Biometals最新文献_第8页

Synergistic interaction between lead and cadmium via metal-transporter gene upregulation in mice 小鼠中铅和镉通过金属转运体基因上调的协同相互作用。

IF 4 3区生物学

Biometals Pub Date : 2026-05-17 DOI: 10.1007/s10534-026-00829-3

Tingting Zhang, Weiqin Xing, James A. Ippolito, Shuangshuang Shao, Xinjun Huang, Yongqiang Yang, Linlin Zhao, Yongxia Cheng, Liping Li

{"title":"Synergistic interaction between lead and cadmium via metal-transporter gene upregulation in mice","authors":"Tingting Zhang, Weiqin Xing, James A. Ippolito, Shuangshuang Shao, Xinjun Huang, Yongqiang Yang, Linlin Zhao, Yongxia Cheng, Liping Li","doi":"10.1007/s10534-026-00829-3","DOIUrl":"10.1007/s10534-026-00829-3","url":null,"abstract":"<div>This study investigated the potential synergistic interactions between Pb and Cd, and assessed the contribution of transporter gene expression to the synergism. Mice were administered varying doses of Pb (15, 30 and 108 mg kg−1) or Cd (1, 2 and 3 mg kg−1), or a combination of both in the feed. Liver, kidney and bone samples were analyzed for Cd, Pb, Cu, Mn, Zn and Fe concentrations. For treatments exhibiting synergistic effects, the relative expression levels of the divalent metal transporter 1 (Dmt1), ZRT-IRE-like protein 8 (Zip8) and Zip14 were quantified in the liver and kidney using Quantitative Real-Time Reverse Transcription Polymerase Chain Reaction (qRT-PCR). At 108 mg kg−1 Pb, increasing Cd doses from 0 to 1 mg kg−1 significantly increased Pb concentrations in the kidney, liver and bone by 10.6, 60.2 and 19.6%, respectively; concurrently, the relative expression of the Zip8 in the kidney increased by 69.5%, while Dmt1 and Zip14 expression in the liver increased by 79.0 and 85.6%, respectively. At Cd doses ≥ 1 mg kg−1, increasing Pb rate resulted in elevated Cd concentrations in the kidney, liver and bone; however, no significant changes in transporter expression levels were observed in the kidney under these treatments, possibly due to the upregulation of transporter genes in the intestines. Results demonstrate that interactions between Pb and Cd can be synergistic, and upregulation of certain transporter genes were responsible for such synergism. These findings offer important insights for mitigating the health risks associated with heavy metal exposure in animal and humans.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1767 - 1781"},"PeriodicalIF":4.0,"publicationDate":"2026-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10534-026-00829-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology for the treatment of iron deficiency anemia: an in vivo review 纳米技术治疗缺铁性贫血：体内综述。

IF 4 3区生物学

Biometals Pub Date : 2026-05-13 DOI: 10.1007/s10534-026-00824-8

Erfan Haghighatseir, Zeinab Karimi, Aydin Berenjian, Alireza Ebrahiminezhad

{"title":"Nanotechnology for the treatment of iron deficiency anemia: an in vivo review","authors":"Erfan Haghighatseir, Zeinab Karimi, Aydin Berenjian, Alireza Ebrahiminezhad","doi":"10.1007/s10534-026-00824-8","DOIUrl":"10.1007/s10534-026-00824-8","url":null,"abstract":"<div>Iron deficiency is the most prevalent nutritional disorder globally. Conventional treatment primarily involves oral supplementation with various iron salts, such as ferrous sulfate. While cost-effective and easily administered, these salts are associated with several challenges, including gastrointestinal irritation, prolonged treatment duration, and poor patient compliance due to adverse side effects. To address these limitations, nanotechnology has been employed to develop improved oral iron supplements with varying degrees of success. Utilizing approaches from nanotechnology and materials science, researchers have engineered diverse iron-containing nanomaterials designed to provide bioavailable iron. However, the efficacy of these nanomaterials as oral supplements is highly dependent on their specific physicochemical properties. An effective nano-based replacement for iron salts must exhibit high bioavailability for efficient iron restoration and low toxicity to minimize side effects. This review consolidates in vivo research on various iron nanomaterials evaluated as oral iron supplements. Furthermore, it proposes a framework for the ideal characteristics of an oral iron nanoparticle supplement by consolidating the current understanding of the mechanisms governing nanoparticle absorption and toxicity.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1323 - 1338"},"PeriodicalIF":4.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species cntQ渗透酶的假原化在耶尔森菌中具有明显的耶尔森碱-金属摄取选择性。

IF 4 3区生物学

Biometals Pub Date : 2026-05-13 DOI: 10.1007/s10534-026-00816-8

Clémentine Laffont, Elizabeth Pradel, Laurent Ouerdane, Amélie Dewitte, Nicolas Oswaldo Gomez, Mathilde Tribout, Catherine Brutesco, Romé Voulhoux, Ryszard Lobinski, Florent Sebbane, Pascal Arnoux

{"title":"Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species","authors":"Clémentine Laffont, Elizabeth Pradel, Laurent Ouerdane, Amélie Dewitte, Nicolas Oswaldo Gomez, Mathilde Tribout, Catherine Brutesco, Romé Voulhoux, Ryszard Lobinski, Florent Sebbane, Pascal Arnoux","doi":"10.1007/s10534-026-00816-8","DOIUrl":"10.1007/s10534-026-00816-8","url":null,"abstract":"<div>Yersinopine, a nicotianamine-like metallophore, was recently identified through biochemical analyses, but its in vivo production and functional role remain uncharacterized. In Yersinia pseudotuberculosis and its recent descendant Yersinia pestis, the cnt operon (cntPQRLMI) putatively encodes the biosynthesis and transport of yersinopine. In Y. pestis, however, two frameshift mutations disrupt cntQ, which encodes the predicted permease for yersinopine-metal complexes. This pseudogenization raises critical questions about the functional relevance of yersinopine in these closely related species. Here, we show that cnt operon expression is repressed by the zinc uptake regulator Zur and that both Y. pestis and Y. pseudotuberculosis secrete yersinopine under zinc-limited conditions. Unexpectedly, the operon mediates iron uptake in Y. pseudotuberculosis but supports zinc acquisition in Y. pestis. Moreover, targeted disruption of cntQ in Y. pseudotuberculosis shifts metal specificity from iron to zinc, mimicking the Y. pestis phenotype. Collectively, our results suggest that a single pseudogenization event could rewire metal uptake specificity. Our findings illustrate how evolutionary genome reduction can reshape bacterial physiology.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1583 - 1593"},"PeriodicalIF":4.0,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10534-026-00816-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147925322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between multiple essential trace metal concentrations and risk of hyperuricemia: insights from a central Chinese population 多种必需微量金属浓度与高尿酸血症风险之间的关系：来自中国中部人群的见解。

IF 4 3区生物学

Biometals Pub Date : 2026-05-12 DOI: 10.1007/s10534-026-00826-6

Huiyong Dai, Huan Chen, Chuqing Hu, Minxue Shen, Fei Yang

{"title":"Associations between multiple essential trace metal concentrations and risk of hyperuricemia: insights from a central Chinese population","authors":"Huiyong Dai, Huan Chen, Chuqing Hu, Minxue Shen, Fei Yang","doi":"10.1007/s10534-026-00826-6","DOIUrl":"10.1007/s10534-026-00826-6","url":null,"abstract":"<div>Previous studies have indicated that levels of individual essential trace metals are related to hyperuricemia (HUA), but evidence on their combined effects is limited. To address this gap, the associations of individual and joint levels of 12 essential trace metals (manganese, selenium, nickel, chromium, cobalt, tin, iron, molybdenum, zinc, strontium, vanadium, and copper) with the risk of HUA were investigated in 2,021 adults recruited from Hunan Province, China. Inductively coupled plasma mass spectrometry (ICP-MS) was employed to determine urinary metal concentrations. Logistic regression, Bayesian kernel machine regression (BKMR), and quantile g calculation (Qgcomp) were applied to evaluate the associations of single and mixture metal concentrations with HUA. Of the participants, 516 (25.53%) were diagnosed with HUA. Inverse associations were found between vanadium, chromium, manganese, iron, cobalt, selenium, strontium, and molybdenum levels and HUA, with ORs ranging from 0.63 to 0.91. Conversely, a positive association was observed between zinc concentration and HUA [OR (95% CI): 1.17 (1.01, 1.37)]. Both BKMR and Qgcomp models showed a negative overall effect of essential trace metals on HUA risk, with strontium (− 43.6%) and vanadium (− 27.8%) being the main contributors. In addition, formal interaction tests revealed significant effect modification by age for tin and by BMI for zinc. In conclusion, the levels of essential trace metals were linked to a decreased risk of HUA, and these associations were modified by age and BMI only for specific metals.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1713 - 1729"},"PeriodicalIF":4.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of genotoxicity by the Allium Test of Haplic Chernozem polluted by heavy metals 重金属污染的黑钙土的大蒜试验遗传毒性评价。

IF 4 3区生物学

Biometals Pub Date : 2026-05-09 DOI: 10.1007/s10534-026-00821-x

Tatiana Minnikova, Sergey Kolesnikov, Ekaterina Paramonova, Natalia Evstegneeva

{"title":"Assessment of genotoxicity by the Allium Test of Haplic Chernozem polluted by heavy metals","authors":"Tatiana Minnikova, Sergey Kolesnikov, Ekaterina Paramonova, Natalia Evstegneeva","doi":"10.1007/s10534-026-00821-x","DOIUrl":"10.1007/s10534-026-00821-x","url":null,"abstract":"<div>Soil pollution with heavy metals manifests itself at both organism and genetic levels, as aberrations. Objectives of the research are to assess genotoxicity by the Allium Test of Haplic Chernozem polluted by heavy metals. Haplic Chernozem polluted by Ag, Bi, Te, and Tl through the oxide and nitrate forms for 30 of conditionally permissible concentrations (CPC). Model experiment lasted 10 days. In the time following, the genotoxicity of the soil was assessed using onion plants (Allium cepa L.), variety \"Stuttgart Riesen\". It was revealed that Haplic Chernozem polluted by Ag, Bi, and Tl oxides caused mitotic pathologies stipulated by the effect of these metals on the mitotic apparatus of cells. Ag and Tl oxides, Tl nitrate had the highest genotoxicity by 12—46% (p < 0.05). Non-disjunction of sister chromatids was observed only upon contamination by Ag, Bi, and Tl oxides, namely 3.4%, 3.22%, and 0.88%, respectively. Asymmetric mitosis was expressed only upon soil contamination by silver oxide and amounted to 7.96%. The greatest number of mitosis types were found in soil contaminated with Bi oxide and nitrate, as well as Te oxide and Ag nitrate. Oxides of Te and Bi are the most genotoxic, while Tl and Ag are less toxic. At the same time, Bi and Ag nitrates are more genotoxic than Tl and Te nitrates. Nitrates of Ag, Bi, Te, and Tl led to an increase in pathological mitoses associated with the impairment of the chromosomes themselves, while oxides had a higher total genotoxicity than nitrates. Genotoxic diagnostics of soils contaminated by oxides and nitrates of heavy metal can be used to assess the health and quality of soils after contamination and its safe agricultural use.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1669 - 1679"},"PeriodicalIF":4.0,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering the role of human peroxiredoxins for combating lead and zinc mediated cellular toxicity using a yeast model 利用酵母模型破译人类过氧化物还毒素对抗铅和锌介导的细胞毒性的作用。

IF 4 3区生物学

Biometals Pub Date : 2026-05-08 DOI: 10.1007/s10534-026-00825-7

Rahul Thakur, Reena V. Saini, Sasanka Chakrabarti, Adesh K. Saini

{"title":"Deciphering the role of human peroxiredoxins for combating lead and zinc mediated cellular toxicity using a yeast model","authors":"Rahul Thakur, Reena V. Saini, Sasanka Chakrabarti, Adesh K. Saini","doi":"10.1007/s10534-026-00825-7","DOIUrl":"10.1007/s10534-026-00825-7","url":null,"abstract":"<div>Elevated levels of heavy metals in cells lead to an imbalance of cellular redox homeostasis which is also seen in zinc and lead ion mediated toxicity. Human peroxiredoxins (hPrxI and hPrxII) are central regulators of redox balance; however, their role in mitigating heavy metal-induced stress remains unclear. Previously, we showed that the Saccharomyces cerevisiae model lacking TSA1 and TSA2 (tsa1tsa2Δ) showed growth defects in the presence of redox stressors that can be rescued by expressing hPrxI and hPrxII. In the present study, we utilized the tsa1tsa2Δ strain to understand the role of human homologs metal ion-induced stress. Growth assays demonstrated that ZnCl2 and PbCl2 markedly impaired the growth of tsa1tsa2Δ cells, whereas plasmid-based expression of hPrxI restored growth under both conditions. In contrast, hPrxII expression conferred protection only against ZnCl2 toxicity. Measurements of intracellular reactive oxygen species (ROS) revealed significant accumulation upon ZnCl2 and PbCl2 exposure, which was alleviated by either hPrxI or hPrxII expression. Immunoblotting analyses indicated that hPrxI undergoes a monomer to dimer transition under heavy metal stress, suggesting redox-dependent structural modulation. Notably, catalytic mutants of both hPrxI and hPrxII partially restored growth and reduced ROS levels, demonstrating that their catalytic residues are not essential for conferring protection. These findings highlight isoforms specific and catalysis-independent roles of human peroxiredoxins in counteracting heavy metal-induced oxidative stress.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1699 - 1712"},"PeriodicalIF":4.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose and duration dependent effects of borax on ovarian structure and function in female rats 硼砂对雌性大鼠卵巢结构和功能的剂量和时间依赖性影响。

IF 4 3区生物学

Biometals Pub Date : 2026-05-07 DOI: 10.1007/s10534-026-00827-5

Ozgur Bulmus, Cagla Celebi, Murat Celebi, Funda Gulcu Bulmus, Hasan Susar, Pakize Nur Akkaya, Fatma Bahar Sunay, Izzet Karahan

{"title":"Dose and duration dependent effects of borax on ovarian structure and function in female rats","authors":"Ozgur Bulmus, Cagla Celebi, Murat Celebi, Funda Gulcu Bulmus, Hasan Susar, Pakize Nur Akkaya, Fatma Bahar Sunay, Izzet Karahan","doi":"10.1007/s10534-026-00827-5","DOIUrl":"10.1007/s10534-026-00827-5","url":null,"abstract":"<div>Boron is an essential trace element with emerging physiological significance; however, its effects on the female reproductive system remain poorly characterized. Most available studies are limited to single-dose applications or short-term exposures. In this study, we investigated the dose and duration dependent effects of oral boron exposure on ovarian follicular reserve, apoptosis, and reproductive hormone profiles in female Wistar albino rats. Animals were assigned to low- and high-dose borax groups (1250 and 5000 mg/kg/day, respectively) and exposed for short-term (7 and 15 days) or long-term (30 and 60 days) periods. At the end of each exposure period, ovarian tissues were collected for histomorphometric evaluation, while apoptosis was assessed using the TUNEL assay. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and anti-Müllerian hormone (AMH) were also measured. Histomorphometric analysis revealed a significant reduction in primordial and primary follicle numbers, indicating depletion of the ovarian reserve, particularly in the high-dose and long-term exposure groups. TUNEL analysis demonstrated a marked increase in apoptotic cell density in ovarian tissues following prolonged boron administration. In parallel, boron exposure induced significant dose and duration dependent alterations in circulating reproductive hormone levels. Collectively, these findings suggest that chronic and high-dose oral boron exposure adversely affects ovarian morphology and function through enhanced apoptotic activity and disruption of endocrine homeostasis. These results highlight the potential reproductive toxicity of long-term boron exposure and underscore the need for further molecular studies to clarify the underlying mechanisms and to evaluate the translational relevance of these effects for human female reproductive health.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1731 - 1745"},"PeriodicalIF":4.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of zinc against testicular dysfunction, oxidative stress, and disturbances in biochemical, molecular, and tissue structure induced by hexavalent chromium 锌对六价铬诱导的睾丸功能障碍、氧化应激和生化、分子和组织结构紊乱的保护作用。

IF 4 3区生物学

Biometals Pub Date : 2026-05-05 DOI: 10.1007/s10534-026-00817-7

Ali Y. Naoom, Ali B. Jebur, Raghda A. El-Sayed, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash

{"title":"Protective effects of zinc against testicular dysfunction, oxidative stress, and disturbances in biochemical, molecular, and tissue structure induced by hexavalent chromium","authors":"Ali Y. Naoom, Ali B. Jebur, Raghda A. El-Sayed, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash","doi":"10.1007/s10534-026-00817-7","DOIUrl":"10.1007/s10534-026-00817-7","url":null,"abstract":"<div>One well-known hazardous pollutant that damages testicles in both humans and animals is chromium hexavalent (CrVI). It has been established that zinc (Zn) is essential for spermatogenesis. Thus, the current work examines how Zn might shield rat testis from the detrimental effects of CrVI. Twenty-eight male rats were assigned to four groups the first was the control group; the second was given zinc sulfate (Zn; 1 mg/kg BW); the third received hexavalent chromium (CrVI; 2.5 mg/kg BW); and the fourth served as the protective group (Zn was given 60 min before CrVI). All treatments were given orally every day for four weeks. According to the results, rats intoxicated with CrVI exhibited a considerable decrease in body weight, enzymatic antioxidants, reduced glutathione, hydroxysteroid dehydrogenases (3β HSD, and 17β HSD), aminotransferases, and acid phosphatase activities, and a significant increase in the oxidative stress profile (TBARS, H2O2, PCC, XO, and NO). Testicular Bax, Cas-3, Bcl-2, Beclin-1, Nrf2, hormone levels, sperm quality, histopathological, and P53 immunohistochemical examinations were also shown to have significant changes compared to the control. Besides that, Zn pretreatment before CrVI intoxication improved the architecture of testicular tissue and P53 expression. Also, it significantly restored the majority of biochemical and molecular markers compared to the CrVI group. Additionally, oxidative stress indicators showed a notable change in response to individual Zn intake compared to the control. In conclusion, Zn significantly protects against CrVI-induced testicular failure, making it a unique strategy for processing heavy metal poisoning.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1595 - 1611"},"PeriodicalIF":4.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Siderophore-metal complexes in Paraburkholderia phymatum: structure elucidation of phymabactin 芽肿副叶氏菌中的铁载体-金属配合物：芽胞蛋白的结构解析。

IF 4 3区生物学

Biometals Pub Date : 2026-05-04 DOI: 10.1007/s10534-026-00823-9

Luca Bürgi, Daphné Golaz, Gabriella Pessi, Laurent Bigler

{"title":"Siderophore-metal complexes in Paraburkholderia phymatum: structure elucidation of phymabactin","authors":"Luca Bürgi, Daphné Golaz, Gabriella Pessi, Laurent Bigler","doi":"10.1007/s10534-026-00823-9","DOIUrl":"10.1007/s10534-026-00823-9","url":null,"abstract":"<div>The symbiotic interaction between rhizobia and host plants takes place inside root nodules. Besides reducing atmospheric nitrogen into ammonium, which is then used by the plant to grow in nitrogen-deficient soils, certain rhizobia produce siderophores which enable iron uptake from the soil. Siderophores are strong iron chelators due to their hydroxamate, catecholate or carboxylate functional groups. In this work, the siderophores of the beta-rhizobial genus Paraburkholderia were analyzed by ultra-high-performance liquid chromatography (UHPLC) coupled to high-resolution mass spectrometry (HRMS). In particular, the production of the novel siderophore phymabactin by Paraburkholderia phymatum was confirmed and the structures of eleven derivatives were elucidated by tandem mass spectrometry (MS/MS) and nuclear magnetic resonance (NMR) spectroscopy. Phymabactins, consisting of a linear tetrapeptide backbone with hydroxamate and hydroxy-carboxylate groups, are structurally closely related to an already described family of siderophores called ornibactins. The acyl chain found in phymabactin derivatives is made up of eight, ten or twelve carbon atoms, contrarily to the more hydrophilic ornibactin derivatives with shorter acyl chains. Interestingly, spontaneous metal complexation of phymabactin derivatives with aluminum was observed. To explore this complexation in more detail, the collision cross sections (CCS) of phymabactins, ornibactins and corresponding metal complexes were determined by trapped ion mobility spectrometry. The CCS values of aluminum-phymabactin complexes were smaller than those of iron-phymabactin complexes, while an inverse relationship was observed for ornibactin complexes. In summary, this study discloses the molecular structures of phymabactins and investigates their metal complex formation.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1681 - 1697"},"PeriodicalIF":4.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategies 化疗中的铂积累：毒性机制、挑战和缓解策略。

IF 4 3区生物学

Biometals Pub Date : 2026-04-29 DOI: 10.1007/s10534-026-00812-y

Yier Lai, Guodong Qiu, Zhiwei Zheng, Xiaoting Huang, Pi Guo, Yuling Zhang, Ling Fang

{"title":"Platinum accumulation in chemotherapy: toxicity mechanisms, challenges, and mitigation strategies","authors":"Yier Lai, Guodong Qiu, Zhiwei Zheng, Xiaoting Huang, Pi Guo, Yuling Zhang, Ling Fang","doi":"10.1007/s10534-026-00812-y","DOIUrl":"10.1007/s10534-026-00812-y","url":null,"abstract":"<div>Platinum-based chemotherapeutic agents constitute the cornerstone of treatment for a wide range of solid tumors. However, residual platinum can persist in the body long after treatment cessation, leading to progressive accumulation, chronic multi-system toxicity, and significant impairment of patients' quality of life. The insidious onset and lack of specific monitoring methods often lead to the oversight of this treatment-related metal accumulation toxicity. This article reviews the environmental and occupational exposure risks of platinum, its unique pharmacokinetic properties, and elucidates how its irreversible binding to proteins and accumulation within mitochondria form the chemical basis for its long-term toxicity. It further elaborates on the core mechanisms underlying platinum accumulation-mediated multi-organ toxicity, including nephrotoxicity, neurotoxicity, and ototoxicity. The aim is to provide insights and directions for improving the long-term prognosis of cancer survivors by clarifying the toxicological mechanisms, clinical impacts, and future strategies for mitigating platinum-induced metal accumulation.</div>","PeriodicalId":491,"journal":{"name":"Biometals","volume":"39 5","pages":"1281 - 1301"},"PeriodicalIF":4.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10534-026-00812-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0