Biometals最新文献

{"title":"Thermally treated FeCrAl alloy as potential biomaterial: surface characterization, corrosion resistance and cytotoxicity studies.","authors":"L Nadaraia, O Tsurtsumia, L Khundadze, T Kukava, P Tchelidze, V Okuneva, S Bakhtiarov, V Perumal, E Kutelia","doi":"10.1007/s10534-025-00686-6","DOIUrl":"10.1007/s10534-025-00686-6","url":null,"abstract":"<p><p>Metal alloys are widely used in implantology due to their excellent mechanical properties. However, their biocompatibility can be compromised by corrosion, which releases toxic metal ions that may provoke adverse biological reactions and contribute to implant failure. This study introduces a novel metal-ceramic composite based on a high-chromium FeCrAl alloy, specifically engineered to form a thermally grown α-Al₂O₃ surface layer. This design aims to significantly enhance biocompatibility and corrosion resistance for potential biomedical implant applications. Samples of the Fe-44Cr-5Al alloy were produced using an arc melting process. The mechanically polished alloy coupons were given a mirror-like finish and underwent high-temperature oxidation at 1050 °C for 20 h in laboratory air to develop a dense and adherent α-Al₂O₃ layer. Both bare and oxidized samples were immersed in artificial saliva at 37 °C for two months to assess their corrosion resistance under simulated oral conditions. Biocompatibility was evaluated through cytotoxicity and mitotic activity tests using primary human gingival fibroblasts cultured on both the bare and oxidized samples. The results showed that thermal oxidation effectively produced a uniform, adherent, and stable α-Al₂O₃ layer on the surface of the FeCrAl alloy. The oxidized samples demonstrated superior corrosion resistance, with negligible metal ion release and no formation of corrosion products. In contrast, the bare (unoxidized) alloy exhibited extensive corrosion and significant ion release. Cytotoxicity tests indicated that the oxidized alloy supported normal cell adhesion, proliferation, and morphology comparable to control samples. Although a slight reduction in cell proliferation was noted on the oxidized metal surface, overall bioactivity remained high. Structural and morphological analyses were performed using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Grazing Incidence X-ray Diffraction (GIXRD) to confirm the formation and integrity of the oxide layer. Post-immersion corrosion tests in artificial saliva and detailed microscopy further validated the favorable biological responses to the oxidized alloy.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"917-934"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavin-dependent enzymatic and photochemical interconversions between phenylarsonic and phenylarsonous acids.","authors":"Igor Kučera, Vojtěch Sedláček","doi":"10.1007/s10534-025-00685-7","DOIUrl":"10.1007/s10534-025-00685-7","url":null,"abstract":"<p><p>Phenylarsonic acid is the parent compound of a group of derivatives that occur as anthropogenic environmental contaminants in both less toxic As(V) and much more toxic As(III) redox states. To elucidate the mechanisms underlying their enzymatic redox conversions, the activities of two flavin reductases, ArsH and FerA, from the soil bacterium Paracoccus denitrificans were compared. The stopped-flow data demonstrated that PhAs(V) oxidized dihydroflavin mononucleotide bound to ArsH, but not to FerA. This result proves that ArsH has some substrate specificity for organoarsenic compounds. Under aerobic conditions, both enzymes accelerated the oxidation of PhAs(III) in a catalase-sensitive manner, indicating that hydrogen peroxide acts as an intermediate. H₂O₂ was shown to react with PhAs(III) in a bimolecular (1:1) irreversible reaction. When exposed to blue light, flavin alone mediated rapid oxidation of PhAs(III) by O₂. Photooxidation by flavin acted in concert with chemical oxidation by transiently accumulating H₂O₂. The described processes may be relevant in the context of arsenic ecotoxicology and remediation.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"903-915"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?","authors":"Ella O'Sullivan, Denis O'Shea, Michael Devereux, Orla Howe","doi":"10.1007/s10534-025-00676-8","DOIUrl":"10.1007/s10534-025-00676-8","url":null,"abstract":"<p><p>Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screening of the complexes demonstrated all the metal-dicarboxylate-phenanthroline complexes exhibit superior activity compared to their non-phenanthroline containing precursors, in addition to cisplatin. The Cu(II) and Mn(II) complexes were shown to induce reactive oxygen species (ROS) but this was not observed for the Ag(I) analogues. Furthermore, apoptosis was found to be induced by all the metal-phenanthroline complexes to varying degrees contingent on the type of metal centre in the complex. Apoptotic gene expression analysis established the predominant activation of the intrinsic apoptotic pathway, with co-stimulation of the extrinsic pathway observed in some cases. The mechanistic data provided within this study highlights the multi-modal activity of the metal-phenanthroline complexes contingent on the type of metal present, warranting continued investigation of their biological modes of action beyond apoptosis induction.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"785-805"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental comparative analysis of 18 elements reveal distinct patterns in benign and malignant thyroid tissues.","authors":"Xueying Liu, Linjing Huang, Youzhi Zhu, Peiwen Wu","doi":"10.1007/s10534-025-00682-w","DOIUrl":"10.1007/s10534-025-00682-w","url":null,"abstract":"<p><p>This study aims to compare variations in 18 trace elements (Al, Na, K, Mg, Ca, Ti, Ba, Sn, Cr, Mn, Fe, Cu, Zn, Se, Mo, Cd, Sr, and Tl) between benign and malignant thyroid tissues. Post-operative thyroid tissue samples were collected from 106 patients (34 benign, 72 malignant), and elemental concentrations were quantified using inductively coupled plasma mass spectrometry. Spearman's correlation analysis revealed positive correlations among these trace elements. Notably, the malignant group exhibited significantly higher concentrations in eight elements (Mg, Al, Fe, Cr, Ti, Sr, Sn, and Ba) compared to the benign group, while levels of six elements (Na, Mn, Cu, Zn, Cd, and Mo) were significantly lower. Orthogonal partial least squares discriminant analysis distinguished three elements (Al, Ti, Sn) for the malignant group and six elements (Na, Mn, Cu, Zn, Cd, and Mo) for the benign group. Multivariate logistic regression further revealed associations between thyroid cancer and levels of Al, Cr, Ti, Sr, Sn, Ba, Mn, Cu, Zn, and Cd. Considering with each elemental biological funcions, these findings suggest that Cu, Mn, and particularly Zn may act as essential antitumor elements with synergistic effects, whereas elevated Ba, Cr, and Al levels are closely related to thyroid malignancies. However deficiencies and excesses of elements may be the consequences of malignant tissues. In conclusion, benign and malignant thyroid tumors exhibit different trace-element profiles.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"873-886"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace elements and cognitions in elderly population: a case-control study.","authors":"Anil Kumar Maurya, Mona Srivastava, Ashish Ashish, Nitish Kumar Singh, Abhay Kumar Yadav, Shani Vishwakarma, Royana Singh","doi":"10.1007/s10534-025-00679-5","DOIUrl":"10.1007/s10534-025-00679-5","url":null,"abstract":"<p><p>There have been almost no studies with trace elements and psychological battery in cognitively impaired elderly individuals. Such research is crucial to enhance diagnostic accuracy. We aim to identify significant differences in blood serum concentration levels of trace elements, Hindi Mini-Mental State Examination (HMMSE), and psychological battery as Hindi Mattis Dementia Rating Scale (HMDRS) scores between case and control groups in the elderly. A cross-sectional research design was conducted with a total of 240 subjects, comprising 120 each from the case and control groups. Trace elements were analyzed using Atomic Absorption Spectrometry. HMMSE and HMDRS tests were administered to assess cognition scores. The chi-square test, t-test, and appropriate statistics were utilized. Our findings indicate significant differences in demographic factors (age, gender, education level) and clinical levels (p < .001), while caste, habitat, and marital status were not significant (p < .05). Concentration levels of Iron (Fe) and Copper (Cu) was higher, Zinc (Zn), Chromium (Cr), and Selenium (Se) were lower, significantly different (p < .001), but Magnesium (Mg) was not (p < .05). Additionally, third HMMSE and HMDRS were significant (p < .001) between the case and control groups in the elderly. The study suggested that higher levels of Fe and Cu, while lower Zn, Cr, and Se blood serum concentrations increased the risk of cognitive impairments in the elderly population, demonstrated by the HMMSE and HMDRS test scores which were lower in the case group.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"831-842"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of biologically and chemically synthesized zinc oxide nanoparticles for preventing Candida auris biofilm.","authors":"Bahgat Fayed, Hoda S El-Sayed, Shanshan Luo, Aisha E Reda","doi":"10.1007/s10534-025-00678-6","DOIUrl":"10.1007/s10534-025-00678-6","url":null,"abstract":"<p><p>Candidozyma auris (formerly Candida auris) is a multidrug-resistant yeast that poses a significant global health threat due to its ability to form biofilms and resist various antifungal treatments. This study evaluates and compares the antifungal efficacy of biologically synthesized zinc oxide nanoparticles (ZnO-NP-B) and chemically synthesized ZnO nanoparticles (ZnO-NP-C1 and ZnO-NP-C2), developed using the dry-wet chemical method and sol-gel method, respectively. ZnO-NP-B was synthesized using Lactobacillus gasseri. The nanoparticles were characterized for size, charge, and morphology using Particle Size Analyzer, photon correlation spectroscopy with a 90 Plus Zetasizer, and scanning electron microscopy (SEM), respectively. The antifungal activity was assessed through minimum inhibitory concentration (MIC₅₀) determination, biofilm inhibition assays by XTT assay, and gene expression analysis. ZnO-NP-C1 exhibited the highest antifungal activity against C. auris planktonic cells, with a MIC₅₀ value of 61.9 ± 3.3 µg/ml, followed by ZnO-NP-C2 (151 ± 7.83 µg/ml), whereas ZnO-NP-B showed limited efficacy (MIC₅₀ = 1 mg/ml). Chemically synthesized ZnO-NPs, particularly ZnO-NP-C2, did not induce overexpression of resistance genes (CDR1, MDR1, ERG2, ERG11, FKS1, CHS1), whereas ZnO-NP-B triggered their upregulation, potentially promoting resistance. ZnO-NP-C1 was the most effective in preventing biofilm formation, reducing C. auris adhesion by 67.9 ± 2.35% at 150 µg/ml, while ZnO-NP-B exhibited negligible inhibition. Gene expression analysis further confirmed that ZnO-NP-C1 significantly downregulated adhesive genes (ALS5, IFF4, CSA1) by up to 0.37 ± 0.006, 0.043 ± 0.002, and 0.06 ± 0.0004, respectively. These findings highlight the potential of ZnO-NP-C1 as a promising antifungal agent for preventing C. auris biofilms, emphasizing the critical role of synthesis methods in optimizing nanoparticle properties for antifungal applications.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"817-830"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of corroles in modern cancer therapy: innovation and prospects.","authors":"Laiba Javaid, Huma Hameed, Mahtab Ahmad Khan, Syed Muhammad Ahmad, Inaba Shujaat Qureshi, Rabia Shahzad, Ali Irfan","doi":"10.1007/s10534-025-00687-5","DOIUrl":"10.1007/s10534-025-00687-5","url":null,"abstract":"<p><p>Corroles, a class of tetrapyrrolic macrocycles, have garnered significant attention for their potential in cancer therapy due to their unique structural chemistry and ability to coordinate with metals. Their remarkable photophysical properties make them beneficial for photodynamic therapy (PDT) and fluorescence imaging, as they can produce reactive oxygen species when activated by light, offering potential for the treatment of various carcinomas, including hepatic, breast, pancreatic, and lung cancers. Despite the encouraging preclinical and clinical data supporting their therapeutic efficacy, challenges remain in optimizing corrole formulations, particularly concerning targeted delivery, stability, and bioavailability. This review highlights current advancements in corrole-based therapies, focusing on novel nanoparticle formulations that enhance drug distribution and therapeutic efficacy. Furthermore, it examines the mechanisms of corrole-mediated cellular death and the role of photodynamic treatment in inducing apoptosis via various signaling pathways. Additional research is necessary to address formulation-related issues while ensuring the safety and effectiveness of corroles in cancer treatment, therefore maximizing their therapeutic potential and adhering to regulatory standards.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"737-761"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated effects of blood metal(loid) exposure and impaired glucose metabolism in patients with gastric precancerous lesions or gastric cancer.","authors":"Yuting Zhu, Xiao Lin, Tingting Wang, Sheng Wang, Wuqi Wang, Mengran Ke, Yan Zhu, Bowen Zhang, Princess Ofosuhemaa, Yalei Wang, Mingjun Hu, Wanshui Yang, Anla Hu, Fen Huang, Qihong Zhao","doi":"10.1007/s10534-025-00684-8","DOIUrl":"10.1007/s10534-025-00684-8","url":null,"abstract":"<p><p>Exposure to metal(loid)s and glucose metabolism may influence the progression of gastric precancerous lesions (GPLs) or gastric cancer (GC), but their combined effects remain unclear. Our study aimed to elucidate the combined impact of metal (including metalloid and trace element) exposure and disturbances in glucose metabolism on the progression of GPLs and GC. From a prospective observational cohort of 1829 individuals, their metal(loid) levels and blood metabolism were analysed via inductively coupled plasma‒mass spectrometry and targeted metabolomics gas chromatography‒mass spectrometry, respectively. From healthy normal controls (NC) or GPLs to GC, we observed that the aluminum and arsenic levels decreased, whereas the vanadium, titanium and rubidium levels increased, but the iron, copper, zinc and barium levels initially decreased but then increased; these changes were not obvious from the NC to GPL group. With respect to glucose homeostasis, most metabolites decreased, except for phosphoenolpyruvate (PEP), which increased. Multiple logistic regression analysis revealed that titanium and phosphoenolpyruvate might be risk factors for GPLs, that barium is a protective factor for GC, and that D-glucaric acid might be a protective factor for GPLs and GC. Selenium, vanadium, titanium, succinate, maleate, isocitrate, PEP, and the tricarboxylic acid cycle (TCA) had good predictive potential for GPL and GC. Additionally, metal(loid)s such as arsenic, titanium, barium, aluminum, and vanadium were significantly correlated with multiple glucose metabolites involved in the TCA cycle in the GPL and GC groups. Our findings imply that metal(loid) exposure disrupts glucose metabolism, jointly influencing GPL and GC progression.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"887-902"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal(oid) profiling of the common site of osteoporotic fractures with bone microarchitecture correlation analysis: a comparative study of hip fracture patients and healthy individuals.","authors":"Aleksandar Cirovic, Danijela Djonic, Vladimir Zivkovic, Slobodan Nikolic, Marija Djuric, Petar Milovanovic","doi":"10.1007/s10534-025-00689-3","DOIUrl":"10.1007/s10534-025-00689-3","url":null,"abstract":"<p><p>Increased urine and blood concentrations of heavy metals are linked to an elevated hip fracture risk, but studies dedicated to directly measuring metal(oid) concentrations in the femoral neck are limited. We investigated whether individuals with fractures exhibit a different pattern of metal(oid) bioaccumulation in the femoral neck and examined potential correlations between the concentrations of various metal(oid)s in the femoral neck and trabecular microarchitecture. To address these objectives, we collected femoral neck specimens from 23 individuals, namely 11 individuals with a positive history of contralateral hip fracture (9 women and 2 men, mean age 77.7 ± 8.1 years) and 12 individuals without fractures (10 women and 2 men, mean age 79.5 ± 5.6 years). All samples were subject to microcomputed tomography (micro-CT) to evaluate bone microarchitecture and inductively coupled plasma-mass spectrometry to determine tissue concentrations of metal(oid)s. In the fully adjusted model (adjusted for bone volume, age, and calcium tissue concentration), individuals with hip fractures exhibited higher aluminum levels (p = 0.047) and lower vanadium levels (p < 0.001). Individuals who sustained fragility fractures also showed lower BV/TV, Tb.Th, Tb.N, and higher Tb.Sp in the femoral neck trabeculae compared with the control group. Several different metal(oid)s were associated with altered patterns of trabecular microarchitecture. In summary, higher aluminum and lower vanadium concentrations in the trabeculae of the femoral neck provide a potential background for the gradual increase in fracture risk. Correlational analysis revealed an association between exposure to certain metals and deteriorated trabecular microarchitecture; however, larger studies are needed to determine the elements independently affecting bone microarchitecture.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"965-981"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity.","authors":"Shokufeh Beglari, Niloofar Rezaie, Fatemeh Haririzadeh Jouriani, Elham Haj Agha Gholizadeh Khiavi, Shadi Aghamohammad, Mahdi Rohani","doi":"10.1007/s10534-025-00681-x","DOIUrl":"10.1007/s10534-025-00681-x","url":null,"abstract":"<p><p>Recent studies have shown that exposure to heavy metals, particularly Nickel, and exacerbates kidney diseases by increasing oxidative stress. Probiotics, recognized for their antioxidant properties, may provide a beneficial approach to mitigate this oxidative damage. This research aims to explore the efficacy of native probiotics in reducing oxidative stress in kidney tissues, potentially leading to improved protective strategies against the toxicity caused by heavy metals. In this study, forty male NMRI mice were exposed to Nickel to induce oxidative stress, followed by probiotic treatment to evaluate its potential protective effects. The impact of these interventions on the antioxidant system was assessed through Real-Time PCR analysis, which measured gene expression profiles in the kidney tissue of the mice. The study demonstrated that native probiotic strains effectively upregulated the expression of genes related to Nrf2 signaling pathway before exposing to oxidant agents. Despite the suppressive effects of Nickel exposure on these gene expressions, the subsequent administration of probiotics after Nickel resulted in a significant increase and enhancement of expression levels. This research underscores the detrimental effects of Nickel, a heavy metal, on kidney health while exploring the protective properties of probiotics, particularly their anti-oxidative effects. Given the substantial risks linked to heavy metal exposure, the integration of probiotics presents a promising strategy to alleviate oxidative stress, thereby potentially preventing various kidney disorders associated with this condition. The findings advocate for a dual approach of addressing heavy metal toxicity and enhancing kidney resilience through probiotic intervention.</p>","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":"863-871"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}