Biometals最新文献_第3页

Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats. 毒理学证据表明甲基汞暴露会放大与大鼠根尖牙周炎相关的骨破坏和全身影响。

IF 4 3区生物学

Biometals Pub Date : 2026-09-05 DOI: 10.1007/s10534-026-00883-x

Daiane Claydes Baia-da-Silva, Paulo Fernando Santos Mendes, Vinicius Ruan Neves Dos Santos, Deiweson Souza-Monteiro, Rayssa Maitê Farias Nazário, Leonardo Oliveira Bittencourt, Charles Miller de Souza Borges, Kelly das Graças Fernandes Dantas, Douglas Magno Guimarães, Fabricio Mezzomo Collares, Rogerio Castilho Jacinto, Rafael Rodrigues Lima

{"title":"Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats.","authors":"Daiane Claydes Baia-da-Silva, Paulo Fernando Santos Mendes, Vinicius Ruan Neves Dos Santos, Deiweson Souza-Monteiro, Rayssa Maitê Farias Nazário, Leonardo Oliveira Bittencourt, Charles Miller de Souza Borges, Kelly das Graças Fernandes Dantas, Douglas Magno Guimarães, Fabricio Mezzomo Collares, Rogerio Castilho Jacinto, Rafael Rodrigues Lima","doi":"10.1007/s10534-026-00883-x","DOIUrl":"https://doi.org/10.1007/s10534-026-00883-x","url":null,"abstract":"This study investigated whether long-term methylmercury exposure aggravates apical periodontitis in Wistar rats. Thirty-two male rats (90 days old) were randomized into four groups (n = 8): control, methylmercury, apical periodontitis, and methylmercury + apical periodontitis. Methylmercury was administered daily by intragastric gavage (0.04 mg/kg/day) for 60 days, while apical periodontitis was induced on day 32 by pulp exposure to the oral cavity for 28 days. After euthanasia, total mercury levels and systemic oxidative stress markers were analyzed in blood; additionally, mandibles were evaluated for lesion volume and alveolar bone quality using micro-computed tomography and histological analysis. Data were analyzed using the Shapiro-Wilk test, followed by two-way ANOVA and Tukey's post hoc test (p < 0.05). The methylmercury + apical periodontitis group showed significantly larger periapical lesions and reduced alveolar bone quality compared to non-exposed animals (p < 0.05), with decreased trabecular thickness, lower bone volume/tissue volume ratio, and increased tissue destruction. Moreover, this group exhibited more intense oxidative alterations, including reduced antioxidant defenses (reduced glutathione and total antioxidant capacity equivalent to Trolox) and increased lipid peroxidation. Therefore, under the conditions of the present experimental model, long-term methylmercury exposure preceding and overlapping with apical periodontitis development resulted in increased lesion volume, impaired alveolar bone quality, and more pronounced systemic oxidative alterations, indicating an aggravation of apical periodontitis.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing cellular copper levels via the post-translational regulation of copper transport. 通过翻译后铜转运调节平衡细胞铜水平。

IF 4 3区生物学

Biometals Pub Date : 2026-09-01 DOI: 10.1007/s10534-026-00879-7

Lauren A Kirn, Richard Burke

{"title":"Balancing cellular copper levels via the post-translational regulation of copper transport.","authors":"Lauren A Kirn, Richard Burke","doi":"10.1007/s10534-026-00879-7","DOIUrl":"https://doi.org/10.1007/s10534-026-00879-7","url":null,"abstract":"Copper (Cu) is essential to life as an enzymatic cofactor, powering a plethora of biological processes. However, cells teeter on a delicate balance where both too much and too little Cu can lead to dysfunction. These risks are exemplified by Menkes disease patients, where Cu deficiency leads to neurodevelopmental delay and early childhood mortality, and those affected by Wilson's disease, where Cu overload results in liver damage, behavioural changes and movement disorders. Cu is also a major cellular stressor, with roles in many other pathologies including neurodegeneration and cancer. Consequently, cells tightly regulate Cu load by highly conserved import, export, and distribution mechanisms. While these have been well documented, less is known about how cells sense and respond to Cu deviations. This function may lie in the extensive post-translational modifications (PTMs) that control the Cu transport proteins, where a chorus of glycosylation, phosphorylation, and ubiquitination affects their activity, intracellular trafficking, and stability. Cu also affects the machinery that applies these PTMs, providing a potential mechanism by which cells 'sense' Cu levels. This review explores this hypothesis, examining our current knowledge of how PTMs are modulated by Cu, and how they control the responses of the Cu transporters to fluctuating Cu load. Further probing of how cells sense and respond to Cu deviations may aid the pursuit of effective diagnosis and treatment of the many disorders associated with mismanaged Cu levels.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of iron and zinc responsive TonB-dependent transporters in Pseudomonas aeruginosa. 铜绿假单胞菌中铁和锌反应性转运蛋白的鉴定。

IF 4 3区生物学

Biometals Pub Date : 2026-08-31 DOI: 10.1007/s10534-026-00880-0

Manon Ferry, Hortense Ferriz, Connor Sharp, Christos Paschalidis, Emmanuel Boutant, Isabelle J Schalk, Olivier Cunrath

{"title":"Identification of iron and zinc responsive TonB-dependent transporters in Pseudomonas aeruginosa.","authors":"Manon Ferry, Hortense Ferriz, Connor Sharp, Christos Paschalidis, Emmanuel Boutant, Isabelle J Schalk, Olivier Cunrath","doi":"10.1007/s10534-026-00880-0","DOIUrl":"https://doi.org/10.1007/s10534-026-00880-0","url":null,"abstract":"Pseudomonas aeruginosa employs a repertoire of TonB-dependent transporters (TBDTs) to acquire essential nutrients, such as iron-siderophore complexes, enabling its adaptation to diverse and often hostile environments. While the roles of some TBDTs in virulence and metal acquisition are well-established, many remain poorly characterized, despite their potential contributions to pathogenicity. Using a domain-based detection approach, we show that TBDTs are broadly conserved across diverse P. aeruginosa isolates and remain highly prevalent in multidrug-resistant (MDR) strains, further highlighting their clinical relevance. Notably, these transporters can be exploited as gateways for antibiotic delivery, as exemplified by the siderophore-antibiotic conjugate cefiderocol. To identify metal specificity TBDTs, we combined bioinformatic promoter analysis with fluorescent transcriptional reporters to validate their response to iron and zinc limitation. This approach identified 19 iron-responsive (bringing it to 21 iron-responsive TBDTs with previously published data) and 4 zinc-responsive TBDTs, including transporters with previously unknown substrates, and revealed that promoter-associated regulatory motifs, rather than protein homology, predict metal-specific regulation. Beyond this initial classification, the reporter library serves as a versatile tool for exogenous siderophore detection by monitoring transporter activity in response to their presence. Furthermore, single-cell analysis of TBDT promoter activity during co-culture with an enterobactin-producing Klebsiella pneumoniae strain revealed homogeneous expression of key TBDTs in P. aeruginosa populations, suggesting coordinated metal acquisition strategies under competitive conditions.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Expression of Concern: Taurine decreases arsenic and microplastic toxicity in broccoli (Brassica oleracea L.) through functional and microstructural alterations. 编辑表达关注：牛磺酸通过功能和微观结构的改变降低西兰花（Brassica oleracea L.）中的砷和微塑性毒性。

IF 4 3区生物学

Biometals Pub Date : 2026-08-21 DOI: 10.1007/s10534-026-00878-8

Shahar Yar, Muhammad Arslan Ashraf, Rizwan Rasheed, Umer Farooq, Arslan Hafeez, Shafaqat Ali, Mudassar Shahid, Pallab K Sarker

引用次数: 0

Biological and mechanistic effects of selenium and zinc in coronary artery bypass surgery: preoperative and postoperative evaluation. 硒和锌在冠状动脉搭桥手术中的生物学和机制作用：术前和术后评价。

IF 4 3区生物学

Biometals Pub Date : 2026-08-20 DOI: 10.1007/s10534-026-00874-y

Gulbin Erdogan, Yeliz Coskun, Burcin Cayhan Karademir, Murat Bulent Rabus

{"title":"Biological and mechanistic effects of selenium and zinc in coronary artery bypass surgery: preoperative and postoperative evaluation.","authors":"Gulbin Erdogan, Yeliz Coskun, Burcin Cayhan Karademir, Murat Bulent Rabus","doi":"10.1007/s10534-026-00874-y","DOIUrl":"https://doi.org/10.1007/s10534-026-00874-y","url":null,"abstract":"Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide. Trace elements such as selenium (Se) and zinc (Zn) play important roles in the development of hypertension and cardiovascular diseases through direct effects on the vascular system and indirect effects on lipoprotein metabolism. Se and Zn are essential components of the antioxidant defense system that help reduce oxidative stress associated with cardiac disorders. In this study, serum Se and Zn levels were evaluated in patients undergoing coronary artery bypass surgery and compared with those of healthy controls. The study population comprised patients diagnosed with coronary heart disease and a control group of healthy individuals. Serum Zn concentrations were measured using flame atomic absorption spectrometry (AAS), while Se levels were determined by graphite furnace atomic absorption spectrometry (GFAAS). Statistical analysis was performed using analysis of variance (ANOVA), followed by Bonferroni-adjusted pairwise test. The mean preoperative serum Se concentration in patients was 25.49 ± 16.83 µg/L, which increased postoperatively to 31.55 ± 22.19 µg/L and to 40.97 ± 30.17 µg/L pre-discharge. In contrast, the control group had a significantly higher Se level of 70.88 ± 13.18 µg/L. Similarly, Zn levels in patients were 116.53 ± 27.85 µg/L preoperatively, decreased to 88.43 ± 23.32 µg/L postoperatively, and increased to 98.43 ± 21.53 µg/L pre-discharge, while controls had 120.46 ± 17.58 µg/L. Both Se and Zn levels were significantly lower in patients compared to controls (p < 0.0001). Based on these findings, we highlight that low Se and Zn levels are associated with coronary heart disease; therefore, randomized controlled trials are needed to determine whether Se and Zn supplementation under medical supervision provides clinically significant benefits.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional auranofin analogues: dual-targeting TSPO/TrxR gold(I) complexes with activity in resistant ovarian cancer. 多功能金嘌呤类似物：在耐药卵巢癌中具有活性的双靶向TSPO/TrxR金(I)复合物

IF 4 3区生物学

Biometals Pub Date : 2026-08-20 DOI: 10.1007/s10534-026-00872-0

Lorenzo Chiaverini, Emma Baglini, Doralice Giorgini, Rosamaria Militello, Chiara Giacomelli, Silvia Salerno, Monica Viviano, Raffaella Belvedere, Maria Rosaria Caruso, Giulio Esposito, Barbara Costa, Alessandro Marrone, Antonello Petrella, Sabrina Castellano, Diego La Mendola, Federico Da Settimo, Tania Gamberi, Iogann Tolbatov, Tiziano Marzo, Elisabetta Barresi, Sabrina Taliani

{"title":"Multifunctional auranofin analogues: dual-targeting TSPO/TrxR gold(I) complexes with activity in resistant ovarian cancer.","authors":"Lorenzo Chiaverini, Emma Baglini, Doralice Giorgini, Rosamaria Militello, Chiara Giacomelli, Silvia Salerno, Monica Viviano, Raffaella Belvedere, Maria Rosaria Caruso, Giulio Esposito, Barbara Costa, Alessandro Marrone, Antonello Petrella, Sabrina Castellano, Diego La Mendola, Federico Da Settimo, Tania Gamberi, Iogann Tolbatov, Tiziano Marzo, Elisabetta Barresi, Sabrina Taliani","doi":"10.1007/s10534-026-00872-0","DOIUrl":"https://doi.org/10.1007/s10534-026-00872-0","url":null,"abstract":"Auranofin (AF) is a clinically approved gold(I) complex used for the treatment of rheumatoid arthritis and currently under investigation for drug repurposing in oncology. Its anticancer activity has been mainly associated with the inhibition of thioredoxin reductase (TrxR), an enzyme crucial for the maintenance of the redox balance of cell. Accordingly, this triggered intense research in the development of novel AF-analogues. Herein, a new series of AF-inspired gold(I) complexes (1-4) was designed and synthesized by replacing the thiosugar moiety with ligands targeting the translocator protein (TSPO), a mitochondrial protein overexpressed in several cancers, including ovarian cancer. The new complexes showed strong TrxR inhibition and sub/low-nanomolar TSPO affinity. All compounds exhibited low-micromolar cytotoxicity in ovarian cancer cells, including cisplatin- and AF-resistant variants, with a milder reduction in activity than AF and cisplatin in resistant models. Computational studies indicated that replacement of the thiosugar moiety with TSPO ligands affects the stability of the Au-S and Au-P bonds, leading to a different activation mode compared with AF. In parallel, ICP-AES analysis revealed comparable intracellular gold accumulation for complexes 1-4 and AF, indicating that differences in biological activity are not mainly driven by cellular uptake, but rather by distinct intracellular processing and target engagement. Overall, these findings support the conjugation of the [Au(PEt3)]+ fragment with mitochondria-targeting ligands as a promising strategy for developing multifunctional Au-based complexes.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untangling the mechanism and potential of Chrysopogon zizanioides as a phytoremediant, responsible for removing heavy metals from surrounding media: in silico insights. 解结金缕草作为植物修复剂的机制和潜力，负责从周围介质中去除重金属：在硅的见解。

IF 4 3区生物学

Biometals Pub Date : 2026-08-19 DOI: 10.1007/s10534-026-00868-w

S Lekshmi, S Smitha Chandran

{"title":"Untangling the mechanism and potential of Chrysopogon zizanioides as a phytoremediant, responsible for removing heavy metals from surrounding media: in silico insights.","authors":"S Lekshmi, S Smitha Chandran","doi":"10.1007/s10534-026-00868-w","DOIUrl":"https://doi.org/10.1007/s10534-026-00868-w","url":null,"abstract":"Advancements in human activities lead to the widespread release of heavy metals into the environment. Zinc, iron, and nickel are heavy metals (HMs) that are teratogenic, carcinogenic, mutagenic, and endocrine disruptors when present at elevated concentrations. A greenhouse study was conducted in a hydroponic setup to investigate the phytoremediation potential of Chrysopogon zizanioides for the removal of zinc, iron, and nickel from aqueous media. The Vetiver grass was exposed to different concentrations of HMs for 15 days, and the samples were collected on the 3rd, 6th, 9th, 12th, and 15th days. The HM accumulation along with the biochemical variation was analysed to assess the plant stress and tolerance. The Vetiver grass shows an average absorption percentage of 52.91% for iron, 38.47% for nickel, and 45.16% for zinc. The biochemical analysis reveals increased phenol and proline content along with decreased carbohydrate, cellulose, and chlorophyll content. The Metal-ion binding site prediction (MIB) docking provides valuable insight into metal-ion-protein interactions. Analysing these interactions through docking contributes to metal homeostasis, transport, and detoxification of heavy metals, offering potential application in phytoremediation. As per the detailed Scopus survey, this is a ground-breaking work documenting metal-plant protein docking during phytoremediation that contributes to advancing sustainable environment strategies. This study advocates for the natural purification of water devoid of chemical interference. Subsequent genetic and agronomic advancements will undoubtedly augment the efficiency of Vetiver grass, particularly in the presence of elevated concentrations.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Hydroxy-1-naphthaldehyde-based organotin(IV) complexes: structural aspects, cytotoxicity, DNA binding interaction, and molecular docking. 2-羟基-1-萘基有机锡（IV）配合物：结构方面、细胞毒性、DNA结合相互作用和分子对接。

IF 4 3区生物学

Biometals Pub Date : 2026-08-19 DOI: 10.1007/s10534-026-00867-x

José Miguel Galván-Hidalgo, Donován Ambrocio-Pérez, Arturo González-Hernández, Karla Daniela Rodríguez-Hernández, Teresa Ramírez-Apan, Omar Gómez-García, Alejandro Dorazco-González, Jorge J Villa-Rivera, Homero Gómez-Velasco, Simón Hernández-Ortega, Elizabeth Gómez

{"title":"2-Hydroxy-1-naphthaldehyde-based organotin(IV) complexes: structural aspects, cytotoxicity, DNA binding interaction, and molecular docking.","authors":"José Miguel Galván-Hidalgo, Donován Ambrocio-Pérez, Arturo González-Hernández, Karla Daniela Rodríguez-Hernández, Teresa Ramírez-Apan, Omar Gómez-García, Alejandro Dorazco-González, Jorge J Villa-Rivera, Homero Gómez-Velasco, Simón Hernández-Ortega, Elizabeth Gómez","doi":"10.1007/s10534-026-00867-x","DOIUrl":"https://doi.org/10.1007/s10534-026-00867-x","url":null,"abstract":"A series of organotin(IV) complexes (2a-2d) derived from 2-hydroxy-1-naphthaldehyde and pyridoxamine were obtained in good yields via a one-pot strategy. 119Sn NMR confirmed hexacoordinated species in solution, and single-crystal X-ray diffraction of 2d revealed a distorted trigonal-bipyramidal geometry (τ = 0.65) with a C2NO2 donor set. UV-Vis and fluorescence titrations with CT-DNA demonstrated intercalative binding (Kb = 7.66-11.0 × 104 M-1), and isothermal titration calorimetry confirmed spontaneous, exothermic binding to ssDNA, with complex 2c showing stronger affinity than 2b due to combined enthalpic and entropic contributions. All complexes exhibited significantly higher cytotoxicity than cisplatin against MCF-7 and MDA-MB-231 breast cancer cell lines; 2c and 2d were the most potent (IC50 = 0.06-0.26 μM), with 2d showing the best selectivity index (SI = 2.33 for MCF-7). Flow cytometry revealed cell-line-dependent mechanisms: MDA-MB-231 cells underwent cytostatic mitotic blockade, with suppression of S and G2/M phases, whereas MCF-7 cells exhibited features of apoptosis and G1 accumulation. Molecular docking against CDK2/cyclin A showed binding energies of -9.31 to -10.27 kcal/mol, substantially higher than cisplatin (- 4.09 kcal/mol), with 2d displaying the strongest affinity, consistent with its higher biological activity.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between metals and anemia indicator: mixed exposure effects and mediation analysis. 金属与贫血指标的关系：混合暴露效应及中介分析。

IF 4 3区生物学

Biometals Pub Date : 2026-08-19 DOI: 10.1007/s10534-026-00866-y

Chenxu Dai, Xiangbin Zheng, Kaihui Li, Ziyi Qian, Linjie Yang, Hongfei Hu, Xijin Xu, Lei Tan, Xia Huo

{"title":"Associations between metals and anemia indicator: mixed exposure effects and mediation analysis.","authors":"Chenxu Dai, Xiangbin Zheng, Kaihui Li, Ziyi Qian, Linjie Yang, Hongfei Hu, Xijin Xu, Lei Tan, Xia Huo","doi":"10.1007/s10534-026-00866-y","DOIUrl":"https://doi.org/10.1007/s10534-026-00866-y","url":null,"abstract":"Exposure to metals is an important cause of anemia. The effects of mixed metal exposure on hemoglobin have been less studied, and the existing research conclusions are inconsistent. Body mass index (BMI) is associated with both metal levels and hemoglobin and may play a mediating role in the association between metals and hemoglobin. This study selected 832 children from the National Health and Nutrition Examination Survey database and further analyzed the association between metals and hemoglobin, an indicator of anemia. We found that zinc (Zn), selenium (Se) and thallium (Tl) were associated with increased hemoglobin levels in children. Copper (Cu), cobalt (Co), and lead (Pb) were associated with decreased hemoglobin levels. Both Bayesian kernel machine regression (BKMR) and Quantile g-computation (Qgcomp) analysis showed that mixed metal exposure levels were positively correlated with hemoglobin levels, and both found that Zn played a major role in this relationship. Stratified analysis showed that mixed metal exposure had a more significant effect on older children and boys. Our analysis suggested BMI as an intermediary in the associations of Pb, Mn, and Tl with hemoglobin, with mediating proportions being 100, 12.6, and 14%, respectively. The mediation analysis also suggested that the relationship between metals and hemoglobin could be explained, in part, by their correlations with other metals. In this study, the impact of mixed metal exposure on hemoglobin, as well as the possible biological mediating pathways involved, was further clarified.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment. 药用植物中的重金属和农药：环境来源、植物反应和人类健康风险评估。

IF 4 3区生物学

Biometals Pub Date : 2026-08-18 DOI: 10.1007/s10534-026-00871-1

Pallavi Shukla, Praveen Gupta, Arpit Singh, Nitesh Singh, Abhishek Maurya, Lav Singh, Divyanshi Rai, Mamta Gour, Tikam Chand Dakal, Gauri Saxena

{"title":"Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment.","authors":"Pallavi Shukla, Praveen Gupta, Arpit Singh, Nitesh Singh, Abhishek Maurya, Lav Singh, Divyanshi Rai, Mamta Gour, Tikam Chand Dakal, Gauri Saxena","doi":"10.1007/s10534-026-00871-1","DOIUrl":"https://doi.org/10.1007/s10534-026-00871-1","url":null,"abstract":"Medicinal plants have served as the foundation of healthcare across cultures for centuries, yet their safety is increasingly undermined by heavy metal and pesticide contamination driven by industrial growth, agrochemical misuse and environmental degradation. Despite widespread concern, the field remains fragmented. Contamination data are scattered across taxa and regions. The link between pollutant bioaccumulation and loss of medicinal potency is rarely explored mechanistically. Moreover, human health risk assessments tailored to herbal consumers remain largely absent from regulatory conversations. This review brings these threads together. It traces how heavy metals including Pb, Cd, As, Hg, Cr and Ni along with pesticide residues enter medicinal plants, disrupt their physiology, impair secondary metabolite production and ultimately reach human consumers. \"Five widely consumed medicinal genera Ocimum, Mentha, Glycyrrhiza, Catharanthus and Withania are examined as illustrative models\". Each offers a distinct perspective on species-specific bioaccumulation patterns, providing a comparative framework rarely found in existing literature. Crucially, this review connects plant level stress responses to real world health outcomes, critically evaluating risk assessment tools such as EDI, HQ, HI and Cancer Risk models within the underexplored context of habitual herbal product use. Detection technologies, regulatory standards and mitigation strategies are assessed with equal rigor. The need for this review is urgent. The absence of unified monitoring frameworks and taxon-specific safety thresholds leaves billions of herbal medicine users inadequately protected. This work provides a consolidated, actionable foundation for researchers, regulators and clinicians working toward safer, evidence-based herbal therapeutics.","PeriodicalId":491,"journal":{"name":"Biometals","volume":" ","pages":""},"PeriodicalIF":4.0,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0