Ultrasound in Medicine and Biology最新文献

{"title":"A Clinical Perspective and Review on the Use of the Subharmonic Signal of Ultrasound Contrast Agents for Noninvasive Pressure Estimation.","authors":"Gautam Babu, Lance De Koninck, Samuel G Rayner, Nico de Jong, Robb W Glenny, Michalakis A Averkiou","doi":"10.1016/j.ultrasmedbio.2026.03.027","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2026.03.027","url":null,"abstract":"<p><p>Changes in physiological pressures play a key role in the development and progression of human disease processes. Thus, the assessment of pressures within blood vessels and other bodily compartment is crucial in the diagnosis and management of multiple medical conditions. Presently, techniques for pressure measurement are invasive or have limited accuracy and scope of assessment. Utilizing the subharmonic signal of ultrasound contrast agents offers a promising solution that could address these limitations. After the initial development of this technology in the late nineties, further investigation has brought subharmonic pressure estimation from in vitro exploration to attempts at clinical implementation. However, lack of availability of subharmonic imaging on most clinical scanners, and variability of subharmonic response with different contrast agents have impeded clinical acceptance and widespread use of this modality. This review examines subharmonic imaging and the use of ultrasound contrast agents for estimating physiological pressures, particularly in the heart and portal venous system. A focus is placed on clinically relevant physiologic pressures and their existing measurement approaches, the physics of subharmonic signal generation, in vitro studies demonstrating key findings, and more recent clinical trials. The review also highlights present limitations and future research directions that may help advance clinical translation.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility of combining focused ultrasound and copper-cystine biohybrid for diabetic wound healing.","authors":"Anik Karan, Abhirup Samaddar, Prakash Adhikari, Madhumitra Subramanian Karthikesh, Mark A DeCoster, Xinmai Yang","doi":"10.1016/j.ultrasmedbio.2026.03.018","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2026.03.018","url":null,"abstract":"<p><strong>Objective: </strong>Chronic wound healing, particularly in diabetic wounds, remains challenging due to the lack of effective therapeutic procedures. Pharmacological treatments are often limited by physical side effects, while surgical procedures carry a risk of site infections. This study aimed to provide an overall complete therapeutic regimen for faster diabetic wound healing through focused ultrasound (FUS) in conjunction with localized copper-cystine biohybrids.</p><p><strong>Methods: </strong>In the current study, we investigated the feasibility of combining FUS performed at 1 MPa, 2500 cycles, 10% duty cycle, 20 Hz pulse repetition frequency and 15-min treatment durations every alternate day over 14 d with localized copper-cystine biohybrid (copper high aspect ratio structures [CuHARS]) treatment, which is a metal-organic biohybrid capable of promoting angiogenesis and exerting a bactericidal effect on wound healing. Therapeutic efficacy was evaluated in diabetic mice with surgically induced dermal wounds using three treatment groups: combined CuHARS-FUS, CuHARS-only and FUS-only over 7- and 14-d periods.</p><p><strong>Results: </strong>The results showed that CuHARS-FUS treatment for 14 ds achieved complete wound closure, whereas the CuHARS-only, FUS-only and control groups exhibited partial or no healing.</p><p><strong>Conclusion: </strong>The synergistic treatment of CuHARS-FUS supports rapid macrovascular structure formation and proper cellular differentiation, leading to granulation tissue formation by providing a controlled mechanism for tissue remodeling during the entire healing phase of diabetic wound healing, starting from an enhanced angiogenic activity and bactericidal effect via the CuHARS through Cu²⁺ ions-based catalytic decomposition of S-nitrosothiols to nitric oxide and the continuation of endothelial activity through enhanced nitric oxide production due to FUS treatment.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematized Review of Quantitative Ultrasound Techniques for Brain Tissue Characterization.","authors":"Laura Castaneda-Martinez, Chrysanthy Ikonomidou, Ivan M Rosado-Mendez","doi":"10.1016/j.ultrasmedbio.2026.03.017","DOIUrl":"https://doi.org/10.1016/j.ultrasmedbio.2026.03.017","url":null,"abstract":"<p><p>Since 1968, acoustic characterization has been used to assess brain tissue properties. This modality has provided critical insights into microstructural characteristics that have not yet been widely translated into clinical practice. This systematized literature review synthesizes advancements in quantitative ultrasound (QUS) techniques for brain tissue characterization, focusing on their potential and current limitations as neuroimaging tools. A comprehensive search of PubMed, Scopus and digital libraries identified 115 publications; after applying the inclusion criteria, 35 were analyzed. The studies were categorized by QUS feature: speed of sound, attenuation, backscatter and speckle statistics, and by experimental model (phantoms, preclinical, human ex vivo and in vivo). Attenuation was the most frequently investigated feature (40% of the total dataset), followed by speed of sound, backscatter and speckle statistics. For the 4 QUS features, most studies were conducted in preclinical settings, highlighting the limited clinical translation of QUS for the brain. Beyond summarizing current evidence, this review examines the methodological and practical barriers to reproducibility, including variability in acquisition protocols, system-dependent signal processing and beamformer assumptions, the lack of reference standards and the absence of calibration frameworks. It also identifies future research opportunities, such as developing traceable phantoms, establishing open repositories of reference phantoms and clinical data and coordinating efforts among research, clinicians, industry and regulatory agencies. This review contextualizes the potential and significance of QUS in brain characterization and outlines the steps needed to establish it as a reliable, quantitative and clinically meaningful neuroimaging modality.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13127805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147787260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Frequency Ultrasound Detects Early Ischemia-Induced Neuroinflammation Following Peripheral Compressive Neuropathy","authors":"Szu-Han Chen ,&nbsp;De-Quan Chen ,&nbsp;Chih-Chung Huang ,&nbsp;Sheng-Che Lin ,&nbsp;Yuan-Yu Hsueh","doi":"10.1016/j.ultrasmedbio.2025.10.020","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.020","url":null,"abstract":"<div><h3>Objective</h3><div>Peripheral compressive neuropathy involves complex ischemic and inflammatory responses, yet early diagnostic tools remain limited. This study evaluated the utility of high-frequency ultrasound (HFUS) for detecting ischemia-induced neuroinflammation and microvascular alterations following sciatic nerve compression.</div></div><div><h3>Methods</h3><div>A chronic constriction injury (CCI) model was established in Sprague–Dawley rats. Intraneural perfusion and vascular density were assessed longitudinally using a 40 MHz HFUS imaging. Immunofluorescence and Western blotting were employed to quantify temporal expression of hypoxia (HIF-1α), inflammation (IL-1β, TNF-α), and angiogenic (VEGF, vWF) markers in sciatic nerve tissue across multiple timepoints post-injury.</div></div><div><h3>Results</h3><div>HFUS detected an immediate reduction in blood flow velocity and vessel density within 30 min of nerve compression. While velocity normalized by Day 7, structural vascular density remained reduced through Day 14. HIF-1α peaked within 2 h, returning to baseline by Day 14. IL-1β and TNF-α were upregulated by Day 1 and persisted for 2 wk. VEGF showed early upregulation peaking at Day 1, while vWF exhibited delayed, prolonged expression, peaking between Days 3–7. Axonal demyelination and Schwann cell remodeling were observed, with partial recovery noted at Day 14.</div></div><div><h3>Conclusion</h3><div>HFUS enables sensitive, non-invasive visualization of acute vascular and inflammatory responses to peripheral nerve compression. These results support its potential in early diagnosis and monitoring of compressive neuropathies, offering insights into the pathophysiological timeline of ischemia, neuroinflammation, and vascular remodeling.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 542-553"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0301-5629(26)00005-0","DOIUrl":"10.1016/S0301-5629(26)00005-0","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Page i"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diagnostic Performance and Interobserver Consistency of Contrast-enhanced Ultrasound Thyroid Imaging Reporting and Data System for Assessing Thyroid Nodules: A Retrospective and Multicenter Study","authors":"Xin Ye ,&nbsp;Ya-Qing Zhang ,&nbsp;Long-Hui Zhang ,&nbsp;Xiao-Wang Bo ,&nbsp;Bo-Yang Zhou ,&nbsp;Xi Wang ,&nbsp;Li-Fang Wang ,&nbsp;Ben-Hua Xu ,&nbsp;Chong-Ke Zhao ,&nbsp;Hui-Xiong Xu","doi":"10.1016/j.ultrasmedbio.2025.11.666","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.666","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the diagnostic performance and inter-observer consistency of contrast-enhanced ultrasound (CEUS) Thyroid Imaging Reporting and Data System (TI-RADS) for the risk stratification of thyroid nodules.</div></div><div><h3>Methods</h3><div>This study retrospectively included consecutive patients with thyroid nodules who underwent non-enhanced US and CEUS examinations from three medical centers between January 2022 and August 2022. Four readers evaluated the US features of these thyroid nodules and classified them according to the American College of Radiology (ACR) TI-RADS and CEUS TI-RADS. The diagnostic performance of CEUS TI-RADS and the unnecessary fine needle aspiration biopsy rate were assessed and compared with ACR TI-RADS. Intra-class correlation coefficients were used for assessing the multi-reader consistency.</div></div><div><h3>Results</h3><div>A total of 483 patients (mean age, 46.8 ± 12.8 years; 354 females) with 515 pathology-proven thyroid nodules (315 malignant) were included. CEUS TI-RADS had better diagnostic accuracy (85.6%–88.5% vs. 77.5%–84.5%, <em>p</em>&lt;0.05) and specificity (68.0%–78.0% vs. 45.5%–62.5%, <em>p</em>&lt;0.05), while obtaining a similar sensitivity as ACR TI-RADS (95.2%–97.1% vs. 97.8%–98.4%, <em>p</em>&gt;0.05). The unnecessary biopsy rate of CEUS TI-RADS was lower than that of ACR TI-RADS (27.8% vs. 35.5%, <em>p</em>&lt;0.05) for 1 cm or larger nodules. Excellent inter-reader consistency was gained in the assessment of the CEUS TI-RADS categories (with an intra-class correlation coefficient of 0.896). Meanwhile, moderate to good inter-reader consistency was obtained in the assessment of the CEUS features (with intra-class correlation coefficients ranging from 0.500 to 0.846).</div></div><div><h3>Conclusion</h3><div>With satisfactory inter-reader consistency, the CEUS TI-RADS criteria significantly improved diagnostic performance and fine needle aspiration biopsy recommendations for thyroid nodules.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 702-713"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Contrast-Enhanced Ultrasound Features and Serum Biomarkers in an Online Tool Optimizes Noninvasive Hepatocellular Carcinoma Diagnosis","authors":"Feihang Wang ,&nbsp;Yanni Chen ,&nbsp;Yadan Xu ,&nbsp;Xi Wang ,&nbsp;Qingyue Xu ,&nbsp;Hansheng Xia ,&nbsp;Kai Yuan ,&nbsp;Yi Dong ,&nbsp;Lingxiao Liu ,&nbsp;Wenping Wang","doi":"10.1016/j.ultrasmedbio.2025.10.239","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.239","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the diagnostic efficacy of the contrast-enhanced ultrasound (CEUS) features combined with serum tumor biomarkers for the diagnosis of hepatocellular carcinoma (HCC).</div></div><div><h3>Methods</h3><div>This retrospective study included 1487 patients who underwent liver CEUS. The reference criteria included histopathological or comprehensive imaging and the clinical follow-up results. Clinical data, serum biomarkers and CEUS features were analyzed via logistic regression analysis to determine independent factors associated with HCC and a nomogram model was built. The diagnostic performance was evaluated in terms of sensitivity, specificity, accuracy, and area under the curve (AUC), and compared with different models.</div></div><div><h3>Results</h3><div>The final model involved sex, age, AFP, DCP, APHE, and late wash-out. The nomogram demonstrated superior diagnostic accuracy for HCC with AUC: 0.934, 95% CI: 0.917–0.950; sensitivity: 0.868, 95% CI: 0.842–0.891; specificity: 0.895, 95% CI: 0.858–0.925) in the training cohort, and with an AUC of 0.929 (95% CI: 0.901–0.957), sensitivity of 0.872 (95% CI: 0.823–0.912), and specificity of 0.890 (95% CI: 0.827–0.936) in the validation cohort. Furthermore, for lesions with a maximum diameter ≤20 mm, the nomogram maintained robust diagnostic accuracy in the training cohort (AUC 0.888, 95% CI: 0.836–0.941; sensitivity 0.804, 95% CI: 0.733–0.863; specificity 0.870, 95% CI: 0.737–0.951), and in the validation cohort (AUC: 0.877, 95% CI: 0.789–0.965; sensitivity: 0.768, 95% CI: 0.636–0.870; specificity: 0.885, 95% CI: 0.698–0.976).</div></div><div><h3>Conclusion</h3><div>CEUS features combined with the serum biomarkers accurately predicted the presence of HCC, achieving an optimal balance. With web-based and mobile calculators for easy use.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 554-563"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound Ablation for Soft Tissue Tumors in Challenging Anatomical Locations: Preliminary Study","authors":"Xiaoyin Guo ,&nbsp;Hui Zhu ,&nbsp;Wei Liu ,&nbsp;Lu Pan ,&nbsp;Bing Fu ,&nbsp;Zhenzhen Zhou ,&nbsp;Jun Zhang ,&nbsp;Kun Zhou","doi":"10.1016/j.ultrasmedbio.2025.11.005","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the feasibility, safety, and preliminary efficacy of high-intensity focused ultrasound (HIFU) ablation for treating soft tissue tumors (STTs) located in challenging anatomical regions (e.g. adjacent to critical nerves, blood vessels, joint areas, or recurrent tumors).</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis was conducted on 11 patients with locally unresectable recurrent STTs treated with under ultrasound-guided HIFU from January 2024 to December 2024. The cohort included recurrent desmoid tumors (3 cases) and other complex soft tissue sarcomas (8 cases), all histologically confirmed. Tumor locations encompassed intra-abdominal, abdominal wall, chest wall, extremities, scapular region, and pelvic region. Treatment efficacy was assessed via ablation volume, adverse events (graded by CTCAE v5.0), and imaging follow-up (contrast-enhanced MRI/CT).</div></div><div><h3>Results</h3><div>All patients underwent successful HIFU treatment, targeting 18 tumor lesions. The median non-perfusion volume ratio (NPVR) post-HIFU was 93.24%. At 3-month follow-up, 12 lesions exhibited significant shrinkage, while 6 remained stable. Mild adverse events included transient skin edema, mild pain, and orange-peel-like skin changes (case 3).</div></div><div><h3>Conclusion</h3><div>As a noninvasive modality, HIFU demonstrated favorable local control and safety in managing STTs in challenging locations. For surgically high risk or recurrent lesions, HIFU effectively controlled tumor progression and improved extremity function.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 602-607"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Assessment of Fluid Tolerance in Critically Ill Patients: Epidemiology of Systemic and Pulmonary Congestion","authors":"Peter Klompmaker ,&nbsp;Amne Mousa ,&nbsp;Dylan J. Allard ,&nbsp;Bram S.H. Hagen ,&nbsp;Tessa Bánki ,&nbsp;Judith van Zwol ,&nbsp;Krijna Opschoor ,&nbsp;Carolien A. den Otter ,&nbsp;Thomas P. Ootjers ,&nbsp;Alexander P.J. Vlaar ,&nbsp;Denise P. Veelo ,&nbsp;Pieter R. Tuinman","doi":"10.1016/j.ultrasmedbio.2025.11.003","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>By using lung ultrasound and Venous Excess Ultrasound Grading System (VExUS) to assess fluid tolerance, four congestion types can be identified: fluid tolerant (no congestion), pulmonary congestion, systemic congestion and both pulmonary and systemic congestion. The primary aim is to describe the epidemiology of these congestions types.</div></div><div><h3>Methods</h3><div>This is a pre-planned secondary analysis of a prospective observational cohort study. Fluid tolerance was defined as absence of congestion on ultrasound. Pulmonary congestion was defined as a bilateral B-profile. Systemic congestion was defined as VExUS ≥ 2, and pulmonary and systemic congestion were used when both were present. Primary outcome was the prevalence of congestion types. Secondary outcomes were associations between congestion types, associations with left (LVF) and right ventricular function (RVF) and cumulative fluid balance.</div></div><div><h3>Results</h3><div>A total of 87 (63%) of 138 patients were fluid tolerant, 36 (27%) had pulmonary congestion, 8 (6%) systemic congestion and 7 (5%) both pulmonary and systemic congestion. Between the first and second measurement 16 out of 87 (18%, 95% CI: 11%–28%) fluid tolerant patients developed pulmonary congestion and 8 out of 36 (22%, 95% CI: 11%–40%) patients with pulmonary congestion switched to fluid tolerance. No association was found between pulmonary and systemic congestion. A positive association was found for reduced LVF and pulmonary congestion (OR 2.1 [95% CI: 1.03–4.6]), and reduced RVF and systemic congestion OR 4.3 (95% CI: 1.5–15.6). No association between cumulative fluid balance and any type of congestion was found.</div></div><div><h3>Conclusion</h3><div>Most critically ill patients are fluid tolerant at admission. Pulmonary congestion is the most prevalent congestion type. Pulmonary and systemic congestion seldom occur simultaneously; therefore, both need to be assessed.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 596-601"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing CEUS-LI-RADS Through Mechanistic and Translational Lenses: Reflections on Machine Learning–Augmented Diagnosis of Hepatocellular Carcinoma","authors":"Nav La ,&nbsp;Schawanya K. Rattanapitoon ,&nbsp;Chutharat Thanchonnang ,&nbsp;Nathkapach K. Rattanapitoon","doi":"10.1016/j.ultrasmedbio.2025.11.664","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.664","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Page 725"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}