Ultrasound in Medicine and Biology最新文献

{"title":"Three-dimensional Contrast-enhanced Ultrasound for Evaluating the Shape and Size of the Microwave Ablation Zone.","authors":"Huiyu Yang, Lin Zhao, Jianmin Ding, Yan Zhou, Yanmin Kan, Xi Chen, Xiang Jing","doi":"10.1016/j.ultrasmedbio.2025.04.015","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.015","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the agreement between three-dimensional contrast-enhanced ultrasound (3D-CEUS) and contrast-enhanced computed tomography (CECT) in assessing microwave ablation (MWA) zone dimensions (size and morphology) in clinical practice, and to quantify differences in ablation characteristics between human patients and ex vivo bovine liver models, thereby optimizing preoperative planning models.</p><p><strong>Methods: </strong>This retrospective study enrolled 33 patients with malignant liver tumors who underwent single-needle, single-insertion percutaneous MWA guided by ultrasound at the department of ultrasound in Tianjin Third Central Hospital from January 1, 2022, to January 31, 2024. We determined the correlation and consistency of 3D-CEUS and CECT in evaluating the long axis diameter (LAD), short diameter (DS), volume, and roundness index (RI) of the MWA zone. We also compared the shape and size of the ablation zones in ex vivo bovine liver models with those of clinical MWA zones.</p><p><strong>Results: </strong>Significant correlations were observed between 3D-CEUS and CECT in evaluating the shape and size of MWA ablation zones. Correlations between both methods were very strong for volume, DS1, and RI (Pearson; 0.96, 0.90, and 0.87) and LAD and DS2 (Spearman; 0.97 and 0.87). 3D-CEUS and CECT showed excellent-to-good consistency in evaluating the parameters of ablation lesions (p < 0.001), with intraclass correlation coefficients ranging from 0.81 to 0.95. Ex vivo bovine liver ablation zones exhibited significantly larger LAD, DS1, DS2, and RI measurements compared with clinical cases (p < 0.001), consistent across both imaging modalities.</p><p><strong>Conclusion: </strong>We found that 3D-CEUS exhibits high accuracy in assessing MWA zone morphology and dimensions. The integration of clinical 3D-CEUS data, rather than data from ex vivo experimental models, would enhance the precision of the preoperative planning system for thermal ablation procedures.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Contrast-Enhanced Ultrasound Fusion With Pretreatment MR/CT for Recurrence Detection in Renal Cell Carcinoma Patients During Post-Ablation Surveillance.","authors":"Aylin Tahmasebi, Tania Siu Xiao, Corinne E Wessner, Cristina M Kuon Yeng Escalante, Andrej Lyshchik, Flemming Forsberg, Ji-Bin Liu, Christopher G Roth, Shuchi K Rodgers, Leann M Kania, Kevin Anton, Anju Yadav, Costas D Lallas, Stephen R Topper, Edouard J Trabulsi, John R Eisenbrey","doi":"10.1016/j.ultrasmedbio.2025.04.021","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.021","url":null,"abstract":"<p><strong>Objective: </strong>Contrast enhanced ultrasound (CEUS) is a cost-effective, safe, and accurate modality for monitoring renal cell carcinoma (RCC) recurrence following percutaneous ablation. However, ultrasound delineation of treated tumor borders can be challenging post-ablation. Here, we demonstrate the feasibility of using post-treatment CEUS fused to preablation MR/CT to detect RCC recurrence during long term follow up.</p><p><strong>Methods: </strong>This study was performed as part of a larger ongoing prospective clinical trial for patients with biopsy-proven RCC treated with percutaneous ablation and receiving contrast enhanced (CE) -CT or -MRI for treatment response monitoring. CEUS with preablation CT/MR fusion was performed within 4 weeks of recurrence screening, and CE-CT/MRI was used as the reference standard. After intravenous injection of an ultrasound contrast agent, CEUS imaging of a single target lesion was performed with ultrasound fused to the patient's pretreatment CT or MRI. RCC recurrence was diagnosed at the bedside based on the presence of iso- to hyper-enhancement within the margins of the ablation cavity compared to normal renal parenchyma.</p><p><strong>Results: </strong>To date, 50 participants have been recruited (76% male and 24% female). All participants tolerated the contrast injections without adverse events. CEUS was successfully fused to the participant's pretreatment cross-sectional imaging in all cases and was found to aid in the delineation of the original treatment zone. Additionally, CEUS correlated perfectly (100% agreement) with CE-CT/MRI findings for all the participants.</p><p><strong>Conclusion: </strong>Preliminary results demonstrate that post-treatment CEUS fused with a pretreatment CT/MRI is feasible and may aid in the correct localization of the treated tumor margins during long-term post-ablation monitoring.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Practical CEUS TI-RADS Refer to Score and Grading of ACR TI-RADS (2017) for Thyroid Nodules.","authors":"Shuxian Xu, Shuang Liang, Honghui Su, Jiehuan Chen, Shumei He, Dongming Guo, Ying Chen, Jia Lin, Haiyu Kang, Ying Liu, Weina Zhang, Huahui Liu, Erjiao Xu","doi":"10.1016/j.ultrasmedbio.2025.05.005","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.05.005","url":null,"abstract":"<p><strong>Objective: </strong>To construct a contrast-enhanced ultrasound thyroid imaging reporting and data system (CEUS TI-RADS) based on ACR TI-RADS (2017) without changing the initial scores of conventional ultrasound features and reduce unnecessary fine-needle aspiration (FNA) of thyroid nodules.</p><p><strong>Methods: </strong>This retrospective study involved patients with thyroid nodules who underwent conventional ultrasound, CEUS, and FNA from October 2020 to June 2024 in three hospitals. Univariable and multivariable logistic regression analysis was employed to filter out useful CEUS features. A CEUS TI-RADS was constructed to differentiate thyroid nodules between benign and malignant and indicate the necessity of FNA.</p><p><strong>Results: </strong>A total of 1275 patients with 1521 thyroid nodules were recruited in this study. Arterial phase intensity, wash-out speed, ring enhancement, and enhancement direction (P-value all<0.001) were independent risk factors for malignant nodules in the training cohort. CEUS TI-RADS outperformed in diagnostic efficacy compared to ACR TI-RADS (AUC_[CEUS] =0.94, 0.94, 0.92 vs AUC_[ACR]=0.92, 0.91, 0.80 in training, internal validation and external validation cohort respectively, P-value all<0.001). CEUS TI-RADS could achieve a lower unnecessary biopsy rate (UBR) of 43% (81 of 190 nodules) in the training cohort, compared with 59% (156 of 264 nodules) of UBR in ACR TI-RADS. Similar results were confirmed concerning the validation cohorts.</p><p><strong>Conclusion: </strong>The CEUS TI-RADS based on ACR TI-RADS (2017) without changing the initial scoring system of conventional ultrasound, was simple and effective in the differential diagnosis of thyroid nodules, which could reduce the unnecessary FNA rate of thyroid nodules than ACR TI-RADS.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0301-5629(25)00141-3","DOIUrl":"10.1016/S0301-5629(25)00141-3","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"51 7","pages":"Page i"},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Common Carotid Artery Intima-Media Thickness and Lagrangian Wall Strain in Relation to Cardiovascular Risk Factors Using Ultrasound.","authors":"Maxwell J Kiernan, Carol Mitchell, Yurim Lee, Yimeng Dou, Zhiwei Zhang, Erica Fletcher, Kristin Hansen, Mark Kliewer, Matthew H Lee, James H Stein, Claudia Korcarz, Timothy Hess, Tomy Varghese","doi":"10.1016/j.ultrasmedbio.2025.04.014","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.014","url":null,"abstract":"<p><strong>Objective: </strong>This study examines the relationship between carotid intima-media thickness (CIMT), carotid artery wall strain indices measured via ultrasound, and their associations with cardiovascular disease (CVD) risk factors in a low CVD risk population.</p><p><strong>Methods: </strong>Eighty healthy volunteers (median age 35 y, 50% female) underwent carotid ultrasound imaging for CIMT and strain indices. Participants' clinical data, including total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, hemoglobin A1c, systolic blood pressure (SBP), diastolic blood pressure, body mass index and smoking status, were collected. Spearman Rho correlations assessed relationships between CIMT and strain indices. Multiple linear regression examined associations between strain indices and CVD risk factors, while Mann-Whitney U tests compared median differences between sexes. Statistical analyses were performed using SPSS.</p><p><strong>Results: </strong>No significant associations were seen between CIMT measurements and strain parameters. After adjustment for CVD risk factors, several strain indices were significantly associated with CVD risk factors. Age was inversely related to all strain parameters. SBP was significantly positively related to axial and shear strain. Hemoglobin A1c was significantly inversely related to most axial and shear strain (all p values <0.05). These relationships are consistent with previous findings in the literature. We also found that BMI was positively related to all strain parameters, which may be due to increased compliance with more gradual arterial remodeling.</p><p><strong>Conclusion: </strong>Strain parameters remained significantly related to several CVD risk factors in fully adjusted models. All strain parameters are associated with age. Axial and shear parameters are associated with SBP and hemoglobin A1c. These findings suggest that strain measures may represent early mechanical changes in the arterial wall and have potential for use as a research tool to characterize arterial health.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of Point-of-Care Ultrasound in Central Venous Pressure Monitoring for Critically Ill Patients. A Comprehensive Systematic Review and Meta-analysis.","authors":"Eman E Shaban, Yavuz Yigit, Benny Ponappan, Ahmed Shaban, Amira Shaban, Mohamed Helmi Ahmed, Yasser Osman Abdelaal, Hany A Zaki","doi":"10.1016/j.ultrasmedbio.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.008","url":null,"abstract":"<p><p>Central venous pressure (CVP) is a critical parameter for assessing volume status in critically ill patients, traditionally measured through invasive central venous catheterization. While effective, this method poses risks such as infection and procedural complications. Point-of-care ultrasound (POCUS) has emerged as a promising, non-invasive alternative, yet its accuracy in estimating CVP remains debated. From inception to December 2024, PubMed, Embase, MEDLINE, Web of Science, and Google Scholar databases were extensively searched. The search strategy used to identify relevant studies from these databases involved combining keywords such as \"Point-of-care ultrasound,\" \"central venous pressure,\" and \"critically ill\" with Boolean expression \"AND\" and \"OR.\" Two independent reviewers then screened all potential studies and included those reporting the accuracy of POCUS in predicting CVP and those reporting the correlation between POCUS-measured indices and invasively-measured CVP in critically ill patients. Additionally, two independent reviewers extracted the relevant data from the included studies. Statistical analyses were conducted using MedCalc and Meta-Disc software, and quality appraisal was assessed using the QUADAS-2 tool. The review included studies evaluating POCUS-derived indices from the inferior vena cava (IVC) and internal jugular vein (IJV). Overall, strong correlations were observed between POCUS measurements and CVP, with IVC parameters showing the strongest associations. IJV measurements also demonstrated moderate reliability, particularly in scenarios where IVC assessments were impractical. Sensitivity and specificity analyses indicated that POCUS-derived indices could predict CVP with variable accuracy. These findings support the use of POCUS as a practical, non-invasive tool for estimating CVP in critically ill patients. IVC measurements appear to provide the most reliable correlations, while IJV assessments serve as a useful alternative. Despite its potential, variability in study methodologies and patient factors highlights the need for further research to refine POCUS-based CVP estimation and improve clinical application.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Ultrasound-Based Characterization of Placental Tissue Microstructure in a Rat Model of Preeclampsia.","authors":"Andrew C Markel, Cameron Hoerig, Allan K N de Alencar, Kenneth F Swan, Alexander D Gleed, Lili Shi, Gabriella Pridjian, Jonathan Mamou, Carolyn L Bayer","doi":"10.1016/j.ultrasmedbio.2025.04.017","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.017","url":null,"abstract":"<p><strong>Objective: </strong>Quantitative ultrasound (QUS) methods were applied to detect changes in placental microstructure in the reduced uterine perfusion pressure (RUPP) model of preeclampsia in rats. Preeclampsia is a life-threatening pregnancy disorder associated with abnormal placental development that is inadequately treated and managed.</p><p><strong>Methods: </strong>Nine timed-pregnant Sprague-Dawley rats were used in this study. On gestational day 14 (GD 14), five rats received RUPP surgery to induce preeclampsia. US radiofrequency data were acquired for QUS analysis on GD18. On GD19, animals were sacrificed and dissected to acquire placental tissue samples. The cell nuclear diameter in each anatomical layer of the placenta was measured to compare with regional effective scatterer diameter (ESD) values.</p><p><strong>Results: </strong>ESD measurements obtained using in vivo QUS imaging correlated well (R² = 0.58, p = 3.8e-6) with cell nucleus diameter measurements from microscopy images. RUPP placentas had significantly smaller junctional zones compared to control placentas (p = 0.013). The average ESD in RUPP placentas was 1.0 µm smaller compared to control placentas (p = 0.040). This decrease in ESD in RUPP placentas is consistent with the decreased size of the junctional zone, which, in comparison to the labyrinth zone and chorionic plate, has larger cell nuclei (p = 3.3e-21 and p = 9.5e-27, respectively) and larger ESD (p = 5.6e-4 and p = 4.5e-8, respectively).</p><p><strong>Conclusion: </strong>These results demonstrate the potential of QUS as a non-invasive tool for detecting critical changes in placental microstructure, improving maternal and fetal outcomes by enabling earlier diagnosis and more timely therapeutic interventions in preeclampsia.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LI-RADS CEUS Nonradiation TRA Version 2024: Application on HCC Patients Treated With Ablation Treatment.","authors":"Jiaying Cao, Yi Dong, Xinliang Xu, Qi Zhang, Wenping Wang, Kathleen Möller, Christoph F Dietrich","doi":"10.1016/j.ultrasmedbio.2025.04.018","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.018","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of Liver Imaging Reporting and Data System (LI-RADS) contrast-enhanced ultrasound (CEUS) Nonradiation treatment response assessment (TRA) categorization v2024 for detecting viable tumors of ablated hepatocellular carcinoma (HCC).</p><p><strong>Methods: </strong>Between June 2020 and December 2022, standardized CEUS data of HCC patients were prospectively collected. A retrospective analysis of LI-RADS CEUS Nonradiation TRA v2024 evaluation on HCCs was conducted by 2 independent radiologists assigning per-lesion TRA (TR-nonviable, TR-equivocal, or TR-viable) categorizations. Inter-reader agreement between the 2 readers and inter-modality agreement between LI-RADS CEUS and CT/MRI LI-RADS TRA were assessed. The diagnostic performance of imaging criteria was explored. The potential influencing factors of LI-RADS TRA categorization across modalities were further analyzed.</p><p><strong>Results: </strong>A total of 101 CEUS-LI-RADS TRA category evaluations of 88 lesions in 83 patients were included. Inter-reader agreement for the 2 readers were substantial to almost perfect (intralesional tumor viability: κ = 0.92, 95% CI: 0.76-1.0; perilesional tumor viability: κ = 0.72, 95% CI: 0.57-0.87; CEUS LR-TR: κ = 0.71, 95% CI: 0.55-0.88). Inter-modality agreements between CEUS and CT/MRI LI-RADS TRA categorizations were excellent (ICC = 0.90). CEUS LR-TRA categorization demonstrated good diagnostic performance, particularly in specificity (88.1%-100 %) and negative predictive value (NPV: 93.9%-97.9 %). Time period and abstract shape were identified as significant factors influencing reader evaluations (p < 0.05).</p><p><strong>Conclusion: </strong>LI-RADS CEUS Nonradiation TRA v2024 demonstrates fine inter-reader and inter-modality agreement, with outstanding diagnostic performance, supporting its potential for clinical application in assessing treatment response for ablated HCC.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Intensity Pulsed Ultrasound Activates Excitatory Synaptic Networks in Cultured Hippocampal Neurons.","authors":"Fenfang Li, Hao Jiang, Jiawei Lin, Chaofeng Qiao, George J Augustine","doi":"10.1016/j.ultrasmedbio.2025.04.011","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.011","url":null,"abstract":"<p><strong>Objective: </strong>Ultrasound can noninvasively penetrate deep into the brain for neuromodulation, demonstrating good potential for clinical application. However, the underlying mechanisms are unclear. So far most in vitro studies have focused on the activation of individual neurons by ultrasound with calcium imaging. As the focal region of ultrasound is typically millimeter or submillimeter size, it is important to investigate yet so far unclear how the mechanical effects of ultrasound would influence the synaptic circuit activity of neurons.</p><p><strong>Methods: </strong>Low-intensity pulse ultrasound was used to stimulate cultured hippocampal neurons. Postsynaptic currents were recorded in individual cells with the whole-cell patch-clamp technique. We also simultaneously imaged intracellular calcium, along with neuronal electrical signals, to resolve neuronal network dynamics during ultrasound stimulation.</p><p><strong>Results: </strong>Excitatory postsynaptic currents (EPSCs) were evoked by ultrasound in high-density neuronal cultures with increased frequency and amplitude, indicating enhanced glutamatergic synaptic transmission. The probability of evoking responses and the total charge of EPSCs increased with ultrasound intensity. Mechanistic analysis reveals that extracellular calcium influx, action potential firing and synaptic transmission are necessary for the responses to ultrasound in high-density culture. In contrast, EPSCs were not enhanced in low-density culture. Simultaneous calcium imaging of neuronal network activity indicates that recurrent excitatory network activity is recruited during ultrasound stimulation in high-density cultures, which lasts over tens to hundreds of seconds.</p><p><strong>Conclusion: </strong>Our study provides insights into the mechanisms involved in the response of the brain to ultrasound and illuminates the potential to use ultrasound to regulate synaptic function in neurological disorders.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Blood-Mimicking Fluids for Quantitative Flow Imaging with Ultrasound.","authors":"Lizbeth Ayala-Dominguez, Cristel Baiu, Laura Castaneda-Martinez, Raul Esquivel-Sirvent, Mehdi Zeighami Salimabad, Ivan M Rosado-Mendez","doi":"10.1016/j.ultrasmedbio.2025.04.012","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2025.04.012","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed at characterizing blood-mimicking fluids (BMFs), focusing on properties relevant to standardizing quantitative imaging biomarkers in vascular and microvascular ultrasound.</p><p><strong>Methods: </strong>Three BMF formulations (BMFs 1-3) were prepared following the International Electrotechnical Commission (IEC)-61685 standard, varying in dynamic viscosity and particle buoyancy. A novel figure of merit (FOM) assessed particle buoyancy over time. Density, dynamic viscosity, speed of sound, attenuation, and backscatter coefficient (BSC) were measured for unfiltered and filtered BMFs and compared to IEC-61685 reference values. BMFs were evaluated using power Doppler and contrast-enhanced ultrasound (CEUS) imaging in a calibrated custom-made microflow phantom at 5 and 20 mm/s, using contrast-to-noise ratio (CNR) as a performance metric.</p><p><strong>Results: </strong>The FOM accurately tracked particle distribution and enabled obtaining neutrally buoyant BMFs. Filtration significantly impacted BSC (p < 0.05) but did not affect other properties. BMF 2 matched all the IEC-61685 reference values (p > 0.05). BMF 1 exhibited the lowest dynamic viscosity, while BMF 3 had the highest BSC. BMF 2 yielded the highest CNR at 5 mm/s in both imaging modes. At 20 mm/s, BMF 3 yielded the highest CNR in power Doppler imaging, while all BMFs performed similarly in CEUS. BMF 2 provided similar CNRs across flow velocities in both imaging modes.</p><p><strong>Conclusion: </strong>A comprehensive methodology for BMF preparation and characterization was developed, which enabled identifying a formulation that aligned with the IEC-61685 standard. This methodology could establish a foundation for developing reproducible and well-characterized BMFs, facilitating the advance of quantitative flow imaging techniques with ultrasound.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}