landmark (62.2° ± 3.9°) showed no significant difference from Graf plane angles (62.9° ± 4.4°, <em>p</em> = 0.08), with good inter-operator reliability (ICC = 0.77). IHRFT enthesis thickness was significantly greater in dysplastic hips (n = 36) vs. normal hips (n = 364) (4.1 ± 1.1 mm vs. 2.4 ± 0.3 mm, <em>p</em> &lt; 0.0001). Enthesis thickness ≥3.2 mm predicted DDH with high accuracy (AUC = 0.91, sensitivity 91%, specificity 88%).</div></div><div><h3>Conclusions</h3><div>Incorporating the posterior margin of the IHRFT enthesis as an adjunct landmark for defining the standard coronal plane enhances inter-operator consistency in alpha angle measurements, reducing dependence on strict neutral positioning. IHRFT enthesis thickening (≥3.2 mm) on axial oblique view is a novel sonographic index for diagnosis of DDH.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 564-569"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of Intracellular Calcium by Piezo1 Activation Mediates UTMD-Activated ATP Release by Rat Erythrocytes","authors":"Anna Xu ,&nbsp;Qiong Zhu ,&nbsp;Yanshuo Shi ,&nbsp;Lei Gao ,&nbsp;Zheng Liu ,&nbsp;Yueheng Wang","doi":"10.1016/j.ultrasmedbio.2025.11.002","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.002","url":null,"abstract":"<div><h3>Objective</h3><div>Ultrasound Targeted Microbubble Destruction (UTMD) technology enhances microvascular blood perfusion, with adenosine triphosphate (ATP) release from red blood cells (RBCs) playing a crucial role. However, the precise mechanisms remain unclear. This study aimed to investigate the role of Piezo1 in regulating ATP release from RBCs by UTMD.</div></div><div><h3>Methods</h3><div>RBCs were collected from rats, and UTMD was carried out using a modified ultrasonic thrombolysis device with lipid-fluorine microbubbles. RBCs were treated with the Piezo1 activator Yoda1, the Piezo1 blocker GsMTx4 or the Pannexin1 (Panx1) blocker carbenoxolone, prior to UTMD. ATP release was assessed using a bioluminescence assay with an in vivo imaging system, and intracellular calcium (Ca²⁺) concentration was determined by laser confocal microscopy. Data-independent acquisition proteomic analysis was conducted to identify differential protein expression in the UTMD and Control groups.</div></div><div><h3>Results</h3><div>UTMD-induced Piezo1 activation promoted ATP release from RBCs by facilitating Ca²⁺ influx. Proteomic analysis highlighted differentially expressed proteins, including Dematin, Protein 4.1, Moesin and Myosin, suggesting their involvement in the process. Additionally, Panx1 likely contributed as a downstream regulator of activated Piezo1.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that UTMD enhances ATP release from RBCs via a synergistic mechanism: Piezo1-mediated Ca²⁺ influx as the primary pathway, and non-Piezo1 pathways (including sonoporation) as complements. UTMD-induced Ca²⁺ influx is dominated by Piezo1-independent mechanisms. Panx1 acts as a key downstream effector. Although our results show Panx1 inhibition reduces ATP release, direct evidence of Piezo1-Panx1 interaction remains to be established. Proteomic data suggest cytoskeletal remodeling may play a role in this process. This knowledge may contribute to the development of new therapeutic strategies for improving microcirculatory perfusion.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 584-595"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TP53 Genotype-Dependent Cellular Responses to DVDMS-Sonodynamic Therapy in Oral Squamous Cell Carcinoma","authors":"Guo-Gang Dong ,&nbsp;Pin-Xiu Pan ,&nbsp;Feng-Ting Zhang ,&nbsp;Xi-Mei Zhang ,&nbsp;Fu-Yu Yang ,&nbsp;Li-Min Jia ,&nbsp;Wei-Han Zhang ,&nbsp;Yan-Hong Lv","doi":"10.1016/j.ultrasmedbio.2025.11.011","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the inhibitory effects and underlying mechanisms of sonodynamic therapy (SDT) mediated by the novel sonosensitizer sinoporphyrin sodium (DVDMS) in oral squamous cell carcinoma (OSCC) cells exhibiting distinct <em>TP53</em> genotypes.</div></div><div><h3>Methods</h3><div>Cytotoxicity, intracellular uptake and localization of DVDMS, reactive oxygen species (ROS) levels, apoptosis and autophagy were assessed in two OSCC cell lines (SAS and HSC-3). Expression levels of p53, Bax, Bcl-2 and LC3B proteins were analyzed. The p53 inhibitor pifithrin-α (PFT-α) was utilized to determine its modulatory effects on SDT-induced cellular responses in SAS cells.</div></div><div><h3>Results</h3><div>DVDMS-mediated SDT significantly inhibited cell proliferation in both SAS and HSC-3 lines. DVDMS predominantly accumulated in the mitochondria, with higher colocalization observed in SAS cells. SDT induced a marked elevation in intracellular ROS and mitochondrial apoptosis, particularly in SAS cells. After 2 h of SDT, there was a significant decrease in autophagic activity in SAS cells, whereas an increase was noted in HSC-3 cells. In SAS cells, SDT resulted in significant upregulation and nucleocytoplasmic translocation of p53 protein. Treatment with PFT-α partially attenuated apoptosis, reversed autophagy inhibition and suppressed p53 translocation in SAS cells.</div></div><div><h3>Conclusion</h3><div>DVDMS-mediated SDT elicited greater cytotoxic responses in OSCC cells harboring wild-type <em>TP53</em> (SAS) compared to mutant <em>TP53</em> (HSC-3) cells. The therapy induced mitochondrial apoptosis and modulated autophagy in both cell lines, with more pronounced responses observed in wild-type <em>TP53</em> cells. These findings suggest that p53 plays a critical regulatory role in mediating SDT-induced mitochondrial apoptosis and autophagy under DVDMS sensitization in OSCC.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 638-647"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145851276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Non-invasive Biomarkers of Pre-term Birth: In Vivo Ultrasound Speckle Statistics in the Human Cervix Throughout Gestation","authors":"Alexandra Christensen ,&nbsp;Ivan Rosado-Mendez ,&nbsp;Helen Feltovich ,&nbsp;Timothy J. Hall","doi":"10.1016/j.ultrasmedbio.2025.11.001","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>Researchers and clinicians have called for early pregnancy biomarkers of pre-term delivery, especially in the uterine cervix, a crucial player in delivery timing. The goal of this study was to develop practical biomarkers that can help predict the timing of delivery using ultrasound images. Here we investigated first-order speckle statistics as a lens into the remodeling microstructure of the cervix throughout gestation.</div></div><div><h3>Methods</h3><div>Thirty low-risk pregnant subjects were analyzed. Transvaginal ultrasound exams with a prototype linear array transducer were performed five times throughout pregnancy and once post-partum. Parameters of the Nakagami and homodyned K distributions were estimated from the envelopes of raw radiofrequency signals at a range of beam steering angles. The steering angle dependence of these parameters was also analyzed to quantify changes in microstructural anisotropy. Linear mixed effects modeling was performed for each speckle statistics metric, using subject age, parity, location of measurement within the cervix and time remaining to delivery as predictors.</div></div><div><h3>Results</h3><div>The metric most influenced by delivery timing was the steering angle dependence of the Nakagami <span><math><mi>m</mi></math></span> parameter in the posterior cervix near the internal os, where the linear mixed effects model showed an increase of <span><math><mrow><mn>1.9</mn><mo>±</mo><mn>0.5</mn><mo>%</mo></mrow></math></span> per wk in the variation of <span><math><mi>m</mi></math></span> with respect to the steering angle compared with a variation of <span><math><mi>m</mi></math></span> with respect to the steering angle at 40 wk from delivery (<span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0.05</mn></mrow></math></span>). All other speckle statistics metrics and their steering angle dependence also had statistically significant relationships with delivery timing. Subject age and parity had a negative correlation with speckle statistics anisotropy metrics, and measurement location (anterior or posterior cervix) was a statistically significant predictor of speckle statistics metrics.</div></div><div><h3>Conclusion</h3><div>This investigation was the first to present an analysis of speckle statistics in the <em>in vivo</em> human cervix in a longitudinal pregnancy study. It was shown that speckle statistics parameter estimates are sensitive to changes in the cervix as it progresses toward delivery, suggesting the clinical potential of these tools for detecting microstructural remodeling in the cervix.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 570-583"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Contrast-Enhanced Ultrasound and CT/MRI in Transarterial Chemoembolization and Hepatic Arterial Infusion Chemotherapy","authors":"Weixuan Kong ,&nbsp;Leixin Qiu ,&nbsp;Qing Li ,&nbsp;Zerong Huang ,&nbsp;Lingling Li ,&nbsp;Ni He ,&nbsp;Chuan Peng ,&nbsp;Xu Han ,&nbsp;Wei Zheng ,&nbsp;Ruhai Zou","doi":"10.1016/j.ultrasmedbio.2025.11.007","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.007","url":null,"abstract":"<div><h3>Objective</h3><div>Early assessment of treatment response following locoregional therapy remains a challenge in managing hepatocellular carcinoma (HCC). Recent advancements in contrast-enhanced ultrasound (CEUS) have demonstrated significant potential in the early assessment of tumor viability. This study compared the evaluation capabilities of CEUS and CT/MRI in assessing treatment response to hepatic arterial infusion chemotherapy (HAIC) and transarterial chemoembolization (TACE).</div></div><div><h3>Materials and methods</h3><div>This study included patients who had received TACE or HAIC between 2010 and 2024. 1:1 propensity score matching was used to reduce confounding bias between the TACE and HAIC groups. A comparative analysis was carried out using pathological complete response of treated lesions as the reference standard to assess the diagnostic performance of CEUS and CT/MRI across different treatment strategies.</div></div><div><h3>Results</h3><div>A total of 154 patients with 167 observations were ultimately included. In the propensity score matching cohort, CEUS and CT/MRI demonstrated similar diagnostic performance, with no significant differences in sensitivity (96% vs 92%, <em>p</em> = 0.07) or specificity (67% vs 57%, <em>p</em> &gt; 0.99). Additionally, CEUS showed comparable results between HAIC and TACE groups in both sensitivity (98% vs 94%, <em>p</em> = 0.61) and specificity (50% vs 77%, <em>p</em> = 0.35).</div></div><div><h3>Conclusion</h3><div>CEUS demonstrated no significant difference in diagnostic performance compared with CT/MRI in evaluating HCC treatment response to HAIC and TACE.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 608-615"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145696378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization and Reliability Assessment of Ultrasound Shear Wave Elastography of the Rectus Femoris: A Methodological Study","authors":"Yating Wang ,&nbsp;Xiaona Liu ,&nbsp;Xuemei Liu ,&nbsp;Kaiyun Chu ,&nbsp;Ling Li ,&nbsp;Huiyu Ge","doi":"10.1016/j.ultrasmedbio.2025.11.012","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.012","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate effects of various sections, operational methods, and measurement techniques of shear wave elastography (SWE) on the assessment of rectus femoris stiffness.</div></div><div><h3>Methods</h3><div>This study included 43 healthy volunteers who underwent rectus femoris SWE using different sections (cross-sectional and longitudinal), operation methods (hand-held, thick coating couplant, and acoustic pad), and measurement methods (circular, multipoint, and tracing). Two sonographers evaluated the inter-observer and intra-observer consistency of SWE longitudinal-section measurements for the first 20 healthy volunteers.</div></div><div><h3>Results</h3><div>The longitudinal section had lower median values of shear wave velocity (SWV) and shear modulus (1.7 m/s vs. 1.9 m/s, 9.3 kPa vs. 11.4 kPa), whereas the transverse section exhibited higher coefficients of variation (17.14% vs. 10.94%, 33.80% vs. 27.70%). Excellent inter-observer agreement on SWV and shear modulus was observed for the longitudinal section (ICC: 0.97, 0.96, 95% CI: 0.883–0.991, 0.800–0.988; <em>p</em> &lt; 0.001). The intra-observer agreement for SWV was substantial (ICC = 0.64) while that for the shear modulus was moderate (ICC = 0.23). Median SWVs of the handheld, thick-coated couplant, and acoustic-pad methods decreased in order (1.9 m/s, 1.7 m/s, 1.6 m/s, respectively). The handheld method had the lowest coefficient of variation (CV) compared to the other two methods (10.94%, 13.87%, and 14.56%, respectively). No statistically significant differences were observed in SWV measurements and CV between circle, multipoint, and tracing methods (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>The longitudinal section and handheld method offered enhanced stability when measuring muscle stiffness; shear SWV exhibited superior consistency compared to shear modulus. The region-of-interest tracing method was straightforward and had an extensive measurement range.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 648-656"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}