Biometals最新文献_第10页

Mycosorption of copper by Aspergillus terreus SJP02: process optimization and underlying mechanism 土曲霉SJP02对铜的菌体吸附：工艺优化及机理研究。

IF 3.6 3区生物学

Biometals Pub Date : 2026-03-11 DOI: 10.1007/s10534-026-00804-y

Shobham, Mamta, Sanjay Kumar Verma, Suresh Gupta, Jitendra Panwar

{"title":"Mycosorption of copper by Aspergillus terreus SJP02: process optimization and underlying mechanism","authors":"Shobham,  Mamta, Sanjay Kumar Verma, Suresh Gupta, Jitendra Panwar","doi":"10.1007/s10534-026-00804-y","DOIUrl":"10.1007/s10534-026-00804-y","url":null,"abstract":"<div>Copper, a naturally occurring element in the Earth’s crust and an essential micronutrient, is widely used in various industries. However, excessive exposure of Cu2+ions often resulting from contaminated drinking water, food and personal health care products can harm human health by impacting the liver, heart, digestive and nervous system. The present study revealed high Cu2+ removal potential of Aspergillus terreus SJP02 isolated from metal contaminated industrial sites. The mycosorbent demonstrated maximum sorption capacity of 11.45 ± 0.2 mg g−1 in 120 min. Acid digestion studies suggested adsorption as primary mechanism (86.79%) for removal of Cu2+. FE-SEM–EDX analysis confirmed deposition of Cu2+ on fungal biomass. FTIR analysis showed presence of various functional groups of proteins and polysaccharides which would have been involved in the adsorption Cu2⁺. Various adsorption isotherms were used to analyze type and bonding between adsorbate and mycosorbent. Pseudo- first and second order were applied to understand the correlation in time course data, rate constant, and kinetic parameters. Langmuir isotherm showed maximum Cu2+ sorption capacity of 11.35 mg g−1. The experimental results correlated with the tested isotherm and kinetic models. The simultaneous removal of Cu2+and Zn2+ ions revealed preferential uptake of Cu2+ over Zn2+ ions by the mycosorbent. Notably, present study demonstrated better sorption capacity in significantly shorter equilibration time in comparison to previous reports and suggests that A. terreus SJP02 holds strong potential for future industrial-scale mycoremediation of Cu2⁺ contaminated wastewater.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"1115 - 1133"},"PeriodicalIF":3.6,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147429572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-exposure to arsenic and nickel induces oxidative stress and mineral imbalance, impairing male reproductive parameters in Wistar rats 砷和镍的共同暴露诱导氧化应激和矿物质失衡，损害雄性Wistar大鼠的生殖参数。

IF 3.6 3区生物学

Biometals Pub Date : 2026-03-05 DOI: 10.1007/s10534-026-00797-8

Thainá Iasbik-Lima, Luiz Otávio Guimarães-Ervilha, Tayná Bolsam da Silva, Renê Chagas da Silva, Mariana Machado-Neves

{"title":"Co-exposure to arsenic and nickel induces oxidative stress and mineral imbalance, impairing male reproductive parameters in Wistar rats","authors":"Thainá Iasbik-Lima, Luiz Otávio Guimarães-Ervilha, Tayná Bolsam da Silva, Renê Chagas da Silva, Mariana Machado-Neves","doi":"10.1007/s10534-026-00797-8","DOIUrl":"10.1007/s10534-026-00797-8","url":null,"abstract":"<div>Simultaneous exposure to multiple toxic metals is a common scenario in environmental contamination. Among these metals, arsenic and nickel are widely distributed pollutants with well-established toxic effects. However, their combined impact on male reproductive physiology and micromineral homeostasis remains poorly understood. This study evaluated the effects of subchronic co-exposure to arsenic (1 mg L−1) and nickel (7 mg L−1) in drinking water for 70 days on the hypothalamus, testis, and epididymis of adult Wistar rats. Exposed rats showed arsenic and nickel retention in all analyzed tissues, low serum testosterone levels, and alterations in the proportion of chemical elements, including copper, zinc, calcium, iron, and manganese. These findings were associated with an antioxidant enzyme dysregulation and high generation of protein carbonyls and nitric oxide in testicular and epididymal tissues, respectively. Consequently, the testes of co-exposed rats exhibited alterations in stereological and morphometric parameters, low daily sperm production, and initial histological changes in response to the toxic metals’ presence. The hypothalamus exhibited focal areas of neuronal degeneration, especially in co-exposed rats. The epididymis of co-exposed animals presented focal areas of inflammatory infiltrates and germ cells within the luminal duct, with an acceleration of sperm transit time. Spermatozoa from all exposed rats showed low motility and high morphological abnormalities in the head, while the co-exposure increased the occurrence of midpiece and tail defects. These findings highlight the synergistic toxicity of arsenic and nickel on the male reproductive system after subchronic exposure, with a direct role of bioaccumulation and trace element dysregulation.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"1013 - 1037"},"PeriodicalIF":3.6,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10534-026-00797-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147353203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic antimicrobial effect of novel heterophase Cu/CuZn/ZnO nanoparticles 新型异相Cu/CuZn/ZnO纳米颗粒的协同抗菌作用。

IF 3.6 3区生物学

Biometals Pub Date : 2026-03-03 DOI: 10.1007/s10534-026-00802-0

O. V. Bakina, A. E. Yafaeva, V. R. Chzhou, M. I. Lerner

引用次数: 0

Proteomic and in silico characterization of stress-responsive proteins in the prawn penaeus indsicus under sublethal copper toxicity 亚致死性铜中毒下赤色对虾应激反应蛋白的蛋白质组学和计算机表征。

IF 3.6 3区生物学

Biometals Pub Date : 2026-03-01 DOI: 10.1007/s10534-026-00798-7

Sravani Mereddy, Suman Polaki, Vani Rupa Paila, Samuel David Raj Thatipaka

{"title":"Proteomic and in silico characterization of stress-responsive proteins in the prawn penaeus indsicus under sublethal copper toxicity","authors":"Sravani Mereddy, Suman Polaki, Vani Rupa Paila, Samuel David Raj Thatipaka","doi":"10.1007/s10534-026-00798-7","DOIUrl":"10.1007/s10534-026-00798-7","url":null,"abstract":"<div>Copper contamination is a major challenge in brackishwater aquaculture, yet the molecular timeline of sublethal metal stress in penaeid prawns remains poorly understood. To address this, we applied time-resolved differential proteomics and in silico analyses to identify copper-responsive proteins in post-larval Penaeus indicus. Larvae were exposed to 0.1641 mg L−3 copper (1/5 LC₅₀) for 24 h, 48 h, 96 h, 10 days, 20 days, and 30 days. Two-dimensional gel electrophoresis and MALDI-TOF/TOF revealed thirteen proteins across forty-one differential spots. Physicochemical and secondary structure characteristics were predicted using ExPASy ProtParam and the Self-Optimized Prediction Method with Alignment (SOPMA). Expression dynamics indicated three temporal phases: (i) early oxidative stress regulators (24–48 h), including thioredoxin and nuclear autoantigenic sperm protein, which were small, hydrophilic (GRAVY ≈ − 0.28), and coil-rich; (ii) mid-phase proteins such as ferritin (48–96 h), with a high α-helical content (61%) and moderate instability index (37.3), supporting metal sequestration and antioxidant buffering; and (iii) late-phase proteins (20–30 days), including variant transformer-2 and ubiquitin-activating enzyme, associated with proteostasis and cellular remodeling. Together, these findings suggest a three-tier biomarker model: thioredoxin (early), ferritin (mid), and variant transformer-2 (late). This timeline-based framework may improve the precision of copper stress monitoring and supports future investigations integrating proteomic data with transcriptomic and functional validation in crustaceans.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"1039 - 1054"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147323913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing lead toxicity induced alterations in expression of transmembrane metal transporter OsHMA9 and physio-biochemical activities of canola 评估铅中毒对油菜跨膜金属转运蛋白OsHMA9表达及生理生化活性的影响。

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-26 DOI: 10.1007/s10534-025-00780-9

Khalid Bilal, Nosheen Noor Elahi, Muhammad Imtiaz, Abebe Bogale, Esmael M. Alyami, Norah Hamdi, Tawaf Ali Shah, Ahmad Mohammad Salamatullah

{"title":"Assessing lead toxicity induced alterations in expression of transmembrane metal transporter OsHMA9 and physio-biochemical activities of canola","authors":"Khalid Bilal, Nosheen Noor Elahi, Muhammad Imtiaz, Abebe Bogale, Esmael M. Alyami, Norah Hamdi, Tawaf Ali Shah, Ahmad Mohammad Salamatullah","doi":"10.1007/s10534-025-00780-9","DOIUrl":"10.1007/s10534-025-00780-9","url":null,"abstract":"<div>Rapid industrialization has accelerated heavy metal contamination of agricultural, posing severe risk to ecosystem, food safety, human and animal health. In the present study, we examined the physiological and biochemical responses of four canola (Brassica napus L.) varieties; CON-II, Super Raya, Dunkeld and Super Canola, to lead (Pb) stress (600 mg kg⁻1 soil). Pb exposure markedly suppressed growth and morphological traits across all varieties; however, Super Raya exhibited comparatively superior performance, maintaining higher plant height, root and shoot biomass (fresh and dry), and root length. The accumulation of Pb in roots and leaves of canola plants posed a toxic effect to biochemical activities thus enhancing malondialdehyde concentration and electrolyte leakage. The disturbance in metabolism of canola plants under Pb stress resulted into depletion in chlorophyll concentration while the activities of antioxidants involving glutathione reduce (GSH), superoxide dismutase (SOD), ascorbic acid (ASA), peroxidase (POD), ascorbate peroxidase (APX), catalase (CAT) and total antioxidant activity were significantly enhanced in order to detoxify its deleterious effects. The translocation factor indicated that Super Raya retained maximum Pb in its roots rather than to translocate in its leaves. Furthermore, b exposure significantly induced OsHMA9 expression in all varieties, with the highest induction observed in Super Raya. The results demonstrate that although Pb stress impairs physio-biochemical functions in canola, Super Raya possesses comparatively stronger tolerance mechanisms, including restricted Pb translocation and enhanced antioxidant defense.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 2","pages":"745 - 755"},"PeriodicalIF":3.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147289043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly cadmium and chromium tolerant rhizosphere bacteria of Albizia julibrissin Durazz on plant growth promoting 合欢根际高耐镉铬细菌对植物生长的促进作用。

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-26 DOI: 10.1007/s10534-026-00801-1

Xinyu Wu, Mengyu Zhang, Chen Du, Mengru Sun, Houpeng Hu, Man Cai

{"title":"Highly cadmium and chromium tolerant rhizosphere bacteria of Albizia julibrissin Durazz on plant growth promoting","authors":"Xinyu Wu, Mengyu Zhang, Chen Du, Mengru Sun, Houpeng Hu, Man Cai","doi":"10.1007/s10534-026-00801-1","DOIUrl":"10.1007/s10534-026-00801-1","url":null,"abstract":"<div>Using plant growth promoting rhizosphere strains combined with woody legumes is an effective strategy to remediate heavy metals co-contaminated pollution in soil. Despite recent breakthroughs in understanding how rhizosphere strains improve phytoremediation, resources for rhizosphere strain resources with high efficiency to Cadmium (Cd) and Chromium (Cr) resistance are still lacking. Albizia julibrissin Durazz is known as one of the most common leguminous plants. Here, four dominant gram-negative, aerobic strains with nitrogen-fixing ability, phosphate solubilization and indole-3-acetic acid production were isolated from the rhizosphere of A. julibrissin Durazz on Ashby N-free medium. All isolates grew in the presence of 0.1 ~ 100 mg/L Cd and Cr alone or combined stress. Strain ADJ4 exhibited the highest removal efficiency of Cd and Cr alone or combined stress (56.71% ~ 70.86%) and selected isolates for plant inoculation assay. Under Cd and Cr alone or combined stress, ADJ4 inoculation increased seed germination by 1.39% ~ 9.23%, aboveground biomass by 6.11% ~ 70.89% and underground biomass by 36.76% ~ 93.04% while enhancing superoxide dismutase (SOD), peroxidase (POD) and proline (Pro) activities by 10.98% ~ 18.90%, 14.35% ~ 19.74% and 23.05% ~ 48.14%, respectively, relative to non-inoculated controls. Our results underscore the significance of the rhizosphere strains application colonization and efficacy, and plant growth promoting for efficient remediation of Cd-Cr co-contaminated.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"1065 - 1076"},"PeriodicalIF":3.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium–glutathione axis 自闭症谱系障碍中汞诱导的兴奋性毒性：谷氨酸能稳态的破坏和硒-谷胱甘肽轴的治疗作用

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-26 DOI: 10.1007/s10534-026-00791-0

Afaf El-Ansary, Laila Al-Ayadhi, Ahmed Dewedar, Ramesa Shafi Bhat, Ramiz Saad, Geir Bjørklund

{"title":"Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium–glutathione axis","authors":"Afaf El-Ansary, Laila Al-Ayadhi, Ahmed Dewedar, Ramesa Shafi Bhat, Ramiz Saad, Geir Bjørklund","doi":"10.1007/s10534-026-00791-0","DOIUrl":"10.1007/s10534-026-00791-0","url":null,"abstract":"<div>Researchers have implicated mercury (Hg) exposure in the pathogenesis of autism spectrum disorder (ASD) through multiple mechanisms, including oxidative stress, mitochondrial dysfunction, and glutamatergic dysregulation. This review delineates the molecular and cellular pathways by which Hg exerts neurotoxic effects, emphasizing its disruption of the glutamate–glutamine–GABA cycle and the resulting excitotoxic activation of NMDA receptors. The selenium (Se)–glutathione (GSH) axis is central to these processes, which play a pivotal role in Hg detoxification and the maintenance of redox balance. Individuals with ASD frequently exhibit impairments in these systems, increasing their susceptibility to Hg-induced neurotoxicity. Nutritional strategies to restore Se and GSH levels may mitigate oxidative stress and neurobehavioral abnormalities in ASD. By integrating findings from molecular studies, animal models, and clinical research, this paper proposes a targeted therapeutic framework to address environmentally mediated biochemical vulnerabilities in ASD.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"809 - 837"},"PeriodicalIF":3.6,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147288827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights on the role of some biometals in mancozeb induced hematological and hepatorenal toxicity in rats and the protective effect of naringin 一些生物金属在代森锰锌引起的大鼠血液学和肝肾毒性中的作用以及柚皮苷的保护作用的新认识。

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-25 DOI: 10.1007/s10534-026-00795-w

Sara S. Elbagwry, Eman I. Hassanen, Rehab A. Azouz, Marwa A. Ibrahim, Rawhia Doghaim

{"title":"New insights on the role of some biometals in mancozeb induced hematological and hepatorenal toxicity in rats and the protective effect of naringin","authors":"Sara S. Elbagwry, Eman I. Hassanen, Rehab A. Azouz, Marwa A. Ibrahim, Rawhia Doghaim","doi":"10.1007/s10534-026-00795-w","DOIUrl":"10.1007/s10534-026-00795-w","url":null,"abstract":"<div>Prolonged exposure to mancozeb (MZ), a frequently used fungicide, may cause oxidative stress damage to several organs; however, the mechanism of toxicity remains obscure. So, the present work sought to assess the contribution of some biometals, including Mn, Zn, Ca, and Fe, to the subacute hepatic and renal injury prompted by MZ-mediated oxidative stress and to evaluate the protective impact of naringin (NAR), a citrus-derived flavonoid, against this toxicity. Twenty-eight male Wistar rats were divided into four groups (n = 7) as follows: (1) control, (2) NAR (20 mg/kg bwt), (3) MZ (250 mg/kg bwt), and (4) NAR + MZ. The daily oral intake of MZ for 54 days induced marked hematological alterations, elevation in some hepatorenal markers, and alteration of the redox status of both liver and kidney tissues. There were marked histopathological alterations in both liver and kidney tissues that were confirmed by the immunohistochemical staining, which demonstrated strong iNOS and Bax along with weak Bcl-2 immunoexpression. The repeated exposure to MZ significantly increased the levels of Mn and decreased the levels of Ca, Zn, and Fe in both liver and kidney tissues, which attributed to upregulation of the mRNA levels of MT-1, CYP1A1, and casp-3 genes. On the other hand, the co-administration of NAR with MZ significantly reversed these toxic effects via improving the hematological profile, restoring antioxidant enzyme activity, and mitigating both hepatorenal function and structure. The data indicated that NAR had considerable protective effects against MZ-induced hepatorenal damage, mostly through enhanced antioxidant capacity, preservation of trace element equilibrium, and modulation of oxidative, inflammatory, and apoptotic pathways.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"973 - 993"},"PeriodicalIF":3.6,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10534-026-00795-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative toxicity of Cr(III) and Cr(VI) to freshwater and marine algae (Chlorella vulgaris, Dunaliella tertiolecta) under varying sulfate concentrations 不同硫酸盐浓度下Cr（III）和Cr（VI）对淡水和海洋藻类（小球藻、杜氏藻）的毒性比较

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-23 DOI: 10.1007/s10534-026-00800-2

Ekaterina Stravinskene, Iurii Grigorev, Nadezhda Artyna

{"title":"Comparative toxicity of Cr(III) and Cr(VI) to freshwater and marine algae (Chlorella vulgaris, Dunaliella tertiolecta) under varying sulfate concentrations","authors":"Ekaterina Stravinskene, Iurii Grigorev, Nadezhda Artyna","doi":"10.1007/s10534-026-00800-2","DOIUrl":"10.1007/s10534-026-00800-2","url":null,"abstract":"<div>Sulfate is known to protect microalgae from Cr(VI) toxicity in seawater. We investigated whether varying sulfate levels could lead to a change in the most toxic chromium species for freshwater and marine algae. For Cr(VI), reducing medium sulfate by 125-fold lowered the EC50 for C. vulgaris from 17.9 to 1.5 µM, and for D. tertiolecta from 413.9 to 18.3 µM. In contrast, Cr(III) toxicity appeared largely independent of sulfate: the EC50 values ranged for C. vulgaris from 5.0 to 4.0 µM, and for D. tertiolecta from 30.8 to 11.5 µM. The Cr(VI):SO42− and Cr(III):SO42− ratios were calculated to compare the toxicity of the chromium species to the microalgae in terms of dependence on ambient sulfate. Total growth inhibition occurred at Cr(VI):sulfate ratios greater than 1:20 for both algae, while toxicity disappeared below 1:2000 (C. vulgaris) and 1:200 (D. tertiolecta). For Cr(III), both complete and negligible inhibition was observed across a wide range of ratios (1:2000 – 1:20). These findings suggest that seawater sulfate-mediated protection may not be effective against Cr(III). In marine cultures, Cr(III) was more toxic than Cr(VI), contradicting conventional assumptions about the greater toxicity of hexavalent chromium.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"1055 - 1064"},"PeriodicalIF":3.6,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling lead-induced toxicity in mammals: the role of oxidative stress and apoptosis and their modulation by emerging therapeutic strategies 揭示铅诱导的哺乳动物毒性：氧化应激和细胞凋亡的作用及其通过新兴治疗策略的调节。

IF 3.6 3区生物学

Biometals Pub Date : 2026-02-22 DOI: 10.1007/s10534-026-00799-6

Reena Sheoran, Sunita Grewal, Jagjeet Singh, Vinay Malik

{"title":"Unravelling lead-induced toxicity in mammals: the role of oxidative stress and apoptosis and their modulation by emerging therapeutic strategies","authors":"Reena Sheoran, Sunita Grewal, Jagjeet Singh, Vinay Malik","doi":"10.1007/s10534-026-00799-6","DOIUrl":"10.1007/s10534-026-00799-6","url":null,"abstract":"<div>Rapid industrialization and technological advancements have led to extensive environmental contamination of lead, disrupting the ecological balance and posing significant risks to biodiversity and ecosystem functionality. Lead remains a critical concern due to its high toxicity, persistence, and ability to bioaccumulate, which can elicit oxidative and metabolic disruptions. Lead toxicity impairs haematological, biochemical, and structural parameters, ultimately compromising hepatic, renal, neurological, and reproductive functions. This review integrates the current understanding of the mechanistic pathways involved in lead-induced toxicity, with a specific focus on oxidative stress and apoptosis. Lead exposure disrupts redox homeostasis, characterized by an increase in reactive oxygen species (ROS) and a reduction in antioxidant defenses, notably superoxide dismutase, catalase, and glutathione levels. Concurrently, it triggers apoptotic signalling via mitochondrial dysfunction, thereby elevating the expression of pro-apoptotic mediators (e.g., Bax, caspases) while suppressing the anti-apoptotic factor Bcl-2. Furthermore, this review discusses emerging strategies for prevention and therapy, highlighting the protective effects of natural phytochemicals and antioxidant-based interventions that may alleviate cellular and tissue damage associated with lead exposure.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 3","pages":"839 - 866"},"PeriodicalIF":3.6,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0