Ultrasound in Medicine and Biology最新文献

{"title":"Response to Comments by Montero on “Evaluating the Role of Point-of-Care Ultrasound in Central Venous Pressure Monitoring for Critically Ill Patients: A Comprehensive Systematic Review and Meta-analysis”","authors":"Eman E. Shaban , Yavuz Yigit , Benny Ponappan , Ahmed Shaban , Amira Shaban , Mohamed Helmi Ahmed , Yasser Osman Abdelaal , Hany A. Zaki","doi":"10.1016/j.ultrasmedbio.2025.11.010","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.010","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 723-724"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Exploration of Discriminative Correlation Filter Network for Real-time Tracking of Inconspicuous Focal Liver Lesions on Conventional Ultrasound","authors":"Jing Yang ,&nbsp;Erjiao Xu ,&nbsp;Shanshan Wu ,&nbsp;Shuang Liang ,&nbsp;Huahui Liu ,&nbsp;Hui Che ,&nbsp;Jian Wu","doi":"10.1016/j.ultrasmedbio.2025.11.663","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.663","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the feasibility of a discriminative correlation filter network (DCFNet)-based algorithm for positioning inconspicuous focal liver lesions (FLLs) on conventional US by tracking surrounding anatomical landmarks (SALs).</div></div><div><h3>Methods</h3><div>We established an algorithm that exploits the relative position characteristics of SALs to achieve tracking of inconspicuous FLLs in real-time US. Multiple SALs were tracked simultaneously using DCFNet, a fast deep learning–based tracking framework. The proposed DCFNet-based algorithm could assist real-time FLLs tracking on US and further guide puncture or ablation. We designed US-visible and US-invisible liver tumor phantoms for tracking and puncture performance evaluation. Algorithm performance was evaluated via matching accuracy, precision and positional error. Puncture verification was assessed in terms of success rate and guidance time on US-invisible liver tumor phantoms.</div></div><div><h3>Results</h3><div>A total of 20 US-visible phantoms, 20 US-invisible phantoms, and initial clinical cases were included. the algorithm achieved a tracking accuracy of 93.2%, precision of 92.9% and mean tumor localization error of 0.7 ± 0.4 mm in US-visible phantoms. For US-invisible phantoms, the puncture success rate was 94.3% with an average duration of 4 (3–5) s.</div></div><div><h3>Conclusion</h3><div>The DCFNet-based algorithm could be used as a potential approach for locating and tracking inconspicuous FLLs on US, with preliminary clinical feasibility that warrants further large-scale validation.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 693-701"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing CEUS Value in Papillary Thyroid Carcinoma: A Dual-Model Framework for Patient Selection Based on Conventional Ultrasound Characteristics","authors":"Liyuan He ,&nbsp;Yinghua Li ,&nbsp;Delin Zhong ,&nbsp;Jing Gao ,&nbsp;Yuan Yuan ,&nbsp;Shuhuan Zhang ,&nbsp;Jianyuan Wang","doi":"10.1016/j.ultrasmedbio.2025.11.668","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.668","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between typical contrast-enhanced ultrasound (CEUS) features and conventional ultrasound characteristics in papillary thyroid carcinoma (PTC) and develop predictive models to identify patients who would benefit from CEUS, thereby improving diagnostic efficiency.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 155 pathologically confirmed PTC cases (October 2021 to December 2024). Based on CEUS features, patients were divided into a hypoenhanced group (<em>n</em> = 89) and a non-hypoenhanced group (<em>n</em> = 66). Differences in conventional ultrasound features (B-mode, color Doppler and elastography) were compared between the two groups. A logistic regression model and a decision tree model were constructed and validated.</div></div><div><h3>Results</h3><div>Univariate analysis showed statistically significant differences (<em>p</em> &lt; 0.01) in nodule location, size, morphology, internal echogenicity homogeneity and calcification between the two groups. Both logistic regression and decision tree models identified size and morphology as independent predictors (<em>p</em> &lt; 0.001). The area under the curves (AUCs) for the two models were 0.846 and 0.844, respectively. The decision tree model achieved accuracy rates of 78.6% (training set) and 76.7% (validation set). The fivefold cross-validation results showed that the logistic regression model and the decision tree model achieved mean AUC-receiver operating characteristic values of 0.835 ± 0.054 and 0.719 ± 0.047, and mean accuracy rates of 0.773 ± 0.070 and 0.709 ± 0.039, respectively.</div></div><div><h3>Conclusion</h3><div>Tumor size and morphology were identified as independent factors associated with characteristic CEUS hypoenhancement in PTC. A 70% probability threshold for hypoenhancement, derived from the node probabilities of our decision tree model, was adopted as a clinically practical criterion for recommending CEUS. Our findings, validated in an independent set, support the following clinical strategy: (i) CEUS is not recommended for suspicious PTC nodules ≤0.5 cm; (ii) CEUS is appropriate as a supplementary diagnostic modality for: (a) suspicious PTC nodules measuring (0.5, 0.9] cm with irregular morphology, and (b) those &gt;0.9 cm irrespective of morphological characteristics.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 714-720"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145890489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Agreement of Speckle-Tracking Ultrasonography for Assessing Muscle Function of the Rotator Cuff in Patients with Subacromial Pain Syndrome","authors":"Anders Falk Brekke ,&nbsp;Katrine Kindtler Krag-Andersen ,&nbsp;Lars Henrik Frich ,&nbsp;Kate Lykke Lambertsen ,&nbsp;Peter Kraglund Jacobsen ,&nbsp;Frederik Sylvest Knold ,&nbsp;Carsten Bogh Juhl ,&nbsp;Anders Holsgaard-Larsen","doi":"10.1016/j.ultrasmedbio.2025.11.662","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.662","url":null,"abstract":"<div><h3>Objective</h3><div>Shoulder pain mainly originates from subacromial pain syndrome (SAPS), with the supraspinatus (SS) and infraspinatus (IS) muscles most often affected. Speckle-tracking ultrasonography (STU) is a non-invasive method to quantify muscle deformation. However, reliability and agreement with software post-processing procedures (inter-rater) and symptom-related variance (test-retest) for the same rater are unknown. This study aimed to assess the inter-rater reliability and agreement of STU post-processing procedures and the test-retest reliability and agreement of STU for evaluating SS and IS muscle function in patients with SAPS and a healthy control group</div></div><div><h3>Methods</h3><div>Twenty-four SAPS patients were assessed for inter-rater and test-retest (+1 week) variability, with the addition of 22 matched (age/gender) controls for the test-retest analysis. STU recordings were post-processed using EchoPAC software. Reliability was assessed using the intra-class correlation coefficient (ICC) and minimal detectable change (MDC). Agreement was evaluated using Bland-Altman plots</div></div><div><h3>Results</h3><div>Inter-rater reliability for SAPS shoulders was good–excellent (ranges: ICC 0.87–0.97; MDC 1.4–2.2% strain) and test-retest poor–moderate (ranges: ICC 0.16–0.59; MDC 3.5–8.9% strain). For the controls, test-retest showed good–excellent reliability (ranges: ICC 0.83–0.96; MDC 1.8–3% strain). Agreement was high for SAPS shoulders between raters. Test-retest agreement was moderate for the controls and low for SAPS shoulders</div></div><div><h3>Conclusion</h3><div>STU showed excellent inter-rater reliability for post-processing strain measurements of the SS and IS muscles. However, test-retest reliability was low in SAPS patients, likely due to symptom-related variability. While STU shows promise for assessing muscle function, its clinical applicability and feasibility remain unexplored.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 684-692"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Coronary Microvascular Perfusion 8 Weeks After Acute Myocardial Infarction Is Associated with Improved Cardiovascular Prognosis: Insights from Myocardial Contrast Echocardiography","authors":"Wuyi Zhan ,&nbsp;Meijuan Lu ,&nbsp;Xixuan Zhao ,&nbsp;Weiwei Tao ,&nbsp;Jiali Cao ,&nbsp;Lingzhun Wang ,&nbsp;Anxia He","doi":"10.1016/j.ultrasmedbio.2025.10.014","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.014","url":null,"abstract":"<div><h3>Objective</h3><div>Coronary microcirculation dysfunction (CMD) after acute myocardial infarction (AMI) significantly affects cardiovascular prognosis. However, the influence of an improvement in microvascular perfusion (MVP) during the recovery period from AMI on the long-term prognosis remains unclear. This study aims to assess the improvement in MVP during the healing process after percutaneous coronary intervention (post-PCI) for AMI using myocardial contrast echocardiography (MCE), and to investigate its correlation with major adverse cardiovascular events (MACE).</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted to evaluate a total of 114 AMI patients successfully treated with percutaneous coronary intervention (PCI). Patients were classified as having normal MVP (nMVP), delayed MVP (dMVP) or microvascular obstruction (MVO) based on perfusion imaging by MCE between 2 and 7 d post-PCI. Clinical data, MCE and cardiac function at baseline (2–7 d post-PCI) and after 8 wk of recovery were compared among the three groups. MACE was followed up every 6 mo over a 2-y period.</div></div><div><h3>Results</h3><div>As detected by MCE, there were 26 (22.8%), 50 (43.9%) and 38 (33.4%) AMI patients in the nMVP group, dMVP group and MVO group, respectively. AMI patients with dMVP and MVO suffered from significantly lower global longitudinal strain (GLS, <em>p</em> = 0.006, <em>p</em> = 0.002), lower left ventricular ejection fraction (LVEF, <em>p</em> = 0.023, <em>p</em> = 0.002), higher myocardial perfusion score index (MPSI, <em>p</em> &lt; 0.001, <em>p</em> &lt; 0.001) and more segments of wall motion abnormalities (WMA, <em>p</em> &lt; 0.001, <em>p</em> &lt; 0.001) than nMVP at both baseline and 8 wk. 23/50 (46.00%) patients in the dMVP group and 5/38 (13.16%) patients in the MVO group achieved complete improvement, while 21/38 (55.26%) patients in the MVO group achieved partial improvement in MVP within 8 wk. AMI patients with complete improvement had exhibited significantly greater improvements in GLS (<em>p</em> = 0.017), and experienced fewer MACE (<em>p</em> = 0.044) compared to those with partial or no improvement.</div></div><div><h3>Conclusion</h3><div>Among patients exhibiting abnormal MVP in the early phase following PCI for AMI, a subset demonstrated complete improvement of MVP at 8 wk. Patients with complete MVP improvement showed greater enhancement in myocardial function and a reduced risk of long-term MACE.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 524-530"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘A 15-Min Method for Hydrophone Spatial Averaging Correction in Transcranial Neuromodulation System Characterization’[Ultrasound in Medicine & Biology 52 (2026) 254-258]","authors":"Keith A. Wear","doi":"10.1016/j.ultrasmedbio.2025.12.001","DOIUrl":"10.1016/j.ultrasmedbio.2025.12.001","url":null,"abstract":"","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Page 726"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative and Quantitative Prediction of Central Cervical Lymph Node Metastases by Utilizing Contrast-enhanced Ultrasound in Papillary Thyroid Carcinoma With a Special Focus on Peak Intensity Ratio","authors":"Jia Zhan,&nbsp;Fang Li,&nbsp;Ji Ma,&nbsp;Xin Li,&nbsp;Long Liu,&nbsp;Rong Wu","doi":"10.1016/j.ultrasmedbio.2025.09.023","DOIUrl":"10.1016/j.ultrasmedbio.2025.09.023","url":null,"abstract":"<div><div>The aim of this study was to explore the qualitative and quantitative characteristics of PTC on contrast-enhanced ultrasound (CEUS) in predicting central cervical lymph node metastases (CLNM). This prospective study analyzed a dataset of grayscale US and CEUS images in 201 nodules with biopsy-confirmed PTC. Seven grayscale US features and five qualitative CEUS parameters were employed to develop the approaches. Four quantitative CEUS parameters of the time-intensity curve were obtained and compared between PTC and adjacent thyroid tissue (ATT), as well as within different PTC groups. The diagnostic performance of an equation with quantitative CEUS parameters were compared with grayscale US features and qualitative CEUS for predicting central CLNM. The patients were divided into three groups based on their final pathological results: 28 patients in the macro-metastases group, 95 patients in micro-metastasis group, 78 patients confirmed to have no metastases. Independent predictive grayscale US and qualitative CEUS features included size, capsule contact and heterogeneity on CEUS. In quantitative CEUS parameters, there were significant differences in peak intensity (PI) between PTC and ATT in all three groups (<em>p</em> &lt; 0.05). Significant differences in PI were also observed among three groups (<em>p</em> &lt; 0.05). A PI ratio of PTC and ATT greater than or equal to 1 was found to be a more sensitive index for predicting central CLNM. The quantitative CEUS-assisted US equation demonstrated the best diagnostic performance. A grayscale US and CEUS equation with PI ratio based on quantitative CEUS was developed for predicting occult central CLNM and it is considered highly valuable in the clinical management of PTC.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 506-513"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Color Doppler Twinkling on Breast Biopsy Markers With Hydrostatic Overpressurization and Micro-CT Imaging","authors":"Benjamin G. Wood ,&nbsp;Andrew Vercnocke ,&nbsp;Jeffrey Marsh ,&nbsp;Christine U. Lee ,&nbsp;Matthew W. Urban","doi":"10.1016/j.ultrasmedbio.2025.11.008","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.008","url":null,"abstract":"<div><h3>Objective</h3><div>Previous development of a breast biopsy marker that can be readily detected using color Doppler twinkling has been reported, but the cause of twinkling remains unclear. The objective is to better understand the mechanism for twinkling by exploring the effects of microbubbles on the surfaces of markers that twinkle compared to those that do not.</div></div><div><h3>Methods</h3><div>Twinkling metallic clinical markers and twinkling polymethyl methacrylate (PMMA) markers were evaluated in a pressure chamber. The hydrostatic pressure around the markers was increased from 0 to 1000 psi. To evaluate the effects of internal and external structures on twinkling, micro-CT scans were conducted to analyze the internal voids and surface roughness of the markers. A low-twinkling PMMA sample and a non-twinkling metal rod were also tested.</div></div><div><h3>Results</h3><div>Twinkling markers exhibited decreased twinkling as the hydrostatic pressure increased. PMMA markers mixed for approximately 75% of the time required to reach the hardening phase of the polymerization reaction exhibited the highest twinkling signals under increased pressure. Internal voids were found to have no correlation with twinkling. Samples with higher surface roughness values (S_a and full width at half maximum in the y-dimension) were found to correlate with twinkling (<em>p</em> = 0.037 and <em>p</em> = 0.011, respectively).</div></div><div><h3>Conclusion</h3><div>These results support oscillating microbubbles on surfaces as a cause of twinkling. Prior work connecting surface roughness to twinkling is, hence, corroborated by the microbubbles present on rougher surfaces.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 616-628"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-in-Human Safety and Efficacy Study on Combination of High-Intensity Focused Ultrasound Sonication and Micellar Nanoparticle-Encapsulated Epirubicin, K-912: A Novel Sonodynamic Therapy for the Treatment of Refractory Abdominal Cancers","authors":"Yoshihiro Muragaki ,&nbsp;Atsushi Sofuni ,&nbsp;Jun Okamoto ,&nbsp;Tohru Satoh ,&nbsp;Hiroshi Iseki ,&nbsp;Soko Ikuta ,&nbsp;Yasutsugu Asai ,&nbsp;Shin Yoshizawa ,&nbsp;Shin-ichiro Umemura ,&nbsp;Takao Itoi","doi":"10.1016/j.ultrasmedbio.2025.10.011","DOIUrl":"10.1016/j.ultrasmedbio.2025.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>Aims of this first-in-human clinical trial were to evaluate the safety and efficacy of sonodynamic therapy (SDT) using a newly developed trigger pulse high-intensity focused ultrasound (HIFU) device, MS-2, and micellar nanoparticle-encapsulated epirubicin, K-912, in patients with unresectable refractory abdominal cancers.</div></div><div><h3>Methods</h3><div>This was a single center prospective exploratory clinical trial. The HIFU sonication power (75 and 150 W at 1 MHz) and K-912 dose (30 and 80 mg/m²) were increased incrementally (4 cohorts) according to 3+3 design. Each cohort consisted of three patients. K-912 was administered intravenously one day before HIFU treatment.</div></div><div><h3>Results</h3><div>A total of 12 patients with stage IV pancreatic cancer (n = 11) and cholangiocellular carcinoma (n = 1) completed the SDT. The mean sonication time and total number of sonication was 22.3 min and 17.4 shots, respectively. No adverse events of grade ≥3 were observed during the trial up to 30 days after HIFU treatment. No adverse events related to K-912 were noted. The HIFU sonication power and K-912 dose considered to be tolerable were 150 W and 80 mg/m², respectively. The rate of complete and partial tumor coagulative necrosis was 33.3% and 41.7%, respectively. The primary disease control rate was 66.7%. Pain was improved in 33.3% of patients.</div></div><div><h3>Conclusions</h3><div>This trial demonstrated that SDT using MS-2 and K-912 was safe and well tolerated in patients with advanced abdominal tumors and showed promising preliminary clinical activity.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 514-523"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145642216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viscosity Plane-Wave Ultrasound Combined With Serum Biomarkers for Detection of Significant Liver Inflammation: A Diagnostic Nomogram Study","authors":"Xinhuan Ding ,&nbsp;Jianping Dou ,&nbsp;Hui Feng ,&nbsp;Yuejuan Gao ,&nbsp;Min Chen ,&nbsp;Shuyue Gao ,&nbsp;Song Feng ,&nbsp;Feng Jiang ,&nbsp;Yuan Liu ,&nbsp;Jie Yu ,&nbsp;Ping Liang","doi":"10.1016/j.ultrasmedbio.2025.11.013","DOIUrl":"10.1016/j.ultrasmedbio.2025.11.013","url":null,"abstract":"<div><h3>Background</h3><div>Accurate prediction of significant liver inflammation is critical for making clinical intervention decisions. This study aims to establish a predictive model for detection of significant liver inflammation and assess its diagnostic performance against established scoring systems.</div></div><div><h3>Method</h3><div>This study enrolled patients who underwent ultrasound-guided liver biopsy between July 26, 2024, and November 30, 2024. Demographic data, laboratory parameters, viscosity plane-wave ultrasound (Vi PLUS), mean values and histopathological inflammation grading, fibrosis stage were collected. A nomogram model was generated based on a multivariate logistic regression analysis to identify potential predictors associated with liver inflammation. The diagnostic performance was evaluated by receiver operating characteristic curve analysis, calibration plot and decision curve.</div></div><div><h3>Result</h3><div>A total of 140 participants were included in this study. 98 patients were classified into the significant inflammation group (≥G2), and 42 patients were categorized as mild inflammation (G0–G1). Based on univariate and multivariate logistic regression analyses, Vi PLUS mean (odds ratios [OR]: 9.060) and aspartate aminotransferase (AST) (OR: 2111.269) were identified as independent risk factors for inflammatory grade (<em>p</em> &lt; 0.05). The area under the curve (AUC) of the nomogram constructed by Vi PLUS mean and AST was 0.941 (95% confidence intervals 0.898–0.983, sensitivity 92.9%, specificity 85.7%), outperforming AST to platelet ratio index (AUC = 0.897), Vi PLUS mean (AUC = 0.897), FIB-4 (AUC = 0.885), AST (AUC = 0.852) and gamma-glutamyl transpeptidase to platelet ratio (AUC = 0.755) (all <em>p</em> &lt; 0.05). Furthermore, a well-fitted calibration curve and a good clinical application value were achieved in the nomogram. The cutoff value of 0.538 was determined to predict significant inflammation.</div></div><div><h3>Conclusion</h3><div>The nomogram exhibits high accuracy in predicting significant liver inflammation and provide a new approach for clinicians to better evaluate inflammatory activity.</div></div>","PeriodicalId":49399,"journal":{"name":"Ultrasound in Medicine and Biology","volume":"52 3","pages":"Pages 657-664"},"PeriodicalIF":2.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}