Biometals最新文献

{"title":"Insight into the role of copper-based materials against the coronaviruses MHV-3, a model for SARS-CoV-2, during the COVID-19 pandemic","authors":"Gislaine S. Jacinto,&nbsp;Leonardo F. G. Dias,&nbsp;Junko Tsukamoto,&nbsp;Paulo N. Lisboa-Filho,&nbsp;Marina T. Souza,&nbsp;Ana Paula de Moraes,&nbsp;Clarice W. Arns","doi":"10.1007/s10534-024-00585-2","DOIUrl":"10.1007/s10534-024-00585-2","url":null,"abstract":"<div><p>Coating high-touch surfaces with inorganic agents, such as metals, appears to be a promising long-term disinfection strategy. However, there is a lack of studies exploring the effectiveness of copper-based products against viruses. In this study, we evaluated the cytotoxicity and virucidal effectiveness of products and materials containing copper against <i>mouse hepatitis virus</i> (MHV-3), a surrogate model for SARS-CoV-2. The results demonstrate that pure CuO and Cu possess activity against the enveloped virus at very low concentrations, ranging from 0.001 to 0.1% (w/v). A greater virucidal efficacy of CuO was found for nanoparticles, which showed activity even against viruses that are more resistant to disinfection such as <i>feline calicivirus</i> (FCV). Most of the evaluated products, with concentrations of Cu or CuO between 0.003 and 15% (w/v), were effective against MHV-3. Cryomicroscopy images of an MHV-3 sample exposed to a CuO-containing surface showed extensive damage to the viral capsid, presumably due to the direct or indirect action of copper ions.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"923 - 941"},"PeriodicalIF":4.1,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the mutual crosstalk between ER stress and PI3K/AKT/mTOR signaling pathway in iron overload-induced liver injury in chicks","authors":"Xiang-Long Lv,&nbsp;Wen-Lei Li,&nbsp;Feng-Jiao Sun,&nbsp;Yu-Zhi An,&nbsp;Ning Sun,&nbsp;Xiao-Ping Lv,&nbsp;Xue-Li Gao","doi":"10.1007/s10534-024-00588-z","DOIUrl":"10.1007/s10534-024-00588-z","url":null,"abstract":"<div><p>Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims to investigate the interaction between the endoplasmic reticulum stress signaling pathway and the PI3K/AKT/mTOR signaling pathway in liver injury induced by iron overload in chicks. Rspectively, 150 one-day-old broilers were divided into three groups and supplemented with 50 (C), 500 (E1), and 1000 (E2) mg ferrous sulfate monohydrate/kg in the basal diet. Samples were taken after continuous feeding for 14 days. The results showed that iron overload could upregulate the levels of ALT and AST. Histopathological examination revealed bleeding in the central vein of the liver accompanied by inflammatory cell infiltration. Hoechst staining showed that the iron overload group showed significant bright blue fluorescence, and ultrastructural observations showed chromatin condensation as well as mitochondrial swelling and cristae disorganization in the iron overload group. RT-qPCR and Western blot results showed that iron overload upregulated the expression of Bax, Caspase-3, Caspase-9, GRP78, GRP94, P-PERK, ATF4, eIF2α, IRE1, and ATF6, while downregulating the expression of Bcl-2 and the PI3K/AKT/mTOR pathway. XBP-1 splicing experiment showed significant splicing of XBP-1 gene after iron overload. PCA and correlation analysis suggested a potential association between endoplasmic reticulum stress, the PI3K/AKT/mTOR signaling pathway, and liver injury in chicks. In summary, iron overload can induce cell apoptosis and liver injury by affecting endoplasmic reticulum stress and the PI3K/AKT/mTOR signaling pathway.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"955 - 969"},"PeriodicalIF":4.1,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140126406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metals and metallothionein evolution in snails: a contribution to the concept of metal-specific functionality from an animal model group","authors":"Reinhard Dallinger","doi":"10.1007/s10534-024-00584-3","DOIUrl":"10.1007/s10534-024-00584-3","url":null,"abstract":"<div><p>This is a critical review of what we know so far about the evolution of metallothioneins (MTs) in Gastropoda (snails, whelks, limpets and slugs), an important class of molluscs with over 90,000 known species. Particular attention will be paid to the evolution of snail MTs in relation to the role of some metallic trace elements (cadmium, zinc and copper) and their interaction with MTs, also compared to MTs from other animal phyla. The article also highlights the important distinction, yet close relationship, between the structural and metal-selective binding properties of gastropod MTs and their physiological functionality in the living organism. It appears that in the course of the evolution of Gastropoda, the trace metal cadmium (Cd) must have played an essential role in the development of Cd-selective MT variants. It is shown how the structures and Cd-selective binding properties in the basal gastropod clades have evolved by testing and optimizing different combinations of ancestral and novel MT domains, and how some of these domains have become established in modern and recent gastropod clades. In this context, the question of how adaptation to new habitats and lifestyles has affected the original MT traits in different gastropod lineages will also be addressed. The 3D structures and their metal binding preferences will be highlighted exemplarily in MTs of modern littorinid and helicid snails. Finally, the importance of the different metal requirements and pathways in snail tissues and cells for the shaping and functionality of the respective MT isoforms will be shown.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 3","pages":"671 - 696"},"PeriodicalIF":4.1,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Ag2O nanoparticles with “Hoja Santa” (Piper auritum) extract: characterization and biological capabilities","authors":"Dalia S. Aguilar-Ávila,&nbsp;M. Reyes-Becerril,&nbsp;Carlos A. Velázquez-Carriles,&nbsp;Gabriela Hinojosa-Ventura,&nbsp;María E. Macías-Rodríguez,&nbsp;Carlos Angulo,&nbsp;Jorge M. Silva-Jara","doi":"10.1007/s10534-024-00589-y","DOIUrl":"10.1007/s10534-024-00589-y","url":null,"abstract":"<div><p>The ‘sacred leaf’ or “Hoja Santa” (<i>Piper auritum</i> Kunth) has a great value for Mexican culture and has gained popularity worldwide for its excellent properties from culinary to remedies. To contribute to its heritage, in this project we proposed the green synthesis of silver oxide nanoparticles (Ag₂O NPs) using an extract of “Hoja Santa” (<i>Piper auritum</i>) as a reducing and stabilizing agent. The synthesized Ag₂O NPs were characterized by UV–Visible spectroscopy (plasmon located at 405 nm), X-ray diffraction (XRD) (particle size diameter of 10 nm), scanning electron microscopy (SEM) (particle size diameter of 13.62 ± 4.61 nm), and Fourier-transform infrared spectroscopy (FTIR) (functional groups from “Hoja Santa” attached to nanoparticles). Antioxidant capacity was evaluated using DPPH, ABTS and FRAP methods. Furthermore, the antimicrobial activity of NPs against a panel of clinically relevant bacterial strains, including both Gram-positive (<i>Staphylococcus aureus</i>) and Gram-negative bacteria (<i>Salmonella</i> Enteritidis and <i>Escherichia coli</i> O157:H7), was over 90% at concentrations of 200 µg/mL. Additionally, we assessed the antibiofilm activity of the NPs against <i>Pseudomonas aeruginosa</i> (reaching 98% of biofilm destruction at 800 µg/mL), as biofilm formation plays a crucial role in bacterial resistance and chronic infections. Moreover, we investigated the impact of Ag₂O NPs on immune cell viability, respiratory burst, and phagocytic activity to understand their effects on the immune system.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"971 - 982"},"PeriodicalIF":4.1,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy","authors":"Dan Shan,&nbsp;Qian Chen,&nbsp;Yupei Xie,&nbsp;Siyu Dai,&nbsp;Yayi Hu","doi":"10.1007/s10534-024-00586-1","DOIUrl":"10.1007/s10534-024-00586-1","url":null,"abstract":"<div><p>Trace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studies have demonstrated the association of ICP with some trace elements. Evidence from retrospective studies in humans further revealed the possible contributing roles of trace elements in the pathogenesis of ICP. The published literature on the association of trace elements with ICP was reviewed. Recent advances in molecular biological techniques from animal studies have helped to elucidate the possible mechanisms by how these trace elements function in regulating oxidative reactions, inflammatory reactions and immune balance in the maternal-fetal interface, as well as the influence on hepato-intestinal circulation of bile acid. The scenario regarding the role of trace elements in the pathogenesis of ICP is still developing. The administration or depletion of these trace elements may have promising effects in alleviating the symptoms and improving the pregnancy outcomes of ICP.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"943 - 953"},"PeriodicalIF":4.1,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium and platinum complexes based on pyridine bases induced anticancer effectiveness via apoptosis protein signaling in cancer cells","authors":"Mohamed M. El-bendary,&nbsp;Abdullah Akhdhar,&nbsp;Abdullah S. Al-Bogami,&nbsp;Doaa Domyati,&nbsp;Abdulaziz A. Kalantan,&nbsp;Faisal Ay Alzahrani,&nbsp;Samer M. Alamoudi,&nbsp;Ryan A. Sheikh,&nbsp;Ehab M. M. Ali","doi":"10.1007/s10534-023-00580-z","DOIUrl":"10.1007/s10534-023-00580-z","url":null,"abstract":"<div><p>Palladium and platinum complexes, especially those that include cisplatin, can be useful chemotherapeutic drugs. Alternatives that have less adverse effects and require lower dosages of treatment could be provided by complexes containing pyridine bases. The complexes <b>[Pd(SCN)</b>_<b>2</b><b>(4-Acpy)</b>_<b>2</b><b>] (1), [Pd(N</b>_<b>3</b><b>)</b>_<b>2</b><b>(4-Acpy)</b>_<b>2</b><b>] (2) [Pd(paOH)</b>_<b>2</b><b>].2Cl</b> (<b>3</b>) <b>and [Pt(SCN)</b>_<b>2</b><b>(paO)</b>_<b>2</b><b>] (4)</b> were prepared by self-assembly method at ambient temperature; (4-Acpy = 4-acetylpyridine and paOH = pyridine-2-carbaldehyde-oxime). The structure of complexes <b>1–4</b> was confirmed using spectroscopic and X-ray crystallography methods. Complexes <b>1–4</b> have similar features in isomerism that include the <i>trans</i> coordination geometry of pyridine ligands with Pd or Pt ion. The 3D network structure of complexes <b>1–4</b> was constructed by an infinite number of discrete mononuclear molecules extending via H-bonds. The Pd and Pt complexes <b>1–4</b> with pyridine ligands were assessed on MCF-7, T47D breast cancer cells and HCT116 colon cancer cells. The study evaluated cell death through apoptosis and cell cycle phases in MCF-7 cells treated with palladium or platinum conjugated with pyridine base. Upon treatment of MCF-7 with these complexes, the expression of apoptotic signals (Bcl2, p53, Bax and c-Myc) and cell cycle signals (p16, CDK1A, CDK1B) were evaluated. Compared to other complexes and cisplatin, IC₅₀ of complex <b>1</b> was lowest in MCF-7 cells and complex <b>2</b> in T47D cells. Complex <b>4</b> has the highest effectiveness on HCT116. The selective index (SI) of complexes <b>1–4</b> has a value of more than two for all cancer cell lines, indicating that the complexes were less toxic to normal cells when given the same dose. MCF-7 cells treated with complex <b>2</b> and platinum complex <b>4</b> exhibited the highest level of early apoptosis. p16 may be signal arrest cells in Sub G, which was observed in cells treated with palladium complexes that suppress excessive cell proliferation. High c-Myc expression of treated cells with four complexes <b>1–4</b> and cisplatin could induce p53. All complexes <b>1–4</b> elevated the expression of Bax and triggered by the tumor suppressor gene p53. p53 was downregulating the expression of Bcl2.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"905 - 921"},"PeriodicalIF":4.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: In vitro assessment of antibacterial and antiviral activity of three copper products after 200 rounds of simulated use","authors":"Marthe K. Charles,&nbsp;Teresa C. Williams,&nbsp;Davood Nakhaie,&nbsp;Tracey Woznow,&nbsp;Billie Velapatino,&nbsp;Ana C. Lorenzo-Leal,&nbsp;Horacio Bach,&nbsp;Elizabeth A. Bryce,&nbsp;Edouard Asselin","doi":"10.1007/s10534-024-00587-0","DOIUrl":"10.1007/s10534-024-00587-0","url":null,"abstract":"","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"857 - 857"},"PeriodicalIF":4.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metals in biological samples of cancer patients: a systematic literature review","authors":"Donatella Coradduzza,&nbsp;Antonella Congiargiu,&nbsp;Emanuela Azara,&nbsp;Ismaeil Mohammed Abulkahar Mammani,&nbsp;Maria Rosaria De Miglio,&nbsp;Angelo Zinellu,&nbsp;Ciriaco Carru,&nbsp;Serenella Medici","doi":"10.1007/s10534-024-00583-4","DOIUrl":"10.1007/s10534-024-00583-4","url":null,"abstract":"<div><p> The majority of the so-called heavy metals are suspected to be involved in a number of pathologies and play a role in human carcinogenesis. Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (Ni)) have been defined as carcinogens, increasing the susceptibility of tumor development and progression in humans. Moreover, Ni, Cr, Cd, Hg, and Pb together with zinc (Zn) and iron (Fe), may be capable of stimulating the progression of breast cancer and reducing a patient’s sensitivity to treatment through alterations to DNA methylation. In patients with gastric cancers, levels of various heavy metals are augmented and hypothesized to amplify the expression of the human epidermal growth factor receptor type 2 gene. Cd may increase the risk of lung cancer development and have a negative impact on the overall survival of lung cancer patients. To investigate the relation between heavy metals in biological samples and risk, occurrence and survival cancer individuals, a comprehensive review work was performed, with a focus on breast, lung, prostate and gastric cancers. An extensive search strategy was devised to ensure relevant literature could be identified, with the PECO framework being adopted to facilitate this and identify key search terms. As evidenced in this review, there is substantial data to support the hypothesis that heavy metals influence tumor development and progression. Unluckily the number of papers dealing with the determination of metals directly in samples from cancer tissues is still rather limited, so we decided to expand the scope of this review also to analyses carried out on other biological samples, as urine, plasma, hair, nail, etc. The studies reviewed showed that several limitations and current knowledge gaps are present in the literature that require further investigation to improve our comprehension of the impact of different heavy metals on tumorigenesis.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"803 - 817"},"PeriodicalIF":4.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum calcium and magnesium levels and quality of life in environmentally exposed populations in Kazakhstan","authors":"Geir Bjørklund,&nbsp;Yuliya Semenova","doi":"10.1007/s10534-023-00579-6","DOIUrl":"10.1007/s10534-023-00579-6","url":null,"abstract":"<div><p>The relationship between the levels of essential elements and various aspects of well-being in environmentally exposed populations still needs to be better understood. The present study aims to investigate the potential connections between serum concentrations of calcium (Ca), magnesium (Mg), and quality of life (QoL) in environmentally exposed populations in Kazakhstan. The present study involved 1881 nominally healthy individuals aged 18–52 years who were permanent residents of Abay, Borodulikha, Ust-Kamenogorsk, Kurchum, Uralsk, Aksay, and Berezovka settlements. These settlements were selected to represent different types of environmental exposure: radioactive fallout from the Semipalatinsk Nuclear Test Site (SNTS), non-ferrous metallurgy, and the condensate gas field, compared to environmentally unexposed territories. The Russian version of the SF-36 questionnaire was used to assess the participants’ quality of life. Serum Ca levels were measured using colorimetry with O-cresolphthalein, and serum Mg concentrations were measured using colorimetry with xylidyl blue. Both elevated and decreased serum Ca levels were more frequently observed in the environmentally exposed populations. The prevalence of hypermagnesemia was highest among residents near the condensate gas field. Environmentally exposed populations residing near the SNTS and in Ust-Kamenogorsk exhibited lower scores in some QoL domains. In contrast, people near the condensate gas field showed comparable or even higher QoL scores than the control population. Only serum Mg demonstrated a significant association with the average QoL scores, while Ca did not show such an association. These findings have important implications for public health interventions.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"895 - 904"},"PeriodicalIF":4.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium transport by mammalian ATP-binding cassette transporters","authors":"Frank Thévenod,&nbsp;Wing-Kee Lee","doi":"10.1007/s10534-024-00582-5","DOIUrl":"10.1007/s10534-024-00582-5","url":null,"abstract":"<div><p>Cellular responses to toxic metals depend on metal accessibility to intracellular targets, reaching interaction sites, and the intracellular metal concentration, which is mainly determined by uptake pathways, binding/sequestration and efflux pathways. ATP-binding cassette (ABC) transporters are ubiquitous in the human body—usually in epithelia—and are responsible for the transfer of indispensable physiological substrates (e.g. lipids and heme), protection against potentially toxic substances, maintenance of fluid composition, and excretion of metabolic waste products. Derailed regulation and gene variants of ABC transporters culminate in a wide array of pathophysiological disease states, such as oncogenic multidrug resistance or cystic fibrosis. Cadmium (Cd) has no known physiological role in mammalians and poses a health risk due to its release into the environment as a result of industrial activities, and eventually passes into the food chain. Epithelial cells, especially within the liver, lungs, gastrointestinal tract and kidneys, are particularly susceptible to the multifaceted effects of Cd because of the plethora of uptake pathways available. Pertinent to their broad substrate spectra, ABC transporters represent a major cellular efflux pathway for Cd and Cd complexes. In this review, we summarize current knowledge concerning transport of Cd and its complexes (mainly Cd bound to glutathione) by the ABC transporters ABCB1 (P-glycoprotein, MDR1), ABCB6, ABCC1 (multidrug resistance related protein 1, MRP1), ABCC7 (cystic fibrosis transmembrane regulator, CFTR), and ABCG2 (breast cancer related protein, BCRP). Potential detoxification strategies underlying ABC transporter-mediated efflux of Cd and Cd complexes are discussed.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 3","pages":"697 - 719"},"PeriodicalIF":4.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139690866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}