美国人群多重金属暴露与合并症肥胖和近视的关系

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Li He, Yalan Liu, Li Zhang, Ying Luo, Zhaofeng Jin
{"title":"美国人群多重金属暴露与合并症肥胖和近视的关系","authors":"Li He,&nbsp;Yalan Liu,&nbsp;Li Zhang,&nbsp;Ying Luo,&nbsp;Zhaofeng Jin","doi":"10.1007/s10534-025-00701-w","DOIUrl":null,"url":null,"abstract":"<div><p>The objective of this study was to examine the relationships between combined metal exposure and the comorbidities of overweight/obesity (OWOB) and myopia. Data from the National Health and Nutrition Examination Survey (2001–2006) were analyzed. The sample comprised 5927 participants aged 12 years and older, with urine measurements of 11 metals obtained through inductively coupled plasma-mass spectrometry. Least absolute shrinkage and selection operator regression models were employed to evaluate the combined effects of the metals. Multivariate logistic regression models and restricted cubic spline functions assessed the connections between metal exposure and comorbidities. The findings indicated that 1290 (21.76%) of the 5927 participants exhibited both OWOB and myopia. High levels of lead (OR = 0.76, 95% CI: 0.62–0.93), platinum (OR = 0.81, 95% CI: 0.68–0.97), and uranium (OR = 0.72, 95% CI: 0.59–0.86) were associated with a reduced risk of these comorbidities (P trend &lt; 0.05). Conversely, elevated exposure to mixed metals was linked to an increased risk of comorbidities (OR = 1.48, 95% CI: 1.23–1.77, P trend &lt; 0.0001). Females had a higher risk of exposure to mixed metals (OR = 4.63, 95% CI: 2.63–8.16) compared to males (OR = 1.45, 95% CI: 0.74–2.82). This study offers preliminary evidence of an association between metal exposure and the comorbidity of OWOB and myopia. Although causality cannot be inferred due to the cross-sectional nature of the study, these results support further longitudinal research.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"38 4","pages":"1223 - 1233"},"PeriodicalIF":3.6000,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of combined exposure to multiple metals with comorbid obesity and myopia in the U.S. population\",\"authors\":\"Li He,&nbsp;Yalan Liu,&nbsp;Li Zhang,&nbsp;Ying Luo,&nbsp;Zhaofeng Jin\",\"doi\":\"10.1007/s10534-025-00701-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The objective of this study was to examine the relationships between combined metal exposure and the comorbidities of overweight/obesity (OWOB) and myopia. Data from the National Health and Nutrition Examination Survey (2001–2006) were analyzed. The sample comprised 5927 participants aged 12 years and older, with urine measurements of 11 metals obtained through inductively coupled plasma-mass spectrometry. Least absolute shrinkage and selection operator regression models were employed to evaluate the combined effects of the metals. Multivariate logistic regression models and restricted cubic spline functions assessed the connections between metal exposure and comorbidities. The findings indicated that 1290 (21.76%) of the 5927 participants exhibited both OWOB and myopia. High levels of lead (OR = 0.76, 95% CI: 0.62–0.93), platinum (OR = 0.81, 95% CI: 0.68–0.97), and uranium (OR = 0.72, 95% CI: 0.59–0.86) were associated with a reduced risk of these comorbidities (P trend &lt; 0.05). Conversely, elevated exposure to mixed metals was linked to an increased risk of comorbidities (OR = 1.48, 95% CI: 1.23–1.77, P trend &lt; 0.0001). Females had a higher risk of exposure to mixed metals (OR = 4.63, 95% CI: 2.63–8.16) compared to males (OR = 1.45, 95% CI: 0.74–2.82). This study offers preliminary evidence of an association between metal exposure and the comorbidity of OWOB and myopia. Although causality cannot be inferred due to the cross-sectional nature of the study, these results support further longitudinal research.</p></div>\",\"PeriodicalId\":491,\"journal\":{\"name\":\"Biometals\",\"volume\":\"38 4\",\"pages\":\"1223 - 1233\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-06-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biometals\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10534-025-00701-w\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biometals","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10534-025-00701-w","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

本研究的目的是研究复合金属暴露与超重/肥胖(OWOB)和近视合并症之间的关系。分析了2001-2006年全国健康和营养检查调查的数据。样本包括5927名年龄在12岁及以上的参与者,通过电感耦合等离子体质谱法测量尿液中的11种金属。采用最小绝对收缩率和选择算子回归模型对金属的综合效应进行了评价。多元逻辑回归模型和限制三次样条函数评估了金属暴露与合并症之间的联系。结果表明,5927名受试者中有1290人(21.76%)同时患有眼外近视和近视。高水平的铅(OR = 0.76, 95% CI: 0.62-0.93)、铂(OR = 0.81, 95% CI: 0.68-0.97)和铀(OR = 0.72, 95% CI: 0.59-0.86)与这些合并症的风险降低相关(P趋势)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of combined exposure to multiple metals with comorbid obesity and myopia in the U.S. population

The objective of this study was to examine the relationships between combined metal exposure and the comorbidities of overweight/obesity (OWOB) and myopia. Data from the National Health and Nutrition Examination Survey (2001–2006) were analyzed. The sample comprised 5927 participants aged 12 years and older, with urine measurements of 11 metals obtained through inductively coupled plasma-mass spectrometry. Least absolute shrinkage and selection operator regression models were employed to evaluate the combined effects of the metals. Multivariate logistic regression models and restricted cubic spline functions assessed the connections between metal exposure and comorbidities. The findings indicated that 1290 (21.76%) of the 5927 participants exhibited both OWOB and myopia. High levels of lead (OR = 0.76, 95% CI: 0.62–0.93), platinum (OR = 0.81, 95% CI: 0.68–0.97), and uranium (OR = 0.72, 95% CI: 0.59–0.86) were associated with a reduced risk of these comorbidities (P trend < 0.05). Conversely, elevated exposure to mixed metals was linked to an increased risk of comorbidities (OR = 1.48, 95% CI: 1.23–1.77, P trend < 0.0001). Females had a higher risk of exposure to mixed metals (OR = 4.63, 95% CI: 2.63–8.16) compared to males (OR = 1.45, 95% CI: 0.74–2.82). This study offers preliminary evidence of an association between metal exposure and the comorbidity of OWOB and myopia. Although causality cannot be inferred due to the cross-sectional nature of the study, these results support further longitudinal research.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信