Biometals最新文献

{"title":"Biogenic Ag2O nanoparticles with “Hoja Santa” (Piper auritum) extract: characterization and biological capabilities","authors":"Dalia S. Aguilar-Ávila,&nbsp;M. Reyes-Becerril,&nbsp;Carlos A. Velázquez-Carriles,&nbsp;Gabriela Hinojosa-Ventura,&nbsp;María E. Macías-Rodríguez,&nbsp;Carlos Angulo,&nbsp;Jorge M. Silva-Jara","doi":"10.1007/s10534-024-00589-y","DOIUrl":"10.1007/s10534-024-00589-y","url":null,"abstract":"<div><p>The ‘sacred leaf’ or “Hoja Santa” (<i>Piper auritum</i> Kunth) has a great value for Mexican culture and has gained popularity worldwide for its excellent properties from culinary to remedies. To contribute to its heritage, in this project we proposed the green synthesis of silver oxide nanoparticles (Ag₂O NPs) using an extract of “Hoja Santa” (<i>Piper auritum</i>) as a reducing and stabilizing agent. The synthesized Ag₂O NPs were characterized by UV–Visible spectroscopy (plasmon located at 405 nm), X-ray diffraction (XRD) (particle size diameter of 10 nm), scanning electron microscopy (SEM) (particle size diameter of 13.62 ± 4.61 nm), and Fourier-transform infrared spectroscopy (FTIR) (functional groups from “Hoja Santa” attached to nanoparticles). Antioxidant capacity was evaluated using DPPH, ABTS and FRAP methods. Furthermore, the antimicrobial activity of NPs against a panel of clinically relevant bacterial strains, including both Gram-positive (<i>Staphylococcus aureus</i>) and Gram-negative bacteria (<i>Salmonella</i> Enteritidis and <i>Escherichia coli</i> O157:H7), was over 90% at concentrations of 200 µg/mL. Additionally, we assessed the antibiofilm activity of the NPs against <i>Pseudomonas aeruginosa</i> (reaching 98% of biofilm destruction at 800 µg/mL), as biofilm formation plays a crucial role in bacterial resistance and chronic infections. Moreover, we investigated the impact of Ag₂O NPs on immune cell viability, respiratory burst, and phagocytic activity to understand their effects on the immune system.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"971 - 982"},"PeriodicalIF":4.1,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139970476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current understanding of essential trace elements in intrahepatic cholestasis of pregnancy","authors":"Dan Shan,&nbsp;Qian Chen,&nbsp;Yupei Xie,&nbsp;Siyu Dai,&nbsp;Yayi Hu","doi":"10.1007/s10534-024-00586-1","DOIUrl":"10.1007/s10534-024-00586-1","url":null,"abstract":"<div><p>Trace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studies have demonstrated the association of ICP with some trace elements. Evidence from retrospective studies in humans further revealed the possible contributing roles of trace elements in the pathogenesis of ICP. The published literature on the association of trace elements with ICP was reviewed. Recent advances in molecular biological techniques from animal studies have helped to elucidate the possible mechanisms by how these trace elements function in regulating oxidative reactions, inflammatory reactions and immune balance in the maternal-fetal interface, as well as the influence on hepato-intestinal circulation of bile acid. The scenario regarding the role of trace elements in the pathogenesis of ICP is still developing. The administration or depletion of these trace elements may have promising effects in alleviating the symptoms and improving the pregnancy outcomes of ICP.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"943 - 953"},"PeriodicalIF":4.1,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139769371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palladium and platinum complexes based on pyridine bases induced anticancer effectiveness via apoptosis protein signaling in cancer cells","authors":"Mohamed M. El-bendary,&nbsp;Abdullah Akhdhar,&nbsp;Abdullah S. Al-Bogami,&nbsp;Doaa Domyati,&nbsp;Abdulaziz A. Kalantan,&nbsp;Faisal Ay Alzahrani,&nbsp;Samer M. Alamoudi,&nbsp;Ryan A. Sheikh,&nbsp;Ehab M. M. Ali","doi":"10.1007/s10534-023-00580-z","DOIUrl":"10.1007/s10534-023-00580-z","url":null,"abstract":"<div><p>Palladium and platinum complexes, especially those that include cisplatin, can be useful chemotherapeutic drugs. Alternatives that have less adverse effects and require lower dosages of treatment could be provided by complexes containing pyridine bases. The complexes <b>[Pd(SCN)</b>_<b>2</b><b>(4-Acpy)</b>_<b>2</b><b>] (1), [Pd(N</b>_<b>3</b><b>)</b>_<b>2</b><b>(4-Acpy)</b>_<b>2</b><b>] (2) [Pd(paOH)</b>_<b>2</b><b>].2Cl</b> (<b>3</b>) <b>and [Pt(SCN)</b>_<b>2</b><b>(paO)</b>_<b>2</b><b>] (4)</b> were prepared by self-assembly method at ambient temperature; (4-Acpy = 4-acetylpyridine and paOH = pyridine-2-carbaldehyde-oxime). The structure of complexes <b>1–4</b> was confirmed using spectroscopic and X-ray crystallography methods. Complexes <b>1–4</b> have similar features in isomerism that include the <i>trans</i> coordination geometry of pyridine ligands with Pd or Pt ion. The 3D network structure of complexes <b>1–4</b> was constructed by an infinite number of discrete mononuclear molecules extending via H-bonds. The Pd and Pt complexes <b>1–4</b> with pyridine ligands were assessed on MCF-7, T47D breast cancer cells and HCT116 colon cancer cells. The study evaluated cell death through apoptosis and cell cycle phases in MCF-7 cells treated with palladium or platinum conjugated with pyridine base. Upon treatment of MCF-7 with these complexes, the expression of apoptotic signals (Bcl2, p53, Bax and c-Myc) and cell cycle signals (p16, CDK1A, CDK1B) were evaluated. Compared to other complexes and cisplatin, IC₅₀ of complex <b>1</b> was lowest in MCF-7 cells and complex <b>2</b> in T47D cells. Complex <b>4</b> has the highest effectiveness on HCT116. The selective index (SI) of complexes <b>1–4</b> has a value of more than two for all cancer cell lines, indicating that the complexes were less toxic to normal cells when given the same dose. MCF-7 cells treated with complex <b>2</b> and platinum complex <b>4</b> exhibited the highest level of early apoptosis. p16 may be signal arrest cells in Sub G, which was observed in cells treated with palladium complexes that suppress excessive cell proliferation. High c-Myc expression of treated cells with four complexes <b>1–4</b> and cisplatin could induce p53. All complexes <b>1–4</b> elevated the expression of Bax and triggered by the tumor suppressor gene p53. p53 was downregulating the expression of Bcl2.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"905 - 921"},"PeriodicalIF":4.1,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: In vitro assessment of antibacterial and antiviral activity of three copper products after 200 rounds of simulated use","authors":"Marthe K. Charles,&nbsp;Teresa C. Williams,&nbsp;Davood Nakhaie,&nbsp;Tracey Woznow,&nbsp;Billie Velapatino,&nbsp;Ana C. Lorenzo-Leal,&nbsp;Horacio Bach,&nbsp;Elizabeth A. Bryce,&nbsp;Edouard Asselin","doi":"10.1007/s10534-024-00587-0","DOIUrl":"10.1007/s10534-024-00587-0","url":null,"abstract":"","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"857 - 857"},"PeriodicalIF":4.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metals in biological samples of cancer patients: a systematic literature review","authors":"Donatella Coradduzza,&nbsp;Antonella Congiargiu,&nbsp;Emanuela Azara,&nbsp;Ismaeil Mohammed Abulkahar Mammani,&nbsp;Maria Rosaria De Miglio,&nbsp;Angelo Zinellu,&nbsp;Ciriaco Carru,&nbsp;Serenella Medici","doi":"10.1007/s10534-024-00583-4","DOIUrl":"10.1007/s10534-024-00583-4","url":null,"abstract":"<div><p> The majority of the so-called heavy metals are suspected to be involved in a number of pathologies and play a role in human carcinogenesis. Some of them (i.e. arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg) and nickel (Ni)) have been defined as carcinogens, increasing the susceptibility of tumor development and progression in humans. Moreover, Ni, Cr, Cd, Hg, and Pb together with zinc (Zn) and iron (Fe), may be capable of stimulating the progression of breast cancer and reducing a patient’s sensitivity to treatment through alterations to DNA methylation. In patients with gastric cancers, levels of various heavy metals are augmented and hypothesized to amplify the expression of the human epidermal growth factor receptor type 2 gene. Cd may increase the risk of lung cancer development and have a negative impact on the overall survival of lung cancer patients. To investigate the relation between heavy metals in biological samples and risk, occurrence and survival cancer individuals, a comprehensive review work was performed, with a focus on breast, lung, prostate and gastric cancers. An extensive search strategy was devised to ensure relevant literature could be identified, with the PECO framework being adopted to facilitate this and identify key search terms. As evidenced in this review, there is substantial data to support the hypothesis that heavy metals influence tumor development and progression. Unluckily the number of papers dealing with the determination of metals directly in samples from cancer tissues is still rather limited, so we decided to expand the scope of this review also to analyses carried out on other biological samples, as urine, plasma, hair, nail, etc. The studies reviewed showed that several limitations and current knowledge gaps are present in the literature that require further investigation to improve our comprehension of the impact of different heavy metals on tumorigenesis.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"803 - 817"},"PeriodicalIF":4.1,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum calcium and magnesium levels and quality of life in environmentally exposed populations in Kazakhstan","authors":"Geir Bjørklund,&nbsp;Yuliya Semenova","doi":"10.1007/s10534-023-00579-6","DOIUrl":"10.1007/s10534-023-00579-6","url":null,"abstract":"<div><p>The relationship between the levels of essential elements and various aspects of well-being in environmentally exposed populations still needs to be better understood. The present study aims to investigate the potential connections between serum concentrations of calcium (Ca), magnesium (Mg), and quality of life (QoL) in environmentally exposed populations in Kazakhstan. The present study involved 1881 nominally healthy individuals aged 18–52 years who were permanent residents of Abay, Borodulikha, Ust-Kamenogorsk, Kurchum, Uralsk, Aksay, and Berezovka settlements. These settlements were selected to represent different types of environmental exposure: radioactive fallout from the Semipalatinsk Nuclear Test Site (SNTS), non-ferrous metallurgy, and the condensate gas field, compared to environmentally unexposed territories. The Russian version of the SF-36 questionnaire was used to assess the participants’ quality of life. Serum Ca levels were measured using colorimetry with O-cresolphthalein, and serum Mg concentrations were measured using colorimetry with xylidyl blue. Both elevated and decreased serum Ca levels were more frequently observed in the environmentally exposed populations. The prevalence of hypermagnesemia was highest among residents near the condensate gas field. Environmentally exposed populations residing near the SNTS and in Ust-Kamenogorsk exhibited lower scores in some QoL domains. In contrast, people near the condensate gas field showed comparable or even higher QoL scores than the control population. Only serum Mg demonstrated a significant association with the average QoL scores, while Ca did not show such an association. These findings have important implications for public health interventions.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"895 - 904"},"PeriodicalIF":4.1,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium transport by mammalian ATP-binding cassette transporters","authors":"Frank Thévenod,&nbsp;Wing-Kee Lee","doi":"10.1007/s10534-024-00582-5","DOIUrl":"10.1007/s10534-024-00582-5","url":null,"abstract":"<div><p>Cellular responses to toxic metals depend on metal accessibility to intracellular targets, reaching interaction sites, and the intracellular metal concentration, which is mainly determined by uptake pathways, binding/sequestration and efflux pathways. ATP-binding cassette (ABC) transporters are ubiquitous in the human body—usually in epithelia—and are responsible for the transfer of indispensable physiological substrates (e.g. lipids and heme), protection against potentially toxic substances, maintenance of fluid composition, and excretion of metabolic waste products. Derailed regulation and gene variants of ABC transporters culminate in a wide array of pathophysiological disease states, such as oncogenic multidrug resistance or cystic fibrosis. Cadmium (Cd) has no known physiological role in mammalians and poses a health risk due to its release into the environment as a result of industrial activities, and eventually passes into the food chain. Epithelial cells, especially within the liver, lungs, gastrointestinal tract and kidneys, are particularly susceptible to the multifaceted effects of Cd because of the plethora of uptake pathways available. Pertinent to their broad substrate spectra, ABC transporters represent a major cellular efflux pathway for Cd and Cd complexes. In this review, we summarize current knowledge concerning transport of Cd and its complexes (mainly Cd bound to glutathione) by the ABC transporters ABCB1 (P-glycoprotein, MDR1), ABCB6, ABCC1 (multidrug resistance related protein 1, MRP1), ABCC7 (cystic fibrosis transmembrane regulator, CFTR), and ABCG2 (breast cancer related protein, BCRP). Potential detoxification strategies underlying ABC transporter-mediated efflux of Cd and Cd complexes are discussed.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 3","pages":"697 - 719"},"PeriodicalIF":4.1,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139690866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential interactions of essential and toxic metal ions with biologically relevant phosphatidic acid and phosphatidylserine membranes","authors":"Travis Issler,&nbsp;Kevin Sule,&nbsp;Anna-Marie Lewrenz,&nbsp;Elmar J. Prenner","doi":"10.1007/s10534-023-00576-9","DOIUrl":"10.1007/s10534-023-00576-9","url":null,"abstract":"<div><p>Metal pollutants are a growing concern due to increased use in mining and other industrial processes. Moreover, the use of metals in daily life is becoming increasingly prevalent. Metals such as manganese (Mn), cobalt (Co), and nickel (Ni) are toxic in high amounts whereas lead (Pb) and cadmium (Cd) are acutely toxic at low µM concentrations. These metals are associated with system dysfunction in humans including cancer, neurodegenerative diseases, Alzheimer’s disease, Parkinson’s disease, and other cellular process’. One known but lesser studied target of these metals are lipids that are key membrane building blocks or serve signalling functions. It was shown that Mn, Co, Ni, Pb, and Cd cause rigidification of liposomes and increase the phase transition in membranes composed of both saturated or partly unsaturated phosphatidic acid (PA) and phosphatidylserine (PS). The selected metals showed differential effects that were more pronounced on saturated lipids. In addition, more rigidity was induced in the biologically relevant liquid-crystalline phase. Moreover, metal affinity, induced rigidification and liposome size increases also varied with the headgroup architecture, whereby the carboxyl group of PS appeared to play an important role. Thus, it can be inferred that Mn, Co, Ni, Cd, and Pb may have preferred binding coordination with the lipid headgroup, degree of acyl chain unsaturation, and membrane phase.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 3","pages":"631 - 648"},"PeriodicalIF":4.1,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity of metal-based nanoparticles: a mini-review","authors":"Marharyta Hancharova,&nbsp;Kinga Halicka-Stępień,&nbsp;Aleksandra Dupla,&nbsp;Anna Lesiak,&nbsp;Jadwiga Sołoducho,&nbsp;Joanna Cabaj","doi":"10.1007/s10534-023-00573-y","DOIUrl":"10.1007/s10534-023-00573-y","url":null,"abstract":"<div><p>The resistance of pathogenic microorganisms to antibiotics is one of the main problems of world health. Of particular concern are multidrug-resistant (MDR) bacteria. Infections caused by these microorganisms affect the appearance of acute or chronic diseases. In this regard, modern technologies, such as nanomaterials (NMs), especially promising nanoparticles (NPs), can possess antimicrobial properties or improve the effectiveness and delivery of known antibiotics. Their diversity and characteristics, combined with surface functionalization, enable multivalent interactions with microbial biomolecules. This article presents an overview of the most current research on replacing antibiotics with NPs, including the prospects and risks involved.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 4","pages":"773 - 801"},"PeriodicalIF":4.1,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium toxicity and autophagy: a review","authors":"Yueting Shao,&nbsp;Liting Zheng,&nbsp;Yiguo Jiang","doi":"10.1007/s10534-023-00581-y","DOIUrl":"10.1007/s10534-023-00581-y","url":null,"abstract":"<div><p>Cadmium (Cd) is an important environmental pollutant that poses a threat to human health and represents a critical component of air pollutants, food sources, and cigarette smoke. Cd is a known carcinogen and has toxic effects on the environment and various organs in humans. Heavy metals within an organism are difficult to biodegrade, and those that enter the respiratory tract are difficult to remove. Autophagy is a key mechanism for counteracting extracellular (microorganisms and foreign bodies) or intracellular (damaged organelles and proteins that cannot be degraded by the proteasome) stress and represents a self-protective mechanism for eukaryotes against heavy metal toxicity. Autophagy maintains cellular homeostasis by isolating and gathering information about foreign chemicals associated with other molecular events. However, autophagy may trigger cell death under certain pathological conditions, including cancer. Autophagy dysfunction is one of the main mechanisms underlying Cd-induced cytotoxicity. In this review, the toxic effects of Cd-induced autophagy on different human organ systems were evaluated, with a focus on hepatotoxicity, nephrotoxicity, respiratory toxicity, and neurotoxicity. This review also highlighted the classical molecular pathways of Cd-induced autophagy, including the ROS-dependent signaling pathways, endoplasmic reticulum (ER) stress pathway, Mammalian target of rapamycin (mTOR) pathway, Beclin-1 and Bcl-2 family, and recently identified molecules associated with Cd. Moreover, research directions for Cd toxicity regarding autophagic function were proposed. This review presents the latest theories to comprehensively reveal autophagy behavior in response to Cd toxicity and proposes novel potential autophagy-targeted prevention and treatment strategies for Cd toxicity and Cd-associated diseases in humans.</p></div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"37 3","pages":"609 - 629"},"PeriodicalIF":4.1,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}