Biometals最新文献

{"title":"Protective effects of melatonin on cadmium subcellular distribution, biochemical, and anatomical alterations in Malva parviflora roots","authors":"Narges Rahnamaei Yahyaabadi,&nbsp;Parzhak Zoufan,&nbsp;Fatemeh Nasernakhaei","doi":"10.1007/s10534-025-00691-9","DOIUrl":"10.1007/s10534-025-00691-9","url":null,"abstract":"<div><p>Plants use various mechanisms to cope with cadmium (Cd) stress. Melatonin’s impact on the root response to Cd stress, which is the first organ to detect its presence, has been less studied. This study aims to investigate the effects of melatonin pretreatment on the root strategies of <i>Malva parviflora</i> in response to Cd stress, focusing on the mechanisms of heavy metal tolerance. The plants, 42 days post-germination, were subjected to a 48-h pretreatment with 50 μM melatonin in a complete nutrient solution under controlled growth conditions. Following pretreatment, plants were exposed to a nutrient solution containing 50 μM Cd for 8 days. Comparative analyses were conducted on root length, weight, anatomical features, Cd content, Cd subcellular distribution, nutrient absorption, glutathione, and lignin. Melatonin pretreatment significantly enhanced root length and weight under Cd stress. It also increased the xylem and phloem area in the roots and promoted the absorption and translocation of essential nutrients such as Fe, Zn, Ca, and Mg to the shoots. Additionally, there was a marked increase in glutathione content and Cd proportion in the cell wall and organelle fractions in melatonin-pretreated roots. Notably, melatonin reduced overall plant Cd content and its translocation from roots to shoots, while decreasing root lignin content. This study demonstrates that melatonin plays an important role in managing Cd toxicity by improving morphological, anatomical, and biochemical characteristics of roots under Cd stress. The findings suggest that melatonin pretreatment can effectively alter Cd subcellular distribution, thereby mitigating its harmful effects in plants.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"997 - 1017"},"PeriodicalIF":3.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models","authors":"Jun Wen,&nbsp;Changfen Wang,&nbsp;Ranyang Liu,&nbsp;Rongjuan Zhuang,&nbsp;Yan Liu,&nbsp;Yishi Li,&nbsp;Shuliang Guo","doi":"10.1007/s10534-025-00690-w","DOIUrl":"10.1007/s10534-025-00690-w","url":null,"abstract":"<div><p>Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 participants for a cross-sectional study from the NHANES. The weighted quantile sum (WQS) regression, bayesian kernel machine regression (BKMR), machine learning models (support vector machines, random forests, decision trees, and XGBoost), restricted cubic spline (RCS), and logistic regression were applied to comprehensively evaluate the performance of urinary metals in predicting chronic cough risk. Finally, the mediation effect model was employed to evaluate the role of systematic inflammation in the relationship between urinary cadmium and the risk of chronic cough. Urinary cadmium correlated with an increasing risk of chronic cough in the multivariate logistic regression model (OR: 2.83, 95% CI: 1.60–4.99). Both the WQS regression and BKMR consistently suggested a positive relationship between urinary mixed metal and chronic cough risk. Among the four machine learning models used to evaluate urinary metals and the risk of chronic cough, the random forests model showed better predictive performance (AUC = 0.69). The random forests suggested that the top five important indicators for predicting chronic cough risk were urinary cadmium, thallium, molybdenum, cesium, and uranium. Finally, the mediation effect model suggested that the systematic inflammation (lymphocytes: 4.24%, systemic immune inflammation index: 5.11%) partially mediated the relationship between urinary cadmium and chronic cough risk. This study discovered that urinary cadmium was elevated in correlation with the increasing risk of chronic cough. Systematic inflammations may partially mediate this association. Improving exposure to urinary cadmium may reduce the risk of chronic cough.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"983 - 995"},"PeriodicalIF":3.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium 8-hydroxyquinoline derivatives in medicine: current state and future outlook","authors":"Tahmineh Kohanfekr,&nbsp;Camelia Gholamrezazadeh,&nbsp;Hasan Ali Hosseini","doi":"10.1007/s10534-025-00683-9","DOIUrl":"10.1007/s10534-025-00683-9","url":null,"abstract":"<div><p>Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"711 - 736"},"PeriodicalIF":3.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals","authors":"Aleksandar Cirovic,&nbsp;Danijela Djonic,&nbsp;Vladimir Zivkovic,&nbsp;Slobodan Nikolic,&nbsp;Marija Djuric,&nbsp;Petar Milovanovic","doi":"10.1007/s10534-025-00689-3","DOIUrl":"10.1007/s10534-025-00689-3","url":null,"abstract":"<div><p>Increased urine and blood concentrations of heavy metals are linked to an elevated hip fracture risk, but studies dedicated to directly measuring metal(oid) concentrations in the femoral neck are limited. We investigated whether individuals with fractures exhibit a different pattern of metal(oid) bioaccumulation in the femoral neck and examined potential correlations between the concentrations of various metal(oid)s in the femoral neck and trabecular microarchitecture. To address these objectives, we collected femoral neck specimens from 23 individuals, namely 11 individuals with a positive history of contralateral hip fracture (9 women and 2 men, mean age 77.7 ± 8.1 years) and 12 individuals without fractures (10 women and 2 men, mean age 79.5 ± 5.6 years). All samples were subject to microcomputed tomography (micro-CT) to evaluate bone microarchitecture and inductively coupled plasma–mass spectrometry to determine tissue concentrations of metal(oid)s. In the fully adjusted model (adjusted for bone volume, age, and calcium tissue concentration), individuals with hip fractures exhibited higher aluminum levels (p = 0.047) and lower vanadium levels (p &lt; 0.001). Individuals who sustained fragility fractures also showed lower BV/TV, Tb.Th, Tb.N, and higher Tb.Sp in the femoral neck trabeculae compared with the control group. Several different metal(oid)s were associated with altered patterns of trabecular microarchitecture. In summary, higher aluminum and lower vanadium concentrations in the trabeculae of the femoral neck provide a potential background for the gradual increase in fracture risk. Correlational analysis revealed an association between exposure to certain metals and deteriorated trabecular microarchitecture; however, larger studies are needed to determine the elements independently affecting bone microarchitecture.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"965 - 981"},"PeriodicalIF":3.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental comparative analysis of 18 elements reveal distinct patterns in benign and malignant thyroid tissues","authors":"Xueying Liu,&nbsp;Linjing Huang,&nbsp;Youzhi Zhu,&nbsp;Peiwen Wu","doi":"10.1007/s10534-025-00682-w","DOIUrl":"10.1007/s10534-025-00682-w","url":null,"abstract":"<div><p>This study aims to compare variations in 18 trace elements (Al, Na, K, Mg, Ca, Ti, Ba, Sn, Cr, Mn, Fe, Cu, Zn, Se, Mo, Cd, Sr, and Tl) between benign and malignant thyroid tissues. Post-operative thyroid tissue samples were collected from 106 patients (34 benign, 72 malignant), and elemental concentrations were quantified using inductively coupled plasma mass spectrometry. Spearman’s correlation analysis revealed positive correlations among these trace elements. Notably, the malignant group exhibited significantly higher concentrations in eight elements (Mg, Al, Fe, Cr, Ti, Sr, Sn, and Ba) compared to the benign group, while levels of six elements (Na, Mn, Cu, Zn, Cd, and Mo) were significantly lower. Orthogonal partial least squares discriminant analysis distinguished three elements (Al, Ti, Sn) for the malignant group and six elements (Na, Mn, Cu, Zn, Cd, and Mo) for the benign group. Multivariate logistic regression further revealed associations between thyroid cancer and levels of Al, Cr, Ti, Sr, Sn, Ba, Mn, Cu, Zn, and Cd. Considering with each elemental biological funcions, these findings suggest that Cu, Mn, and particularly Zn may act as essential antitumor elements with synergistic effects, whereas elevated Ba, Cr, and Al levels are closely related to thyroid malignancies. However deficiencies and excesses of elements may be the consequences of malignant tissues. In conclusion, benign and malignant thyroid tumors exhibit different trace-element profiles.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"873 - 886"},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally treated FeCrAl alloy as potential biomaterial: surface characterization, corrosion resistance and cytotoxicity studies","authors":"L. Nadaraia,&nbsp;O. Tsurtsumia,&nbsp;L. Khundadze,&nbsp;T. Kukava,&nbsp;P. Tchelidze,&nbsp;V. Okuneva,&nbsp;S. Bakhtiarov,&nbsp;V. Perumal,&nbsp;E. Kutelia","doi":"10.1007/s10534-025-00686-6","DOIUrl":"10.1007/s10534-025-00686-6","url":null,"abstract":"<div><p>Metal alloys are widely used in implantology due to their excellent mechanical properties. However, their biocompatibility can be compromised by corrosion, which releases toxic metal ions that may provoke adverse biological reactions and contribute to implant failure. This study introduces a novel metal-ceramic composite based on a high-chromium FeCrAl alloy, specifically engineered to form a thermally grown α-Al₂O₃ surface layer. This design aims to significantly enhance biocompatibility and corrosion resistance for potential biomedical implant applications. Samples of the Fe-44Cr-5Al alloy were produced using an arc melting process. The mechanically polished alloy coupons were given a mirror-like finish and underwent high-temperature oxidation at 1050 °C for 20 h in laboratory air to develop a dense and adherent α-Al₂O₃ layer. Both bare and oxidized samples were immersed in artificial saliva at 37 °C for two months to assess their corrosion resistance under simulated oral conditions. Biocompatibility was evaluated through cytotoxicity and mitotic activity tests using primary human gingival fibroblasts cultured on both the bare and oxidized samples. The results showed that thermal oxidation effectively produced a uniform, adherent, and stable α-Al₂O₃ layer on the surface of the FeCrAl alloy. The oxidized samples demonstrated superior corrosion resistance, with negligible metal ion release and no formation of corrosion products. In contrast, the bare (unoxidized) alloy exhibited extensive corrosion and significant ion release. Cytotoxicity tests indicated that the oxidized alloy supported normal cell adhesion, proliferation, and morphology comparable to control samples. Although a slight reduction in cell proliferation was noted on the oxidized metal surface, overall bioactivity remained high. Structural and morphological analyses were performed using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Grazing Incidence X-ray Diffraction (GIXRD) to confirm the formation and integrity of the oxide layer. Post-immersion corrosion tests in artificial saliva and detailed microscopy further validated the favorable biological responses to the oxidized alloy.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"917 - 934"},"PeriodicalIF":3.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of corroles in modern cancer therapy: innovation and prospects","authors":"Laiba Javaid,&nbsp;Huma Hameed,&nbsp;Mahtab Ahmad Khan,&nbsp;Syed Muhammad Ahmad,&nbsp;Inaba Shujaat Qureshi,&nbsp;Rabia Shahzad,&nbsp;Ali Irfan","doi":"10.1007/s10534-025-00687-5","DOIUrl":"10.1007/s10534-025-00687-5","url":null,"abstract":"<div><p>Corroles, a class of tetrapyrrolic macrocycles, have garnered significant attention for their potential in cancer therapy due to their unique structural chemistry and ability to coordinate with metals. Their remarkable photophysical properties make them beneficial for photodynamic therapy (PDT) and fluorescence imaging, as they can produce reactive oxygen species when activated by light, offering potential for the treatment of various carcinomas, including hepatic, breast, pancreatic, and lung cancers. Despite the encouraging preclinical and clinical data supporting their therapeutic efficacy, challenges remain in optimizing corrole formulations, particularly concerning targeted delivery, stability, and bioavailability. This review highlights current advancements in corrole-based therapies, focusing on novel nanoparticle formulations that enhance drug distribution and therapeutic efficacy. Furthermore, it examines the mechanisms of corrole-mediated cellular death and the role of photodynamic treatment in inducing apoptosis via various signaling pathways. Additional research is necessary to address formulation-related issues while ensuring the safety and effectiveness of corroles in cancer treatment, therefore maximizing their therapeutic potential and adhering to regulatory standards.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"737 - 761"},"PeriodicalIF":3.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavin-dependent enzymatic and photochemical interconversions between phenylarsonic and phenylarsonous acids","authors":"Igor Kučera,&nbsp;Vojtěch Sedláček","doi":"10.1007/s10534-025-00685-7","DOIUrl":"10.1007/s10534-025-00685-7","url":null,"abstract":"<div><p>Phenylarsonic acid is the parent compound of a group of derivatives that occur as anthropogenic environmental contaminants in both less toxic As(V) and much more toxic As(III) redox states. To elucidate the mechanisms underlying their enzymatic redox conversions, the activities of two flavin reductases, ArsH and FerA, from the soil bacterium <i>Paracoccus denitrificans</i> were compared. The stopped-flow data demonstrated that PhAs(V) oxidized dihydroflavin mononucleotide bound to ArsH, but not to FerA. This result proves that ArsH has some substrate specificity for organoarsenic compounds. Under aerobic conditions, both enzymes accelerated the oxidation of PhAs(III) in a catalase-sensitive manner, indicating that hydrogen peroxide acts as an intermediate. H₂O₂ was shown to react with PhAs(III) in a bimolecular (1:1) irreversible reaction. When exposed to blue light, flavin alone mediated rapid oxidation of PhAs(III) by O₂. Photooxidation by flavin acted in concert with chemical oxidation by transiently accumulating H₂O₂. The described processes may be relevant in the context of arsenic ecotoxicology and remediation.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"903 - 915"},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated effects of blood metal(loid) exposure and impaired glucose metabolism in patients with gastric precancerous lesions or gastric cancer","authors":"Yuting Zhu,&nbsp;Xiao Lin,&nbsp;Tingting Wang,&nbsp;Sheng Wang,&nbsp;Wuqi Wang,&nbsp;Mengran Ke,&nbsp;Yan Zhu,&nbsp;Bowen Zhang,&nbsp;Princess Ofosuhemaa,&nbsp;Yalei Wang,&nbsp;Mingjun Hu,&nbsp;Wanshui Yang,&nbsp;Anla Hu,&nbsp;Fen Huang,&nbsp;Qihong Zhao","doi":"10.1007/s10534-025-00684-8","DOIUrl":"10.1007/s10534-025-00684-8","url":null,"abstract":"<div><p>Exposure to metal(loid)s and glucose metabolism may influence the progression of gastric precancerous lesions (GPLs) or gastric cancer (GC), but their combined effects remain unclear. Our study aimed to elucidate the combined impact of metal (including metalloid and trace element) exposure and disturbances in glucose metabolism on the progression of GPLs and GC. From a prospective observational cohort of 1829 individuals, their metal(loid) levels and blood metabolism were analysed via inductively coupled plasma‒mass spectrometry and targeted metabolomics gas chromatography‒mass spectrometry, respectively. From healthy normal controls (NC) or GPLs to GC, we observed that the aluminum and arsenic levels decreased, whereas the vanadium, titanium and rubidium levels increased, but the iron, copper, zinc and barium levels initially decreased but then increased; these changes were not obvious from the NC to GPL group. With respect to glucose homeostasis, most metabolites decreased, except for phosphoenolpyruvate (PEP), which increased. Multiple logistic regression analysis revealed that titanium and phosphoenolpyruvate might be risk factors for GPLs, that barium is a protective factor for GC, and that D-glucaric acid might be a protective factor for GPLs and GC. Selenium, vanadium, titanium, succinate, maleate, isocitrate, PEP, and the tricarboxylic acid cycle (TCA) had good predictive potential for GPL and GC. Additionally, metal(loid)s such as arsenic, titanium, barium, aluminum, and vanadium were significantly correlated with multiple glucose metabolites involved in the TCA cycle in the GPL and GC groups. Our findings imply that metal(loid) exposure disrupts glucose metabolism, jointly influencing GPL and GC progression.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"887 - 902"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Black phosphorus-incorporated novel Ti-12Mo-10Zr implant for multimodal treatment of osteosarcoma","authors":"Bianyun Cai,&nbsp;Leizhen Huang,&nbsp;Xueke Zhou,&nbsp;Xuan Zhou,&nbsp;Kun Lei,&nbsp;Meng Han,&nbsp;Zilin Zhang,&nbsp;Xiaofang Li,&nbsp;Guangda Li","doi":"10.1007/s10534-025-00674-w","DOIUrl":"10.1007/s10534-025-00674-w","url":null,"abstract":"","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 3","pages":"1019 - 1025"},"PeriodicalIF":3.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}