IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1007/s10534-025-00693-7

Shivam Kumar Pandey, Anjuman Nanda, Avtar Singh Gautam, Apurva Chittoda, Aman Tiwari, Rakesh Kumar Singh

{"title":"Ferrous sulfate and lipopolysaccharide co-exposure induce neuroinflammation, neurobehavioral motor deficits, neurodegenerative and histopathological biomarkers relevant to Parkinson's disease-like symptoms in Wistar rats.","authors":"Shivam Kumar Pandey, Anjuman Nanda, Avtar Singh Gautam, Apurva Chittoda, Aman Tiwari, Rakesh Kumar Singh","doi":"10.1007/s10534-025-00693-7","DOIUrl":"10.1007/s10534-025-00693-7","url":null,"abstract":"Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra region of the brain. Although iron is one of the essential micronutrients in the brain, its excess exposure and accumulation in the brain substantia nigra and striatum regions may induce critical pathological changes relevant to PD. This study has evaluated neurobehavioral, biochemical, and structural alterations resembling PD-like symptoms induced through a 4-week co-exposure of ferrous sulfate (FeSO4) with lipopolysaccharide (LPS) in Wistar rats. Our results revealed motor deficits, oxidative stress, neuroinflammation, iron dysregulation, protein aggregation, ferroptosis, and apoptotic cell death. Notably, we observed decreased tyrosine hydroxylase levels and increased α-synuclein accumulation, consistent with PD pathology. The immunohistopathological assessments showed astrocyte activation and iron deposition, supporting their roles in neuroinflammation and oxidative stress. Furthermore, we identified alterations in apoptosis and ferroptosis markers, suggesting dose-related involvement of FeSO4 in neuronal death in the rat brain. These findings have highlighted the multifaceted mechanisms during the co-exposure of FeSO4 and LPS-induced neurodegeneration and neuroinflammation relevant to PD. This study emphasizes that therapeutic targeting of these pathological mechanisms may offer a promising therapeutic intervention in PD.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1083-1107"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization and biological potential of nitroso-R salt with transition metal complexes. 含过渡金属配合物的亚硝基r盐的合成、表征及生物潜力。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-05-29 DOI: 10.1007/s10534-025-00698-2

Saddam Hussain, Mehreen Zafar, Nauman Ali, Takashiro Akitsu, Waseem Hassan

{"title":"Synthesis, characterization and biological potential of nitroso-R salt with transition metal complexes.","authors":"Saddam Hussain, Mehreen Zafar, Nauman Ali, Takashiro Akitsu, Waseem Hassan","doi":"10.1007/s10534-025-00698-2","DOIUrl":"10.1007/s10534-025-00698-2","url":null,"abstract":"Coordination complexes exhibited interesting potentials in different fields such as medical, industrial, pharmaceutical, and analytical. They possess versatile biological applications in drugs synthesis, extraction of noble metals like silver and gold from their ores and in metals purification. In current project we aim to synthesized and characterized transition metal complexes like Mn, Fe, Co, Ni, Cu and Zn using Nitroso-R Salt as a ligand. This study presents a novel approach to develop stable metal complexes using Nitroso R Salt, a ligand comprising nitrosyl, hydroxyl, and sulfonate groups. This study offers a combined analysis of both chemical and functional properties, which was not commonly investigated with NRS, by combining biological screening with thorough structural characterizations (FTIR, CHN, XRD and UV). The complexes were then subjected to various tests to explore their deoxyribose degradation inhibition potential, antioxidant and antimicrobial potential. Copper and Zinc Complexes showed good potential 173 and 182% against iron at 100 mM. The highest potential was recorded for Nickel complex potential 2, 7 and 14% against H2O2, Fe (II) and in combine form. It was further confirmed respectively by antioxidant DPPH assay. Ligand and complexes showed good inhibitory potential by showing 18.66, 39.32, 38.22, 28.89, 20.71, 19.14 and 28.89% for NRS, Iron, Cobalt, Nickel, Zinc, Copper and Manganese complexes at high concentration of 200uM, respectively. The complexes showed promising antibacterial and antioxidant properties. Nickel complexes demonstrated a strong inhibition against reactive species, but copper and zinc complexes showed a notably high antioxidant capacity. Effective inhibitory zones were found in antimicrobial testing, especially for Fe, Mn, Co, and Cu complexes against Klebsiella pneumoniae and Bacillus subtilis. However, further studies are needed to examine the exact mechanisms of action of these discoveries, which point to possible biomedical uses.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1165-1177"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism for the decrease of Cd uptake and transport within wheat plants in the presence of dissolved Fe(II). 溶解铁（II）存在下小麦植株Cd吸收和转运减少的机制

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-06-12 DOI: 10.1007/s10534-025-00697-3

Xianjie Duan, Ling Liu, Tao Lu, Ziwei Wang, Sheliang Wang, Chengshuai Liu, Guohong Qiu

{"title":"Mechanism for the decrease of Cd uptake and transport within wheat plants in the presence of dissolved Fe(II).","authors":"Xianjie Duan, Ling Liu, Tao Lu, Ziwei Wang, Sheliang Wang, Chengshuai Liu, Guohong Qiu","doi":"10.1007/s10534-025-00697-3","DOIUrl":"10.1007/s10534-025-00697-3","url":null,"abstract":"Dissolved Fe(II) influences Cd uptake and transport within wheat plants, but the specific interaction process remains elusive. This study used synchrotron radiation technology, Fourier transform infrared spectroscopy, high-performance liquid chromatography, ion chromatography, and RT-PCR to analyze the interaction processes of Fe(II) and Cd(II) ions in the roots of wheat grown in hydroponic systems containing Cd(II). The results indicated that dissolved Fe(II) decreases Cd uptake due to rhizosphere passivation, cell wall binding or blocking, and competitive absorption and regulation. Poorly crystalline Fe(III) oxides were newly formed, which facilitated the immobilization of Cd(II) on the rhizoplane (over 78%) in a hydroponic system with 5 μmol L-1 Cd(II). Binding of Cd(II) by cell wall depended on pectin and phosphate contents in the presence of Fe(II). Higher accumulation of lignin in the root endodermis blocked Cd(II) transport at 1000 μmol L-1 Fe(II). The Fe(II) level influenced Cd uptake by regulating the content of rhizosphere Cd(II) ions and the expression of Cd(II) uptake genes in a hydroponic system with 5 μmol L-1 Cd(II). The content of CaCl2-extractable Cd(II) was decreased by 45.4% and the expression of Cd(II) uptake genes was significantly down-regulated with Fe(II) concentration increasing from 15 to 1000 μmol L-1. In the high-concentration Cd(II) (15 μmol L-1) system, the inhibitory effect of dissolved Fe(II) on Cd uptake decreased due to increases in rhizosphere Cd content and expression of Cd(II) uptake genes. This work suggests that dissolved Fe(II) can reduce Cd uptake of wheat plants and provides fundamental data for food security.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1145-1164"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of combined exposure to multiple metals with comorbid obesity and myopia in the U.S. population. 美国人群多重金属暴露与合并症肥胖和近视的关系

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI: 10.1007/s10534-025-00701-w

Li He, Yalan Liu, Li Zhang, Ying Luo, Zhaofeng Jin

{"title":"Association of combined exposure to multiple metals with comorbid obesity and myopia in the U.S. population.","authors":"Li He, Yalan Liu, Li Zhang, Ying Luo, Zhaofeng Jin","doi":"10.1007/s10534-025-00701-w","DOIUrl":"10.1007/s10534-025-00701-w","url":null,"abstract":"The objective of this study was to examine the relationships between combined metal exposure and the comorbidities of overweight/obesity (OWOB) and myopia. Data from the National Health and Nutrition Examination Survey (2001-2006) were analyzed. The sample comprised 5927 participants aged 12 years and older, with urine measurements of 11 metals obtained through inductively coupled plasma-mass spectrometry. Least absolute shrinkage and selection operator regression models were employed to evaluate the combined effects of the metals. Multivariate logistic regression models and restricted cubic spline functions assessed the connections between metal exposure and comorbidities. The findings indicated that 1290 (21.76%) of the 5927 participants exhibited both OWOB and myopia. High levels of lead (OR = 0.76, 95% CI: 0.62-0.93), platinum (OR = 0.81, 95% CI: 0.68-0.97), and uranium (OR = 0.72, 95% CI: 0.59-0.86) were associated with a reduced risk of these comorbidities (P trend < 0.05). Conversely, elevated exposure to mixed metals was linked to an increased risk of comorbidities (OR = 1.48, 95% CI: 1.23-1.77, P trend < 0.0001). Females had a higher risk of exposure to mixed metals (OR = 4.63, 95% CI: 2.63-8.16) compared to males (OR = 1.45, 95% CI: 0.74-2.82). This study offers preliminary evidence of an association between metal exposure and the comorbidity of OWOB and myopia. Although causality cannot be inferred due to the cross-sectional nature of the study, these results support further longitudinal research.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1223-1233"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial heterogeneity in copper distribution changed antioxidant capacity of container-grown Camphora officinarum roots under excessive copper stress. 铜分布的空间异质性改变了容器樟树根在过量铜胁迫下的抗氧化能力。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-06-16 DOI: 10.1007/s10534-025-00707-4

Boya Chen, Shiyun Wu, Ying Zhang, Ming Yang, Chunliang Zhou, Yumei Zhou

{"title":"Spatial heterogeneity in copper distribution changed antioxidant capacity of container-grown Camphora officinarum roots under excessive copper stress.","authors":"Boya Chen, Shiyun Wu, Ying Zhang, Ming Yang, Chunliang Zhou, Yumei Zhou","doi":"10.1007/s10534-025-00707-4","DOIUrl":"10.1007/s10534-025-00707-4","url":null,"abstract":"Coating high concentrations of copper (Cu) on the inner wall of containers prevents root entanglement by inhibiting root tip elongation. However, it remains uncertain whether roots near and far from the container wall differentially absorb Cu, thereby triggering varied defense responses. Two-year-old Camphora officinarum were planted in containers coated with 120 (T1) and 200 (T2) g L-1 Cu(OH)2 with latex as the carrier. After six months of treatment, obvious root entanglement in containers only coated with latex (T0) and control containers was observed, while no entanglement in T1 and T2. Cu(OH)2 treatment increased soil and root Cu concentration, which exhibited significant position differences (near-wall vs. far-wall) in T1 and T2. Root Cu concentration near the container wall in T1 and T2 was 3.5 and 3.0 times higher than that far from the container wall, and 19.3 and 32.1 times higher than that in the control. Oxidative stress biomarkers increased with increasing root Cu concentration with the highest levels near the container wall in T2. Excessive Cu increased antioxidant enzyme activities and non-enzymatic antioxidant contents with higher superoxide dismutase, glutathione reductase, glutathione peroxidase, ascorbate peroxidase, ascorbate acid, and reduced glutathione in T1 and higher dehydroascorbate reductase and monodehydroascorbate in T2. Overall, antioxidant enzyme activity in roots was higher near the container wall in T1 while far from the container wall in T2. Excessive and uneven Cu distribution and oxidative stress biomarkers effectively inhibited peripheral root elongation and entanglement. During this process, although antioxidant defense responses were induced, defense capacity was impaired by supra-optimal Cu.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1299-1314"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermophiles in nanosized biocalcification: a novel approach for heavy metal remediation. 纳米级生物钙化中的嗜热菌：重金属修复的新方法。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-05-24 DOI: 10.1007/s10534-025-00700-x

Sujata Negi, Shagun Sharma, Deepak Pant, Sonali Sharma, Kalpana Chauhan, Anand Giri, Manoj Kumar, Kulamani Parida

{"title":"Thermophiles in nanosized biocalcification: a novel approach for heavy metal remediation.","authors":"Sujata Negi, Shagun Sharma, Deepak Pant, Sonali Sharma, Kalpana Chauhan, Anand Giri, Manoj Kumar, Kulamani Parida","doi":"10.1007/s10534-025-00700-x","DOIUrl":"10.1007/s10534-025-00700-x","url":null,"abstract":"Bio deposition of minerals is a prevalent occurrence in the biological realm, facilitated by various organisms such as bacteria, fungi, protists, and plants. Calcium carbonate is one such mineral that precipitates naturally as a consequence of microbial metabolic processes. This study investigates an innovative approach for MICP- mediated heavy metal remediation, carbon dioxide (CO2) sequestration by utilizing thermophilic microorganisms isolated from such geographical area which is not yet been subjected to any systematic scientific study. Beyond the well-established urea hydrolysis pathway, this research highlights the contribution of non-ureolytic MICP mechanisms driven by the oxidation of organic compounds within the bacterial extracellular polymeric substances and cell wall components of Bacillus licheniformis. Notably, both strains of Bacillus licheniformis redirect its great potential towards biocalcification yielding 89.36 ± 1.8, 88.21 ± 1.5 mg CaCO3 cells/ml and 90% efficiency for heavy metal remediation with the formation of nanosized (35.85 nm, 38.58 nm) biominerals. The influence of various parameters, such as temperature, pH, incubation time, CO2 concentration, and calcium concentration on maximum CaCO3 biosynthesis was evaluated. FTIR, XRD, and SEM-EDX analyses confirmed characteristic peaks for both calcite and vaterite polymorphs, consistent with these Pb incorporation into the mineral structure, rather than surface adsorption is observed. These comparative findings provide valuable insights for promising bioremediation approach for the sustainable, eco-friendly, energy-efficient immobilization of metal contaminants and bio-based carbonate production for efficient CO2 sequestration.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1203-1221"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hexavalent chromium induced bioaccumulation, oxidative responses and histological anomalies in freshwater carp Labeo rohita (Hamilton, 1822). 六价铬诱导淡水鲤鱼Labeo rohita的生物蓄积、氧化反应和组织学异常（Hamilton, 1822）。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1007/s10534-025-00708-3

Archisman Ray, Debashri Mondal, Debapriyo Mukherjee, Nabanita Chakraborty

{"title":"Hexavalent chromium induced bioaccumulation, oxidative responses and histological anomalies in freshwater carp Labeo rohita (Hamilton, 1822).","authors":"Archisman Ray, Debashri Mondal, Debapriyo Mukherjee, Nabanita Chakraborty","doi":"10.1007/s10534-025-00708-3","DOIUrl":"10.1007/s10534-025-00708-3","url":null,"abstract":"The toxicity of chromium, in its hexavalent form (Cr(VI)), is extremely harmful to living organisms owing to its potent oxidizing properties. The present research focused in exploring the hexavalent chromium induced bioaccumulation, oxidative responses and histological anomalies in widely cultured freshwater carp Labeo rohita. Fingerlings of L. rohita were exposed to four sub-lethal waterborne concentrations of 96 h LC50 (1/40th, 1/20th, 1/10th and 1/5th) of the Cr(VI). The impact of chromium was assessed in 5, 15 and 30 days exhibiting significant accumulation (P < 0.05) in the fish tissues (gill > kidney > liver > muscles) with increasing concentration. The bioaccumulation factor (BAF) also exhibited the highest in the liver tissue and least in muscle. Antioxidant enzymes like superoxidase dismutase (SOD) in the gill, liver and kidney increased significantly with the concentrations, while catalase (CAT) activity was found to fluctuate along different concentrations. Significant reduction in growth performance i.e. SGR and reduced feeding intensity was also observed after 30th day. The histopathological examination revealed epithelial hyperplasia in the gill tissues and vacuolization and shrinkage of hepatocytes in the liver tissues. Chromium toxicity-induced alterations in kidney tissues were also characterized by glomerular shrinkage and an increase in Bowman's space. Overall, the study demonstrated that hexavalent chromium exerts significant impact on accumulation, oxidative stress, and histological anomalies, particularly at higher concentrations, in the fingerlings of L. rohita. Therefore, effective treatment of wastewater below the studied concentrations from anthropogenic sources prior to its release into aquatic environments is vital to avert pollution and safeguard the sustainability of aquatic life.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1315-1335"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biogenic synthesis of zinc oxide nanoparticles using leaf extract of Oxalis stricta and its effect on colon cancer: an in vitro and in silico approach. 草叶提取物生物合成氧化锌纳米颗粒及其对结肠癌的影响：体外和计算机方法。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-07-04 DOI: 10.1007/s10534-025-00710-9

Sathyapriya Chandramohan, Anjali Suresh Nair, Richa Das, Suhail Ahmad Bhat, Guguloth Sai Krishna, Neena Yadav, V K Archana, Rukkumani Rajagopalan

{"title":"Biogenic synthesis of zinc oxide nanoparticles using leaf extract of Oxalis stricta and its effect on colon cancer: an in vitro and in silico approach.","authors":"Sathyapriya Chandramohan, Anjali Suresh Nair, Richa Das, Suhail Ahmad Bhat, Guguloth Sai Krishna, Neena Yadav, V K Archana, Rukkumani Rajagopalan","doi":"10.1007/s10534-025-00710-9","DOIUrl":"10.1007/s10534-025-00710-9","url":null,"abstract":"Colon cancer is among the most common colorectal malignancies and a leading cause of cancer-related mortality worldwide. Conventional therapies, including chemotherapy, often cause severe side effects and drug resistance, underscoring the need for safer and more effective alternatives. Green nanotechnology has emerged as a promising approach in cancer therapy, offering sustainable and biocompatible therapeutic options. In this study, Zinc oxide nanoparticles (ZnO NPs) were synthesized using Oxalis stricta leaf extract via an eco-friendly green synthesis approach and evaluated for their anticancer potential against colon cancer. Characterization by UV-VIS spectroscopy, Dynamic Light Scattering, Scanning Electron Microscopy, Fourier-transform Infrared spectroscopy, and X-ray Photoelectron Spectroscopy confirmed the nanoscale size, stability, and surface functionalization of the ZnO NPs. Cytotoxicity evaluation using the MTT assay revealed a dose-dependent anti-proliferative effect on colon cancer cells, with an IC₅₀ value of 30.27 µg/mL. Hemolysis assay indicated good biocompatibility with minimal red blood cell lysis. Apoptosis induction was evidenced by fluorescence staining techniques, including DAPI, AO/EB, DCF-DA, and Rhodamine 123, revealing nuclear condensation, oxidative stress, and mitochondrial membrane disruption. In silico molecular docking demonstrated strong binding interactions between phytoconstituents of Oxalis stricta and cancer-related targets MMP-9, GSK3β, and Bcr-Abl. Furthermore, ZnO NPs inhibited cell migration and matrix metalloproteinase activity, as evidenced by wound healing and gelatin zymography assays. These findings suggest that Oxalis stricta mediated ZnO NPs hold significant promise as a biocompatible, multi-targeted nanotherapeutic agent for colon cancer treatment.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1355-1380"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-modal approach to lung cancer treatment: in vitro and in silico. Evaluation of a hybrid nanocomposite for synergistic chemotherapy. 肺癌治疗的双模态方法：体外和计算机。混合纳米复合材料协同化疗的评价。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI: 10.1007/s10534-025-00694-6

Omar Alnasra, Fawwaz I Khalili, Lama Hamadneh, Mohammad Alwahsh, Rana Omar, Amani AlDoridee, Aya Hasan

{"title":"A dual-modal approach to lung cancer treatment: in vitro and in silico. Evaluation of a hybrid nanocomposite for synergistic chemotherapy.","authors":"Omar Alnasra, Fawwaz I Khalili, Lama Hamadneh, Mohammad Alwahsh, Rana Omar, Amani AlDoridee, Aya Hasan","doi":"10.1007/s10534-025-00694-6","DOIUrl":"10.1007/s10534-025-00694-6","url":null,"abstract":"This study investigates the therapeutic potential of a nanosilica-cysteine composite loaded with arsenic trioxide (SC-As) in combination with cisplatin (CIS), paclitaxel (PTX), and doxorubicin (DOX) for lung/breast cancer treatment. Through comprehensive synthesis, characterization (ATR-FTIR, XRD, SEM, TEM, DLS), and cytotoxicity assessments, SC-As demonstrated superior potency with IC₅₀ values as low as 7.29 ± 1.40 µM in lung cancer (A549) and 8.60 ± 1.20 µM in breast cancer (MCF-7) cell lines. This study employs a dual-modal approach, combining in silico computational predictions (CompuSyn) with in vitro experiments to evaluate synergistic chemotherapy regimens, ensuring robust validation of therapeutic outcomes. The computational synergy analysis and the experimental validation in lung cancer cell lines revealed synergistic interactions between SC-As and CIS (CI < 1), enabling significant dose reductions (DRI > 1). Conversely, antagonism was observed with PTX and DOX in A549 cells, though H1299 cells exhibited unanticipated synergistic interactions with PTX/DOX. Given that H1299 cells represent a more aggressive and metastatic form of lung cancer, these results suggest that PTX and DOX combinations may have enhanced therapeutic potential in treating highly malignant lung cancer subtypes. These findings underscore the composite's potential as a targeted delivery system and highlight the necessity of integrating computational predictions with empirical validation to optimize combinatorial efficacy and minimize toxicity, providing a foundation for future in vivo and clinical studies.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1109-1130"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic applications of quercetin-metallic complexes: a review. 槲皮素-金属配合物的治疗应用综述。

IF 3.6 3区生物学

Biometals Pub Date : 2025-08-01 Epub Date: 2025-05-22 DOI: 10.1007/s10534-025-00696-4

Nasreen Ramzan, Huma Butt, Muhammad Azeem, Muhammad Hanif, Khalid Mahmood, Sadia Rehman, Dure Shahwar, Muhammad Zeeshan, Qurat-Ul-Ain Ahmad, Mehreen Jabeen

{"title":"Therapeutic applications of quercetin-metallic complexes: a review.","authors":"Nasreen Ramzan, Huma Butt, Muhammad Azeem, Muhammad Hanif, Khalid Mahmood, Sadia Rehman, Dure Shahwar, Muhammad Zeeshan, Qurat-Ul-Ain Ahmad, Mehreen Jabeen","doi":"10.1007/s10534-025-00696-4","DOIUrl":"10.1007/s10534-025-00696-4","url":null,"abstract":"Flavonoids, especially quercetin, are widely recognized for their antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, and anti-tumor properties, but their clinical application is limited by poor permeability. Different techniques of permeability enhancement of quercetin, i.e., preparation of phytosomes, conjugation with glucose, and interaction of piperine, are reported extensively, but formation of metal complexes is considered more precise and reliable. This review focuses on research conducted on the chelation of quercetin with metals, i.e., copper (II), zinc (II), iron and ruthenium. In-vitro and in-vivo therapeutic activities, biomedical applications of metal/quercetin inclusion complexes and discussions of stability concerns of quercetin alone and its metallic complexes. Conjugation of metals with quercetin augments its potential to the next level. Numerous studies revealed that quercetin/copper (Q/Cu) and quercetin/zinc (Q/Zn) can become efficacious candidates in acute myeloid leukaemia, orthopaedics and severe acute respiratory syndrome coronavirus (SARS-CoV) infection.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"1027-1048"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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