Biometals最新文献

{"title":"Exploring the antitumor effects of Pd(II) complexes with nitrogen donor ligands towards breast carcinoma.","authors":"Shazia Hussain, Sara Masood, Shabeeb Hussain, Irfan Hussain, Fouzia Malik, Muhammad Nadeem Akhtar, M Naveed Zafar","doi":"10.1007/s10534-025-00702-9","DOIUrl":"https://doi.org/10.1007/s10534-025-00702-9","url":null,"abstract":"<p><p>Pd(II)-containing complexes exhibit considerable potential as therapeutic agents against cancer owing to their proficiency in selectively targeting neoplastic cells compared to cisplatin. In this context, we describe the synthesis of square planar palladium complexes of the general formula [Pd(L^1-8)₂] from imino-amido-based asymmetrical (NN) proligands (HL^1-8) and characterized based on melting point, CHN analysis, spectroscopic techniques (FT-IR, ¹H NMR, ¹³C NMR), and ESI-MS. DFT computations are employed to elucidate the characteristics of the frontier orbitals and MEP analysis. In the current investigation, the precursors, proligands, Pd(II) complexes and cisplatin were systematically assessed for their anticancer efficacy against breast carcinoma (BT-474, BT-483, and BT-459) by MTT assay. Among the compounds subjected to evaluation, the complex [Pd(L⁷)₂] demonstrated superior capacity in inhibiting the proliferation of breast cancer cells, exhibiting median inhibitory concentration (IC₅₀) values of 6.10, 9.01, and 7.20 µM than standard cisplatin (IC₅₀ = 18.70, 19.40, 19.30 µM), respectively. Cellular apoptosis assessment of [Pd(L^5-8)₂] exhibited characteristic apoptotic phenomena including membrane blebbing and DNA condensation. Furthermore, electronic spectroscopy was used to evaluate the binding modalities of complexes with CT DNA, supported by the in silico docking studies. [Pd(L⁷)₂] exhibited the mixed binding mode with a binding affinity in the range of 10⁴ M^-1.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanadium 8-hydroxyquinoline derivatives in medicine: current state and future outlook.","authors":"Tahmineh Kohanfekr, Camelia Gholamrezazadeh, Hasan Ali Hosseini","doi":"10.1007/s10534-025-00683-9","DOIUrl":"10.1007/s10534-025-00683-9","url":null,"abstract":"<p><p>Vanadium complexes featuring 8-hydroxyquinoline ligands and their derivatives have emerged as a promising class of compounds with potential therapeutic applications, particularly as antimicrobial and anticancer agents. This comprehensive review offers a timely and insightful analysis of the current landscape of vanadium complexes with HQ ligand or its derivatives, whether alone or in combination with organic coligands. This review covers synthetic strategies, and mechanisms that underlie their antibacterial and anticancer activities. A significant focus of this review is the thorough evaluation of the antibacterial and anticancer properties of these complexes, providing an invaluable resource for researchers in the interdisciplinary fields of inorganic chemistry, medicinal chemistry, and drug discovery. By compiling and synthesizing the existing knowledge on vanadium-8-hydroxyquinoline (VO-8HQ) complexes, this review addresses a critical gap in the literature. Ongoing research, including rigorous preclinical and clinical evaluations, is essential for fully exploring the therapeutic potential of this promising class of metallodrugs.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"711-736"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of antifungal and antibiofilm activities of green synthesized silver nanoparticles against Candida glabrata.","authors":"Irshad Ahamad, Tasneem Fatma","doi":"10.1007/s10534-025-00680-y","DOIUrl":"10.1007/s10534-025-00680-y","url":null,"abstract":"<p><p>Candida glabrata is an important human fungal pathogen known to cause life-threatening infections in people with impaired immune systems. In the mouth cavities, trachea, and catheters, Candida glabrata biofilm grows unhindered and is the primary etiological factor in the pathophysiology of candidiasis, in the worst cases, this leads to systemic infections. Therefore, developing novel biofilm preventative and therapeutic agents is urgently required. Here, in the present study, an effort was made to monitor the function of silver nanoparticles (AgNPs) generated from a cyanobacterium (Anabaena variabilis) as a novel antibiofilm agent focusing on candidiasis. Anabaena variabilis cell extract was used to synthesize AgNPs, characterized by UV-visible spectroscopy. The minimum inhibitory concentration (MIC) of AgNPs was observed at 25 µg/mL in Candida glabrata. At the concentration of 2MIC of AgNPs (50 µg/mL), 67 ± 0.84% membrane permeability was noticed at the same concentration the viable cells were found at only 2.8 ± 2.0%; while in the early phase of apoptosis, were found at 15.5 ± 1.5%; and in the late phase of apoptosis, were found at 81.8 ± 4.2%, thus confirming the cell's death. Additionally, a cell-cycle study also declared the halted cycle in the S phase by increasing the number of cells. The growth inhibition assay shows that the test organism's growth steadily decreased in comparison to the control with increasing AgNPs concentrations. Additionally, in the scanning electron microscopic pictures of Candida glabrata treated with AgNPs, which exhibited deep wrinkles and deformity, confirming the cells death. At the concentrations of 2MIC of AgNPs (50 µg/mL) showed 72 ± 0.86% of biofilm inhibition and 80 ± 1.3% degradation during the biofilm study. In conclusion, all results demonstrate that AgNPs have great antifungal potential; therefore, AgNPs could be used to control biofilm produced by emerging multidrug-resistant Candida glabrata.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"843-861"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrations of the serum long-chain omega-3 polyunsaturated fatty acids and hair mercury in men in different apolipoprotein E phenotypes.","authors":"Unna Fagerholm, Heli E K Virtanen, Tomi-Pekka Tuomainen, Jukka T Salonen, Jyrki K Virtanen","doi":"10.1007/s10534-025-00677-7","DOIUrl":"10.1007/s10534-025-00677-7","url":null,"abstract":"<p><p>Fish is a source of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) and methylmercury, a toxic heavy metal, with opposite effects on cardiovascular disease risk and cognitive decline. Besides diet, the apolipoprotein E (APOE) genotype may affect LC n-3 PUFA and mercury concentrations in the body, but the evidence is inconsistent. The subjects were 1159 men aged 42-60 years, examined in 1984-1989. ANCOVA and linear regression were used in the analyses. The mean ± SD concentrations of serum eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) were 1.57 ± 0.82, 0.55 ± 0.10 and 2.45 ± 0.75%, respectively. There were no differences in LC n-3 PUFA concentrations between APOE4 carriers and non-carriers (P-values ≥ 0.60). The mean ± SD hair mercury concentration was 1.55 ± 1.3 µg/g. The concentrations were slightly higher in APOE4 carriers vs. non-carriers (difference 0.16 µg/g, 95% confidence interval = 0.01-0.32,P = 0.04). Overall, fish consumption was associated with higher hair mercury and serum EPA and DHA concentrations, but no differences in the associations were found between APOE4 carriers and non-carriers (P-interactions ≥ 0.30). Hair mercury, but not serum LC n-3 PUFA concentrations, were higher in APOE4 carriers vs. non-carriers. However, as no differences were found in the associations of fish intake with LC n-3 PUFA and mercury concentrations, the results could be due to differences in mercury accumulation.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"807-816"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of melatonin on cadmium subcellular distribution, biochemical, and anatomical alterations in Malva parviflora roots.","authors":"Narges Rahnamaei Yahyaabadi, Parzhak Zoufan, Fatemeh Nasernakhaei","doi":"10.1007/s10534-025-00691-9","DOIUrl":"10.1007/s10534-025-00691-9","url":null,"abstract":"<p><p>Plants use various mechanisms to cope with cadmium (Cd) stress. Melatonin's impact on the root response to Cd stress, which is the first organ to detect its presence, has been less studied. This study aims to investigate the effects of melatonin pretreatment on the root strategies of Malva parviflora in response to Cd stress, focusing on the mechanisms of heavy metal tolerance. The plants, 42 days post-germination, were subjected to a 48-h pretreatment with 50 μM melatonin in a complete nutrient solution under controlled growth conditions. Following pretreatment, plants were exposed to a nutrient solution containing 50 μM Cd for 8 days. Comparative analyses were conducted on root length, weight, anatomical features, Cd content, Cd subcellular distribution, nutrient absorption, glutathione, and lignin. Melatonin pretreatment significantly enhanced root length and weight under Cd stress. It also increased the xylem and phloem area in the roots and promoted the absorption and translocation of essential nutrients such as Fe, Zn, Ca, and Mg to the shoots. Additionally, there was a marked increase in glutathione content and Cd proportion in the cell wall and organelle fractions in melatonin-pretreated roots. Notably, melatonin reduced overall plant Cd content and its translocation from roots to shoots, while decreasing root lignin content. This study demonstrates that melatonin plays an important role in managing Cd toxicity by improving morphological, anatomical, and biochemical characteristics of roots under Cd stress. The findings suggest that melatonin pretreatment can effectively alter Cd subcellular distribution, thereby mitigating its harmful effects in plants.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"997-1017"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.","authors":"Jun Wen, Changfen Wang, Ranyang Liu, Rongjuan Zhuang, Yan Liu, Yishi Li, Shuliang Guo","doi":"10.1007/s10534-025-00690-w","DOIUrl":"10.1007/s10534-025-00690-w","url":null,"abstract":"<p><p>Epidemiological research examining the relationship between urinary cadmium and the risk of chronic cough remains scarce. This study included 2965 participants for a cross-sectional study from the NHANES. The weighted quantile sum (WQS) regression, bayesian kernel machine regression (BKMR), machine learning models (support vector machines, random forests, decision trees, and XGBoost), restricted cubic spline (RCS), and logistic regression were applied to comprehensively evaluate the performance of urinary metals in predicting chronic cough risk. Finally, the mediation effect model was employed to evaluate the role of systematic inflammation in the relationship between urinary cadmium and the risk of chronic cough. Urinary cadmium correlated with an increasing risk of chronic cough in the multivariate logistic regression model (OR: 2.83, 95% CI: 1.60-4.99). Both the WQS regression and BKMR consistently suggested a positive relationship between urinary mixed metal and chronic cough risk. Among the four machine learning models used to evaluate urinary metals and the risk of chronic cough, the random forests model showed better predictive performance (AUC = 0.69). The random forests suggested that the top five important indicators for predicting chronic cough risk were urinary cadmium, thallium, molybdenum, cesium, and uranium. Finally, the mediation effect model suggested that the systematic inflammation (lymphocytes: 4.24%, systemic immune inflammation index: 5.11%) partially mediated the relationship between urinary cadmium and chronic cough risk. This study discovered that urinary cadmium was elevated in correlation with the increasing risk of chronic cough. Systematic inflammations may partially mediate this association. Improving exposure to urinary cadmium may reduce the risk of chronic cough.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"983-995"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, biological evaluation and molecular docking of a Schiff base ligand and its metal complexes.","authors":"Elsayed M AbouElleef, Rania A Saad, M A Diab, M M El-Zahed, A Z El-Sonbati, Sh M Morgan","doi":"10.1007/s10534-025-00688-4","DOIUrl":"10.1007/s10534-025-00688-4","url":null,"abstract":"<p><p>Condensation of 2,3-diaminopyridine with 2,4-dihyrodybenzaldehyde yielded a 4,4'-[(1E,1 ~ E)-(pyridine-2,3-diyl)bis(azanylylidene)]bis(methanylylidene)bis(benzene-1,3-diol) monobasic tridentate Schiff base ligand (HL) with an ONN donor sequence. Elemental analyses, conductivity tests, magnetic susceptibility data, FT-IR, UV-vis spectra, x-ray diffraction, and mass spectrum data of the ligand and its complexes were used for the characterization of the structures. Computational HF/3-21G calculations were performed to optimize their geometrical structures and assess their HOMO-LUMO energy gaps. The low molar conductance of the complexes indicates that they are not electrolytic. From the spectrophotometric and gravimetric analyses, the complexes (2-4) are in the ratio of 1:2, while complexes (1 & 5) (1:1) metal to ligand. 2,3-Diaminopyridine, 2,4-dihydroxybenzaldehyde, ligand (HL) and its complexes were screened for antibacterial and antifungal activities against some bacterial (Enterococcus faecalis, Salmonella typhi, and Staphylococcus epidermidis) and fungal isolates (Aspergillus flavus, Alternaria solani, and Candida albicans). The result reveals that 2,4-dihyrodybenzaldehyde has the strongest antibacterial activity among the other compounds followed by Mn(II) complex. The antimicrobial activity increases by increasing the compound concentration. To assess the inhibitory impact of ligand and its complexes on binding sites of B. cereus (PDB ID: 1FEZ), S. epidermidis (PDB ID: 3KP7), E. faecalis (PDB ID: 5V5U) and S. typhi (PDB ID: 5V2W) proteins, molecular modeling has been implemented offer a fresh concept for medication design. Molecular docking studies confirmed strong binding interactions between the metal complexes and bacterial proteins, validating their biological potential. These findings demonstrate the promising antimicrobial properties of Schiff base metal complexes, making them potential candidates for pharmaceutical and medicinal applications.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"935-963"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermally treated FeCrAl alloy as potential biomaterial: surface characterization, corrosion resistance and cytotoxicity studies.","authors":"L Nadaraia, O Tsurtsumia, L Khundadze, T Kukava, P Tchelidze, V Okuneva, S Bakhtiarov, V Perumal, E Kutelia","doi":"10.1007/s10534-025-00686-6","DOIUrl":"10.1007/s10534-025-00686-6","url":null,"abstract":"<p><p>Metal alloys are widely used in implantology due to their excellent mechanical properties. However, their biocompatibility can be compromised by corrosion, which releases toxic metal ions that may provoke adverse biological reactions and contribute to implant failure. This study introduces a novel metal-ceramic composite based on a high-chromium FeCrAl alloy, specifically engineered to form a thermally grown α-Al₂O₃ surface layer. This design aims to significantly enhance biocompatibility and corrosion resistance for potential biomedical implant applications. Samples of the Fe-44Cr-5Al alloy were produced using an arc melting process. The mechanically polished alloy coupons were given a mirror-like finish and underwent high-temperature oxidation at 1050 °C for 20 h in laboratory air to develop a dense and adherent α-Al₂O₃ layer. Both bare and oxidized samples were immersed in artificial saliva at 37 °C for two months to assess their corrosion resistance under simulated oral conditions. Biocompatibility was evaluated through cytotoxicity and mitotic activity tests using primary human gingival fibroblasts cultured on both the bare and oxidized samples. The results showed that thermal oxidation effectively produced a uniform, adherent, and stable α-Al₂O₃ layer on the surface of the FeCrAl alloy. The oxidized samples demonstrated superior corrosion resistance, with negligible metal ion release and no formation of corrosion products. In contrast, the bare (unoxidized) alloy exhibited extensive corrosion and significant ion release. Cytotoxicity tests indicated that the oxidized alloy supported normal cell adhesion, proliferation, and morphology comparable to control samples. Although a slight reduction in cell proliferation was noted on the oxidized metal surface, overall bioactivity remained high. Structural and morphological analyses were performed using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Grazing Incidence X-ray Diffraction (GIXRD) to confirm the formation and integrity of the oxide layer. Post-immersion corrosion tests in artificial saliva and detailed microscopy further validated the favorable biological responses to the oxidized alloy.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"917-934"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavin-dependent enzymatic and photochemical interconversions between phenylarsonic and phenylarsonous acids.","authors":"Igor Kučera, Vojtěch Sedláček","doi":"10.1007/s10534-025-00685-7","DOIUrl":"10.1007/s10534-025-00685-7","url":null,"abstract":"<p><p>Phenylarsonic acid is the parent compound of a group of derivatives that occur as anthropogenic environmental contaminants in both less toxic As(V) and much more toxic As(III) redox states. To elucidate the mechanisms underlying their enzymatic redox conversions, the activities of two flavin reductases, ArsH and FerA, from the soil bacterium Paracoccus denitrificans were compared. The stopped-flow data demonstrated that PhAs(V) oxidized dihydroflavin mononucleotide bound to ArsH, but not to FerA. This result proves that ArsH has some substrate specificity for organoarsenic compounds. Under aerobic conditions, both enzymes accelerated the oxidation of PhAs(III) in a catalase-sensitive manner, indicating that hydrogen peroxide acts as an intermediate. H₂O₂ was shown to react with PhAs(III) in a bimolecular (1:1) irreversible reaction. When exposed to blue light, flavin alone mediated rapid oxidation of PhAs(III) by O₂. Photooxidation by flavin acted in concert with chemical oxidation by transiently accumulating H₂O₂. The described processes may be relevant in the context of arsenic ecotoxicology and remediation.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"903-915"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?","authors":"Ella O'Sullivan, Denis O'Shea, Michael Devereux, Orla Howe","doi":"10.1007/s10534-025-00676-8","DOIUrl":"10.1007/s10534-025-00676-8","url":null,"abstract":"<p><p>Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screening of the complexes demonstrated all the metal-dicarboxylate-phenanthroline complexes exhibit superior activity compared to their non-phenanthroline containing precursors, in addition to cisplatin. The Cu(II) and Mn(II) complexes were shown to induce reactive oxygen species (ROS) but this was not observed for the Ag(I) analogues. Furthermore, apoptosis was found to be induced by all the metal-phenanthroline complexes to varying degrees contingent on the type of metal centre in the complex. Apoptotic gene expression analysis established the predominant activation of the intrinsic apoptotic pathway, with co-stimulation of the extrinsic pathway observed in some cases. The mechanistic data provided within this study highlights the multi-modal activity of the metal-phenanthroline complexes contingent on the type of metal present, warranting continued investigation of their biological modes of action beyond apoptosis induction.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"785-805"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}