Contrast-enhanced Ultrasound Features of Primary Hepatic Lymphoma Are Different From Common Malignant Hepatic Tumors: A Comparative Study.

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-06-21 DOI:10.1016/j.ultrasmedbio.2025.05.002

Chen Yanni, Wang Feihang, Xu Yadan, Zhang Xiaolong, Qin Hong, Qiu Qixuan, Yuan Kai, Wang Wenping

{"title":"Contrast-enhanced Ultrasound Features of Primary Hepatic Lymphoma Are Different From Common Malignant Hepatic Tumors: A Comparative Study.","authors":"Chen Yanni, Wang Feihang, Xu Yadan, Zhang Xiaolong, Qin Hong, Qiu Qixuan, Yuan Kai, Wang Wenping","doi":"10.1016/j.ultrasmedbio.2025.05.002","DOIUrl":null,"url":null,"abstract":"Objective: To investigate and compare the ultrasonic features of primary hepatic lymphoma (PHL) and other common hepatic malignancies, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, and colorectal liver metastasis (CRLM).Methods: The ultrasound features and clinical data of pathologically proven PHL (n = 26) were compared with HCC (n = 26), intrahepatic cholangiocarcinoma (n = 26), and CRLM (n = 26).Results: There were significant differences in elevated lactate dehydrogenase levels between the PHL group and the other three groups (p < 0.05). The probability of PHL infection with the hepatitis B virus was lower than that of the HCC groups (p < 0.05). The probability of elevated serum tumor markers in PHL was significantly lower than that in the other three groups (p < 0.05). On conventional ultrasound, the probability of regular morphology in PHL was significantly higher than that in the other three groups (p < 0.05). On contrast-enhanced ultrasound examination, the proportion of vessel penetration signs in PHL was significantly higher than that of the other three groups (p < 0.001). The proportion of PHL with isoenhancement or hypoenhancement in the arterial phase was significantly higher than in the HCC and CRLM groups (p < 0.05). The enhancement type of PHL was different than that of the CRLM group (p < 0.05).Conclusion: Contrast-enhanced ultrasound features are useful in the preoperative and noninvasive differentiation of primary hepatic lymphoma and other malignant hepatic tumors.","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasound in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ultrasmedbio.2025.05.002","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ACOUSTICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To investigate and compare the ultrasonic features of primary hepatic lymphoma (PHL) and other common hepatic malignancies, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, and colorectal liver metastasis (CRLM).

Methods: The ultrasound features and clinical data of pathologically proven PHL (n = 26) were compared with HCC (n = 26), intrahepatic cholangiocarcinoma (n = 26), and CRLM (n = 26).

Results: There were significant differences in elevated lactate dehydrogenase levels between the PHL group and the other three groups (p < 0.05). The probability of PHL infection with the hepatitis B virus was lower than that of the HCC groups (p < 0.05). The probability of elevated serum tumor markers in PHL was significantly lower than that in the other three groups (p < 0.05). On conventional ultrasound, the probability of regular morphology in PHL was significantly higher than that in the other three groups (p < 0.05). On contrast-enhanced ultrasound examination, the proportion of vessel penetration signs in PHL was significantly higher than that of the other three groups (p < 0.001). The proportion of PHL with isoenhancement or hypoenhancement in the arterial phase was significantly higher than in the HCC and CRLM groups (p < 0.05). The enhancement type of PHL was different than that of the CRLM group (p < 0.05).

Conclusion: Contrast-enhanced ultrasound features are useful in the preoperative and noninvasive differentiation of primary hepatic lymphoma and other malignant hepatic tumors.

查看原文本刊更多论文

原发性肝淋巴瘤与普通肝恶性肿瘤超声增强特征的比较研究。

目的：探讨原发性肝淋巴瘤（PHL）与肝细胞癌（HCC）、肝内胆管癌、结直肠肝转移（CRLM）等常见肝脏恶性肿瘤的超声特征并进行比较。方法：将经病理证实的PHL（26例）与HCC（26例）、肝内胆管癌（26例）、CRLM（26例）的超声表现及临床资料进行比较。结果：PHL组乳酸脱氢酶水平升高与其他3组比较差异有统计学意义（p < 0.05）。PHL感染乙型肝炎病毒的概率低于HCC组（p < 0.05）。PHL组血清肿瘤标志物升高的概率显著低于其他三组（p < 0.05）。常规超声显示PHL形态规则的概率显著高于其他三组（p < 0.05）。超声造影检查，PHL组血管穿透征象的比例显著高于其他三组（p < 0.001）。动脉期等强化或低强化的PHL比例明显高于HCC组和CRLM组（p < 0.05）。PHL增强类型与CRLM组差异有统计学意义（p < 0.05）。结论：超声造影对原发性肝淋巴瘤及其他肝恶性肿瘤的术前和无创鉴别诊断有重要价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.