Ultrasound in Medicine and Biology最新文献

{"title":"High-Frequency Ultrasound Detects Early Ischemia-Induced Neuroinflammation Following Peripheral Compressive Neuropathy","authors":"Szu-Han Chen ,&nbsp;De-Quan Chen ,&nbsp;Chih-Chung Huang ,&nbsp;Sheng-Che Lin ,&nbsp;Yuan-Yu Hsueh","doi":"10.1016/j.ultrasmedbio.2025.10.020","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.020","url":null,"abstract":"<div><h3>Objective</h3><div>Peripheral compressive neuropathy involves complex ischemic and inflammatory responses, yet early diagnostic tools remain limited. This study evaluated the utility of high-frequency ultrasound (HFUS) for detecting ischemia-induced neuroinflammation and microvascular alterations following sciatic nerve compression.</div></div><div><h3>Methods</h3><div>A chronic constriction injury (CCI) model was established in Sprague–Dawley rats. Intraneural perfusion and vascular density were assessed longitudinally using a 40 MHz HFUS imaging. Immunofluorescence and Western blotting were employed to quantify temporal expression of hypoxia (HIF-1α), inflammation (IL-1β, TNF-α), and angiogenic (VEGF, vWF) markers in sciatic nerve tissue across multiple timepoints post-injury.</div></div><div><h3>Results</h3><div>HFUS detected an immediate reduction in blood flow velocity and vessel density within 30 min of nerve compression. While velocity normalized by Day 7, structural vascular density remained reduced through Day 14. HIF-1α peaked within 2 h, returning to baseline by Day 14. IL-1β and TNF-α were upregulated by Day 1 and persisted for 2 wk. VEGF showed early upregulation peaking at Day 1, while vWF exhibited delayed, prolonged expression, peaking between Days 3–7. Axonal demyelination and Schwann cell remodeling were observed, with partial recovery noted at Day 14.</div></div><div><h3>Conclusion</h3><div>HFUS enables sensitive, non-invasive visualization of acute vascular and inflammatory responses to peripheral nerve compression. These results support its potential in early diagnosis and monitoring of compressive neuropathies, offering insights into the pathophysiological timeline of ischemia, neuroinflammation, and vascular remodeling.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 542-553"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0301-5629(26)00005-0","DOIUrl":"10.1016/S0301-5629(26)00005-0","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Page i"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Performance and Interobserver Consistency of Contrast-enhanced Ultrasound Thyroid Imaging Reporting and Data System for Assessing Thyroid Nodules: A Retrospective and Multicenter Study","authors":"Xin Ye ,&nbsp;Ya-Qing Zhang ,&nbsp;Long-Hui Zhang ,&nbsp;Xiao-Wang Bo ,&nbsp;Bo-Yang Zhou ,&nbsp;Xi Wang ,&nbsp;Li-Fang Wang ,&nbsp;Ben-Hua Xu ,&nbsp;Chong-Ke Zhao ,&nbsp;Hui-Xiong Xu","doi":"10.1016/j.ultrasmedbio.2025.11.666","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.666","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the diagnostic performance and inter-observer consistency of contrast-enhanced ultrasound (CEUS) Thyroid Imaging Reporting and Data System (TI-RADS) for the risk stratification of thyroid nodules.</div></div><div><h3>Methods</h3><div>This study retrospectively included consecutive patients with thyroid nodules who underwent non-enhanced US and CEUS examinations from three medical centers between January 2022 and August 2022. Four readers evaluated the US features of these thyroid nodules and classified them according to the American College of Radiology (ACR) TI-RADS and CEUS TI-RADS. The diagnostic performance of CEUS TI-RADS and the unnecessary fine needle aspiration biopsy rate were assessed and compared with ACR TI-RADS. Intra-class correlation coefficients were used for assessing the multi-reader consistency.</div></div><div><h3>Results</h3><div>A total of 483 patients (mean age, 46.8 ± 12.8 years; 354 females) with 515 pathology-proven thyroid nodules (315 malignant) were included. CEUS TI-RADS had better diagnostic accuracy (85.6%–88.5% vs. 77.5%–84.5%, <em>p</em>&lt;0.05) and specificity (68.0%–78.0% vs. 45.5%–62.5%, <em>p</em>&lt;0.05), while obtaining a similar sensitivity as ACR TI-RADS (95.2%–97.1% vs. 97.8%–98.4%, <em>p</em>&gt;0.05). The unnecessary biopsy rate of CEUS TI-RADS was lower than that of ACR TI-RADS (27.8% vs. 35.5%, <em>p</em>&lt;0.05) for 1 cm or larger nodules. Excellent inter-reader consistency was gained in the assessment of the CEUS TI-RADS categories (with an intra-class correlation coefficient of 0.896). Meanwhile, moderate to good inter-reader consistency was obtained in the assessment of the CEUS features (with intra-class correlation coefficients ranging from 0.500 to 0.846).</div></div><div><h3>Conclusion</h3><div>With satisfactory inter-reader consistency, the CEUS TI-RADS criteria significantly improved diagnostic performance and fine needle aspiration biopsy recommendations for thyroid nodules.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 702-713"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Contrast-Enhanced Ultrasound Features and Serum Biomarkers in an Online Tool Optimizes Noninvasive Hepatocellular Carcinoma Diagnosis","authors":"Feihang Wang ,&nbsp;Yanni Chen ,&nbsp;Yadan Xu ,&nbsp;Xi Wang ,&nbsp;Qingyue Xu ,&nbsp;Hansheng Xia ,&nbsp;Kai Yuan ,&nbsp;Yi Dong ,&nbsp;Lingxiao Liu ,&nbsp;Wenping Wang","doi":"10.1016/j.ultrasmedbio.2025.10.239","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.239","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the diagnostic efficacy of the contrast-enhanced ultrasound (CEUS) features combined with serum tumor biomarkers for the diagnosis of hepatocellular carcinoma (HCC).</div></div><div><h3>Methods</h3><div>This retrospective study included 1487 patients who underwent liver CEUS. The reference criteria included histopathological or comprehensive imaging and the clinical follow-up results. Clinical data, serum biomarkers and CEUS features were analyzed via logistic regression analysis to determine independent factors associated with HCC and a nomogram model was built. The diagnostic performance was evaluated in terms of sensitivity, specificity, accuracy, and area under the curve (AUC), and compared with different models.</div></div><div><h3>Results</h3><div>The final model involved sex, age, AFP, DCP, APHE, and late wash-out. The nomogram demonstrated superior diagnostic accuracy for HCC with AUC: 0.934, 95% CI: 0.917–0.950; sensitivity: 0.868, 95% CI: 0.842–0.891; specificity: 0.895, 95% CI: 0.858–0.925) in the training cohort, and with an AUC of 0.929 (95% CI: 0.901–0.957), sensitivity of 0.872 (95% CI: 0.823–0.912), and specificity of 0.890 (95% CI: 0.827–0.936) in the validation cohort. Furthermore, for lesions with a maximum diameter ≤20 mm, the nomogram maintained robust diagnostic accuracy in the training cohort (AUC 0.888, 95% CI: 0.836–0.941; sensitivity 0.804, 95% CI: 0.733–0.863; specificity 0.870, 95% CI: 0.737–0.951), and in the validation cohort (AUC: 0.877, 95% CI: 0.789–0.965; sensitivity: 0.768, 95% CI: 0.636–0.870; specificity: 0.885, 95% CI: 0.698–0.976).</div></div><div><h3>Conclusion</h3><div>CEUS features combined with the serum biomarkers accurately predicted the presence of HCC, achieving an optimal balance. With web-based and mobile calculators for easy use.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 554-563"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound Ablation for Soft Tissue Tumors in Challenging Anatomical Locations: Preliminary Study","authors":"Xiaoyin Guo ,&nbsp;Hui Zhu ,&nbsp;Wei Liu ,&nbsp;Lu Pan ,&nbsp;Bing Fu ,&nbsp;Zhenzhen Zhou ,&nbsp;Jun Zhang ,&nbsp;Kun Zhou","doi":"10.1016/j.ultrasmedbio.2025.11.005","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the feasibility, safety, and preliminary efficacy of high-intensity focused ultrasound (HIFU) ablation for treating soft tissue tumors (STTs) located in challenging anatomical regions (e.g. adjacent to critical nerves, blood vessels, joint areas, or recurrent tumors).</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis was conducted on 11 patients with locally unresectable recurrent STTs treated with under ultrasound-guided HIFU from January 2024 to December 2024. The cohort included recurrent desmoid tumors (3 cases) and other complex soft tissue sarcomas (8 cases), all histologically confirmed. Tumor locations encompassed intra-abdominal, abdominal wall, chest wall, extremities, scapular region, and pelvic region. Treatment efficacy was assessed via ablation volume, adverse events (graded by CTCAE v5.0), and imaging follow-up (contrast-enhanced MRI/CT).</div></div><div><h3>Results</h3><div>All patients underwent successful HIFU treatment, targeting 18 tumor lesions. The median non-perfusion volume ratio (NPVR) post-HIFU was 93.24%. At 3-month follow-up, 12 lesions exhibited significant shrinkage, while 6 remained stable. Mild adverse events included transient skin edema, mild pain, and orange-peel-like skin changes (case 3).</div></div><div><h3>Conclusion</h3><div>As a noninvasive modality, HIFU demonstrated favorable local control and safety in managing STTs in challenging locations. For surgically high risk or recurrent lesions, HIFU effectively controlled tumor progression and improved extremity function.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 602-607"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Assessment of Fluid Tolerance in Critically Ill Patients: Epidemiology of Systemic and Pulmonary Congestion","authors":"Peter Klompmaker ,&nbsp;Amne Mousa ,&nbsp;Dylan J. Allard ,&nbsp;Bram S.H. Hagen ,&nbsp;Tessa Bánki ,&nbsp;Judith van Zwol ,&nbsp;Krijna Opschoor ,&nbsp;Carolien A. den Otter ,&nbsp;Thomas P. Ootjers ,&nbsp;Alexander P.J. Vlaar ,&nbsp;Denise P. Veelo ,&nbsp;Pieter R. Tuinman","doi":"10.1016/j.ultrasmedbio.2025.11.003","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>By using lung ultrasound and Venous Excess Ultrasound Grading System (VExUS) to assess fluid tolerance, four congestion types can be identified: fluid tolerant (no congestion), pulmonary congestion, systemic congestion and both pulmonary and systemic congestion. The primary aim is to describe the epidemiology of these congestions types.</div></div><div><h3>Methods</h3><div>This is a pre-planned secondary analysis of a prospective observational cohort study. Fluid tolerance was defined as absence of congestion on ultrasound. Pulmonary congestion was defined as a bilateral B-profile. Systemic congestion was defined as VExUS ≥ 2, and pulmonary and systemic congestion were used when both were present. Primary outcome was the prevalence of congestion types. Secondary outcomes were associations between congestion types, associations with left (LVF) and right ventricular function (RVF) and cumulative fluid balance.</div></div><div><h3>Results</h3><div>A total of 87 (63%) of 138 patients were fluid tolerant, 36 (27%) had pulmonary congestion, 8 (6%) systemic congestion and 7 (5%) both pulmonary and systemic congestion. Between the first and second measurement 16 out of 87 (18%, 95% CI: 11%–28%) fluid tolerant patients developed pulmonary congestion and 8 out of 36 (22%, 95% CI: 11%–40%) patients with pulmonary congestion switched to fluid tolerance. No association was found between pulmonary and systemic congestion. A positive association was found for reduced LVF and pulmonary congestion (OR 2.1 [95% CI: 1.03–4.6]), and reduced RVF and systemic congestion OR 4.3 (95% CI: 1.5–15.6). No association between cumulative fluid balance and any type of congestion was found.</div></div><div><h3>Conclusion</h3><div>Most critically ill patients are fluid tolerant at admission. Pulmonary congestion is the most prevalent congestion type. Pulmonary and systemic congestion seldom occur simultaneously; therefore, both need to be assessed.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 596-601"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing CEUS-LI-RADS Through Mechanistic and Translational Lenses: Reflections on Machine Learning–Augmented Diagnosis of Hepatocellular Carcinoma","authors":"Nav La ,&nbsp;Schawanya K. Rattanapitoon ,&nbsp;Chutharat Thanchonnang ,&nbsp;Nathkapach K. Rattanapitoon","doi":"10.1016/j.ultrasmedbio.2025.11.664","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.664","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Page 725"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Role of Point-of-Care Ultrasound in Central Venous Pressure Monitoring for Critically Ill Patients. A Comprehensive Systematic Review and Meta-analysis","authors":"Eman E. Shaban ,&nbsp;Yavuz Yigit ,&nbsp;Benny Ponappan ,&nbsp;Ahmed Shaban ,&nbsp;Amira Shaban ,&nbsp;Mohamed Helmi Ahmed ,&nbsp;Yasser Osman Abdelaal ,&nbsp;Hany A. Zaki","doi":"10.1016/j.ultrasmedbio.2025.04.008","DOIUrl":"10.1016/j.ultrasmedbio.2025.04.008","url":null,"abstract":"<div><div>Central venous pressure (CVP) is a critical parameter for assessing volume status in critically ill patients, traditionally measured through invasive central venous catheterization. While effective, this method poses risks such as infection and procedural complications. Point-of-care ultrasound (POCUS) has emerged as a promising, non-invasive alternative, yet its accuracy in estimating CVP remains debated.</div><div>From inception to December 2024, PubMed, Embase, MEDLINE, Web of Science, and Google Scholar databases were extensively searched. The search strategy used to identify relevant studies from these databases involved combining keywords such as “Point-of-care ultrasound,” “central venous pressure,” and “critically ill” with Boolean expression “AND” and “OR.” Two independent reviewers then screened all potential studies and included those reporting the accuracy of POCUS in predicting CVP and those reporting the correlation between POCUS-measured indices and invasively-measured CVP in critically ill patients. Additionally, two independent reviewers extracted the relevant data from the included studies. Statistical analyses were conducted using MedCalc and Meta-Disc software, and quality appraisal was assessed using the QUADAS-2 tool.</div><div>The review included studies evaluating POCUS-derived indices from the inferior vena cava (IVC) and internal jugular vein (IJV). Overall, strong correlations were observed between POCUS measurements and CVP, with IVC parameters showing the strongest associations. IJV measurements also demonstrated moderate reliability, particularly in scenarios where IVC assessments were impractical. Sensitivity and specificity analyses indicated that POCUS-derived indices could predict CVP with variable accuracy.</div><div>These findings support the use of POCUS as a practical, non-invasive tool for estimating CVP in critically ill patients. IVC measurements appear to provide the most reliable correlations, while IJV assessments serve as a useful alternative. Despite its potential, variability in study methodologies and patient factors highlights the need for further research to refine POCUS-based CVP estimation and improve clinical application.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 473-484"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acoustic Activation Imaging of Intravenous Perfluoropropane Droplets To Detect Risk Area and Ultimate Infarct Size in a Large Animal Model of Ischemia/Reperfusion","authors":"Shouqiang Li ,&nbsp;Cheng Chen ,&nbsp;John Lof ,&nbsp;Elizabeth A. Stolze ,&nbsp;Jiri Sklenar ,&nbsp;Xucai Chen ,&nbsp;John J. Pacella ,&nbsp;Flordeliza S. Villanueva ,&nbsp;Terry O. Matsunaga ,&nbsp;E. Carr Everbach ,&nbsp;Stanley F.J. Radio ,&nbsp;Sruti Shiva ,&nbsp;Chad Hovseth ,&nbsp;Feng Xie ,&nbsp;Xiaoping Leng ,&nbsp;Thomas R. Porter","doi":"10.1016/j.ultrasmedbio.2025.10.016","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.016","url":null,"abstract":"<div><h3>Objective</h3><div>Acoustically activatable perfluoropropane droplets (PD) have been utilized to enhance the reperfused zone in acute myocardial infarction small animal models. Despite the correlation with infarct size, the enhanced area consistently overestimates infarct size. We hypothesized that the enhanced area correlates with risk area, and that hypo-enhanced areas (HEA) within the enhanced zone represent the ultimate infarct size.</div></div><div><h3>Methods</h3><div>Intravenous PD was administered in the reperfusion period following a 90 min period of ischemia in 30 pigs. Injections were given at either 30 min, 1 d or 7 d following reperfusion to determine what the enhanced regions within the reperfused zone following acoustic activation (AA) were detecting. Correlations of the enhanced and unenhanced regions with the infarct size using delayed enhancement magnetic resonance imaging (DE-MRI) were determined.</div></div><div><h3>Results</h3><div>AA within the reperfused zone was evident in 26 pigs (9/10 pigs injected at 30 min post-reperfusion, 9/10 pigs injected at 1 d and 8/10 pigs injected at 7 d). In the 26 pigs with AA, the extent of enhancement was significantly larger than the infarct size by DE-MRI, and correlated more closely with risk area (<em>r</em> = 0.55, <em>p</em> = 0.0002). A HEA within the enhanced region was observed in 21 of the 26 pigs with AA, and the spatial extent of HEA correlated with infarct size (<em>r</em> = 0.85; <em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>AA of intravenous PD enhances the risk area following reperfusion. However, it is the extent of hypo-enhancement within the enhanced region that predicts infarct size irrespective of the time AA is performed following reperfusion.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 531-541"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145847066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state Functional Ultrasound Imaging of Cerebral Blood Flow and Functional Connectivity Changes in Hibernating Mice","authors":"Yanjun Zhang ,&nbsp;Yijun Zhou ,&nbsp;Yang Liu ,&nbsp;Yongchao Wang ,&nbsp;Lihai Fan ,&nbsp;Kun Song ,&nbsp;Jianbo Tang","doi":"10.1016/j.ultrasmedbio.2025.11.660","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.660","url":null,"abstract":"<div><div>Hibernation can significantly reduce energy consumption and prolong survival by decreasing the metabolic rate and body temperature. Understanding the brain regulatory mechanisms may help overcome challenges in applying hibernation techniques to humans. In this study, we induced hibernation-like state in mice using pharmacological agents and monitored the process within the brain using resting-state functional ultrasound imaging. During hibernation and recovery, we measured various physiological parameters, including heart rate, body temperature, and cerebral blood volume. Additionally, we observed cerebral hemodynamic metrics and brain functional connectivity (FC) patterns. The results revealed significant reductions in heart rate, body temperature, and cerebral blood volume during this state. Notably, cerebral blood flow (CBF) decreased by about 50% on average, with the thalamus showing a more pronounced and delayed decline compared to other examined regions, accompanied by corresponding alterations in FC. A strong correlation (<em>r</em> = 0.82) was observed between changes in CBF and brain FC. This study provides insights into the unique regulation of CBF during hibernation, offering a deeper understanding of the brain regulation in this process.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 665-672"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}