Therapeutic applications of quercetin-metallic complexes: a review

IF 3.6 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biometals Pub Date : 2025-05-22 DOI:10.1007/s10534-025-00696-4

Nasreen Ramzan, Huma butt, Muhammad Azeem, Muhammad Hanif, Khalid Mahmood, Sadia Rehman, Dure shahwar, Muhammad Zeeshan, Qurat-ul-Ain Ahmad, Mehreen Jabeen

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Abstract

Flavonoids, especially quercetin, are widely recognized for their antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, and anti-tumor properties, but their clinical application is limited by poor permeability. Different techniques of permeability enhancement of quercetin, i.e., preparation of phytosomes, conjugation with glucose, and interaction of piperine, are reported extensively, but formation of metal complexes is considered more precise and reliable. This review focuses on research conducted on the chelation of quercetin with metals, i.e., copper (II), zinc (II), iron and ruthenium. In-vitro and in-vivo therapeutic activities, biomedical applications of metal/quercetin inclusion complexes and discussions of stability concerns of quercetin alone and its metallic complexes. Conjugation of metals with quercetin augments its potential to the next level. Numerous studies revealed that quercetin/copper (Q/Cu) and quercetin/zinc (Q/Zn) can become efficacious candidates in acute myeloid leukaemia, orthopaedics and severe acute respiratory syndrome coronavirus (SARS-CoV) infection.

Graphical abstract

Graphical representation of Q/Zn and Q/Cu complexes and their biomedical applications.

Abstract Image

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槲皮素-金属配合物的治疗应用综述。

黄酮类化合物，特别是槲皮素具有抗氧化、抗炎、抗微生物、抗糖尿病和抗肿瘤等特性，但其渗透性差，限制了其临床应用。槲皮素渗透性增强的不同技术，即制备磷脂体、与葡萄糖结合以及与胡椒碱的相互作用，已被广泛报道，但金属配合物的形成被认为更精确和可靠。本文综述了槲皮素与铜（II）、锌（II）、铁和钌等金属螯合的研究进展。金属/槲皮素包合物的体外和体内治疗活性、生物医学应用以及槲皮素及其金属配合物稳定性问题的讨论。金属与槲皮素的结合将其潜力提升到一个新的水平。大量研究表明，槲皮素/铜（Q/Cu）和槲皮素/锌（Q/Zn）可成为治疗急性髓性白血病、骨科和严重急性呼吸综合征冠状病毒（SARS-CoV）感染的有效候选药物。

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来源期刊

Biometals 生物-生化与分子生物学

CiteScore

5.90

自引率

8.60%

发文量

111

审稿时长

3 months

期刊介绍： BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.