Ultrasound in Medicine and Biology最新文献

{"title":"Integration of Anterior and Posterior Ultrasonography for Comprehensive Anterior Cruciate Ligament Visualization: A Novel Approach","authors":"Yeong-Jang Chen ,&nbsp;Ping-Chun Yeh ,&nbsp;Chia-Hung Hung ,&nbsp;Chueh-Hung Wu ,&nbsp;Yu-Jen Chen ,&nbsp;Ching-Chuan Jiang ,&nbsp;Hsing-Kuo Wang","doi":"10.1016/j.ultrasmedbio.2025.02.002","DOIUrl":"10.1016/j.ultrasmedbio.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Alternative medical imaging techniques are necessary to address the limitations of magnetic resonance imaging (MRI). Therefore, this study aimed to develop an ultrasonographic method that integrates anterior and posterior approaches for measuring the entire length of the anterior cruciate ligament (ACL). We validated this method by identifying the middle ACL during arthroscopy and comparing the results to those of MRI. We hypothesized that the ACL length measurements obtained via ultrasonography and MRI would not differ significantly and that the posterior approach would provide a longer visual field of the ACL than the anterior approach.</div></div><div><h3>Methods</h3><div>Thirty-six patients (21 males, 15 females) diagnosed with meniscal injury or internal knee derangement were included. During arthroscopy, the surgeon identified the middle ACL using Ti-Cron™ sutures. Ultrasonographic approaches from the anterior and posterior perspectives were used to identify the distal and proximal ACL, respectively. The ACL length was measured using both ultrasonography and MRI, and the visual fields from both approaches were compared.</div></div><div><h3>Results</h3><div>One participant was excluded because of a torn ACL, and seven participants were excluded because of poor ultrasonographic image quality. The ACL length of the 28 included patients did not differ significantly between ultrasonography and MRI, with a moderate correlation between the two measurements. The visualized proportion of the ACL was greater through the posterior approach than through the anterior approach.</div></div><div><h3>Conclusions</h3><div>This ultrasonographic method visualizes the entire ACL length by combining anterior and posterior approaches, with the posterior offering a more extensive and clinically significant visual field.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 896-902"},"PeriodicalIF":2.4,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143415990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clutter-Generating Phantom Material. Part II: Utilization in the Comparison of Conventional and Regularized Ultrasound Attenuation Estimation","authors":"Hayley M. Whitson ,&nbsp;Ivan M. Rosado-Mendez ,&nbsp;Timothy J. Hall","doi":"10.1016/j.ultrasmedbio.2025.01.006","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.006","url":null,"abstract":"<div><div>A particular challenge in clinical ultrasound imaging is acoustic clutter, which arises from the heterogeneity of the speed of sound and reverberations between layered tissue types. Although clutter is common when imaging through complex tissue such as the abdominal wall, few studies have investigated its effects on quantitative ultrasound (QUS) parameter estimation. The ultrasonic attenuation coefficient (AC) has shown promise as a biomarker for multiple applications. Recently, multiple regularized methods of AC estimation have been developed; however, their performance must be evaluated in clinically relevant scenarios such as in the presence of clutter. In a companion paper to this work, a material that produces clutter similar to that seen in clinical imaging was developed and characterized. Here, we utilize this clutter-generating phantom material to compare the bias and variance of AC estimates resulting from a conventional estimation method known as the spectral difference method (SDM) and a regularized method known as Analytical Global Regularized Backscatter Quantitative Ultrasound (ALGEBRA), which can either be implemented in 1D or 2D. A B-mode, target-based contrast-to-noise ratio was used to quantify the amount of clutter in data collected from a phantom with known AC. Estimation reliability was determined using the normalized root mean square error (NRMSE) and the percent bias. On average, 1D-ALGEBRA had a 22.86% smaller bias and a 32.19% smaller NRMSE than the SDM, while 2D-ALGEBRA had a 17.59% smaller bias and a 25.66% smaller NRMSE than the SDM. An analysis of variance model indicated that ALGEBRA is more robust to the presence of clutter than the SDM. Further statistical tests showed that the reduction in variance resulting from ALGEBRA was the main contributor to the reduction in NRMSE. This work demonstrates the utility of this clutter-generating phantom material in objective testing of QUS parameter estimation, as well as performance improvements obtained in phantoms with regularized methods from QUS parameter estimation in the presence of acoustic clutter.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 777-787"},"PeriodicalIF":2.4,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clutter-Generating Phantom Material. Part I: Development of a Tunable, Acoustic Clutter-Generating Layer for Use With Ultrasound Tissue-Mimicking Phantoms","authors":"Katelyn Flint ,&nbsp;Matthew Huber ,&nbsp;James Long ,&nbsp;Gregg Trahey ,&nbsp;Timothy Hall","doi":"10.1016/j.ultrasmedbio.2024.12.018","DOIUrl":"10.1016/j.ultrasmedbio.2024.12.018","url":null,"abstract":"<div><h3>Objective</h3><div>Acoustic clutter is a major source of image degradation for <em>in vivo</em> ultrasound imaging. However, clutter is often not represented in laboratory testing of ultrasound equipment. A phantom material is proposed that can be used to add calibrated amounts of clutter in the laboratory environment.</div></div><div><h3>Methods</h3><div>Previously, the speed of sound in agar has been adjusted by varying the concentration of propanol to which the agar is exposed. That property was leveraged in this work to create a phantom with an adjustable amount of clutter. Agar spheres were soaked in propanol solution, then strained and placed in mineral oil.</div></div><div><h3>Results</h3><div>Image quality measurements showed an approximate range of achievable contrast degradation levels of 15 dB. Stability studies with the phantom material showed that it can be stored for at least 21 d after the speed of sound tuning in propanol, but once introduced to mineral oil the clutter will change over time.</div></div><div><h3>Conclusion</h3><div>This work demonstrates a clutter-generating phantom material that can be used in conjunction with standard ultrasound imaging phantoms.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 768-776"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic-Based Radiomics Signature With Machine Learning for Differentiating Prognostic Subsets of Pediatric Peripheral Neuroblastic Tumors: A Retrospective Study","authors":"Hui Zhu ,&nbsp;Jiazong Ye ,&nbsp;Hongxia Luo ,&nbsp;Shuangshuang Ni ,&nbsp;Yin Pan ,&nbsp;Zhilin Zhao ,&nbsp;Yan Yang","doi":"10.1016/j.ultrasmedbio.2025.01.013","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.013","url":null,"abstract":"<div><h3>Objective</h3><div>To construct and select a better model based on ultrasonic-based radiomics features and clinical characteristics for prognostic subsets of pediatric neuroblastic tumors.</div></div><div><h3>Methods</h3><div>Data from 73 children with neuroblastic tumors were included and divided into a training group and a validation group. Data 1 contained the subjects’ radiomics features and clinical characteristics, while data 2 contained radiomics features. With the help of machine learning, five models were constructed for data 1 and data 2, respectively. The model with the highest accuracy and area under the curve was selected as the combined model and radiomics model for data 1 and data 2, respectively. A superior model was then chosen from the models after further comparison.</div></div><div><h3>Results</h3><div>The extreme gradient-boosting model for data 1 was chosen as the combined model and the extreme gradient-boosting model for data 2 was chosen as the radiomics model. The area under the curve of the combined and radiomics models in the validation group was 0.941 and 0.918 (<em>p</em> = 0.6906). The balanced accuracy, kappa value and F1 score of the radiomics model (0.9045, 0.8091 and 0.9091, respectively) were higher than those of the combined model (0.8545, 0.7123 and 0.8696, respectively). The top eight features of the radiomics model included five first-order statistical features and three textural features, all of which were high-dimensional features.</div></div><div><h3>Conclusion</h3><div>Our study proved that the radiomics model outperformed the combined model at differentiating prognostic subsets of pediatric neuroblastic tumors. Additionally, we found that high-dimensional ultrasonic-based radiomics features surpassed other features and clinical characteristics.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 852-859"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Shear Wave Elastography and Shear Wave Dispersion: Correlation with Histopathological Changes in Autoimmune Hepatitis Patients","authors":"Rawi Hazzan ,&nbsp;Tor Regev-Sadeh ,&nbsp;Tamar Dola ,&nbsp;Hila Shemer-Shamay ,&nbsp;Alona Umansky ,&nbsp;Ehud Zigmond ,&nbsp;Ziv Neeman","doi":"10.1016/j.ultrasmedbio.2025.01.009","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.009","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the correlation between liver viscosity, as measured by shear wave dispersion (SWD), and fibrosis and inflammation in patients with autoimmune hepatitis (AIH). Additionally, to assess its potential as a non-invasive biomarker for hepatic fibrosis compared to shear wave elastography (SWE).</div></div><div><h3>Methods</h3><div>This prospective study included 25 AIH patients who underwent pre-biopsy SWD and SWE measurements using the SuperSonic Mach30 system. Liver biopsy samples were assessed for fibrosis using the Scheuer grading system and for inflammation using the modified Hepatic Activity Index (mHAI). Correlations between viscosity, elastography, fibrosis, and inflammation were analysed using Spearman's correlation coefficients.</div></div><div><h3>Results</h3><div>Viscosity demonstrated a significant correlation with fibrosis stages (Spearman's coefficient: 0.58, <em>p</em> = 0.002), while SWE showed a weaker correlation (Spearman's coefficient: 0.50, <em>p</em> = 0.01). Viscosity measurements also correlated moderately with the mHAI score (Spearman's coefficient: 0.62, <em>p</em> = 0.001). Subgroup analyses revealed weak to moderate correlations between viscosity and mHAI components across fibrosis stages.</div></div><div><h3>Conclusion</h3><div>Our study suggests that viscosity may be better than SWE as a non-invasive marker for assessing hepatic fibrosis in AIH, particularly in the pre-treatment period when inflammation levels are elevated. However, we could not conclusively determine the relationship between viscosity and hepatic inflammation, as a small sample size limited our findings. Further research with a larger cohort of AIH patients is necessary to better understand the correlation between viscosity and inflammation in this rare condition.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 823-829"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Different Ultrasound Intensity Stimulation on Brown Adipose Tissue for the Treatment of Type 2 Diabetes","authors":"Badamgarav Bat-Erdene ,&nbsp;Min He ,&nbsp;Jingsong Dong ,&nbsp;Ying Li ,&nbsp;Dean Ta","doi":"10.1016/j.ultrasmedbio.2025.01.010","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.010","url":null,"abstract":"<div><div>Type 2 diabetes (T2D) is a persistent illness that has a high incidence rate. Still, there is no conclusive evidence on effectively improving blood sugar levels in patients through physical therapy. This study examined the regulatory effects of different intensities of low-intensity pulsed ultrasound (LIPUS) on T2D by stimulating brown adipose tissue (BAT). Eight-week-old C57BL/6J mice were divided into six groups (n = 10 per group): Control sham (C-Sham), Control-LIPUS (C-LIPUS), T2D-sham (T2D-Sham), T2D groups treated with LIPUS at spatial average-temporal-average intensity (<em>I_sata</em>) of 60mW/cm² (T2D-L-60), 80mW/cm² (T2D-L-80), and 100mW/cm² (T2D-L-100). T2D models were induced by intraperitoneal injection of 40 mg/kg streptozotocin (STZ) three times after 12 wks of high-fat diet (HFD). The T2D-LIPUS group received LIPUS stimulation for 20 minutes per day for 6 weeks. The LIPUS stimulation had a duty cycle of 20%, a frequency of 1 MHz, and <em>I_sata</em> of 60mW/cm², 80mW/cm², 100mW/cm². Subsequently, glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were performed, and body fat content in mice was analyzed using nuclear magnetic resonance (NMR). Metabolic changes were monitored using metabolic cages. The results indicated that 80mW/cm² intensity level significantly improved glucose tolerance, insulin sensitivity, and metabolic function after LIPUS exposure. Significant reductions in body fat content and enhanced thermogenesis were observed, highlighting the potential of LIPUS in T2D management. This provides the basis for the dose study of LIPUS in the treatment of T2D.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 830-840"},"PeriodicalIF":2.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity Pulsed Ultrasound Stimulation of the Intestine Improves Insulin Resistance in Type 2 Diabetes","authors":"Huan Wang ,&nbsp;Min He ,&nbsp;Badamgarav Bat-Erdene,&nbsp;Ying Li,&nbsp;Dean Ta","doi":"10.1016/j.ultrasmedbio.2025.01.004","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>Ultrasound stimulation of internal organs and peripheral nerves has demonstrated promising potential in regulating blood glucose metabolism. This study aims to assess the effectiveness of low-intensity pulsed ultrasound stimulation (LIPUS) on intestine in improving insulin resistance with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>C57BL/6J mice, both normal and T2DM, were randomly divided into three groups: Control, T2D-sham, and T2D-LIPUS. The T2D-LIPUS group received LIPUS stimulation in the intestine. The parameters were as follows: 1 MHz frequency, 1.0 kHz pulse repetition frequency (PRF), 20% duty cycle, 100 mW/cm² intensity spatial average temporal average (I_SATA), for 20 minutes per session, five days per week, over four weeks.</div></div><div><h3>Results</h3><div>Blood glucose analysis indicated that mice in the T2D-LIPUS group displayed significantly lower area under the curve (AUC) of glucose tolerance tests (GTT) and insulin tolerance tests (ITT) (<em>p</em> &lt; 0.001), HOMA-IR (<em>p</em> &lt; 0.001), and fasting serum insulin levels (<em>p</em> &lt; 0.01) compared to the T2D-sham group. LIPUS treatment effectively lowered serum levels of IL-1β (<em>p</em> &lt; 0.001) and TNF-α (<em>p</em> &lt; 0.01) along with mRNA expression levels of IL-1β (<em>p</em> &lt; 0.01) and IL-18 (<em>p</em> &lt; 0.001) in the intestines of T2DM mice. Additionally, Western blot analysis revealed a reduction in the protein levels of NLRP3, caspase-1, and GSDMD-N in the intestinal tissues of mice treated with LIPUS.</div></div><div><h3>Conclusion</h3><div>These findings suggest that LIPUS can reduce inflammation and cellular apoptosis, while improving insulin resistance by inhibiting the NLRP3/Caspase-1/GSDMD signaling pathway. This research introduces a novel, non-pharmacological approach for managing T2DM.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 797-806"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Shear Wave Elastography as Evidenced From Carotid Artery Strain and Strain Rate Induced by Acoustic Radiation Force Impulse and Arterial Pulsations","authors":"Tim Nordenfur ,&nbsp;Kenneth Caidahl ,&nbsp;Linnea Lindberg ,&nbsp;Matthew W. Urban ,&nbsp;Matilda Larsson","doi":"10.1016/j.ultrasmedbio.2024.12.004","DOIUrl":"10.1016/j.ultrasmedbio.2024.12.004","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the mechanical effects of carotid shear wave elastography (SWE) <em>in vivo</em> as its effects on the arterial wall have not been thoroughly examined.</div></div><div><h3>Methods</h3><div>We evaluated the mechanical effects of carotid SWE <em>in vivo</em> in terms of the radial strain and strain rate to which acoustic radiation force impulses (ARFIs) expose the arterial wall, and compared them with the strain and strain rate induced by arterial pulsation in 13 healthy study subjects (seven individuals 20–35 y of age and six individuals 50–65 y of age). Additionally, we explored whether mechanical effects vary with timing of ARFI and subject age.</div></div><div><h3>Results</h3><div>The young cohort was found to have, compared with the old cohort, a higher diastolic ARFI-induced peak strain (<em>p</em> = 0.002) and peak strain rate (<em>p</em> = 0.001), and a lower diastolic ARFI-induced peak negative strain rate (<em>p</em> = 0.013). When comparing cardiac phases, diastolic ARFIs were found to induce a lower peak negative strain rate than systolic ARFIs (<em>p</em> = 0.006). Importantly, ARFI-induced peak strain was lower than that caused by arterial pulsation in both age cohorts (<em>p</em> &lt; 0.0001). The ARFI-induced peak strain rate was slightly higher than that caused by arterial pulsation at rest but lower than published exercise data. The ARFI-induced peak negative strain rate was similar to that caused by arterial pulsation.</div></div><div><h3>Conclusion</h3><div>Our results indicate that arterial SWE does not expose the arterial wall to any higher strain or strain rate than is experienced during normal arterial pulsation. Further research is required to validate the results in arteries containing vulnerable plaques.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 742-750"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143371257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Salivary Gland Tumors Using Ultrasound Radiomics","authors":"Ping-Chia Cheng ,&nbsp;Wu-Chia Lo ,&nbsp;Li-Jen Liao ,&nbsp;Huihua Kenny Chiang","doi":"10.1016/j.ultrasmedbio.2025.01.008","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.008","url":null,"abstract":"<div><h3>Objective</h3><div>The current diagnosis of salivary gland tumors (SGTs) is dependent on subjective ultrasound features. Here we aimed to develop an objective method using ultrasound radiomics.</div></div><div><h3>Methods</h3><div>We collected 248 benign and 46 malignant images and divided them into training (80%) and testing (20%) groups, with 105 radiomic features extracted from each image. Data re-sampling, feature selection and classification were conducted. The diagnostic accuracy of different combinations was evaluated.</div></div><div><h3>Results</h3><div>After data re-sampling using the Synthetic Minority Over Sampling Technique (SMOTE) and feature selection with LASSO+ANOVA, 10 radiomic features were selected. Using the Random Forest classifier, the testing set achieved an area under the receiver operating characteristic curve of 0.85, accuracy of 90%, sensitivity of 78% and specificity of 92% for diagnosing SGTs. It maintained an accuracy of 85% in a separate internal validation set.</div></div><div><h3>Conclusion</h3><div>This study offers significant insights into the use of radiomics for the diagnosis of SGTs. When selected properly and paired with a suitable classification model, radiomics can be used to differentiate between benign and malignant SGTs.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 815-822"},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonosensitizers for Sonodynamic Therapy: Current Progress and Future Perspectives","authors":"Ting Wang ,&nbsp;Meng Du ,&nbsp;Zhiyi Chen","doi":"10.1016/j.ultrasmedbio.2025.01.011","DOIUrl":"10.1016/j.ultrasmedbio.2025.01.011","url":null,"abstract":"<div><div>Sonodynamic therapy (SDT) is a novel non-invasive treatment method that combines low-intensity ultrasound and sonosensitizers. Compared with photodynamic therapy, SDT has the advantages of deeper tissue penetration, higher accuracy and fewer adverse reactions. Sonosensitizers are essential for the efficacy of SDT. Sonosensitizers have the advantages of clear structure, easy monitoring, evaluation of drug metabolism and clinical transformation, etc. Notably, biochemical techniques can be used in the field of sonosensitizers and SDT to overcome inherent barriers and achieve sustainable innovation. This article first summarizes the molecular mechanism of SDT, focusing on organic sonosensitizers, inorganic nano-sonosensitizers and multi-functional drug delivery systems with targeting, penetration and imaging functions after a series of modifications. This review provides ideas and references for the design of sonosensitizers and SDT and promotes their future transformation into clinical applications.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 5","pages":"Pages 727-734"},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}