Journal of Sport and Health Science最新文献

{"title":"Beyond the scale: Strengthening the role of physical activity in obesity care.","authors":"Mariz Rochelle Canonigo Sedon","doi":"10.1016/j.jshs.2026.101147","DOIUrl":"10.1016/j.jshs.2026.101147","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101147"},"PeriodicalIF":13.1,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher’s Note to “Effects of different types of exercise over 24 weeks on bone mineral density in postmenopausal women: A systematic review with pairwise and network meta-analysis of randomized controlled trials” [21 April 2026]","authors":"Zhining Zhou, Xiaoyu Wei, Xinwen Zhang, Barbara E. Ainsworth, Jiaojiao Lü, Yu Liu","doi":"10.1016/j.jshs.2026.101145","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101145","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"102 1","pages":"101145"},"PeriodicalIF":11.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148286123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction.","authors":"Graeme J Koelwyn, Sayyed Hamed Shahoei, Courtenay Graham, Geoffrey M Nonis, Milad Vahedi, Puneet Sidhu, Emily J Brown, Alireza Khodadadi-Jamayran, Juan Liu, Elisa De Stanchina, Kathryn J Moore, Jason W Locasale, Erik R Nelson, Lee W Jones","doi":"10.1016/j.jshs.2026.101146","DOIUrl":"10.1016/j.jshs.2026.101146","url":null,"abstract":"<p><strong>Background: </strong>Exercise links with improved cancer outcomes following a diagnosis of primary breast cancer but experimental evidence and molecular mechanistic interrogation from preclinical studies are limited. The purpose of this study was to evaluate the effects, and dose‒response, of exercise in mouse models of breast cancer, as well as elucidate cancer cell extrinsic and intrinsic responses.</p><p><strong>Methods: </strong>Independent in vivo modeling was used to investigate the effects of exercise across distinct breast cancer models. Unbiased transcriptomic and metabolomic analyses, alongside cellular and proteomic interrogation, were used to determine tumor microenvironment (TME)- and cancer cell-specific effects.</p><p><strong>Results: </strong>Exercise inhibited breast cancer growth and metastasis across multiple syngeneic mouse models compared to sham control. Tumor growth inhibition was independent of estrogen receptor status, and in the 4T1 model, exercise exerted non-dose-dependent effects. In the Met1 model, exercise decreased TME immune cell content, particularly tumor-associated macrophages, while promoting an activated anticancer innate immune cell gene signature. Concurrent in vivo cancer cell-intrinsic effects were characterized by broad transcriptomic reprogramming including downregulation of metabolic pathways and upregulation of pathways regulating proliferation and apoptosis. Whole tumor metabolomic analyses unveiled broad shifts including decreased nicotinamide adenine dinucleotide (NAD+) and lactate, as well as availability of biosynthetic precursors. Finally, in silico analyses identified TME ligands, such as High Mobility Group Box 2 (HMGB2) and Cardiotrophin-1 (CTF1) as candidate drivers of downstream gene expression changes in cancer cells.</p><p><strong>Conclusion: </strong>Exercise suppresses breast cancer progression, which occurs in conjunction with broad reprogramming of immune TME-cancer processes and their interaction.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101146"},"PeriodicalIF":13.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147976096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning approach predicts improvement of physical exercise capacity based on pulse wave analysis in coronary artery disease patients.","authors":"Hendrik Schäfer, Vassilis Tsakanikas, René Garbsch, Mona Kotewitsch, Marc Teschler, Dimitris Gatsios, Dimitrios I Fotiadis, Frank C Mooren, Boris Schmitz","doi":"10.1016/j.jshs.2026.101144","DOIUrl":"10.1016/j.jshs.2026.101144","url":null,"abstract":"<p><strong>Background: </strong>Patients with stable coronary artery disease (CAD) have a residual risk of adverse events and all-cause mortality. Enhancing exercise capacity by exercise training (ET) during cardiac rehabilitation (CR) is a Class 1A guideline recommendation. However, there is a high number of ET non-responders (NR) in CR. We aimed to develop a machine learning (ML) prediction model for the early identification of NR using baseline cardiopulmonary exercise testing (CPET) and pulse wave analysis (PWA) data.</p><p><strong>Methods: </strong>Participants included 393 CAD patients after myocardial infarction and/or percutaneous coronary intervention and/or coronary artery bypass graft who underwent 3-4 weeks of CR; CPET was conducted at the beginning and end of CR. Responders (R) were defined as participants who demonstrated an increase in exercise capacity (peak oxygen uptake (V̇O₂_peak)) greater than 1 typical error away from 0, all other patients were defined as NR. Only baseline data including diagnosis, medication, PWA, and CPET data were used for modeling, and ML models included 10 different supervised algorithms. The dataset was split into training and test sets, and 10-fold cross-validation was used. Recursive Feature Elimination was used for feature selection to reduce dimensionality and improve generalizability. Independent external validation was performed in a dataset of CAD patients (n = 120) enrolled at 2 different centers (Germany and Spain). Predictions were explained using the model-agnostic SHapley Additive exPlanation methodology.</p><p><strong>Results: </strong>After data cleaning, 353 patients (20.4% women) with age of 55.8 ± 7.1 years (mean ± SD) were included for analysis, and 225 patients (63.7%) were classified as NR (22% women; age = 56.2 ± 7.1 years). ET participation rates were similar (R: 93.6% ± 7.5%; NR: 92.6% ± 9.3%; p = 0.764). For the prediction model, the Random Forest classifier provided the best mean balanced accuracy of 77.0%. The most influential features were breathing reserve/frequency, oxygen uptake combined with pulse wave velocity, cardiac output, and augmentation time. Of note, primary diagnosis and disease severity had only limited influence on the model. External validation of the Random Forest model showed 82.8% accuracy, with high specificity and moderate sensitivity in long-term outcome prediction.</p><p><strong>Conclusion: </strong>The developed ML-based model enables an early identification of ET NR, allowing individual patient-centered ET adaptations to improve CR.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101144"},"PeriodicalIF":13.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13475370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-induced musclin enhances efferocytosis via metabolic reprogramming to alleviate periprosthetic joint infection.","authors":"Zhiwei Fu, Jintao Wu, Shutao Zhang, Juyang Jiao, Qimin Hong, Yihan Wang, Liangjun Zheng, Xinhua Qu, Bing Yue","doi":"10.1016/j.jshs.2026.101143","DOIUrl":"10.1016/j.jshs.2026.101143","url":null,"abstract":"<p><strong>Background: </strong>In periprosthetic joint infection (PJI), impaired macrophage efferocytosis limits bacterial clearance and sustains inflammation. Clinical therapies for restoring macrophage efferocytosis in the infectious microenvironment are limited. Here, we elucidate the mechanistic links between regular exercise, musclin release, and macrophage efferocytosis.</p><p><strong>Methods: </strong>We established a murine PJI model to investigate the therapeutic potential of regular exercise. Agar plate colony counting, histological assessment, immunofluorescence staining, radiographic evaluation, and micro-CT were employed to assess bacterial burden, inflammation, tissue fibrosis, and the extent of osteolysis. Bulk RNA sequencing was performed to identify key exercise-responsive molecules. Flow cytometry, immunoprecipitation coupled with mass spectrometry, Seahorse metabolic analysis, and genetic overexpression and inhibition techniques were used to reveal the impacts on macrophage efferocytosis and metabolism. Finally, we evaluated the synergistic therapeutic effects of a key exercise-associated secretory protein combined with antibiotics in PJI mice.</p><p><strong>Results: </strong>Regular exercise significantly alleviated bacterial burden and inflammatory osteolysis in PJI mice. The exogenous administration of musclin-identified as a key exercise-responsive myokine-replicated the protective effects of exercise, with the core mechanism involving restoration and enhancement of macrophage efferocytosis. Mechanistically, musclin bound to formyl peptide receptor 2 (FPR2) on macrophages to reprogram their metabolic phenotype, significantly suppressing the glycolytic pathway while restoring oxidative phosphorylation. Therefore, FPR2-mediated metabolic reprogramming was crucial for enhancing efferocytotic capacity. Furthermore, combination therapy of musclin and oxacillin synergistically reduced bone destruction and tissue fibrosis, while being associated with partial restoration of adaptive immunity.</p><p><strong>Conclusion: </strong>Musclin mitigates PJI by enhancing macrophage efferocytosis via FPR2-mediated metabolic reprogramming. By revealing the mechanism through which exercise ameliorates PJI and establishing musclin as a promising therapeutic candidate, this study provides new strategies for the prevention and treatment of PJI.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101143"},"PeriodicalIF":13.1,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biceps femoris long-head motor unit discharge rates and recruitment thresholds vary across 9 weeks of eccentric training","authors":"Max H. Andrews, Eduardo Martinez-Valdes, Glen A. Lichtwark, Patricio A. Pincheira","doi":"10.1016/j.jshs.2026.101142","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101142","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"23 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the aerobic-first paradigm: Optimizing functional capacity through combined aerobic and resistance training in heart failure","authors":"Wenfei Zhu, Jiaming Yan, Yuliang Sun","doi":"10.1016/j.jshs.2026.101139","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101139","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"21 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional reallocations of sitting time, physical activity, and sleep in relation to risk of all-cause mortality and cardiovascular disease: An analysis of the Prospective Urban Rural Epidemiology (PURE)-China cohort study","authors":"Yilin Huang, Jun Hao, Bo Hu, Yang Wang, Lap Ah Tse, Weida Liu, Qiujing Cai, Biyan Wang, Zhiguang Liu, Tong Bu, Sumathy Rangarajan, Scott A. Lear, Wei Li, PURE-China Investigators","doi":"10.1016/j.jshs.2026.101140","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101140","url":null,"abstract":"Prolonged sedentary time is associated with adverse outcomes, but evidence in low-exposure ranges remains limited. The health effects of reallocating time between sitting, physical activity, and sleep have not been comprehensively examined.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"33 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of resisted movement training on change-of-direction speed in recreationally active and trained individuals: A systematic review with network meta-analysis and meta-regression","authors":"Mingyang Zhang, Urs Granacher, Ruixiang Yan, Hallvard Nygaard Falch, Rodrigo Ramirez-Campillo, Kai Xu, Xing Zhang, Jinming Li, Shubo Xu, Yulin Luo, Duanying Li, Jian Sun","doi":"10.1016/j.jshs.2026.101141","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101141","url":null,"abstract":"The ability to change directions quickly is critical for performance and injury prevention in multidirectional sports, yet the influence of resisted movement training (R-MT) on change-of-direction (COD) speed remains uncertain. Therefore, we aimed to examine the effectiveness of various R-MT methods on COD speed in individuals ranging from recreational to international level and to determine the relationship between test angle and COD adaptations.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"67 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise-based interventions for smoking cessation: A systematic review and meta-analysis.","authors":"Ben Singh,Jasmine Petersen,Aaron Miatke,Dot Dumuid,Kimberley Szeto,Kylie A Dankiw,Maddison L Mellow,Sowmya Jayatheertha Vaikar,Emily Eglitis,Mason Zhou,Rachel Curtis,Catherine Simpson,Joshua Hassan,Serhat Kavlakoglu,Lochlan Gotch,Carol Maher","doi":"10.1016/j.jshs.2026.101138","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101138","url":null,"abstract":"BACKGROUNDTobacco smoking and e-cigarette use remain major global public health challenges, with current cessation strategies often limited by poor adherence, modest effectiveness, and accessibility barriers. Exercise is a promising behavioral strategy for nicotine cessation, but its effects on smoking and vaping outcomes are unclear. This systematic review and meta-analysis aimed to synthesize evidence on the effects of single-bout and long-term exercise interventions on smoking and vaping cessation, cravings, withdrawal symptoms, and mood in adults.METHODSEleven databases were searched up to March 28, 2025. Eligible studies were randomized controlled trials (RCTs) evaluating exercise interventions in adults reporting smoking- or vaping-related outcomes. Outcomes included continuous and point prevalence abstinence, cigarette consumption, and cravings. Risk of bias (ROB2) and certainty of evidence (Grading of Recommendations Assessment, Development and Evaluation (GRADE)) were assessed. Random-effects meta-analyses and subgroup analyses were conducted.RESULTSFifty-nine RCTs (n = 9083) were included: 43 exercise training studies (n = 8548) and 16 single-bout studies (n = 535). Exercise training increased continuous abstinence (risk ratio (RR) = 1.15; 95% confidence interval (95%CI): 1.01‒1.32; p = 0.04; 23 RCTs; n = 5512) and 7-day point prevalence abstinence (RR = 1.21; 95%CI: 1.03 to 1.43; p = 0.02; 18 RCTs; n = 4455), and reduced cigarettes/day (mean difference = -2.12; 95%CI: -3.30 to -0.93). Single-bout exercise reduced acute cravings immediately and up to 30 min post-exercise (standardized mean difference range: -0.88 to -0.52) but not longer-term cravings. Aerobic exercise improved continuous abstinence in training studies, while higher-intensity bouts produced greater craving reductions in single-bout studies. Evidence for resistance training, yoga, and other non-aerobic modalities was more limited but suggested potential benefits for cravings and smoking outcomes, although data were insufficient for modality-specific pooled estimates. No trials assessed vaping cessation outcomes.CONCLUSIONExercise is associated with modest improvements in cigarette consumption and acute suppression of cravings, supporting its potential as a low-risk behavioral aid for nicotine cessation. Future research should target vaping-specific outcomes and optimal intervention delivery. Exercise represents a promising smoking cessation intervention.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"21 1","pages":"101138"},"PeriodicalIF":11.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}