以MRI脂肪分数为参考标准的超声肝脂肪定量评价肝脂肪变性的性能。

IF 2.4 3区 医学 Q2 ACOUSTICS
Roberto Cannella, Francesco Matteini, Domenico Salvatore Gagliano, Mariasole Mazzola, Francesco Agnello, Maurizio Soresi, Salvatore Petta, Tommaso Vincenzo Bartolotta
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引用次数: 0

摘要

目的:评价超声肝脂肪定量(LFQ)评价肝脂肪变性的性能和可重复性。方法:本前瞻性研究纳入了当天通过超声和磁共振成像(MRI)量化肝脂肪变性的成年患者。基于两名操作员进行的10次测量的中位数,使用LFQ获取超声以测量肝实质的衰减,肝肾指数和二维剪切波弹性成像。参考标准是基于在3T-MRI上使用mDixonQuant序列获得的脂肪分数定量。用约登指数计算了接收算子曲线下的面积和最佳截止点。使用类内相关系数评估观察者之间和观察者内部的信度。结果:共纳入152例患者(男性77例,中位年龄64.0岁)。MRI上分别有39例(25.7%)、11例(7.2%)和10例(6.6%)为1级、2级和3级脂肪变性。中位LFQ为0.58 dB/cm/MHz,成功率为100%。操作者内部和操作者之间的信度良好,类内相关系数分别为0.88和0.85。≥1级脂肪变性患者的LFQ曲线下面积为0.919(截断>0.60,敏感性80.3%,特异性92.4%),≥2级脂肪变性患者的LFQ曲线下面积为0.970(截断>0.64,敏感性95.2%,特异性85.5%),3级脂肪变性患者的LFQ曲线下面积为0.974(截断>0.69,敏感性100%,特异性93.7%)。对于所有脂肪变性等级,LFQ性能显著高于肝肾指数。结论:超声LFQ诊断肝脂肪变性具有良好的诊断效果,重复性高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Performance of Ultrasound Liver Fat Quantification for the Assessment of Hepatic Steatosis Using MRI Fat Fraction as a Reference Standard.

Objective: To evaluate the performance and reproducibility of ultrasound-based liver fat quantification (LFQ) for the assessment of hepatic steatosis.

Methods: This prospective study included adult patients who underwent quantification of hepatic steatosis with ultrasound and magnetic resonance imaging (MRI) on the same day. Ultrasounds were acquired with LFQ to measure attenuation of the liver parenchyma, hepatorenal index and 2-D shear-wave elastography, based on the median of 10 measurements taken by two operators. The reference standard was based on fat fraction quantification obtained using the mDixonQuant sequence on a 3T-MRI. Areas under the receiver operator curve and optimal cutoffs with the Youden index were calculated. Inter- and intra-observer reliability was assessed using the intra-class correlation coefficient.

Results: A total of 152 patients (77 males, median age 64.0 years) were enrolled. On MRI, 39 (25.7%), 11 (7.2%) and 10 (6.6%) patients had grade 1, 2 and 3 steatosis, respectively. The median LFQ was 0.58 dB/cm/MHz, with a 100% success rate. Intra- and inter-operator reliability was good, with an intra-class correlation coefficient of 0.88 and 0.85, respectively. The areas under the receiver operator curve of LFQ were 0.919 (cutoff >0.60, sensitivity 80.3%, specificity 92.4%) for grade ≥1 steatosis, 0.970 (cutoff >0.64, sensitivity 95.2%, specificity 85.5%) for grade ≥2 steatosis and 0.974 (cutoff >0.69, sensitivity 100%, specificity 93.7%) for grade 3 steatosis. For all steatosis grades, LFQ performance was significantly higher than the hepatorenal index.

Conclusion: Ultrasound-based LFQ provides excellent performance for the diagnosis of hepatic steatosis with high reproducibility.

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来源期刊
CiteScore
6.20
自引率
6.90%
发文量
325
审稿时长
70 days
期刊介绍: Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.
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