IF 4.1 3区生物学

Biometals Pub Date : 2024-12-23 DOI: 10.1007/s10534-024-00655-5

Indu Sindhu, Anshul Singh

{"title":"Nitro Substituted Co(II), Ni(II) and Cu(II) Schiff Base Metal complexes: design, spectral analysis, antimicrobial and in-silico molecular docking investigation.","authors":"Indu Sindhu, Anshul Singh","doi":"10.1007/s10534-024-00655-5","DOIUrl":"https://doi.org/10.1007/s10534-024-00655-5","url":null,"abstract":"The Schiff base metal complexes containing the transition metal ions Co(II), Ni(II) and Cu(II) were synthesized using their nitrate and acetate salts. An octahedral environment encircling metal complexes has been demonstrated by the findings of multiple spectroscopic approaches that were employed to demonstrate the structure of the metal complexes. The Coats-Redfern method of thermal analysis was employed to carry out the kinetic and thermodynamic calculations. The crystalline size of ligand was 36.67 nm and for the metal complexes it varies from 22.43 to 49.21 nm. To assess the biological effectiveness of these compounds, molecular docking studies were emanated. The docking binding studies were established through the interaction of metal complexes with human cancer protein, such as 3W2S (ovarian cancer) and 4ZVM (breast cancer). The results exemplified that the complexes are more efficient towards ovarian cancer (3W2S) in contrast to breast cancer (4ZVM) while among complexes, the nickel acetate (- 7.0 kcal/mol) and copper acetate (- 7.9 kcal/mol) complex were more efficient towards 4ZVM and 3W2S receptors respectively. Additionally, DNA binding studies against 1BNA receptor protein was examined from docking evaluations and the finding concludes the highest efficiency of nickel (- 8.1 kcal/mol) complexes. Further, a number of bacterial and fungal strains have been implemented in antimicrobial examinations to assess the compounds effectualness. The results untangled the extreme potential of copper nitrate (0.0051-0.0102 µmol/mL) and copper acetate (0.0051-0.0103 µmol/mL) complexes against all bacterial and fungal strains except for S. aureus in which nickel acetate proved out to be highly competent.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper induced augmentation of antibiotic resistance in Acinetobacter baumannii MCC 3114.

IF 4.1 3区生物学

Biometals Pub Date : 2024-12-21 DOI: 10.1007/s10534-024-00657-3

Ravi Chauhan, Hardi Patel, Bhavna Bhardwaj, Vijay Suryawanshi, Seema Rawat

{"title":"Copper induced augmentation of antibiotic resistance in Acinetobacter baumannii MCC 3114.","authors":"Ravi Chauhan, Hardi Patel, Bhavna Bhardwaj, Vijay Suryawanshi, Seema Rawat","doi":"10.1007/s10534-024-00657-3","DOIUrl":"https://doi.org/10.1007/s10534-024-00657-3","url":null,"abstract":"Increasing antibiotic resistance among the common nosocomial pathogen i.e. Acinetobacter baumannii poses life threat to the health care workers as well as to the society. The dissemination of antibiotic resistance in this pathogen at an alarming rate could be not only due to the overuse of antibiotics but also due to the stress caused by exposure of bacterium to several environmental contaminants in their niches. In the present study, effect of copper stress on augmentation in the antibiotic resistance of A. baumannii MCC 3114 against three clinically used antibiotics was investigated along with the phenotypic and genotypic alterations in the cell. It induced 8, 44 and 22-fold increase in resistance against colistin, ciprofloxacin and levofloxacin, respectively. Moreover, the biofilm formation of adapted culture was significantly enhanced due to a dense EPS around the cell (as revealed by SEM images). The structural changes in EPS were demonstrated by FTIR spectroscopy. The adequate growth of adapted MCC 3114 despite increased level of ROS indicates its persistence in copper and ROS stress. The physiological alterations in cell viz., increased efflux pump activity and decreased membrane permeability was observed. Molecular analysis revealed increased expression of efflux pump related genes, oxidative stress genes, integron and antibiotic resistance genes. In sum, our study revealed that the exposure of the critical pathogen, A. baunmannii to copper in hospital settings and environmental reservoirs can impose adaptive pressure which may lead to genotypic as well phenotypic changes in cell resulting into the augmentation of antibiotic resistance.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.

IF 4.1 3区生物学

Biometals Pub Date : 2024-12-16 DOI: 10.1007/s10534-024-00656-4

Shivsharan B Dhadde, Mallinath S Kalshetti

{"title":"Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.","authors":"Shivsharan B Dhadde, Mallinath S Kalshetti","doi":"10.1007/s10534-024-00656-4","DOIUrl":"https://doi.org/10.1007/s10534-024-00656-4","url":null,"abstract":"The interaction of metal ions with biological systems plays a critical role in cellular functions, including oxidative stress regulation and metabolic health. This study aimed to explore the effects of the chromium-histidine complex [Cr(hist)3] on reproductive success, developmental processes, and oxidative stress defence in Drosophila melanogaster. Wild-type D. melanogaster flies were exposed to Cr(hist)3 at concentrations of 5, 10, 15, and 20 µg/ml, and physiological parameters-including fecundity, fertility, developmental timelines, and antioxidant enzyme activity-were measured. Our results indicate that Cr(hist)3 at 15 µg/ml optimally enhanced reproductive health and developmental efficiency. Specifically, fecundity and fertility increased by 15.6% and 15.5%, respectively, and egg-to-adult viability improved by 15.6% compared to controls. Developmental timelines were shortened, with larval and pupal periods reduced by 7.6% and 7.1%. Additionally, Cr(hist)3 treatment led to a significant downregulation of lipid peroxidation (MDA) by 17.54% and upregulation in antioxidant enzymes (catalase, glutathione-S-transferase, and superoxide dismutase), indicating improved cellular defence against oxidative damage. Flies treated with 15 µg/ml Cr(hist)33 also exhibited a 9.7% increase in lifespan. These findings suggest that Cr(hist)3 enhances reproductive success and developmental dynamics through oxidative stress regulation, highlighting its potential for applications in insect health and stress management. This study contributes to the understanding of metal ion interactions in biological systems and their physiological effects.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent superparamagnetic magnetite-silica nanocomposites as carriers of a platinum diimine complex for photodynamic therapy.

IF 4.1 3区生物学

Biometals Pub Date : 2024-12-02 DOI: 10.1007/s10534-024-00654-6

Yuxin Lu, Xuemei Guo, Xin Wang, Xu Zhang, Hongfei Wang, Zhigang Zhang

{"title":"Fluorescent superparamagnetic magnetite-silica nanocomposites as carriers of a platinum diimine complex for photodynamic therapy.","authors":"Yuxin Lu, Xuemei Guo, Xin Wang, Xu Zhang, Hongfei Wang, Zhigang Zhang","doi":"10.1007/s10534-024-00654-6","DOIUrl":"https://doi.org/10.1007/s10534-024-00654-6","url":null,"abstract":"Novel fluorescent superparamagnetic nanocomposites have been fabricated by introduction of the coumarin group on the surface of amine-functionalized magnetite-silica nanocomposites, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy, fluorescence spectra, dynamic light scattering and vibrating sample magnetometer techniques. The nanocomposites were employed as delivery vehicles of a photoactive platinum diimine complex. The cellular uptake and photocytotoxicity of the photosensitizer-loaded nanocomposites in HeLa cells (human cervical cancer line) or HL-7702 cells (human liver cell line) have been studied by fluorescence spectra and cell viability assay, respectively. The results suggest that the nanocomposites can be used to monitor the cellular uptake of the photosensitizer, and can significantly enhance the photocytotoxicity of the photosensitizer towards cancer cells when employed as carriers of the photosensitizer. Also, the photosensitizer-loaded nanocomposites are almost nontoxic to human normal cells either in the dark or after irradiation.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of plasma essential element concentrations to explore markers of acute myocardial infarction.

IF 4.1 3区生物学

Biometals Pub Date : 2024-12-02 DOI: 10.1007/s10534-024-00653-7

Junko Fujihara, Naoki Nishimoto, Yoshikazu Takinami

{"title":"Study of plasma essential element concentrations to explore markers of acute myocardial infarction.","authors":"Junko Fujihara, Naoki Nishimoto, Yoshikazu Takinami","doi":"10.1007/s10534-024-00653-7","DOIUrl":"https://doi.org/10.1007/s10534-024-00653-7","url":null,"abstract":"Essential element concentrations in biological samples may be related to the pathogenesis of various diseases. Previous studies have reported that serum iron (Fe), zinc (Zn), and copper (Cu) were related to acute myocardial infarction (AMI). However, the differences in element concentrations between AMI and other cardiac disease has not been investigated. In this study, differences in plasma Fe, magnesium (Mg), Zn, Cu, calcium (Ca), inorganic phosphorus (P), and cardiac troponin T (TnT) levels in heart disease patients (AMI, angina, heart failure, and chest pain) were investigated to explore potential markers of AMI. Fe, Mg, Zn, and Cu concentrations were assayed by using a Metallo Assay kit; Ca and inorganic P were determined by using an automatic biochemical analyzer; and cardiac TnT levels were assayed by using enzyme-linked immunosorbent assay. Plasma TnT levels were higher in AMI than in other heart diseases and were negatively correlated with Cu and Ca. Fe, Cu, and inorganic P levels were within the normal range, while Mg and Ca levels were lower, and Zn levels were higher than the normal range in heart disease patients. Except Mg, no significant differences in element levels were observed among heart diseases: Mg levels were significantly higher in AMI than in heart failure. These results suggest that lower Cu and Ca levels and a higher Mg level compared with other heart diseases may be a marker of AMI.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, characterization, and bioactivity of Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) complexes with benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde: experimental and computational insights.

IF 4.1 3区生物学

Biometals Pub Date : 2024-11-29 DOI: 10.1007/s10534-024-00652-8

Shravan Kumar Singh, Abhay Bagul, Aisha Tufail, Perwez Alam, Santosh Waman Kulkarni, Sheetal Sharma, Amit Dubey

引用次数: 0

Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles. Agaricus blazei Murill 多糖对纳米氧化铜（II）的合成、稳定、急性毒性和抗真菌活性的影响。

IF 4.1 3区生物学

Biometals Pub Date : 2024-11-21 DOI: 10.1007/s10534-024-00650-w

Álamo Lourenço de Souza, Matheus da Silva Campelo, Gabriel de Sousa Mesquita, Augusto Feynman Dias Nobre, Vitória Maria de Freitas Franco, Antônio César Honorato Barreto, Jeanlex Soares de Sousa, José Eduardo Ribeiro Honório Júnior, Raimunda Sâmia Nogueira Brilhante, Nágila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Maria Elenir Nobre Pinho Ribeiro

{"title":"Influence of Agaricus blazei Murill polysaccharides on synthesis, stabilization, acute toxicity and antifungal activity of copper (II) oxide nanoparticles.","authors":"Álamo Lourenço de Souza, Matheus da Silva Campelo, Gabriel de Sousa Mesquita, Augusto Feynman Dias Nobre, Vitória Maria de Freitas Franco, Antônio César Honorato Barreto, Jeanlex Soares de Sousa, José Eduardo Ribeiro Honório Júnior, Raimunda Sâmia Nogueira Brilhante, Nágila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Maria Elenir Nobre Pinho Ribeiro","doi":"10.1007/s10534-024-00650-w","DOIUrl":"https://doi.org/10.1007/s10534-024-00650-w","url":null,"abstract":"In general, nanomaterials tend to have better physical, chemical and biological properties than conventional materials. Furthermore, the polysaccharides from Agaricus blazei Murill mushroom have several pharmacological properties, in addition to low cytotoxicity and high biocompatibility. This work sought to merge the properties of CuO nanoparticles and Agaricus blazei Murill polysaccharides through syntheses and coatings with the aim of evaluating their toxicity in adult zebrafish and antifungal activity against C. albicans and C. parapsilosis. The nanoparticles were synthesized using the coprecipitation method and subsequently characterized in terms of their physicochemical properties using spectroscopic and thermoanalytical techniques. Furthermore, their composition was determined by X-Ray Diffraction and their morphology was studied using different microscopic techniques. CuO nanoparticles coated with Agaricus blazei Murill polysaccharides showed smaller particle size. Dispersions of nanoparticles coated with the polysaccharides were found to be more stable than their uncoated counterparts. The nanoparticles also showed antifungal activity against Candida sp. strains, with MIC50 values between 64 and 512 µg mL-1. It was observed that coating the materials with polysaccharides preserved their antifungal properties and reduced acute toxicity against adult zebrafish. Therefore, it is estimated that the CuO nanoparticles coated with Agaricus blazei Murill polysaccharides are innovative nanomaterials with potential for future clinical applications, especially in the topical treatment of candidiasis.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis. 在多发性硬化症大鼠模型中，小檗碱负载的氧化铁纳米粒子可减轻铜绿素诱导的星形胶质细胞反应。

IF 4.1 3区生物学

Biometals Pub Date : 2024-11-14 DOI: 10.1007/s10534-024-00648-4

Ghadha Ibrahim Fouad, Mostafa Mabrouk, Sara A M El-Sayed, Mohamed F Abdelhameed, Maha Z Rizk, Hanan H Beherei

{"title":"Berberine-loaded iron oxide nanoparticles alleviate cuprizone-induced astrocytic reactivity in a rat model of multiple sclerosis.","authors":"Ghadha Ibrahim Fouad, Mostafa Mabrouk, Sara A M El-Sayed, Mohamed F Abdelhameed, Maha Z Rizk, Hanan H Beherei","doi":"10.1007/s10534-024-00648-4","DOIUrl":"https://doi.org/10.1007/s10534-024-00648-4","url":null,"abstract":"Berberine (BBN) is a naturally occurring alkaloid as a secondary metabolite in many plants and exhibits several benefits including neuroprotective activities. However, data on the neuromodulating potential of nanoformulated BBN are still lacking. In the present study, BBN loaded within iron oxide nanoparticles (BBN-IONP) were prepared and characterized by transmission electron microscopy FTIR, X-ray photoelectron spectroscopy particle-size distribution, zeta potential, and HPLC. The remyelinating neuroprotective potential of BBN-IONP relative to free BBN was evaluated against cuprizone (CPZ)-induced neurotoxicity (rats administered 0.2% CPZ powder (w/w) for five weeks). CPZ rats were treated with either free BBN or IONP-BBN (50 mg/kg/day, orally) for 14 days. Cognitive function was estimated using Y-maze. Biochemically, total antioxidant capacity lipid peroxides and reduced glutathione in the brain tissue, as well as, serum interferon-gamma levels were estimated. Moreover, the genetic expression contents of myelin basic protein Matrix metallopeptidase-9 Tumor necrosis factor-α (TNF-α), and S100β were measured. The histopathological patterns and immunohistochemical assessment of Glial Fibrillary Acidic Protein in both cerebral cortex and hippocampus CA1 regions were investigated. CPZ-rats treated with either free BBN or IONP-BBN demonstrated memory restoring, anti-oxidative, anti-inflammatory, anti-astrocytic, and remyelinating activities. Comparing free BBN with IONP-BBN revealed that the latter altered the neuromodulating activities of BBN, showing superior neuroprotective activities of IONP-BBN relative to BBN. In conclusion, both forms of BBN possess neuroprotective potential. However, the use of IONPs for brain delivery and the safety of these nano-based forms need further investigation.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of mosses in 'clean and green' phytoremediation technology: a review paper. 苔藓在 "清洁和绿色 "植物修复技术中的作用：综述论文。

IF 4.1 3区生物学

Biometals Pub Date : 2024-11-14 DOI: 10.1007/s10534-024-00649-3

Abiy Gezahegn, Eve Bohnett, Siraj Mammo

{"title":"The role of mosses in 'clean and green' phytoremediation technology: a review paper.","authors":"Abiy Gezahegn, Eve Bohnett, Siraj Mammo","doi":"10.1007/s10534-024-00649-3","DOIUrl":"https://doi.org/10.1007/s10534-024-00649-3","url":null,"abstract":"Phytoremediation, the practice of removing heavy metals from contaminated sites using plants, has emerged as a cost-effective, environmentally friendly green technology to restore damaged ecosystems. Mosses, in particular, demonstrate high phytoremediation potential due to their ability to accumulate heavy metals such as lead, zinc, copper, chromium, cadmium, and iron from contaminated soil and water. This review systematically examines 37 research articles published from 2000 to 2022, focusing on the on the use of mosses for phytoremediation. Moss species, such as Funaria hygrometrica Hedw, Scopelophila cataractae (Mitten) Brotherus, Dicranum scoparium Hedw, Dicranum polysetum Sw. ex anon, Hypnum cupressiforme Hedw, Physcomitrium cyathicarpum Mitt, Barbula constricta Mitt, and Leptodictyum riparium (Hedw.) Warnst. have been identified as ideal candidates for phytoremediation efforts. Specific species of mosses, such as Dicranum species, are noted for their excellent bioaccumulation capabilities of elements like vanadium, manganese, and rubidium, serving as indicators of air pollution. Additionally, Hypnum cupressiforme has proven to be a reliable indicator of sulfur dioxide in natural and anthropogenic sources. This comprehensive review highlights the significant phytoremediation potential of mosses, emphasizing their role as valuable bioaccumulators and indicators of heavy metals and pollutants. The findings highlight the necessity of further research to enhance the application of mosses in environmental management and remediation strategies, ultimately contributing to the development of sustainable and effective solutions for pollution control.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallic nanoparticles: a promising novel therapeutic tool against antimicrobial resistance and spread of superbugs. 金属纳米粒子：一种有前途的新型治疗工具，可对抗抗菌药耐药性和超级细菌的传播。

IF 4.1 3区生物学

Biometals Pub Date : 2024-10-24 DOI: 10.1007/s10534-024-00647-5

Naheem Adekilekun Tijani, Joseph Hokello, Emmanuel Eilu, Saheed Adekunle Akinola, Abdullateef Opeyemi Afolabi, Danladi Makeri, Tonny Wotoyitide Lukwago, Irene M Mutuku, Alex Mwesigwa, Andrew Baguma, Ismail Abiola Adebayo

{"title":"Metallic nanoparticles: a promising novel therapeutic tool against antimicrobial resistance and spread of superbugs.","authors":"Naheem Adekilekun Tijani, Joseph Hokello, Emmanuel Eilu, Saheed Adekunle Akinola, Abdullateef Opeyemi Afolabi, Danladi Makeri, Tonny Wotoyitide Lukwago, Irene M Mutuku, Alex Mwesigwa, Andrew Baguma, Ismail Abiola Adebayo","doi":"10.1007/s10534-024-00647-5","DOIUrl":"https://doi.org/10.1007/s10534-024-00647-5","url":null,"abstract":"In recent years, antimicrobial resistance (AMR) has become an alarming threat to global health as notable increase in morbidity and mortality has been ascribed to the emergence of superbugs. The increase in microbial resistance because of harboured or inherited resistomes has been complicated by the lack of new and effective antimicrobial agents, as well as misuse and failure of existing ones. These problems have generated severe and growing public health concern, due to high burden of bacterial infections resulting from scarce financial resources and poor functioning health systems, among others. It is therefore, highly pressing to search for novel and more efficacious alternatives for combating the action of these super bacteria and their infection. The application of metallic nanoparticles (MNPs) with their distinctive physical and chemical attributes appears as promising tools in fighting off these deadly superbugs. The simple, inexpensive and eco-friendly model for enhanced biologically inspired MNPs with exceptional antimicrobial effect and diverse mechanisms of action againsts multiple cell components seems to offer the most promising option and said to have enticed many researchers who now show tremendous interest. This synopsis offers critical discussion on application of MNPs as the foremost intervening strategy to curb the menace posed by the spread of superbugs. As such, this review explores how antimicrobial properties of the metallic nanoparticles which demonstrated considerable efficacy against several multi-drugs resistant bacteria, could be adopted as promising approach in subduing the threat of AMR and harvoc resulting from the spread of superbugs.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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