Biometals最新文献

{"title":"Ferrous sulfate and lipopolysaccharide co-exposure induce neuroinflammation, neurobehavioral motor deficits, neurodegenerative and histopathological biomarkers relevant to Parkinson's disease-like symptoms in Wistar rats.","authors":"Shivam Kumar Pandey, Anjuman Nanda, Avtar Singh Gautam, Apurva Chittoda, Aman Tiwari, Rakesh Kumar Singh","doi":"10.1007/s10534-025-00693-7","DOIUrl":"https://doi.org/10.1007/s10534-025-00693-7","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra region of the brain. Although iron is one of the essential micronutrients in the brain, its excess exposure and accumulation in the brain substantia nigra and striatum regions may induce critical pathological changes relevant to PD. This study has evaluated neurobehavioral, biochemical, and structural alterations resembling PD-like symptoms induced through a 4-week co-exposure of ferrous sulfate (FeSO₄) with lipopolysaccharide (LPS) in Wistar rats. Our results revealed motor deficits, oxidative stress, neuroinflammation, iron dysregulation, protein aggregation, ferroptosis, and apoptotic cell death. Notably, we observed decreased tyrosine hydroxylase levels and increased α-synuclein accumulation, consistent with PD pathology. The immunohistopathological assessments showed astrocyte activation and iron deposition, supporting their roles in neuroinflammation and oxidative stress. Furthermore, we identified alterations in apoptosis and ferroptosis markers, suggesting dose-related involvement of FeSO₄ in neuronal death in the rat brain. These findings have highlighted the multifaceted mechanisms during the co-exposure of FeSO₄ and LPS-induced neurodegeneration and neuroinflammation relevant to PD. This study emphasizes that therapeutic targeting of these pathological mechanisms may offer a promising therapeutic intervention in PD.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, biological evaluation and molecular docking of a Schiff base ligand and its metal complexes.","authors":"Elsayed M AbouElleef, Rania A Saad, M A Diab, M M El-Zahed, A Z El-Sonbati, Sh M Morgan","doi":"10.1007/s10534-025-00688-4","DOIUrl":"https://doi.org/10.1007/s10534-025-00688-4","url":null,"abstract":"<p><p>Condensation of 2,3-diaminopyridine with 2,4-dihyrodybenzaldehyde yielded a 4,4'-[(1E,1 ~ E)-(pyridine-2,3-diyl)bis(azanylylidene)]bis(methanylylidene)bis(benzene-1,3-diol) monobasic tridentate Schiff base ligand (HL) with an ONN donor sequence. Elemental analyses, conductivity tests, magnetic susceptibility data, FT-IR, UV-vis spectra, x-ray diffraction, and mass spectrum data of the ligand and its complexes were used for the characterization of the structures. Computational HF/3-21G calculations were performed to optimize their geometrical structures and assess their HOMO-LUMO energy gaps. The low molar conductance of the complexes indicates that they are not electrolytic. From the spectrophotometric and gravimetric analyses, the complexes (2-4) are in the ratio of 1:2, while complexes (1 & 5) (1:1) metal to ligand. 2,3-Diaminopyridine, 2,4-dihydroxybenzaldehyde, ligand (HL) and its complexes were screened for antibacterial and antifungal activities against some bacterial (Enterococcus faecalis, Salmonella typhi, and Staphylococcus epidermidis) and fungal isolates (Aspergillus flavus, Alternaria solani, and Candida albicans). The result reveals that 2,4-dihyrodybenzaldehyde has the strongest antibacterial activity among the other compounds followed by Mn(II) complex. The antimicrobial activity increases by increasing the compound concentration. To assess the inhibitory impact of ligand and its complexes on binding sites of B. cereus (PDB ID: 1FEZ), S. epidermidis (PDB ID: 3KP7), E. faecalis (PDB ID: 5V5U) and S. typhi (PDB ID: 5V2W) proteins, molecular modeling has been implemented offer a fresh concept for medication design. Molecular docking studies confirmed strong binding interactions between the metal complexes and bacterial proteins, validating their biological potential. These findings demonstrate the promising antimicrobial properties of Schiff base metal complexes, making them potential candidates for pharmaceutical and medicinal applications.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-modal approach to lung cancer treatment: in vitro and in silico. Evaluation of a hybrid nanocomposite for synergistic chemotherapy.","authors":"Omar Alnasra, Fawwaz I Khalili, Lama Hamadneh, Mohammad Alwahsh, Rana Omar, Amani AlDoridee, Aya Hasan","doi":"10.1007/s10534-025-00694-6","DOIUrl":"https://doi.org/10.1007/s10534-025-00694-6","url":null,"abstract":"<p><p>This study investigates the therapeutic potential of a nanosilica-cysteine composite loaded with arsenic trioxide (SC-As) in combination with cisplatin (CIS), paclitaxel (PTX), and doxorubicin (DOX) for lung/breast cancer treatment. Through comprehensive synthesis, characterization (ATR-FTIR, XRD, SEM, TEM, DLS), and cytotoxicity assessments, SC-As demonstrated superior potency with IC₅₀ values as low as 7.29 ± 1.40 µM in lung cancer (A549) and 8.60 ± 1.20 µM in breast cancer (MCF-7) cell lines. This study employs a dual-modal approach, combining in silico computational predictions (CompuSyn) with in vitro experiments to evaluate synergistic chemotherapy regimens, ensuring robust validation of therapeutic outcomes. The computational synergy analysis and the experimental validation in lung cancer cell lines revealed synergistic interactions between SC-As and CIS (CI < 1), enabling significant dose reductions (DRI > 1). Conversely, antagonism was observed with PTX and DOX in A549 cells, though H1299 cells exhibited unanticipated synergistic interactions with PTX/DOX. Given that H1299 cells represent a more aggressive and metastatic form of lung cancer, these results suggest that PTX and DOX combinations may have enhanced therapeutic potential in treating highly malignant lung cancer subtypes. These findings underscore the composite's potential as a targeted delivery system and highlight the necessity of integrating computational predictions with empirical validation to optimize combinatorial efficacy and minimize toxicity, providing a foundation for future in vivo and clinical studies.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of melatonin on cadmium subcellular distribution, biochemical, and anatomical alterations in Malva parviflora roots.","authors":"Narges Rahnamaei Yahyaabadi, Parzhak Zoufan, Fatemeh Nasernakhaei","doi":"10.1007/s10534-025-00691-9","DOIUrl":"https://doi.org/10.1007/s10534-025-00691-9","url":null,"abstract":"<p><p>Plants use various mechanisms to cope with cadmium (Cd) stress. Melatonin's impact on the root response to Cd stress, which is the first organ to detect its presence, has been less studied. This study aims to investigate the effects of melatonin pretreatment on the root strategies of Malva parviflora in response to Cd stress, focusing on the mechanisms of heavy metal tolerance. The plants, 42 days post-germination, were subjected to a 48-h pretreatment with 50 μM melatonin in a complete nutrient solution under controlled growth conditions. Following pretreatment, plants were exposed to a nutrient solution containing 50 μM Cd for 8 days. Comparative analyses were conducted on root length, weight, anatomical features, Cd content, Cd subcellular distribution, nutrient absorption, glutathione, and lignin. Melatonin pretreatment significantly enhanced root length and weight under Cd stress. It also increased the xylem and phloem area in the roots and promoted the absorption and translocation of essential nutrients such as Fe, Zn, Ca, and Mg to the shoots. Additionally, there was a marked increase in glutathione content and Cd proportion in the cell wall and organelle fractions in melatonin-pretreated roots. Notably, melatonin reduced overall plant Cd content and its translocation from roots to shoots, while decreasing root lignin content. This study demonstrates that melatonin plays an important role in managing Cd toxicity by improving morphological, anatomical, and biochemical characteristics of roots under Cd stress. The findings suggest that melatonin pretreatment can effectively alter Cd subcellular distribution, thereby mitigating its harmful effects in plants.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.","authors":"Jun Wen, Changfen Wang, Ranyang Liu, Rongjuan Zhuang, Yan Liu, Yishi Li, Shuliang Guo","doi":"10.1007/s10534-025-00690-w","DOIUrl":"https://doi.org/10.1007/s10534-025-00690-w","url":null,"abstract":"<p><p>Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 participants for a cross-sectional study from the NHANES. The weighted quantile sum (WQS) regression, bayesian kernel machine regression (BKMR), machine learning models (support vector machines, random forests, decision trees, and XGBoost), restricted cubic spline (RCS), and logistic regression were applied to comprehensively evaluate the performance of urinary metals in predicting chronic cough risk. Finally, the mediation effect model was employed to evaluate the role of systematic inflammation in the relationship between urinary cadmium and the risk of chronic cough. Urinary cadmium correlated with an increasing risk of chronic cough in the multivariate logistic regression model (OR: 2.83, 95% CI: 1.60-4.99). Both the WQS regression and BKMR consistently suggested a positive relationship between urinary mixed metal and chronic cough risk. Among the four machine learning models used to evaluate urinary metals and the risk of chronic cough, the random forests model showed better predictive performance (AUC = 0.69). The random forests suggested that the top five important indicators for predicting chronic cough risk were urinary cadmium, thallium, molybdenum, cesium, and uranium. Finally, the mediation effect model suggested that the systematic inflammation (lymphocytes: 4.24%, systemic immune inflammation index: 5.11%) partially mediated the relationship between urinary cadmium and chronic cough risk. This study discovered that urinary cadmium was elevated in correlation with the increasing risk of chronic cough. Systematic inflammations may partially mediate this association. Improving exposure to urinary cadmium may reduce the risk of chronic cough.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium 8-hydroxyquinoline derivatives in medicine: current state and future outlook.","authors":"Tahmineh Kohanfekr, Camelia Gholamrezazadeh, Hasan Ali Hosseini","doi":"10.1007/s10534-025-00683-9","DOIUrl":"https://doi.org/10.1007/s10534-025-00683-9","url":null,"abstract":"<p><p>Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.","authors":"Aleksandar Cirovic, Danijela Djonic, Vladimir Zivkovic, Slobodan Nikolic, Marija Djuric, Petar Milovanovic","doi":"10.1007/s10534-025-00689-3","DOIUrl":"https://doi.org/10.1007/s10534-025-00689-3","url":null,"abstract":"<p><p>Increased urine and blood concentrations of heavy metals are linked to an elevated hip fracture risk, but studies dedicated to directly measuring metal(oid) concentrations in the femoral neck are limited. We investigated whether individuals with fractures exhibit a different pattern of metal(oid) bioaccumulation in the femoral neck and examined potential correlations between the concentrations of various metal(oid)s in the femoral neck and trabecular microarchitecture. To address these objectives, we collected femoral neck specimens from 23 individuals, namely 11 individuals with a positive history of contralateral hip fracture (9 women and 2 men, mean age 77.7 ± 8.1 years) and 12 individuals without fractures (10 women and 2 men, mean age 79.5 ± 5.6 years). All samples were subject to microcomputed tomography (micro-CT) to evaluate bone microarchitecture and inductively coupled plasma-mass spectrometry to determine tissue concentrations of metal(oid)s. In the fully adjusted model (adjusted for bone volume, age, and calcium tissue concentration), individuals with hip fractures exhibited higher aluminum levels (p = 0.047) and lower vanadium levels (p < 0.001). Individuals who sustained fragility fractures also showed lower BV/TV, Tb.Th, Tb.N, and higher Tb.Sp in the femoral neck trabeculae compared with the control group. Several different metal(oid)s were associated with altered patterns of trabecular microarchitecture. In summary, higher aluminum and lower vanadium concentrations in the trabeculae of the femoral neck provide a potential background for the gradual increase in fracture risk. Correlational analysis revealed an association between exposure to certain metals and deteriorated trabecular microarchitecture; however, larger studies are needed to determine the elements independently affecting bone microarchitecture.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental comparative analysis of 18 elements reveal distinct patterns in benign and malignant thyroid tissues.","authors":"Xueying Liu, Linjing Huang, Youzhi Zhu, Peiwen Wu","doi":"10.1007/s10534-025-00682-w","DOIUrl":"https://doi.org/10.1007/s10534-025-00682-w","url":null,"abstract":"<p><p>This study aims to compare variations in 18 trace elements (Al, Na, K, Mg, Ca, Ti, Ba, Sn, Cr, Mn, Fe, Cu, Zn, Se, Mo, Cd, Sr, and Tl) between benign and malignant thyroid tissues. Post-operative thyroid tissue samples were collected from 106 patients (34 benign, 72 malignant), and elemental concentrations were quantified using inductively coupled plasma mass spectrometry. Spearman's correlation analysis revealed positive correlations among these trace elements. Notably, the malignant group exhibited significantly higher concentrations in eight elements (Mg, Al, Fe, Cr, Ti, Sr, Sn, and Ba) compared to the benign group, while levels of six elements (Na, Mn, Cu, Zn, Cd, and Mo) were significantly lower. Orthogonal partial least squares discriminant analysis distinguished three elements (Al, Ti, Sn) for the malignant group and six elements (Na, Mn, Cu, Zn, Cd, and Mo) for the benign group. Multivariate logistic regression further revealed associations between thyroid cancer and levels of Al, Cr, Ti, Sr, Sn, Ba, Mn, Cu, Zn, and Cd. Considering with each elemental biological funcions, these findings suggest that Cu, Mn, and particularly Zn may act as essential antitumor elements with synergistic effects, whereas elevated Ba, Cr, and Al levels are closely related to thyroid malignancies. However deficiencies and excesses of elements may be the consequences of malignant tissues. In conclusion, benign and malignant thyroid tumors exhibit different trace-element profiles.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally treated FeCrAl alloy as potential biomaterial: surface characterization, corrosion resistance and cytotoxicity studies.","authors":"L Nadaraia, O Tsurtsumia, L Khundadze, T Kukava, P Tchelidze, V Okuneva, S Bakhtiarov, V Perumal, E Kutelia","doi":"10.1007/s10534-025-00686-6","DOIUrl":"https://doi.org/10.1007/s10534-025-00686-6","url":null,"abstract":"<p><p>Metal alloys are widely used in implantology due to their excellent mechanical properties. However, their biocompatibility can be compromised by corrosion, which releases toxic metal ions that may provoke adverse biological reactions and contribute to implant failure. This study introduces a novel metal-ceramic composite based on a high-chromium FeCrAl alloy, specifically engineered to form a thermally grown α-Al₂O₃ surface layer. This design aims to significantly enhance biocompatibility and corrosion resistance for potential biomedical implant applications. Samples of the Fe-44Cr-5Al alloy were produced using an arc melting process. The mechanically polished alloy coupons were given a mirror-like finish and underwent high-temperature oxidation at 1050 °C for 20 h in laboratory air to develop a dense and adherent α-Al₂O₃ layer. Both bare and oxidized samples were immersed in artificial saliva at 37 °C for two months to assess their corrosion resistance under simulated oral conditions. Biocompatibility was evaluated through cytotoxicity and mitotic activity tests using primary human gingival fibroblasts cultured on both the bare and oxidized samples. The results showed that thermal oxidation effectively produced a uniform, adherent, and stable α-Al₂O₃ layer on the surface of the FeCrAl alloy. The oxidized samples demonstrated superior corrosion resistance, with negligible metal ion release and no formation of corrosion products. In contrast, the bare (unoxidized) alloy exhibited extensive corrosion and significant ion release. Cytotoxicity tests indicated that the oxidized alloy supported normal cell adhesion, proliferation, and morphology comparable to control samples. Although a slight reduction in cell proliferation was noted on the oxidized metal surface, overall bioactivity remained high. Structural and morphological analyses were performed using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Grazing Incidence X-ray Diffraction (GIXRD) to confirm the formation and integrity of the oxide layer. Post-immersion corrosion tests in artificial saliva and detailed microscopy further validated the favorable biological responses to the oxidized alloy.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of corroles in modern cancer therapy: innovation and prospects.","authors":"Laiba Javaid, Huma Hameed, Mahtab Ahmad Khan, Syed Muhammad Ahmad, Inaba Shujaat Qureshi, Rabia Shahzad, Ali Irfan","doi":"10.1007/s10534-025-00687-5","DOIUrl":"https://doi.org/10.1007/s10534-025-00687-5","url":null,"abstract":"<p><p>Corroles, a class of tetrapyrrolic macrocycles, have garnered significant attention for their potential in cancer therapy due to their unique structural chemistry and ability to coordinate with metals. Their remarkable photophysical properties make them beneficial for photodynamic therapy (PDT) and fluorescence imaging, as they can produce reactive oxygen species when activated by light, offering potential for the treatment of various carcinomas, including hepatic, breast, pancreatic, and lung cancers. Despite the encouraging preclinical and clinical data supporting their therapeutic efficacy, challenges remain in optimizing corrole formulations, particularly concerning targeted delivery, stability, and bioavailability. This review highlights current advancements in corrole-based therapies, focusing on novel nanoparticle formulations that enhance drug distribution and therapeutic efficacy. Furthermore, it examines the mechanisms of corrole-mediated cellular death and the role of photodynamic treatment in inducing apoptosis via various signaling pathways. Additional research is necessary to address formulation-related issues while ensuring the safety and effectiveness of corroles in cancer treatment, therefore maximizing their therapeutic potential and adhering to regulatory standards.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}