Roberto Cannella, Francesco Matteini, Domenico Salvatore Gagliano, Mariasole Mazzola, Francesco Agnello, Maurizio Soresi, Salvatore Petta, Tommaso Vincenzo Bartolotta
{"title":"以MRI脂肪分数为参考标准的超声肝脂肪定量评价肝脂肪变性的性能。","authors":"Roberto Cannella, Francesco Matteini, Domenico Salvatore Gagliano, Mariasole Mazzola, Francesco Agnello, Maurizio Soresi, Salvatore Petta, Tommaso Vincenzo Bartolotta","doi":"10.1016/j.ultrasmedbio.2025.05.020","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance and reproducibility of ultrasound-based liver fat quantification (LFQ) for the assessment of hepatic steatosis.</p><p><strong>Methods: </strong>This prospective study included adult patients who underwent quantification of hepatic steatosis with ultrasound and magnetic resonance imaging (MRI) on the same day. Ultrasounds were acquired with LFQ to measure attenuation of the liver parenchyma, hepatorenal index and 2-D shear-wave elastography, based on the median of 10 measurements taken by two operators. The reference standard was based on fat fraction quantification obtained using the mDixonQuant sequence on a 3T-MRI. Areas under the receiver operator curve and optimal cutoffs with the Youden index were calculated. Inter- and intra-observer reliability was assessed using the intra-class correlation coefficient.</p><p><strong>Results: </strong>A total of 152 patients (77 males, median age 64.0 years) were enrolled. On MRI, 39 (25.7%), 11 (7.2%) and 10 (6.6%) patients had grade 1, 2 and 3 steatosis, respectively. The median LFQ was 0.58 dB/cm/MHz, with a 100% success rate. Intra- and inter-operator reliability was good, with an intra-class correlation coefficient of 0.88 and 0.85, respectively. The areas under the receiver operator curve of LFQ were 0.919 (cutoff >0.60, sensitivity 80.3%, specificity 92.4%) for grade ≥1 steatosis, 0.970 (cutoff >0.64, sensitivity 95.2%, specificity 85.5%) for grade ≥2 steatosis and 0.974 (cutoff >0.69, sensitivity 100%, specificity 93.7%) for grade 3 steatosis. For all steatosis grades, LFQ performance was significantly higher than the hepatorenal index.</p><p><strong>Conclusion: </strong>Ultrasound-based LFQ provides excellent performance for the diagnosis of hepatic steatosis with high reproducibility.</p>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Performance of Ultrasound Liver Fat Quantification for the Assessment of Hepatic Steatosis Using MRI Fat Fraction as a Reference Standard.\",\"authors\":\"Roberto Cannella, Francesco Matteini, Domenico Salvatore Gagliano, Mariasole Mazzola, Francesco Agnello, Maurizio Soresi, Salvatore Petta, Tommaso Vincenzo Bartolotta\",\"doi\":\"10.1016/j.ultrasmedbio.2025.05.020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the performance and reproducibility of ultrasound-based liver fat quantification (LFQ) for the assessment of hepatic steatosis.</p><p><strong>Methods: </strong>This prospective study included adult patients who underwent quantification of hepatic steatosis with ultrasound and magnetic resonance imaging (MRI) on the same day. Ultrasounds were acquired with LFQ to measure attenuation of the liver parenchyma, hepatorenal index and 2-D shear-wave elastography, based on the median of 10 measurements taken by two operators. The reference standard was based on fat fraction quantification obtained using the mDixonQuant sequence on a 3T-MRI. Areas under the receiver operator curve and optimal cutoffs with the Youden index were calculated. Inter- and intra-observer reliability was assessed using the intra-class correlation coefficient.</p><p><strong>Results: </strong>A total of 152 patients (77 males, median age 64.0 years) were enrolled. On MRI, 39 (25.7%), 11 (7.2%) and 10 (6.6%) patients had grade 1, 2 and 3 steatosis, respectively. The median LFQ was 0.58 dB/cm/MHz, with a 100% success rate. Intra- and inter-operator reliability was good, with an intra-class correlation coefficient of 0.88 and 0.85, respectively. The areas under the receiver operator curve of LFQ were 0.919 (cutoff >0.60, sensitivity 80.3%, specificity 92.4%) for grade ≥1 steatosis, 0.970 (cutoff >0.64, sensitivity 95.2%, specificity 85.5%) for grade ≥2 steatosis and 0.974 (cutoff >0.69, sensitivity 100%, specificity 93.7%) for grade 3 steatosis. For all steatosis grades, LFQ performance was significantly higher than the hepatorenal index.</p><p><strong>Conclusion: </strong>Ultrasound-based LFQ provides excellent performance for the diagnosis of hepatic steatosis with high reproducibility.</p>\",\"PeriodicalId\":49399,\"journal\":{\"name\":\"Ultrasound in Medicine and Biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ultrasound in Medicine and Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ultrasmedbio.2025.05.020\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ACOUSTICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ultrasound in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ultrasmedbio.2025.05.020","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ACOUSTICS","Score":null,"Total":0}
Performance of Ultrasound Liver Fat Quantification for the Assessment of Hepatic Steatosis Using MRI Fat Fraction as a Reference Standard.
Objective: To evaluate the performance and reproducibility of ultrasound-based liver fat quantification (LFQ) for the assessment of hepatic steatosis.
Methods: This prospective study included adult patients who underwent quantification of hepatic steatosis with ultrasound and magnetic resonance imaging (MRI) on the same day. Ultrasounds were acquired with LFQ to measure attenuation of the liver parenchyma, hepatorenal index and 2-D shear-wave elastography, based on the median of 10 measurements taken by two operators. The reference standard was based on fat fraction quantification obtained using the mDixonQuant sequence on a 3T-MRI. Areas under the receiver operator curve and optimal cutoffs with the Youden index were calculated. Inter- and intra-observer reliability was assessed using the intra-class correlation coefficient.
Results: A total of 152 patients (77 males, median age 64.0 years) were enrolled. On MRI, 39 (25.7%), 11 (7.2%) and 10 (6.6%) patients had grade 1, 2 and 3 steatosis, respectively. The median LFQ was 0.58 dB/cm/MHz, with a 100% success rate. Intra- and inter-operator reliability was good, with an intra-class correlation coefficient of 0.88 and 0.85, respectively. The areas under the receiver operator curve of LFQ were 0.919 (cutoff >0.60, sensitivity 80.3%, specificity 92.4%) for grade ≥1 steatosis, 0.970 (cutoff >0.64, sensitivity 95.2%, specificity 85.5%) for grade ≥2 steatosis and 0.974 (cutoff >0.69, sensitivity 100%, specificity 93.7%) for grade 3 steatosis. For all steatosis grades, LFQ performance was significantly higher than the hepatorenal index.
Conclusion: Ultrasound-based LFQ provides excellent performance for the diagnosis of hepatic steatosis with high reproducibility.
期刊介绍:
Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.