Biometals最新文献

{"title":"Yhk8 as a genomic modifier of copper susceptibility in yeast.","authors":"Valeria Olguín, Sofia Contreras, Francisca Arriagada, Javier Saavedra, Benjamín Szenfeld, Francisco A Cubillos, Andrés D Klein","doi":"10.1007/s10534-026-00905-8","DOIUrl":"https://doi.org/10.1007/s10534-026-00905-8","url":null,"abstract":"<p><p>Copper is essential for life as an enzymatic cofactor and antioxidant participant, but in excess, it is toxic to all living organisms, including yeast. Because this toxicity varies by genetic background, we investigated the underlying modifier loci using a panel of four genetically diverse strains-Sake (SA), North American (NA), West African (WA), and Wine/European (WE)-and their segregants. Copper sulfate (CuSO₄) susceptibility, quantified by the maximum growth rate (µMax), was strain-dependent, with resistance decreasing in the order SA > WE > WA > NA. Furthermore, cellular growth was inversely correlated with intracellular superoxide levels measured via dihydroethidium staining. By analyzing µMax in 96 segregants from an SA x NA cross exposed to CuSO₄, we performed quantitative trait locus (QTL) mapping and prioritized 16 candidate modifiers. Functional validations in a Yhk8 deletant resulted in impaired growth and elevated superoxide levels upon copper exposure. Finally, bioinformatics structural predictions support that Yhk8 is a putative drug/proton antiporter with functional analogy to human SLC47A1, containing a predicted copper-binding site. Together, these findings support Yhk8 as a key genetic modifier of copper response in yeast.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149356995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aluminum-induced disruption of mineral homeostasis and oxidative imbalance in rats: modulation by bromelain.","authors":"Cagatay Ozbey, Onur Atakisi","doi":"10.1007/s10534-026-00906-7","DOIUrl":"https://doi.org/10.1007/s10534-026-00906-7","url":null,"abstract":"<p><p>Aluminum toxicity is associated with disruption of mineral homeostasis and oxidative stress; however, comprehensive characterization of simultaneous alterations in serum mineral elements remains limited. This study investigated systemic changes in serum mineral homeostasis during chronic aluminum exposure and evaluated whether bromelain modulates these alterations together with oxidative status in rats. Twenty-four male Sprague-Dawley rats were randomly assigned to four groups (control, aluminum, aluminum plus bromelain, and bromelain; n = 6 per group). Aluminum chloride (34 mg/kg/day, intraperitoneally) and bromelain (250 mg/kg/day, orally) were administered for 45 days. Serum concentrations of aluminum (Al), calcium (Ca), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), and selenium (Se) were simultaneously determined by inductively coupled plasma-optical emission spectrometry (ICP-OES). Plasma total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), homocysteine, and correlations between serum aluminum and mineral elements were also evaluated. Chronic aluminum exposure markedly increased serum aluminum concentrations while significantly decreasing serum Ca, Fe, K, Mg, Na, and Se concentrations (all P < 0.001), demonstrating profound disruption of mineral homeostasis. Serum aluminum concentrations were inversely correlated with all measured mineral elements, with the strongest correlations observed for calcium, sodium, and selenium. Aluminum exposure also decreased TAS and increased TOS and NO levels, indicating systemic oxidative imbalance. Bromelain administration partially restored mineral concentrations and improved systemic redox status without significantly affecting homocysteine levels. These findings demonstrate that chronic aluminum exposure induces coordinated disturbances in mineral homeostasis accompanied by oxidative imbalance. Simultaneous multi-element analysis revealed a close association between aluminum accumulation and depletion of essential minerals. Bromelain partially restored mineral homeostasis together with systemic redox status, suggesting that preservation of mineral homeostasis may contribute to its protective effects against aluminum toxicity.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper overload induces oxidative stress in mesenteric PVAT and modulates vascular reactivity.","authors":"Nina Bruna de Souza Mawandji, Ingridy Reinholz Grafites Schereider, Júlia Martins Vieira, Nayara Ariel da Silva Lisboa, Karolini Zuqui Nunes, Dalton Valentim Vassallo, Andressa Bolsoni-Lopes","doi":"10.1007/s10534-026-00904-9","DOIUrl":"https://doi.org/10.1007/s10534-026-00904-9","url":null,"abstract":"<p><p>Copper is an essential micronutrient involved in several physiological function; however, elevated copper levels are associated with vascular dysfunction. Previous evidence indi-cates that copper overload promotes inflammation in perivascular adipose tissue (PVAT), a key regulator of vascular function. In this context, we investigated whether chronic copper overload modulates the redox profile of mesenteric PVAT and vascular reactivity. Male Wistar rats, 8 weeks old, were divided into two groups: Control (saline, i.p.) and Copper (25.72 µg/kg/day of Cu, i.p., for 30 days). Mesenteric PVAT was collected for analysis of re-active oxygen species (ROS) production, nitric oxide (NO) bioavailability, H₂O₂ levels, total SOD activity, eNOS gene expression, and SOD1, catalase, and NOX4 protein expression. Vascular reactivity to phenylephrine was also evaluated. Serum samples were used for bio-chemical analyses. Chronic copper overload increased the fluorescent signal associated with ROS production in mesenteric PVAT, accompanied by reduced SOD1 protein expres-sion and increased NOX4 protein expression. No significant differences were observed in total SOD activity, eNOS gene expression, or catalase protein levels. NO bioavailability and H₂O₂ levels also remained unchanged. In mesenteric artery rings, copper treatment reduced vascular responsiveness to phenylephrine in the absence of PVAT, while the anticontractile effect of PVAT was maintained after copper exposure. Alterations in redox-related parame-ters were observed in mesenteric PVAT of Wistar rats that received copper, along with a re-duction in phenylephrine-induced contractile responses in mesenteric arteries in the ab-sence of PVAT. However, this reduced vasoconstrictor response was not observed in the presence of PVAT.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial perturbation in heavy metal-induced neuroinflammation and neurodegeneration: mechanisms, phenotypic plasticity, and therapeutic prospects.","authors":"Rademene Sunday Oria, Ugochukwu Godfrey Esomonu, Kenneth Igbang Sunday, Peter Arinze Oge","doi":"10.1007/s10534-026-00895-7","DOIUrl":"https://doi.org/10.1007/s10534-026-00895-7","url":null,"abstract":"<p><p>Heavy metal exposure has emerged as a significant environmental contributor to neurodegenerative disease, and a substantial body of mechanistic evidence implicates microglia in the pathological cascades that follow. Lead, cadmium, arsenic, manganese, copper, cobalt, mercury, and zinc disrupt central nervous system homeostasis through multiple cellular targets, but the resident innate immune cells of the brain are well placed to translate these insults into sustained neuroinflammation. Evidence for this critical narrative review was assembled through a purposive search of PubMed, MEDLINE, and Google Scholar for mechanistically informative studies reporting glial endpoints, with reference lists searched by hand and no systematic protocol applied. This review synthesizes current understanding of how individual metals engage microglial signaling networks, with particular attention to oxidative stress, NF-κB activation, NLRP3 inflammasome assembly, MAPK cascades, and suppression of the Nrf2 antioxidant axis. We examine the phenotypic spectrum that extends well beyond the classical M1/M2 dichotomy, including disease-associated microglia, lipid-droplet-accumulating microglia, and interferon-responsive states, and consider how metal-specific signatures map onto these transcriptional programs. Manganese-driven inflammasome assembly, cadmium-induced mitochondrial impairment, lead-mediated disruption of calcium homeostasis, and mercury-evoked autophagic dysfunction are discussed as illustrative examples of mechanistic divergence within a common neuroinflammatory framework. Glial responses to metal mixtures, which better represent real exposure than single-element designs, are considered separately, and the evidence for greater-than-additive effects is appraised. Downstream consequences for astrocyte reactivity, blood-brain barrier integrity, synaptic remodeling, and neuronal viability are placed in the context of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Therapeutic avenues are appraised, including chelation, natural antioxidants, NLRP3 inhibitors, TREM2 modulation, and microglial replacement strategies. Methodological constraints, particularly the overreliance on BV-2 cells and acute high-dose exposure paradigms, are critically considered. The review concludes by identifying priorities for translational research, including longitudinal human cohort studies, single-cell transcriptomic profiling of metal-exposed microglia, and the development of region-specific exposure models that better reflect chronic environmental realities.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into the versatility of the metallothionein NmtA in a filamentous cyanobacterium.","authors":"T V Divya, Mehzabin Vivek Pimple, Celin Acharya","doi":"10.1007/s10534-026-00902-x","DOIUrl":"https://doi.org/10.1007/s10534-026-00902-x","url":null,"abstract":"<p><p>Metallothioneins (MTs) are low molecular weight, intracellular, metal sequestering proteins that are unusually rich in cysteine content. Although physiologically comparable to well defined eukaryotic MTs, studies on the roles of prokaryotic MTs are limited. We had previously characterized unannotated prokaryotic MT, namely nmtA in the diazotrophic filamentous cyanobacterium, Anabaena PCC 7120. In the present study, by modulation of the in vivo levels of NmtA, we identified its role in metal homeostasis and detoxification and antioxidant protection in Anabaena 7120. While overexpression of NmtA in Anabaena (AnnmtA⁺) resulted in enhanced accumulation of Zn²⁺ and resistance to Cd²⁺, downregulation of NmtA (AnASnmtA) caused increased Cd²⁺ sensitivity and lesser accumulation of Zn²⁺. Probing into metal dependent expression of nmtA, we identified metal sensing motifs in α5 helix of AzuR, the negative regulator of NmtA by site directed mutagenesis. Transcriptome analysis of recombinant Anabaena overexpressing AzuR (AnazuR⁺) recognized differential gene expression that regulated Zn²⁺ metabolism. The protective role under oxidative stress of NmtA was affirmed by free radical scavenging ability via oxidative stress-induced Zn²⁺ mobilization by NmtA and enhanced sensitivity of AnASnmtA to H₂O₂ stress. The metal binding potential of NmtA prompted us to immobilize NmtA onto citrate functionalized magnetic nanoparticles (CMNP-NmtA) that demonstrated ~ 51% Cd²⁺ removal from industrial wastewater supplemented with 10 µg/mL Cd in presence of other heavy metals. Overall, this study established the multifaceted functions of metallothionein from diazotrophic, filamentous cyanobacterium advancing information on the otherwise less explored prokaryotic MT diversity.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive skin trace elementomics reveals a characteristic pattern of essential element deficiency and toxic element accumulation in children with ADHD.","authors":"Yan Lei, Shujin Li, Yanhui Sun, Zhongqin Jiang, Bin Liu, Yong Zhang, Yu Ling, Li Li","doi":"10.1007/s10534-026-00901-y","DOIUrl":"https://doi.org/10.1007/s10534-026-00901-y","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder in childhood. Its clinical diagnosis primarily relies on behavioral assessments, lacking objective and non-invasive biological indicators. Trace elements are involved in neurotransmitter synthesis, myelin development, and prefrontal cortex function regulation, and their imbalance may be associated with the pathogenesis of ADHD. However, previous studies have mostly focused on single elements, lacking systematic evidence at the omics level. To analyze the differences in 30 skin element levels between children with ADHD and healthy controls, and to explore the associations of elemental imbalances with core symptoms, anxiety, and executive function, thereby providing a basis for non-invasive screening of childhood ADHD. A total of 549 children with ADHD and 963 healthy controls were enrolled. Skin element levels were measured using a non-invasive high-throughput technique. Behavioral assessments were performed using the CONNERS, SNAP‑IV, SCARED, and WEISS scales. Analysis of covariance (ANCOVA) with age as a covariate was used to compare intergroup differences in element levels. Partial correlation analysis was applied to control for age as a confounding factor. The Benjamini‑Hochberg method was used to control the false discovery rate (FDR) for multiple comparison correction, with a significance threshold of q < 0.05. After adjusting for age and FDR correction, 28 elements showed significant differences between the ADHD group and the control group. In the ADHD group, essential/potentially beneficial elements such as Mg, Zn, I, Cr, Li and Ge were decreased, whereas B and harmful elements including Pb, Hg, Cd, As, Al, Be, and Ba were increased. Multiple elements exhibited stable associations with inattention, hyperactivity-impulsivity, anxiety, and risk-taking behavior. Children with ADHD displayed a complex network pattern of synergistic and antagonistic inter-element relationships. Children with ADHD exhibit a characteristic skin trace elementomic imbalance, characterized by decreased beneficial elements and increased harmful elements, which is closely associated with behavioral symptoms. Non-invasive skin elementomics may serve as a reference indicator for population-based risk screening of childhood ADHD and holds promise for population-based screening.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplemented acetylated whey comparing to N-acetylcysteine exerted promising chelation activity for overload iron-induction lung injury in rats.","authors":"Sara A Atta, A Y Nassar, Fatma Y Meligy, Salwa Fares Ahmed, Fathy Fahim, Eslam Ekram, Gamal A Y Nassar, Amany Abdelrahman Osman","doi":"10.1007/s10534-026-00886-8","DOIUrl":"https://doi.org/10.1007/s10534-026-00886-8","url":null,"abstract":"<p><p>Concentrations of heavy metal residues in the environment are increasing due to human activity and climate change. Iron is one of the most elements that increased in the environment, as a byproduct of industrial activities, fertilizers, and mining, leading to its deposition in the soil and subsequent transfer to plants and groundwater. In addition, iron is available as over the counter drug without prescriptions, and reported as the second common overdose drug during pregnancy. Iron poisoning affects the cells and tissues, and accumulated iron in lungs is risk and causes health problems, hematological diseases and aging processes. Iron overload chelation therapy is depending on the chelating agents such as deferoxamine. The antioxidant and anti-inflammatory therapeutic N-acetylcysteine (NAC) is also working as metal chelator, but it would be limited in some improper circumstances. This study hypothesized that the prepared acetylated whey protein (AWP) could be alternative to NAC. This study designed to investigate the impact of iron overload on the structure and function of the respiratory system in mammals, regardless of the mechanism behind the iron accumulation. The study aims to identify food supplemented compound that is at least as effective as N-acetyl cysteine (NAC) in mitigating or preventing the risks associated with high doses or prolonged exposure of NAC. Albino male rats were used as animal model. Forty-eight rats were randomized selected equally and divided into four groups. treated groups were intoxicated by iron dextran interperitoneally. Two groups were orally supplemented with N-Acetylcysteine and Acetylated whey protein individually. The pulmonary histopathological examinations and biochemical markers were done. Reduced glutathione, nitric oxide and malondialdehyde as oxidative stress markers. Lung tissue Ferritin and vascular endothelial growth factor (VEGF) were measured. All oxidative stress markers were significantly improved with both NAC and AWP groups especially AWP group. Tissue ferritin and VEGF exhibited significant improvement in the lung tissue. Acetylated whey protein can play crucial chelation therapeutic role of intoxicated individuals with iron as supplement in safe and no effects for short- or long-term treatment.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of zinc supplementation in rheumatoid arthritis: clinical evidence, molecular mechanisms, and formulation-specific effects.","authors":"Alina Khan, Mohammad Hasan, Md Aashique, Haider Ali Khan","doi":"10.1007/s10534-026-00876-w","DOIUrl":"https://doi.org/10.1007/s10534-026-00876-w","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder primarily affecting the synovial joints, characterized by persistent synovitis, progressive joint destruction, and systemic complications that contribute to significant morbidity. Despite advances in disease-modifying anti-rheumatic drugs and biologic therapies, many patients fail to achieve sustained disease control or experience treatment-related adverse effects, highlighting the need for safe adjunctive strategies. Zinc, an essential trace element with critical roles in immune regulation, antioxidant defense, and inflammatory signaling, has gained increasing attention in the pathogenesis and management of RA. Clinical studies consistently report altered zinc homeostasis and reduced circulating zinc levels in RA, which are associated with increased disease activity, oxidative stress, and immune dysregulation. However, human interventional studies evaluating zinc supplementation remain limited, involve relatively small sample sizes, and report heterogeneous findings. In contrast, experimental studies in validated animal models have more consistently demonstrated anti-inflammatory and immunomodulatory effects of zinc, including modulation of macrophage and T-cell activation, cytokine production, synovial fibroblast behaviour, and bone remodelling. Importantly, the therapeutic effects of zinc appear to be formulation-dependent, as organic zinc salts, chelated forms, and emerging nano-based formulations have demonstrated superior bioavailability and anti-inflammatory efficacy compared with conventional inorganic salts. This review aims to explain the molecular and immunological mechanisms underlying the effect of zinc in RA, evaluates findings from clinical and preclinical studies of zinc supplementation, and highlights formulation-specific considerations relevant to clinical practice. While existing evidence supports the potential of zinc as a safe and beneficial adjunct to conventional RA therapy, further well-designed randomized clinical trials are required to establish optimal dosing strategies and identify patient populations most likely to benefit.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between urinary heavy metal(loid)s exposure and dyslipidemia in children from e-waste dismantling areas.","authors":"Rui Sun, Shuhan Qu, Jieting Chen, Rongyi Kang, Jian Zhang, Xijin Xu, Lei Tan, Xia Huo","doi":"10.1007/s10534-026-00899-3","DOIUrl":"https://doi.org/10.1007/s10534-026-00899-3","url":null,"abstract":"<p><p>To assess temporal trends of urinary heavy metal(loid)s burden and lipid levels, and explore the single and joint associations of heavy metal(loid)s exposure with lipid profiles among children in Guiyu, a typical e-waste dismantling area in China. Based on 2016 and 2024 surveys in Guiyu, 197 children (aged 3-7) were enrolled. Urinary concentrations of 13 heavy metal(loid)s were determined using inductively coupled plasma mass spectrometry (ICP-MS). Serum lipid parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured, and non-high-density lipoprotein cholesterol (non-HDL-C) was calculated. To investigate the independent and combined associations between metals and blood lipid profiles, multiple linear regression and Bayesian kernel machine regression (BKMR) models were employed. Urinary concentrations of Chromium (Cr), Nickel (Ni), Copper (Cu), Cadmium (Cd), and Lead (Pb) in 2024 were significantly lower than those in 2016 (all P < 0.05). In adjusted models, Manganese (Mn), Cobalt (Co), Cd, and Pb were positively associated with TC and non-HDL-C, while Cd and Pb were negatively associated with HDL-C (all P < 0.05). BKMR confirmed a significant joint positive effect of a 12-metal mixture on TC and non-HDL-C, and a negative effect on HDL-C. Despite decreased individual metal levels over the eight-year interval, the biological risk from co‑exposure to these metals remains a critical concern These findings highlight the need for vigilance regarding the synergistic cardiovascular toxicity of heavy metals on pediatric lipid homeostasis.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum element levels with cardiovascular diseases and type 2 diabetes mellitus risk in a Kurdish population of western Iran.","authors":"Samaneh Nakhaee, Alexey A Tinkov, Borhan Mansouri, Zana Ramazani, Kimia Fooladi, Ali Elahinia","doi":"10.1007/s10534-026-00903-w","DOIUrl":"https://doi.org/10.1007/s10534-026-00903-w","url":null,"abstract":"<p><p>Non-communicable diseases (NCDs) are a significant public health concern globally. Among the most prevalent NCDs the study aims to explore the association of some elements with the the likelihood of cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2D) development. In this cross-sectional case control study, 300 individuals with CVDs (n = 110), T2D (n = 70), and a control group (n = 120) from the Ravansar Non-Communicable Disease (RaNCD) cohort in western Iran were examined. The RaNCD cohort is part of the PERSIAN cohort study, consisting of 10,000 adults. Participants aged 35-65 were stratified into three clusters based on their health status. Various elements, including aluminum (Al), calcium (Ca), magnesium (Mg), phosphorus (P), manganese (Mn), potassium (K), cobalt (Co), lithium (Li), boron (B), molybdenum (Mo), and vanadium (V) in the blood serum was performed using the ICP-MS method, and data were analyzed using multivariable techniques, including logistic regression and clustering analysis. Our analysis revealed a notable association between most elements and the risks of CVD and T2D in the logistic regression model after adjusting for age and gender. Specifically, increased odds ratios of CVD and T2D were identified for higher Ca, Mn, Mg, Li, V, Al, P, and Mo levels. In the T2D group, four clusters were identified: Al-B, Mn-Co-Mo, K-P, and V-Li-Ca-Mg. In the CVD group, five clusters were observed: K, B-Co-Mo, Li-Mg, Ca-P, and Mn-Al-V. The study provides valuable insights into the role of some essential elements in the development of CVDs and T2D. The key elements that are most linked to the elevated risk of CVDs and T2D include calcium, manganese, molybdenum, vanadium, lithium, aluminum, phosphorus, and magnesium. Further exploration of the intricate relationships between elements and disease risk could enhance our understanding of preventive strategies and personalized interventions for individuals at risk of CVDs and T2D.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}