- Book学术

发布求助

文献互助智能选刊最新文献

IF 4.1 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biometals Pub Date : 2024-12-16 DOI:10.1007/s10534-024-00656-4

Shivsharan B Dhadde, Mallinath S Kalshetti

{"title":"Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.","authors":"Shivsharan B Dhadde, Mallinath S Kalshetti","doi":"10.1007/s10534-024-00656-4","DOIUrl":null,"url":null,"abstract":"The interaction of metal ions with biological systems plays a critical role in cellular functions, including oxidative stress regulation and metabolic health. This study aimed to explore the effects of the chromium-histidine complex [Cr(hist)3] on reproductive success, developmental processes, and oxidative stress defence in Drosophila melanogaster. Wild-type D. melanogaster flies were exposed to Cr(hist)3 at concentrations of 5, 10, 15, and 20 µg/ml, and physiological parameters-including fecundity, fertility, developmental timelines, and antioxidant enzyme activity-were measured. Our results indicate that Cr(hist)3 at 15 µg/ml optimally enhanced reproductive health and developmental efficiency. Specifically, fecundity and fertility increased by 15.6% and 15.5%, respectively, and egg-to-adult viability improved by 15.6% compared to controls. Developmental timelines were shortened, with larval and pupal periods reduced by 7.6% and 7.1%. Additionally, Cr(hist)3 treatment led to a significant downregulation of lipid peroxidation (MDA) by 17.54% and upregulation in antioxidant enzymes (catalase, glutathione-S-transferase, and superoxide dismutase), indicating improved cellular defence against oxidative damage. Flies treated with 15 µg/ml Cr(hist)33 also exhibited a 9.7% increase in lifespan. These findings suggest that Cr(hist)3 enhances reproductive success and developmental dynamics through oxidative stress regulation, highlighting its potential for applications in insect health and stress management. This study contributes to the understanding of metal ion interactions in biological systems and their physiological effects.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometals","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s10534-024-00656-4","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

金属离子与生物系统的相互作用在细胞功能（包括氧化应激调节和代谢健康）中发挥着关键作用。本研究旨在探讨铬组氨酸复合物[Cr(hist)3]对黑腹果蝇繁殖成功率、发育过程和氧化应激防御的影响。将野生型黑腹果蝇暴露于浓度为 5、10、15 和 20 µg/ml 的铬组氨酸复合物，并测量其生理参数，包括生殖力、繁殖力、发育时间和抗氧化酶活性。我们的研究结果表明，15 微克/毫升的Cr(hist)3能最大程度地提高生殖健康和发育效率。具体而言，与对照组相比，受精率和生殖力分别提高了15.6%和15.5%，卵到成体的存活率提高了15.6%。发育时间缩短，幼虫期和化蛹期分别缩短了 7.6% 和 7.1%。此外，Cr(hist)3 处理导致脂质过氧化物（MDA）显著降低 17.54%，抗氧化酶（过氧化氢酶、谷胱甘肽-S-转移酶和超氧化物歧化酶）上调，表明细胞对氧化损伤的防御能力提高。用 15 µg/ml Cr(hist)33 处理的苍蝇寿命也延长了 9.7%。这些研究结果表明，Cr(hist)3 可通过氧化应激调节提高繁殖成功率和发育动态，突出了其在昆虫健康和应激管理方面的应用潜力。这项研究有助于人们了解金属离子在生物系统中的相互作用及其生理效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Chromium-histidine complex enhances reproductive physiology and development in Drosophila melanogaster by modulating oxidative stress.

The interaction of metal ions with biological systems plays a critical role in cellular functions, including oxidative stress regulation and metabolic health. This study aimed to explore the effects of the chromium-histidine complex [Cr(hist)₃] on reproductive success, developmental processes, and oxidative stress defence in Drosophila melanogaster. Wild-type D. melanogaster flies were exposed to Cr(hist)₃ at concentrations of 5, 10, 15, and 20 µg/ml, and physiological parameters-including fecundity, fertility, developmental timelines, and antioxidant enzyme activity-were measured. Our results indicate that Cr(hist)₃ at 15 µg/ml optimally enhanced reproductive health and developmental efficiency. Specifically, fecundity and fertility increased by 15.6% and 15.5%, respectively, and egg-to-adult viability improved by 15.6% compared to controls. Developmental timelines were shortened, with larval and pupal periods reduced by 7.6% and 7.1%. Additionally, Cr(hist)₃ treatment led to a significant downregulation of lipid peroxidation (MDA) by 17.54% and upregulation in antioxidant enzymes (catalase, glutathione-S-transferase, and superoxide dismutase), indicating improved cellular defence against oxidative damage. Flies treated with 15 µg/ml Cr(hist)₃₃ also exhibited a 9.7% increase in lifespan. These findings suggest that Cr(hist)₃ enhances reproductive success and developmental dynamics through oxidative stress regulation, highlighting its potential for applications in insect health and stress management. This study contributes to the understanding of metal ion interactions in biological systems and their physiological effects.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Biometals 生物-生化与分子生物学

CiteScore

5.90

自引率

8.60%

发文量

111

审稿时长

3 months

期刊介绍： BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.